• International Journal of Oral Biology
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• v.30 no.1
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• pp.23-30
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• 2005

Bone remodeling is a process controlled by the action of two major bone cells; the bone forming osteoblast and the bone resorbing osteoclast. In the process of osteoclastogenesis, stromal cells and osteoblast produce RANKL, OPG, and M-CSF, which in turn regulate the osteoclastogenesis. During the bone resorption by activated osteoclasts, extracellular $Ca^{2+}/{PO_4}^{2-}$ concentration and degraded organic materials goes up, providing the hypertonic microenvironment. In this study, we tested the effects of hypertonicity due to the degraded organic materials on osteoclastogenesis in co-culture system. It was examined the cellular response of osteoblastic cell in terms of osteoclastogenesis by applying the sucrose, and mannitol, as a substitute of degraded organic materials to co-culture system. Apart from the sucrose, mannitol, and NaCl was tested to be compared to the effect of organic osmotic particles. The addition of sucrose and mannitol (25, 50, 100, 150, or 200 mM) to co-culture medium inhibited the number of tartrate-resistant acid phosphatase (TRAP) positive multinucleated cells induced by 10 nM $1{\alpha},25(OH)_2vitaminD_3$ ($1{\alpha},25(OH)_2D_3$). However, NaCl did exert harmful effect upon the cells in this co-culture system, which is attributed to DNA damage in high concentration of NaCl. To further investigate the mechanism by which hypertonicity inhibits $1{\alpha},25(OH)_2D_3$-induced osteoclastogenesis, the mRNA expressions of receptor activator of nuclear factor (NF)-kB ligand (RANKL) and osteoprotegerin (OPG) were monitored by RT-PCR. In the presence of sucrose (50 mM), RANKL mRNA expression was decreased in a dose-dependent manner, while the change in OPG and M-CSF mRNA were not occurred in significantly. The RANKL mRNA expression was inhibited for 48 hours in the presence of sucrose (50 mM), but such a decrement recovered after 72 hours. However, there were no considerable changes in the expression of OPG and M-CSF mRNA. Conclusively, these findings strongly suggest that hypertonic stress down-regulates $1{\alpha},25(OH)_2D_3$-induced osteoclastogenesis via RANKL signal pathway in osteoblastic cell, and may playa pivotal role as a regulator that modulates osteoclastogenesis.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.7 no.1
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• pp.23-31
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• 2007

In this paper, UWB system did research about effect that interference effect with neighborhood single equipment or group equipment gets in broadcasting communication service. For this, 2.6425GHz SDMB(Satellite Digital Multimedia Broadcasting) that a special of electric wave interference is near frequency-band including interference of signal by unnecessary radiation level that is radiated in UWB system, and degree of 3.4125GHz broadcasting relay net that is In-band frequency-band and interference effect that get in service analyzed comparison and, modulation of broadcasting relay net and interference measurement equipment used Impulse and OFDM methods. Impulse method was $BER\;=\;1{\times}\;10^{-4}$ that broadcasting signal receiption is possible at 1.4m point because interference effect happens from 2m point in SDMB system, and it was $BER\;=\;1{\times}\;10^{-4}$ that OFDM method receives interference effect from 0.8m point and broadcasting signal receiption is possible at 0.5m point. Also, about Gap-Filler center frequency, In case of space interval more than 0.01m, there was no interference effect. Therefore, for the electric wave of UWB system that is small output applies to system without interference effect in broadcasting communication service, confirmed that UWB system of OFDM method is less interference effect than UWB system of Impulse method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.7
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• pp.365-371
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• 2014

Chaos communication system is possible to improve the system security by using chaos signal. Further, it is possible to reduce the possibility of eavesdropping, and have strong characteristics from interference signal and jamming signal. However, BER(Bit Error Rate) performance of chaos system is worse than digital communication system. By this reason, researches in order to improve the BER performance of chaos communication system are being actively studied. In previous studies, we proposed a novel chaos map for BER performance improvement, and called it 'Boss map'. Also, we proposed a novel chaos transceiver for BER performance improvement. However, BER performance is evaluated differently according to delay time in transceiver. Therefore, in order to use Boss map effectively, we should find the optimal delay time in proposed chaos transceiver. In this paper, when Boss map is used, we evaluate BER performance of CDSK(Correlation Delay Shift Keying) system and novel chaos transceiver according to delay time. After evaluation of BER performance according to delay time, we find a delay time that is possible to have best BER performance in CDSK system and novel chaos transceiver.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.4A
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• pp.440-449
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• 2008

