• 한국식품과학회지
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• 제22권2호
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• pp.221-226
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• 1990

어육을 발효하여 정미성분 생산 가능성을 검토하기 위하여 명태육에 전분을 첨가한 발효기질에 8종의 곰팡이를 접종, 발효하여 성분의 변화를 검토하였다. 시험에 사용한 균주는 모두 어육발효 배지에서 왕성히 증식하였고, $30^{\circ}C$에서 48시간 배양 이후 특징적인 포자를 형성하였으며, 냄새는 균종에 따라 각각 다른 양상을 보였다. 발효어육의 $NH_2-N$ 함량은 명태육에 비하여 25-26배, Ex-N은 6-15배 증가하였고, 명태육으로부터 ADP 생성능력이 높은 균주는 IMP와 GMP 생성능력도 높았다. 발효어육 중의 유리아미노산은 사용균주에 따라 차이는 있으나 일반적으로 lysine 함량이 가장 높고 arginine, glutamic acid, leucine, alanine 순이었다. 발효어육 추출액의 관능검사한 핵산 관련물질, $NH_2-N$ 및 Ex-N의 함량과 아미노산 조성 등을 종합적으로 검토할 때 어육발효에 비교적 우수한 균주는 Aspergillus oryzae KFCC 11371, Asp. oryzae KFCC 32343, Penicillium roqueforti KFCC 11269 및 Asp. quercinus KFCC 11956이었다.

• Clinical and Experimental Pediatrics
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• 제56권6호
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• pp.247-253
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• 2013

Purpose: In children with acute leukemia, bone marrow genetic abnormalities (GA) have prognostic significance, and may be the basis for minimal residual disease monitoring. Since April 2007, we have used a multiplex reverse transcriptase-polymerase chain reaction tool (HemaVision) to detect of GA. Methods: In this study, we reviewed the results of HemaVision screening in 270 children with acute leukemia, newly diagnosed at The Catholic University of Korea from April 2007 to December 2011, and compared the results with those of fluorescence in situ hybridization (FISH), and G-band karyotyping. Results: Among the 270 children (153 males, 117 females), 187 acute lymphoblastic leukemia and 74 acute myeloid leukemia patients were identified. Overall, GA was detected in 230 patients (85.2%). HemaVision, FISH, and G-band karyotyping identified GA in 125 (46.3%), 126 (46.7%), and 215 patients (79.6%), respectively. TEL-AML1 (20.9%, 39/187) and AML1-ETO (27%, 20/74) were the most common GA in ALL and AML, respectively. Overall sensitivity of HemaVision was 98.4%, with false-negative results in 2 instances: 1 each for TEL-AML1 and MLL-AF4. An aggregate of diseases-specific FISH showed 100% sensitivity in detection of GA covered by HemaVision for actual probes utilized. G-band karyotype revealed GA other than those covered by HemaVison screening in 133 patients (49.3%). Except for hyperdiplody and hypodiploidy, recurrent GA as defined by the World Health Organizationthat were not screened by HemaVision, were absent in the karyotype. Conclusion: HemaVision, supported by an aggregate of FISH tests for important translocations, may allow for accurate diagnosis of GA in Korean children with acute leukemia.

• Structural Monitoring and Maintenance
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• 제5권1호
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• pp.151-171
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• 2018

Transmission tower-line systems are commonly slender and generally possess a small stiffness and low structural damping. They are prone to impulsive excitations induced by cable rupture and may experience strong vibration. Excessive deformation and vibration of a transmission tower-line system subjected to cable rupture may induce a local destruction and even failure event. A little work has yet been carried out to evaluate the performance of transmission tower-line systems in mountain areas subjected to cable rupture. In addition, the control for cable rupture induced vibration of a transmission tower-line system has not been systematically conducted. In this regard, the dynamic response analysis of a transmission tower-line system in mountain areas subjected to cable rupture is conducted. Furthermore, the feasibility of using viscous fluid dampers to suppress the cable rupture-induced vibration is also investigated. The three dimensional (3D) finite element (FE) model of a transmission tower-line system is first established and the mathematical model of a mountain is developed to describe the equivalent scale and configuration of a mountain. The model of a tower-line-mountain system is developed by taking a real transmission tower-line system constructed in China as an example. The mechanical model for the dynamic interaction between the ground and transmission lines is proposed and the mechanical model of a viscous fluid damper is also presented. The equations of motion of the transmission tower-line system subjected to cable rupture without/with viscous fluid dampers are established. The field measurement is carried out to verify the analytical FE model and determine the damping ratios of the example transmission tower-line system. The dynamic analysis of the tower-line system is carried out to investigate structural performance under cable rupture and the validity of the proposed control approach based on viscous fluid dampers is examined. The made observations demonstrate that cable rupture may induce strong structural vibration and the implementation of viscous fluid dampers with optimal parameters can effectively suppress structural responses.

