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http://dx.doi.org/10.22722/KJPM.2018.26.2.164

The Relationship between Suicide Attempts and Serum Lipids in Patients Admitted with Depression  

Park, Sun Hong (Department of Psychiatry, Konyang University Hospital)
Kim, Seung-Jun (Department of Psychiatry, Konyang University Hospital)
Kim, Ji-Woong (Department of Psychiatry, Konyang University Hospital)
Oh, Hong-Seok (Department of Psychiatry, Konyang University Hospital)
Lee, Sang Min (Department of Psychiatry, Kyung Hee University Hospital)
Jun, Jin Yong (Department of Psychiatry, National Center for Mental Health)
Im, Woo Young (Department of Psychiatry, Konyang University Hospital)
Publication Information
Korean Journal of Psychosomatic Medicine / v.26, no.2, 2018 , pp. 164-171 More about this Journal
Abstract
Objectives : Depression is a common mental illness and a major cause of suicide. Although serum lipids have been associated with depression and suicide, there has been much debate. In this study, we investigated the relationship between depression, suicide, and serum lipids in patients admitted with depressed mood. Methods : A total of 134 subjects were divided into 86 non-suicide patients and 48 suicide attempters. The serum lipid levels and sub-scores of the Korean Symptom Checklist-95 (KSCL95) were compared. We also investigated the relationship between serum lipids and sub-scores of KSCL95 and investigated whether serum lipids were risk factors for suicide attempts. Results : There was no difference in serum lipids between the two groups. Among the sub-items of KSCL95, obsession was higher in non-suicide group. Triglyceride showed positive correlations with anxiety, phobic anxiety, agoraphobia, schizophrenia, and self-regulation problem. High triglyceride was a risk factor for suicide attempts. Conclusions : Triglyceride is associated with depression, anxiety, and self - regulation, and high serum triglyceride levels may be a risk factor for suicide attempts.
Keywords
Depression; Suicide; Self-mutilating behavior; Suicide-related behavior; Serum lipid; Triglyceride; Cholesterol;
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  • Reference
1 Status. OohotiH: OECD (2018), Suicide rates (indicator).
2 2018 KNSO. 2017 death and cause of death in Korea.
3 Bradvik L, Mattisson C, Bogren M, Nettelbladt P. Long-term suicide risk of depression in the Lundby cohort 1947-1997--severity and gender. Acta Psychiatr Scand 2008;117: 185-191.   DOI
4 McGirr A, Renaud J, Seguin M, Alda M, Turecki G. Course of major depressive disorder and suicide outcome: a psychological autopsy study. J Clin Psychiatry 2008; 69:966-970.   DOI
5 Holma KM, Melartin TK, Haukka J, Holma IA, Sokero TP, Isometsa ET. Incidence and predictors of suicide attempts in DSM-IV major depressive disorder: a five-year prospective study. Am J Psychiatry 2010;167:801-808.   DOI
6 Suominen K, Haukka J, Valtonen HM, Lonnqvist J. Outcome of patients with major depressive disorder after serious suicide attempt. J Clin Psychiatry 2009;70: 1372-1378.   DOI
7 Eon HJ. Epidemiologic studies on depression and suicide. J Korean Med Assoc 2012;55:322-328.   DOI
8 Muldoon MF, Manuck SB, Matthews KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ 1990; 301:309-314.   DOI
9 Stewart RA, Sharples KJ, North FM, Menkes DB, Baker J, Simes J. Long-term assessment of psychological well-being in a randomized placebo-controlled trial of cholesterol reduction with pravastatin. The LIPID Study Investigators. Arch Intern Med 2000;160:3144-3152.   DOI
10 Wu S, Ding Y, Wu F, Xie G, Hou J, Mao P. Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies. J Psychiatry Neurosci: JPN 2016;41:56-69.   DOI
11 Young-Xu Y, Chan KA, Liao JK, Ravid S, Blatt CM. Longterm statin use and psychological well-being. J Am Coll Cardiol 2003;42:690-697.   DOI
12 Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry 2007;68:1056-1061.   DOI
13 Prevention. MoHaWKCfDCa. Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII-1). http://knhanescdcgokr/. 2017:250-253.
14 Daigle MS, Cote G. Nonfatal suicide-related behavior among inmates: testing for gender and type differences. Suicide Life Threat Behav 2006;36:670-681.   DOI
15 Jeon HJ. Depression and suicide. J Korean Med Assoc 2011; 54:370-375.   DOI
16 Kwon SJ. Implementation guidelines of Korean-Symptom Check List95 (KSCL95). Jung Ang Juk Sung Publisher;2015. p.5-26.
17 Roh SJ, Kim HN, Shim U, Kim BH, Kim SJ, Chung HW, Lee H, Sung YA, Kim HL. Association between blood lipid levels and personality traits in young Korean women. PloS One 2014;9:e108406. Available from URL:https://journals.plos. org/plosone/article?id=10.1371/journal.pone.0108406.   DOI
18 Sutin AR, Terracciano A, Deiana B, Uda M, Schlessinger D, Lakatta EG, Costa PT, Jr. Cholesterol, triglycerides, and the Five-Factor Model of personality. Biol Psychol 2010;84:186-191.   DOI
19 Hong HJ, Min SK, Koh KB, Kim JH. Relationship between Serum Lipids and Psychiatric Symptoms. Korean J Psychopharmacol 1999;10:120-129.
20 Peter H, Hand I, Hohagen F, Koenig A, Mindermann O, Oeder F, Wittich M. Serum cholesterol level comparison: control subjects, anxiety disorder patients, and obsessive-compulsive disorder patients. Can J Psychiatry 2002;47:557-561.   DOI
21 Brunner J, Bronisch T, Pfister H, Jacobi F, Hofler M, Wittchen HU. High cholesterol, triglycerides, and body-mass index in suicide attempters. Arch Suicide Res 2006;10:1-9.   DOI
22 Jun TY, Toh KY, Jeong JH, Kweon YS, Kim SS. Serum Cholesterol and Violent Behavior in Psychiatric Inpatients. J Korean Neuropsychiatr Assoc 1998;37:878-884.
23 Oh J, Kim TS. Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014. J Affect Disord 2017; 213:51-58.   DOI