In this paper, we propose a 16-QAM carrier recovery loop which is suitable for the implementation of Inmarsat M4 system receiver. Because the frequency offset of ${\pm}924\;Hz$ on signal bandwidth 33.6 kHz is recommended in Inmarsat M4 system specification, carrier recovery loop having stable operation in the channel environment with large relative frequency offset is required. the carrier recovery loop which adopts only PLL can't be stable in relatively large frequency offset environment. Therefore, we propose a carrier recovery loop which has stable operation in large relative frequency offset environment for Inmarsat M4 system. The proposed carrier recovery loop employed differential filter-based noncoherent UW detector which is robust to frequency offset, CP-AFC for initial frequency offset acquisition using UW signal, and 16-QAM DD-PLL for phase tracking using data signal to overcome large relative frequency offset and achieve stable carrier recovery performance. Simulation results show that the proposed carrier recovery loop has stable operation and satisfactory performance in large relative frequency offset environment for Inmarsat M4 system.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.07b
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• pp.851-856
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• 2003

We have investigated the material and electrical properties of $Bi_{4-x}La_xTi_3O_{12}$ (BLT) ferroelectric thin film for ferroelectric nonvolatile memory applications of capacitor type and single transistor type. The 120nm thick BLT films were deposited on $Pt/Ti/SiO_2/Si$ and $SiO_2/Nitride/SiO_2$ (ONO) substrates by the sol-gel spin coating method and were annealed at $700^{\circ}C$. It was observed that the crystallographic orientation of BLT thin films were strongly affected by the excess Bi content and the intermediate rapid thermal annealing (RTA) treatment conditions regardeless of two type substrates. However, the surface microstructure and roughness of BLT films showed dependence of two different type substrates with orientation of (111) plane and amorphous phase. As increase excess Bi content, the crystallographic orientation of the BLT films varied drastically in BLT films and exhibited well-crystallized phase. Also, the conversion of crystallographic orientation at intermediate RTA temperature of above $450^{\circ}C$ started to be observed in BLT thin films with above excess 6.5% Bi content and the rms roughness of films is decreased. We found that the electrical properties of BLT films such as the P-V hysteresis loop and leakage current were effectively modulated by the crystallographic orientations change of thin films.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.2
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• pp.9-17
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• 2010

Recently, there has been much interest in orthogonal frequency division multiplexing (OFDM) for next generation wireless wideband communication systems. OFDM is a special case of multicarrier transmission, where a single data stream is transmitted over a number of lower-rate subcarriers. One of the main reasons to use OFDM is to increase robustness against frequency-selective fading or narrowband interference. However, in the radio systems it is also important to distortion introduced by high power amplifiers (HPA's) such as solid state power amplifier (SSPA) considered in this paper. Since the signal amplitude of the OFDM system is Rayleigh-distributed, the performance of the OFDM system is significantly degraded by the nonlinearity of the HPA in the OFDM transmitter. In this paper, we propose a canonical piecewise-linear (PWL) model based digital predistorter to prevent signal distortion and spectral re-growth due to the high peak-to-average power ratio (PAPR) of OFDM signal and the nonlinearity of HPA's. Computer simulation on an OFDM system under additive white Gaussian noise (AWGN) channels with QPSK, 16-QAM and 64-QAM modulation schemes and modulator/demodulator implemented with 1024-point FFT/IFFT, demonstrate that the proposed predistorter achieves significant performance improvement by effectively compensating for the nonlinearity introduced by the SSPA.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.48 no.1
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• pp.16-24
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• 2011

The sound speed of seawater can be calculated by the empirical formula as a function of temperature, salinity and pressure. It is little affected by salinity because the average salinity is 34 psu and varies within a few psu seasonally and spatially in the ocean. Recently, low-salinity water of 24 psu flows into the western sea area of Jeju Island due to the flood of the Yangtze River in China during summer, affecting sound speed profile. In this paper, it was analyzed how environmental changes affected to the underwater communication - the sound speed of low-salinity water was calculated, and the communication channel was estimated by the simulated acoustic rays while the transmitting and receiving depth and the range were varied with and without the low-salinity layer. And The BER (Bit error rate) was calculated by BPSK(Binary phase shift key) modulation and the effects of the low-salinity water on the BER was investigated. The sound speed profile was changed to have positive slope by the low-salinity layer at the sub-surface up to 20 m of depth, forming acoustic wave propagation channel at the sub-surface resulting in the decrease of most of the BER Consequently, this paper suggests that it is important to consider changes of the ocean environment for correctly analyzing the underwater communication and the detection capability.

