• 인간행동과 음악연구
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• 제9권1호
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• pp.37-53
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• 2012

본 연구는 성인 정신보건센터의 성인들을 위한 임상 음악치료에서 음악적 표현 동기의 과정과 패턴을 분석하기 위하여 수행되었다. 참가자들은 27에서 53세 사이의 1년 이상 음악치료를 경험한 8명의 의도 표집된 정신보건센터 회원들이였다. 주요 범주와 분석은 Strauss와 Corbin의 근거이론 방법에 의하여 이루어졌다. 질적 분석 결과 음악치료에서 자발적 음악표현 동기는 치료사와 세션에서 사용되는 노래에 의해 결정된다. 치료사의 친화적 태도, 높은 음악적 역량, 선곡된 노래의 친숙성 그리고 선곡된 노래 가사에 대한 의미부여가 중심현상의 인과적 조건으로 작용한다. 이때 음악치료사에 대한 전문인으로서 인격적, 음악적 신뢰도 정도와 세션에서 사용된 노래의 긍정적 환기가 맥락적 조건으로 작용한다. 음악치료에서 자발적 음악 표현은 공감이라는 중재조건을 통해 현실 도피, 스트레스 해소 그리고 나눔이라는 작용을 일으키며 이것은 무드조절, 희망의 고취 그리고 집단 응집력이라는 결과를 가져왔다. 음악치료에서 참여 동기 유형은 3가지로 내재적 동기, 관계 의존적인 외재적 동기 그리고 회피적 동기유형이 발견되었다.

• 대한불안의학회지
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• 제12권1호
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• pp.13-20
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• 2016

Objective : The purpose of this study was to verify the differences of expressed character strengths graded as per the Korean Strength Scale, based on the type of work. Methods : A total of 2,444 conglomerate workers were classified into two groups: 1,356 office workers and 1,088 production workers. The subjects were examined through a web or mobile application based on the Korean Strength Scale. The Korean Strength Scale consists of a total of four top entries and 25 sub-items with appropriate validity. Results : The difference in the average score of sum of character strengths between the two groups was not significant. In the office worker group, character strengths such as love of learning, creativity, perspective, curiosity, facilitation, judgment and faith had significantly high scores. On the other hands, modesty, hope, gratitude, sincerity, magnanimity and self-regulation were high in the production worker group. The results remained unchanged in additional analysis of covariants as sex, age and education level, except for self-regulation and faith. Conclusion : Our results suggest significant differences in the character strengths between the two types of work; however, the average of sum of character strength score remains unchanged. These results may help to understand differences between work environments and thus help to establish a positive foundation.

• 대한불안의학회지
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• 제15권2호
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• pp.122-126
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• 2019

Objective : Dynamic proteolysis, through the ubiquitin-proteasome system, is an important molecular mechanism for the constant regulation of synaptic plasticity and stress responses in humans. In this study, we examined whether genetic variants in the ubiquitin-specific peptidase (USP) genes were associated with psychological traits of resilience and susceptibility to neuropsychiatric disorders for each gender. Methods : A total of 344 Korean healthy youths (190 males, 154 females) were included in the study. A genotyping of rs2241646 of USP2 and rs346006 of USP46 was performed. The Connor-Davidson Resilience Scale and Brief Fear of Negative Evaluation Scale were administered for measuring trait resilience and social anxiety, respectively. The genetic associations of the USP variants were tested using multiple analyses of covariance with psychological traits as dependent variables after controlling for age in each gender. Results : For USP2 rs2241646, women with the TT genotype showed significantly higher resilience and lower social anxiety, as compared to those carrying the C allele. There were no associations between USP46 rs346005 and the psychological traits in both genders. Conclusions : The present study showed a possible genetic association between the USP2 rs2241646 and stress resilience and trait anxiety in women. The findings suggest that ubiquitin-proteasome system may be related to the resilience and susceptibility to stress-related neuropsychiatric disorders such as anxiety disorders, possibly through the regulation of dynamic proteolysis responses to stress.

