• Title/Summary/Keyword: Model-based analysis

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A Study of Dopamine Transporter Imaging and Comparison of Noninvasive Simplified Quantitative Methods in Normal Controls and Parkinson's Patients ([I-123]IPT SPECT를 이용한 정상인과 파킨슨 환자의 도파민 운반체의 영상화 및 단순화된 정량분석 방법들의 비교연구)

  • Bong, Jung-Kyun;Kim, Hee-Joung;Im, Joo-Hyuck;Yang, Seoung-Oh;Moon, Dae-Hyuk;Ryu, Jin-Sook;Nam, Ki-Pyo;Cheon, Jun-Hong;Kwon, Soo-Il;Lee, Hee-Kyung
    • The Korean Journal of Nuclear Medicine
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    • v.30 no.3
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    • pp.315-324
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    • 1996
  • The purpose of this study was to compare the specific binding ratio method with model-based methods in estimating the transporter parameter $k_3/k_4$ in normal controls and Parkinson's patients with [I-123]IPT SPECT and to evaluate the usefulness of [I-123]IPT SPECT. $6.5{\pm}1.1$ mCi ($239.0{\pm}40.3$ MBq) of [$^{123}I$]IPT was intravenouly injected as a bolus into six normal controls(age:$45{\pm}13$) and seventeen patients(age:$55{\pm}8$) with Pakinson's disease(PD). The transporter parameter $k_3/k_4$ was derived using the Ichise's graphical method($R_v$) and Lassen's area ratio method($R_A$) for the dynamic IPT SPECT data without blood samples. Then, the relationships between the transporter parameter $R-v,\;R_A$ and the ratio of (BG-OCC)/OCC at 115 minutes were evaluated by linear regression analysis. $R_vs$ by Ichise's graphical method for NC and PD were $2.08{\pm}0.29$ and $0.78{\pm}0.31$, respectively. $R_As$ by Lassen's area ratio method for NC and PD were $1.48{\pm}0.16$ and $0.65{\pm}0.24$, respectively. The correlation coefficients between (BG-OCC)/OCC and $R_v$, (BG-OCC)/OCC and $R_A$, and $R_v$ and $R_A$ were 0.93, 0.90, 0.99 and their corresponding slopes were 0.54, 0.34, and 0.65, respectively. The $R_v$ and $R_A$ of NC were significantly higher than the ones of PD. That is, the $k_3/k_4$ of NC was clearly separated from the one of PD. $k_3/k_4$ showed a good correlation with the ratio of (BG-OCC)/OCC. The results indicate that the noninvasive simplified quantitative methods may be useful to measure the transporter parameter $k_3/k_4$ and the specific binding ratio method can be used for quantitative studies of dopamine transporter with [I-123]IPT SPECT in humans brains.

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Feasibility of Ocean Survey by using Ocean Acoustic Tomography in southwestern part of the East Sea (동해 남서해역에서 해양음향 토모그래피 운용에 의한 해양탐사 가능성)

  • Han, Sang-Kyu;Na, Jung-Yul
    • The Journal of the Acoustical Society of Korea
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    • v.13 no.6
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    • pp.75-82
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    • 1994
  • The ray paths and travel times of sound wave in the ocean depend on the physical properties of the propagating media. Ocean Acoustic Tomography(OAT), which is inversely estimate the travel time variations between fixed sources and receivers the physical properties of the corresponding media can he understood. To apply ocean survey technology by using the OAT, the tomographic procedure requires forward problem that variation of the travel times be identified with the variability of the medium. Also, received signals must be satisfied the necessary conditions of ray path stability, identification and resolution in order for OAT to work. The canonical ocean has been determined based on the historical data and its travel time and ray path are used as reference values. The sound speed of canonical ocean in the East Sea is about 1523 m/s at the surface and 1458 m/s at the sound channel axis(400m). Sound speeds in the East Sea are perturbed by warm eddy whose horizontal extension is more than 100 km with deeper than 200 m in depth scale. In this study, an acoustic source and receiver are placed at the depth above the sound channel axis, 350 m, and are separated by 200 km range. Ray paths are identified by the ray theory methed in a range dependent medium whose sound speeds are functions of a range and depth. The eigenray information obtained from interpolation between the rays bracketing the receiver are used to simulate the received signal by convolution of source signal with the eigenray informations. The source signal is taken as a 400 Hz rectangular pulse signal, bandwidth is 16 Hz and pulse length is 64 ms. According to the analysis of the received signal and identified ray path by using numerical model of underwater sound propagation, simulated signals satisfy the necessary conditions of OAT, applied in the East Sea.