• JSTS:Journal of Semiconductor Technology and Science
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• v.16 no.1
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• pp.126-142
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• 2016

This paper presents a wide-frequency-range, low-power transceiver with an automatic impedance-matching calibration for TV-white-space (TVWS) application. The wide-range automatic impedance matching calibration (AIMC) is proposed for the Drive Amplifier (DA) and LNA. The optimal $S_{22}$ and $S_{11}$ matching capacitances are selected in the DA and LNA, respectively. Also, the Single Pole Double Throw (SPDT) switch is integrated to share the antenna and matching network between the transmitter and receiver, thereby minimizing the systemic cost. An N-path filter is proposed to reject the large interferers in the TVWS frequency band. The current-driven mixer with a 25% duty LO generator is designed to achieve the high-gain and low-noise figures; also, the frequency synthesizer is designed to generate the wide-range LO signals, and it is used to implement the FSK modulation with a programmable loop bandwidth for multi-rate communication. The TVWS transceiver is implemented in $0.13{\mu}m$, 1-poly, 6-metal CMOS technology. The die area of the transceiver is $4mm{\times}3mm$. The power consumption levels of the transmitter and receiver are 64.35 mW and 39.8 mW, respectively, when the output-power level of the transmitter is +10 dBm at a supply voltage of 3.3 V. The phase noise of the PLL output at Band 2 is -128.3 dBc/Hz with a 1 MHz offset.

• Korean Journal of Ichthyology
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• v.23 no.1
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• pp.61-69
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• 2011

Gene and promoter structures of metallothionein(MT) from Miho spine loach (Cobitis choii; Cypriniformes) were characterized, and the transcriptional responses to experimental exposures to heavy metals and heat stress were examined. The C. choii metallothionein displayed well-conserved features of teleostean metallothioneins at gDNA, mRNA and amino acid levels. Bioinformatic analysis predicted that the C. choii MT regulatory region potentially possessed various motifs or elements targeted by various transcription factors associated with metal-coordinating regulation (e.g., metal transcription factor-1), immune responses (e.g., nuclear factor kappa B), and thermal modulations (e.g., heat shock factor). Acute heavy-metal exposures to 0.5 or $1.0\;{\mu}M$ of cadmium (Cd), copper (Cu), manganese (Mn), nickel (Ni) or zinc (Zn) showed that MT transcription was significantly stimulated by Cd (9.6-fold relative to non-exposed control) and Cu (10.4-fold), only moderately by Mn (2.4-fold), but hardly by Ni and Zn. Elevation of water temperature from $25^{\circ}C$ to $31^{\circ}C$ caused a rapid modulation of MT mRNAs toward upregulation to 9.5-fold; however, afterward the elevated mRNA level slightly decreased during further incubation at $31^{\circ}C$ for 6 h. Results from this study suggest that MT-based expression assay could be a useful basis for better understanding the metal- and/or heat-caused stresses in this endangered fish species.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.1
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• pp.39-47
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• 2005

The range of hardware implementation increases in communication systems as high-speed processing is required for high data rate. In the broadband wireless access (BWA) system based on IEEE standard 802.16 the functions of higher part in the MAC layer to Provide data needed for generating MAC PDU are implemented in software, and the tasks from formatting MAC PDUs by using those data to transmitting the messages in a modem are implemented in hardware. In this paper, the interface hardware for efficient message exchange between MAC and PHY layers in the BWA system is designed. The hardware performs the following functions including those of the transmission convergence(TC) sublayer; (1) formatting TC PDU(Protocol data unit) from/to MAC PDU, (2) Reed-solomon(RS) encoding/decoding, and (3) resolving DL MAP and UL MAP, so that it controls transmission slot and uplink and downlink traffic according to the modulation scheme of burst profile. Also, it provides various control signal for PHY modem. In addition, the truncated binary exponential backoff (TBEB) algorithm is implemented in a subscriber station to avoid collision on contention-based transmission of messages. The VLSI architecture performing all these functions is implemented and verified in VHDL.