• 정신신체의학
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• 제6권2호
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• pp.221-227
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• 1998

Although there has been a considerable research in psychoneuroendocrinology, particularly in relation to the biology of mood disorders, there has been a paucity of research regarding the effects of psychological factors on endocrine diseases. Of the existing literature, the most research is focused on diabetes mellitus, graves' disease. Especially diabetes appears to be the only endocrine disease that has been the focus of recent research studies. Most of the studies had retrospective designs or several methodological flaw. There has been no consistent results demonstrating that psychological factors affect the onset of diabetes mellitus. Several studies have suggested that psychological factors affect the course of diabetes. A small number of studies showed some evidence that psychological stress was associated with changes in glucose regulation in a subset of diabetic patients. There was also evidence to suggest that some temperament and coping skill influence glycemic control in child, adolescent diabetics. Studies of behavioral or psychosocial intervention on diabetic control have been small and have produced mixed results. There was a few controlled study suggested that stressful life events might be a causal role in Cushing's disease and Graves'disease, but there is no presently sufficient evidence to suggest that psychological factors affect the onset and the course of Cushing's disease and Graves' disease. In future, there is need for a well-designed biopsychosocial research with prospective designs, well defined patient population and control groups to study the relationship between psychological factors and endocrine diseases.

• 혜화의학회지
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• 제8권2호
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• pp.133-152
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• 2000

1. At the Menstruation Period, the uterus is easy to be invaded by a toxin because of its patency. Take cleanliness and hygiene into consideration. 2. At the Menstruation Period, much attention must be paid at the regulation of coldness and heat to harmonize the Menstruation. 3. At the Menstruation Period, excessive exercise must be avoided. Appropriate labor can help the circulation of vital energy & blood and reinforce the immunity of body. 4. The nourishing, plain, warming, digestible food is good at the Menstruation Period. Hot, stenched, stimulating food must be avoided and nuts & water fruit must not be overeaten. 5. At the Menstruation Period, sharpness & excessiveness of emotion must be avoided and a comfortable mood must be maintained. Especially premenstrual or postmenstrual period, peaceful spirit and sufficient sleep must be kept. 6. Women generally feel uncomfortable at the Menstruation Period, but it disappears spontaneously after menstruation. Don't take an overdose of medicine because it can disturb the normal condition.

• 대한불안의학회지
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• 제11권2호
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• pp.155-161
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• 2015

Objective : The purpose of this study was to verify the effect of a single-session, positive psychology-based, strength-enhancing workshop for psychiatrists. The program is composed of lecture about positive psychology and workshop activities for identifying and utilizing character strengths. Methods : A total of 42 psychiatrists participated in this study. The program consisted of a lecture about positive psychology and workshop activities for identifying and utilizing character strengths. Results of a positive resources test, given before and after the session, were used to assess changes in the personal positive resources of the participants as a result of the program. Results : We noted significant increases in participants' satisfaction with life, positive affect, gratitude, acceptance, positive and cognitive emotion regulation, orientation of life, growth, spirit, autonomy, social support, and care factors after completion of the program. On additional analysis, spirit and care scores of female participants's were significantly increased than male participants's. Conclusion : The findings are meaningful in verifying the efficacy of a short-term intervention to improve psychiatrists's positive resources.

• 대한간호학회지
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• 제27권2호
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• pp.329-340
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• 1997

Resourcefulness was analyzed by Walker and Avant's method to make a theoretical framework for nursing. Also, the appropriate Korean terminology was identified.“Resourcefulness”means the ability to use internal and external resources to eliminate or to control stress. '자원동원성' is chosen to be the most appropriate term to reflect the concept of resourcefulness. Upon the concept analysis, availability, controllability, confidence, and self-instruction were identified as the defining characteristics of resourcefulness. Contrary to other work, "availability" means the ability to use the social resources as well as the internal cognitive-behavioral resources. “Controllability” means the ability to delay or control immediate gratification of one's needs or to divert one's own mood in order to solve problem. "Confidence" is the self-efficacy belief in one's control ability. "Self-instruction" is the cognitive ability to instruct oneself positively. Resourcefulness is learned by active experience, vicarious experience, and formal or informal instruction, and it is cued in the presence of a stressful situation or a need for change. As a result of the use of resourcefulness, the target behavior performed immediately and ultimately improve the quality of life or adaptation. Therefore, it is necessary to develop the instrument including the defining attributes identified in this study. Also, it is necessary to simultaneously analyze the related concepts of self-efficacy, self-control, and self-regulation for appropriate use.

