• Journal of Microbiology and Biotechnology
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• v.6 no.1
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• pp.43-49
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• 1996

Modulation of the catabolic PEP-pathway of Anaerobiospirillum succiniciproducens was tried using some enzymatic inhibitors such as gases and chemicals in order to enhance succinic acid production. 10$\%$ CO increased the succinic acid/acetic acid (S/A) ratio but inhibited growth as well as production of succinic and acetic acid. Hydrogen gas also increased the S/A ratio and inhibited the synthesis of pyruvate: ferredoxin oxidoreductase when used in mixture with $CO_2$, Catabolic repression by acetic, lactic and formic acid was not recognized and other modulators such as glyoxylate, pyruvate derivatives, arsenic salt, phosphate and sulfate were shown not to be effective. Magesium carbonate was shown effective for repressing acetate production. Palmitic acid, myristic acid and phenylalanine did not affect acetate production but carprylic acid completely inhibited growth.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.375-385
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• 2010

Conventional cancer chemotherapy is seriously limited by tumor cells exhibiting multidrug resistance (MDR), which is caused by changes in the levels or activity of membrane transporters that mediate energy-dependent drug efflux and of proteins that affect drug metabolism and/or drug action. Cancer scientists and oncologists have worked together for some time to understand anticancer drug resistance and develop pharmacological strategies to overcome such resistance. Much focus has been on the reversal of the MDR phenotype by inhibition of ATP-binding cassette (ABC) drug transporters. ABC transporters are a family of transporter proteins that mediate drug resistance and low drug bioavailability by pumping various drugs out of cells at the expense of ATP hydrolysis. Many inhibitors of MDR transporters have been identified, and though some are currently undergoing clinical trials, none are in clinical use. Herein, we briefly review the status of MDR in human cancer, explore the pathways of MDR in chemotherapy, and outline recent advances in the design and development of MDR modulators.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.568-573
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• 2003

This paper describes a study of terrestrial digital TV transmission systems using wideband opto-electronic techniques such as electro-absorption modulators, wavelength division multiplex to support cost effective, high speed, flexible and interactive digital TV networks including ultra-high speed subscriber networks. In particular, the national DTV networks to be installed is required huge amount of cost. Therefore, the network should be carefully designed for DTV, communication and multimedia services in the future. In this paper, wideband optoelectronic DTV systems are suggested.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.5
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• pp.415-421
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• 2014

This study proposes a model-based predictive control for interleaved multi-phase DC/DC converters. The power values necessary to adjust the output voltage in the succeeding are predicted using a converter model. The output power is controlled by selecting the optimal duty cycle. The proposed method does not require controller loops and modulators for converter switching. This method can control the converter by calculating the optimal duty cycle, which minimizes the error between the reference and actual output voltage. The effectiveness of the proposed method is verified through simulations and experiments.

• Journal of Microbiology and Biotechnology
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• v.23 no.11
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• pp.1636-1640
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• 2013

We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.43 no.6
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• pp.936-945
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• 1994

This paper proposes a new power converter which consists of two identical 3-phase PWM modulators and a novel resonant circuit. A new control strategy is integrated to realize the bidirectional power converter without an electrolytic link capacitor. The power flow between converters is bidirectional and the regenerative braking is inherent. The source side currents maintain sinusoidal waveforms with a unity power factor. It is observed in the experiment that by balancing the active power between the source and load side, the voltage across a small ceramic link capacitor can be maintained within a small deviation from the reference. Simulation results and experimental results are presented to verify the operational principles.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.188.2-189
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• 2003

To develop cytochrome P450 (P450) modulators with low toxicity from natural products, we have evaluated more than 20 compounds in mouse and rat models. Among those, the effects of 1,8-cineole and diallyl sulfide (DAS) were most profound in modulating P450 expression. In this presentation, the effects of 1,8-cineole and diallyl sulfide (DAS) on P450 expression were introduced. (omitted)

• Current Optics and Photonics
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• v.2 no.1
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• pp.34-38
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• 2018

An X-band microwave photonic (MWP) filter using switch-based fiber-optic delay lines has been proposed and experimentally demonstrated. It is composed of two electro-optic modulators (EOMs) and $2{\times}2$ optical MEMS-switch-based fiber-optic delay lines. By changing time-delay difference and coefficients of each wavelength signal by using fiber-optic delay lines and an electro-optic modulator, respectively, a bandpass filter or a notch filter can be implemented. For an X-band MWP filter with four channel elements, fiber-optic delay lines with the unit time-delay of 50 ps have been experimentally realized and the frequency responses corresponding to the time-delays has been measured. The measured frequency response error at center frequency and the time-delay difference error were 180 MHz at 10 GHz and 3.2 ps, respectively, when the fiber-optic delay line has the time-delay difference of 50 ps.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.5
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• pp.93-99
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• 1998

The chirping characteristics of InGaAsP electroabsorption modulatiors have been analyzed. The effective .alpha. parameters for large signal modulation were estimated by comparing the pulse shape after fiber transmission with constant chirping assumption.We investigated the structure and the operating condition of the modulator to improve the chirping characteristics. The .alpha. parameters were calculated as the function of wavelength detuning and the bias voltage. To minimize the chirping performance, high bias voltage and a small wavelength detuning and the bias voltage. To minimize the chirping performance, high bias voltage and a small wavelength detuning were preferred. An negative .alpha. value is achieved at the wavelength detuning below 30meV with a proper bias voltage so that pulse compression effect was expected.

• JSTS:Journal of Semiconductor Technology and Science
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• v.2 no.4
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• pp.280-287
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• 2002

We present technical issues involved in the development of actuators and sensors for applications to high-precision Micro Electro Mechanical System (MEMS). The technical issues include fabrication uncertainty and noise disturbance, causing major difficulties for MEMS to achieve high-precision actuation and detection functions. For nano-precision actuators, we solve the fabrication instability and electrical noise problems using digital actuators coupled with nonlinear mechanical modulators. For the high-precision capacitive sensors, we present a branched finger electrodes using high-amplitude anti-phase sensing signals. We also demonstrate the potential applications of the nanoactuators and nanodetectors to high-precision positioning MEMS.