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HACCP Model for Quality Control of Sushi Production in the Eine Japanese Restaurants in Korea (일본전문식당의 급식품질 개선을 위한 HACCP 시스템 적용 연구)

  • 김혜경;이복희;김인호;조경동
    • Journal of the East Asian Society of Dietary Life
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    • v.13 no.1
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    • pp.25-38
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    • 2003
  • This study was conducted to establish the microbiological quality standards applying the HACCP system on sushi items of Japanese restaurant in Korea. The study evaluated hygienic conditions of kitchen and workers, pH time-temperature relationship, and microbial assessments during whole process of sushi making in 2001. Overall hygienic conditions were normal for both kitchen and for workers by 3 point scale, but hygienic controls against the cross-contamination were still needed. Each process of sushi making was performed under the risk of microbial contamination, since pH value of most of ingredients was over pH 4.6 and also production time(3.5~6 hrs) were long enough to cause problems. Microorganisms were high enough to cause foodborne illness ranged 8.0$\times$10$^2$~3.3$\times$10$^{6}$ CFU/g of TPC and 1.0$\times$10$^1$~1.6$\times$10$^3$CFU/g of coliforms, although TPC, coliforms and Staphylcoccus aureus were within the standard limits (TPC 10$^2$~10$^{6}$ CFU/g, coliforms 10$^3$CFU/g). However, Salmonella and Vibrio parahaemolyticus were not detected. High populations TPC and coliforms were also found in the cooks' hands and cooking utensils(TPC 10$^2$~10$^{6}$ CFU/100cm$^2$and Coliforms 10$^1$~10$^3$CFU/100cm$^2$). Based on the CCP decision tree analysis, the CCPs were the holding steps far six sushi production line except the tuna and the thawing step for tuna sushi. In conclusion, overall state of sushi production was fairly good but much improvement was still needed.

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Investigation of O4 Air Mass Factor Sensitivity to Aerosol Peak Height Using UV-VIS Hyperspectral Synthetic Radiance in Various Measurement Conditions (UV-VIS 초분광 위성센서 모의복사휘도를 활용한 다양한 관측환경에서의 에어로솔 유효고도에 대한 O4 대기질량인자 민감도 조사)

  • Choi, Wonei;Lee, Hanlim;Choi, Chuluong;Lee, Yangwon;Noh, Youngmin
    • Korean Journal of Remote Sensing
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    • v.36 no.2_1
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    • pp.155-165
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    • 2020
  • In this present study, the sensitivity of O4 Air Mass Factor (AMF) to Aerosol Peak Height (APH) has been investigated using radiative transfer model according to various parameters(wavelength (340 nm and 477 nm), aerosol type (smoke, dust, sulfate), aerosol optical depth (AOD), surface reflectance, solar zenith angle, and viewing zenith angle). In general, it was found that O4 AMF at 477 nm is more sensitive to APH than that at 340 nm and is stably retrieved with low spectral fitting error in Differential Optical Absorption Spectroscopy (DOAS) analysis. In high AOD condition, sensitivity of O4 AMF on APH tends to increase. O4 AMF at 340 nm decreased with increasing solar zenith angle. This dependency isthought to be induced by the decrease in length of the light path where O4 absorption occurs due to the shielding effect caused by Rayleigh and Mie scattering at high solar zenith angles above 40°. At 477 nm, as the solar zenith angle increased, multiple scattering caused by Rayleigh and Mie scattering partly leads to the increase of O4 AMF in nonlinear function. Based on synthetic radiance, APHs have been retrieved using O4 AMF. Additionally, the effect of AOD uncertainty on APH retrieval error has been investigated. Among three aerosol types, APH retrieval for sulfate type is found to have the largest APH retrieval error due to uncertainty of AOD. In the case of dust aerosol, it was found that the influence of AOD uncertainty is negligible. It indicates that aerosol types affect APH retrieval error since absorption scattering characteristics of each aerosol type are various.