• Biomolecules & Therapeutics
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• 제19권1호
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• pp.1-8
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• 2011

G-protein coupled receptors (GPCRs) constitute an important class of drug targets and are involved in every aspect of human physiology including sleep regulation, blood pressure, mood, food intake, perception of pain, control of cancer growth, and immune response. Radiometric assays have been the classic method used during the search for potential therapeutics acting at various GPCRs for most GPCR-based drug discovery research programs. An increasing number of diverse small molecules, together with novel GPCR targets identified from genomics efforts, necessitates the use of high-throughput assays with a good sensitivity and specificity. Currently, a wide array of high-throughput tools for research on GPCRs is available and can be used to study receptor-ligand interaction, receptor driven functional response, receptor-receptor interaction,and receptor internalization. Many of the assay technologies are based on luminescence or fluorescence and can be easily applied in cell based models to reduce gaps between in vitro and in vivo studies for drug discovery processes. Especially, cell based models for GPCR can be efficiently employed to deconvolute the integrated information concerning the ligand-receptor-function axis obtained from label-free detection technology. This review covers various platform technologies used for the research of GPCRs, concentrating on the principal, non-radiometric homogeneous assay technologies. As current technology is rapidly advancing, the combination of probe chemistry, optical instruments, and GPCR biology will provide us with many new technologies to apply in the future.

• BMB Reports
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• 제56권10호
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• pp.527-536
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• 2023

Serotonin receptors, also known as 5-HT receptors, belong to the G protein-coupled receptors (GPCRs) superfamily. They mediate the effects of serotonin, a neurotransmitter that plays a key role in a wide range of functions including mood regulation, cognition and appetite. The functions of serotonin are mediated by a family of 5-HT receptors including 12 GPCRs belonging to six major families: 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₅, 5-HT₆ and 5-HT₇. Despite their distinct characteristics and functions, these receptors' subtypes share common structural features and signaling mechanisms. Understanding the structure, functions and pharmacology of the serotonin receptor family is essential for unraveling the complexities of serotonin signaling and developing targeted therapeutics for neuropsychiatric disorders. However, developing drugs that selectively target specific receptor subtypes is challenging due to the structural similarities in their orthosteric binding sites. This review focuses on the recent advancements in the structural studies of 5-HT receptors, highlighting the key structural features of each subtype and shedding light on their potential as targets for mental health and neurological disorders (such as depression, anxiety, schizophrenia, and migraine) drugs.

• 정신신체의학
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• 제26권2호
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• pp.164-171
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• 2018

연구목적 우울증은 흔한 정신 질환이며 자살의 주요 원인이다. 혈청 지질이 우울증, 자살과 연관이 있다는 연구가 지속되어 왔으나 아직 논란의 여지가 있다. 본 연구에서는 우울감을 주호소로 입원한 환자를 대상으로 우울과 자살, 혈청 지질과의 연관성을 조사하였다. 방 법 134명의 연구대상자를 자살 비시도자 86명, 자살 시도자 48명으로 분류하여 혈청 지질 수치, 간이정신상태 검사 II (KSCL95) 하위 항목 점수를 비교하였다. 또한 지질과 KSCL95 하위 항목의 상관 관계를 조사하였고, 혈청 지질이 자살 시도의 위험 요인으로 작용하는지 알아보았다. 결 과 두 집단은 서로 혈청 지질의 차이를 보이지 않았으나, KSCL95 하위 항목 중 강박증(obsession, OBS)이 자살 비시도군에서 더 높게 나타났다. 중성지방은 우울(depression, DEP), 공포 불안(phobic anxiety, PHOB), 광장 공포(agoraphobia, AGO), 정신증(schizophrenia, SCH), 낮은 자기 조절력(self-regulation problem, RGP) 항목과 양의 상관 관계를 보였다. 혈청 지질 중 높은 중성 지방이 자살 시도의 위험 요인으로 확인되었다. 결 론 중성 지방이 우울, 불안, 자기 조절감과 관련이 있으며, 높은 혈청 중성 지방 농도는 자살 시도의 위험 요인으로 작용하고 있음을 확인하였다.