• Journal of Yeungnam Medical Science
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• 제13권1호
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• pp.110-115
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• 1996

적혈구 침강속도는 전통적인 검사의 하나로서 진단에 있어서는 다소 비특이적인 검사이지만 몇몇 질병의 activity를 평가하고 추적검사에 유용한 것으로 평가되고 있다. Westergren법이 표준화된 검사법으로 인정받고 있으나 보고자에 따라 CV값이 0.8-22.9%로 보고되고 있다. 저자들은 143명의 검체를 대상으로 ESR 자동화 기기인$SEDIsystem^{TM}$ 사용하여 ESR을 측정하고 modified Westergren법, Wintrobe법과 비교하여 임상에 적용될 수 있는지를 검토하였다. $SEDIsystem^{TM}$로 측정한 ESR 결과와 modified Westergren법으로 측정한 ESR 결과사이의 상관식 및 상관계수(r)는 y = 0.863x - 1.69 (r=0.830)이었고, $SEDIsystem^{TM}$로 측정한 ESR 결과와 Wintrobe법으로 측정한 ESR 결과사이의 상관식 및 상관계수(r)는 y = 1. 14x - 14.7 (r=0.789)이었고, 검체의 안정성을 평가하기 위해 시간에 따른 ESR의 반복 측정치는 통계적으로 유의한 차이는 없었다. 위의 결과로 볼 때 $SEDIsystem^{TM}$을 이용한 검사는 기존의 modified Westergren, Wintrobe법들과의 상관성이 높았고 4시간까지 안정된 결과를 보였으며 또한 대량의 검체를 신속하게 보고할 수 있어서 임상 혈액검사실에서 이용하기에 적합하다고 생각된다.

• 한국콘텐츠학회논문지
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• 제20권5호
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• pp.204-211
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• 2020

본 연구에서는 부산광역시 및 부산 16개 구·군의 「사회복지사 등의 처우개선 및 지위향상을 위한 조례」를 비교분석하고 실제 이행여부를 확인함으로써 조례안의 개선점을 도출하고 실효성 확보를 위한 방안을 제안하고자 하였다. 이용재외(2014)에서 활용한 조례분석모 형에 조항이행여부를 추가한 분석모형을 사용하여 17개 조례를 분석하였다. 분석결과에 따른 개선방안은 다음과 같다. 첫째, 지방자치단체장의 책무조항이 반드시 명시되어야 한다. 둘째, 실태조사는 명확한 주기와 구체적인 내용이 담긴 독립적인 조항으로 명시되어야 한다. 셋째, 지원계획은 실태조사와 함께 모든 구·군의 조례에 포함되어야 한다. 넷째, 처우개선위원회와 관련된 조항이 부존재한 구·군이 가장 많았으므로 사회복지사의 입장과 권리를 실질적으로 대변할 수 있는 위원회 관련 조항을 반드시 추가해야 한다. 다음은 조례의 실효성 확보를 위한 방안으로 첫째, 조례가 규범력과 강제성을 갖기 위하여 의무사항에 대한 구체적인 명시와 이행하지 않았을 시 따르는 벌칙이 마련되어야 한다. 둘째, 조례의 내용에 사회복지사의 의사가 잘 반영될 수 있도록 해야 한다. 셋째, 조례입법평가를 통하여 당초 입안 목적에 맞게 잘 이행되고 있는지에 대한 체계적인 조사와 평가 모니터링이 필요하다.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.466-475
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• 2017