Quantitative Analysis of Magnetization Transfer by Phase Sensitive Method in Knee Disorder (무릎 이상에 대한 자화전이 위상감각에 의한 정량분석법)

  • Yoon, Moon-Hyun;Sung, Mi-Sook;Yin, Chang-Sik;Lee, Heung-Kyu;Choe, Bo-Young
    • Investigative Magnetic Resonance Imaging
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    • v.10 no.2
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    • pp.98-107
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    • 2006
  • Magnetization Transfer (MT) imaging generates contrast dependent on the phenomenon of magnetization exchange between free water proton and restricted proton in macromolecules. In biological materials in knee, MT or cross-relaxation is commonly modeled using two spin pools identified by their different T2 relaxation times. Two models for cross-relaxation emphasize the role of proton chemical exchange between protons of water and exchangeable protons on macromolecules, as well as through dipole-dipole interaction between the water and macromolecule protons. The most essential tool in medical image manipulation is the ability to adjust the contrast and intensity. Thus, it is desirable to adjust the contrast and intensity of an image interactively in the real time. The proton density (PD) and T2-weighted SE MR images allow the depiction of knee structures and can demonstrate defects and gross morphologic changes. The PD- and T2-weighted images also show the cartilage internal pathology due to the more intermediate signal of the knee joint in these sequences. Suppression of fat extends the dynamic range of tissue contrast, removes chemical shift artifacts, and decreases motion-related ghost artifacts. Like fat saturation, phase sensitive methods are also based on the difference in precession frequencies of water and fat. In this study, phase sensitive methods look at the phase difference that is accumulated in time as a result of Larmor frequency differences rather than using this difference directly. Although how MT work was given with clinical evidence that leads to quantitative model for MT in tissues, the mathematical formalism used to describe the MT effect applies to explaining to evaluate knee disorder, such as anterior cruciate ligament (ACL) tear and meniscal tear. Calculation of the effect of the effect of the MT saturation is given in the magnetization transfer ratio (MTR) which is a quantitative measure of the relative decrease in signal intensity due to the MT pulse.

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The Evaluation of Potential Invasive Species in the Gangneungnamdae Stream in Korea using a Fish Invasiveness Screening Kit (FISK (Fish Invasiveness Screening Kit)를 이용한 강릉남대천의 잠재적 침습 이입종 평가)

  • Kim, Jeong Eun;Lee, Hwang Goo
    • Korean Journal of Environmental Biology
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    • v.36 no.1
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    • pp.73-81
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    • 2018
  • This study was conducted to understand the current status of the translocated species using a precede study and a model to evaluate the potential invasiveness that could adversely affect the aquatic ecosystem in the Gangneungnamdae Stream. A total of 12 translocated species were investigated and identified from 9 sites in a precede study, and steadily increased since 1982. For the study, which utilized research based on the total FISK (Fish Invasivenss Screening Kit) scores, all of the non-native fishes in Gangneungnamdae Stream were classified into two groups: namely as a high and a medium risk of becoming invasive. It was determined that there were two species (Zacco platypus and Pseudorasbora parva) that were determined to have posed the highest risk. The study determined that the mean scores were shown to have ranged from $3.06({\pm}0.16)-3.42({\pm}0.13)$. Consequently, the habitat analysis showed that the determined QHEI (Qualitative Habitat Evaluation Index) values in the stream averaged 146 (88-171), indicating that an optimal habitat condition did exist in that locale. It can be inferred that compared to land use in the surrounding watersheds, the QHEI values and frequency of translocated species showed the lower the altitude of stream, the QHEI values were decreased and in case of land use pattern, a noted decreased forest and grassland area, and gradually increased urbanized area was seen to exist in the region. The correlation between the fish assemblage, QHEI, land use pattern of surrounding watershed and number of translocated species was identified and analyzed when the stream altitude decreased, and the number of species was increased (r= - 0.782, p=0.0127), the number of species was decreased (r= - 0.737, p=0.0234), and finally when the QHEI values were decreased, it was noted that the urbanized area was increased (r=0.292, p=0.446). In the case of the number of translocated species, when the number of translocated species was increased, the associated urbanized area was increased.

