Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Orally Administered Lactobacillus brevis HY7401 in a Food Allergy Mouse Model

  • Lee, Jeongmin (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University) ;
  • Bang, Jieun (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University) ;
  • Woo, Hee-Jong (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
  • Received : 2013.06.19
  • Accepted : 2013.08.27
  • Published : 2013.11.28
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Abstract

We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.

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References

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