본 논문은 요양병원의 감염관리 현황을 파악하기 위하여 2016년 5월 1일부터 7월 31일까지 영남지역의 인증평가를 받은 156개 요양병원을 대상으로 자료 수집을 하였다. 현황 파악에서 있으면 '예', 없으면 '아니오', 중요도 인식은 5점 척도의 총 85문항으로 구성된 설문지를 이용하였다. 자료 분석에 사용된 설문지는 107부이며 자료 분석은 SPSS/WIN 22.0 Program을 이용하였다. 감염관리위원회는 80.4%에서 있다고 하였으며 중요도는 3.79로 나타났고, 감염관리 담당자는 86.0%에서 있으며 대부분 겸임이다. 감염관리규정은 손위생을 포함한 7개 문항에서 100% 구비하고 있으며 규정에 대한 중요도는 손위생이 4.47로 가장 높게 인식하고 있다. 감염관리 활동은 직원교육이 시행 빈도와 중요도 인식에서 가장 높게 나타났으며, 감염관리 수행률은 멸균물품 유효기간 준수율이 96.3%이고 중요도가 4.64로 가장 높게 나타났다. 요양병원의 감염관리 규정은 어느 정도 갖추어져 있으나 감염관리 전담인력 부족과 요양병원에서 적용 가능한 감염관리 규정 미비로 감염관리 활동이 제대로 이루어지지 못하고 있는 것으로 나타났다. 그러므로 요양병원에 적용 가능한 감염감시기준 및 감염관리 가이드라인 개발과 이를 적용할 감염관리 전담인력이 필요하다.

• 한국산학기술학회논문지
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• 제19권1호
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• pp.644-653
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• 2018

최근 기후변화로 인한 집중호우, 태풍 등의 영향으로 산사태가 빈번히 발생하고 있다. 산사태를 예방할 수 있는 효율적인 방법은 사방사업이다. 이러한 사방사업의 효율성을 높이기 위해서는 산지에서 유출되는 토사량에 대한 정량적 측정이 필요하다. 본 연구에서는 산지계류에 Load-cell 센서를 설치하고, 분동테스트를 통하여 계류에서의 적용성과 재하 형태에 따른 출력값을 비교하였다. 개별 및 복합 하중시험을 실시한 결과, Site 1에서 평균 0.4kgf, Site 2에서 평균 0.6kgf 차이로 재하 형태의 영향은 낮게 나타났다. 또한 측정값의 정확도를 높이기 위해 하중계수를 산정하였다. 하중계수를 Load-cell 측정 값에 적용하여 보정한 결과, 두 사이트에서 출력율이 각각 14.8%p, 24.6%p 상승하여 기준값에 근사하게 산정되었다. Load-cell 센서는 수위, 강우 등과 함께 시계열 분석을 통하여 산지 토사유출량을 정량적으로 산정할 수 있었다. 모니터링이 장기간 이루어진다면 산림유역에 대한 토사유출 매커니즘 구명에도 활용할 수 있을 것이다. 또한 Load-cell과 같은 센서를 산지 계곡에 적용함으로써 계측센서 등 관련분야 산업 발전에 기여할 수 있을 것으로 기대된다.

• Journal of Korean Neurosurgical Society
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• 제29권10호
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• pp.1289-1295
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• 2000

Purpose : Recent evidence suggests a possible role for leukocytes in brain injury following ischemia and reperfusion. This study examined the temporal profile of ischemic tissue damage and leukocyte response after transient middle cerebral artery occlusion(MCAO) with reperfusion in the mouse. Methods : Focal cerebral ischemia was made by temporary occluding of the stem of the proximal MCA. Two groups of the mouse were investigated : (1) sham operation(n＝10), and (2)those having the arterial occlusion released after 90 minute(n＝20). By 4 hours(n＝10) and 24 hours(n＝10) after the onset of ischemia-reperfusion, fluorescein videoimages were under-taken in the pial venules of the mouse using a closed cranial window technique. Rhodamine 6G was administered as a $80-100{\mu}l/min$ i.v. loading dose and a $30-40{\mu}l/min$ i.v. maintenance dose in saline to selectively label circulating leukocytes. Neuropathologic evaluation for brain injury was accomplished using the histochemical stain 2,3,5-triphen-yltetrazolium chloride(TTC) and hematoxylin and eosin(H & E) stain. Results : The mean number of adherent leukocytes to cerebral venules in the 90 minutes MCAO and 24 hours reperfusion group were $306{\pm}24$ compared with $72{\pm}8$ in the sham operation group. In the TTC staining method, the cortical infarct affecting 34.8% of hemispheric volume were created in all of animals (n＝10) undergoing 90 minute MCAO with 24 hours reperfusion, but the infarcted area were not found in the other(sham operation and 90 minute MCAO with 4 hours reperfusion)groups. In the H & E stain, the brain tissue following 90 minute MCAO with 4 hours reperfusion revealed only a pyknosis of the nuclei with shrunken cytoplasm, but infiltrated leukocytes were not observed. After 24 hours of reperfusion, a many leukocytes were infiltrated within parenchyma and blood vessles. Conclusions : These findings demonstrate the feasiblity of continous in vivo monitoring of leukocyte adherence in cerebral venules and suggest that reperfusion induced leukocyte adherence to venular endothelium may contribute to tissue injury following focal cerebral ischemia.

