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http://dx.doi.org/10.4014/jmb.1306.06047

Effect of Orally Administered Lactobacillus brevis HY7401 in a Food Allergy Mouse Model  

Lee, Jeongmin (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
Bang, Jieun (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
Woo, Hee-Jong (Laboratory of Immunology, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Microbiology and Biotechnology / v.23, no.11, 2013 , pp. 1636-1640 More about this Journal
Abstract
We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
Keywords
Food allergy; probiotics; immunomodulation; Th1 Th2 cytokines; OVA-TCR transgenic mice;
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