• Nutrition Research and Practice
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• 제9권2호
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• pp.207-212
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• 2015

BACKGROUND/OBJECTIVES: The Recaller app was developed to help individuals record their food intakes. This pilot study evaluated the usability of this new food picture application (app), which operates on a smartphone with an embedded camera and Internet capability. SUBJECTS/METHODS: Adults aged 19 to 28 years (23 males and 22 females) were assigned to use the Recaller app on six designated, nonconsecutive days in order to capture an image of each meal and snack before and after eating. The images were automatically time-stamped and uploaded by the app to the Recaller website. A trained nutritionist administered a 24-hour dietary recall interview 1 day after food images were taken. Participants' opinions of the Recaller app and its usability were determined by a follow-up survey. As an evaluation indicator of usability, the number of images taken was analyzed and multivariate Poisson regression used to model the factors determining the number of images sent. RESULTS: A total of 3,315 food images were uploaded throughout the study period. The median number of images taken per day was nine for males and 13 for females. The survey showed that the Recaller app was easy to use, and 50% of the participants would consider using the app daily. Predictors of a higher number of images were as follows: greater interval (hours) between the first and last food images sent, weekend, and female. CONCLUSIONS: The results of this pilot study provide valuable information for understanding the usability of the Recaller smartphone food picture app as well as other similarly designed apps. This study provides a model for assisting nutrition educators in their collection of food intake information by using tools available on smartphones. This innovative approach has the potential to improve recall of foods eaten and monitoring of dietary intake in nutritional studies.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9731-9737
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• 2014

Large scale secular registry or surveillance systems have been accumulating vast data that allow mathematical modeling of cancer incidence and mortality rates. Most contemporary models in this regard use time series and APC (age-period-cohort) methods and focus primarily on predicting or analyzing cancer epidemiology with little attention being paid to implications for designing cancer registry, surveillance or evaluation initiatives. This research models age-specific cancer incidence rates using logistic growth equations and explores their performance under different scenarios of data completeness in the hope of deriving clues for reshaping relevant data collection. The study used China Cancer Registry Report 2012 as the data source. It employed 3-parameter logistic growth equations and modeled the age-specific incidence rates of all and the top 10 cancers presented in the registry report. The study performed 3 types of modeling, namely full age-span by fitting, multiple 5-year-segment fitting and single-segment fitting. Measurement of model performance adopted adjusted goodness of fit that combines sum of squred residuals and relative errors. Both model simulation and performance evalation utilized self-developed algorithms programed using C# languade and MS Visual Studio 2008. For models built upon full age-span data, predicted age-specific cancer incidence rates fitted very well with observed values for most (except cervical and breast) cancers with estimated goodness of fit (Rs) being over 0.96. When a given cancer is concerned, the R valuae of the logistic growth model derived using observed data from urban residents was greater than or at least equal to that of the same model built on data from rural people. For models based on multiple-5-year-segment data, the Rs remained fairly high (over 0.89) until 3-fourths of the data segments were excluded. For models using a fixed length single-segment of observed data, the older the age covered by the corresponding data segment, the higher the resulting Rs. Logistic growth models describe age-specific incidence rates perfectly for most cancers and may be used to inform data collection for purposes of monitoring and analyzing cancer epidemic. Helped by appropriate logistic growth equations, the work vomume of contemporary data collection, e.g., cancer registry and surveilance systems, may be reduced substantially.