The influences of sustainability management at institutional foodservice on store image and behavioral intention (소비자가 인식하는 산업체 급식업체의 지속가능경영활동이 점포이미지와 행동의도에 미치는 영향)

  • Ahn, Jiyoon;Seo, Sunhee
    • Journal of Nutrition and Health
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    • v.48 no.2
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    • pp.199-210
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    • 2015
  • Purpose: The purpose of this study was to determine the influence of sustainability management in institutional foodservice on store image and behavioral intention (revisit intention, word of mouth, willingness to pay a premium). Methods: Based on a total of 371 samples obtained from the empirical research, this study reviewed the reliability and fitness of the model. Results: According to results of exploratory factor analysis, sustainability management derived three factors, economic value, socially responsible, and environmentally sound. The structural equation modeling showed that social responsibility in sustainability management had a significant positive effect on store image and behavioral intention. In addition, customer's perceived store image in foodservice had a significant positive effect on behavioral intention. The relationship between sustainability management and behavioral intention was found to be a partially significant effect. Conclusion: The results of this study revealed the importance of sustainability management of foodservice to improve store image and behavioral intention.

Estimation of Surface Solar Radiation using Ground-based Remote Sensing Data on the Seoul Metropolitan Area (수도권지역의 지상기반 원격탐사자료를 이용한 지표면 태양에너지 산출)

  • Jee, Joon-Bum;Min, Jae-Sik;Lee, Hankyung;Chae, Jung-Hoon;Kim, Sangil
    • Journal of the Korean earth science society
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    • v.39 no.3
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    • pp.228-240
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    • 2018
  • Solar energy is calculated using meteorological (14 station), ceilometer (2 station) and microwave radiometer (MWR, 7 station)) data observed from the Weather Information Service Engine (WISE) on the Seoul metropolitan area. The cloud optical thickness and the cloud fraction are calculated using the back-scattering coefficient (BSC) of the ceilometer and liquid water path of the MWR. The solar energy on the surface is calculated using solar radiation model with cloud fraction from the ceilometer and the MWR. The estimated solar energy is underestimated compared to observations both at Jungnang and Gwanghwamun stations. In linear regression analysis, the slope is less than 0.8 and the bias is negative which is less than $-20W/m^2$. The estimated solar energy using MWR is more improved (i.e., deterministic coefficient (average $R^2=0.8$) and Root Mean Square Error (average $RMSE=110W/m^2$)) than when using ceilometer. The monthly cloud fraction and solar energy calculated by ceilometer is greater than 0.09 and lower than $50W/m^2$ compared to MWR. While there is a difference depending on the locations, RMSE of estimated solar radiation is large over $50W/m^2$ in July and September compared to other months. As a result, the estimation of a daily accumulated solar radiation shows the highest correlation at Gwanghwamun ($R^2=0.80$, RMSE=2.87 MJ/day) station and the lowest correlation at Gooro ($R^2=0.63$, RMSE=4.77 MJ/day) station.

A Study on the Characteristics of Jobs in Academic Libraries According to Different Generations (대학도서관 업무의 시대별 변천에 따른 특성 연구)

  • Cho, Chul-Hyun
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.26 no.1
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    • pp.135-170
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    • 2015
  • This study aimed to investigate the transition of academic libraries' jobs by developing a model based on a shift of library generations including Library 1.0, Library 2.0, and Library 3.0 corresponding to the shift of web generations and to explore generational characteristics of library duties as well. The research used three phases of procedure: literature review about different library generations; job analyses for academic libraries in South Korea and the U.S.A.; the Delphi technique in tree sequential order. The research findings were as follows. First of all, there were 170 duties that continued from Library 1.0 to Library 3.0. There were 58 duties which continued from Library 2.0 to Library 3.0 whereas three duties that continued from Library 1.0 to Library 2.0. In addition, three distinctive duties existed only in Library 1.0 whereas one unique duty was only in Library 2.0. Library 3.0 generated 25 new duties. Secondly, considering general characteristics which cover specific parts of individual duties, there was a significant increase in importance, difficulty, and frequency of library administration throughout the three generations. In terms of importance, difficulty, and frequency of collection development and management, there was a significant increase only from Library 2.0 to Library 3.0. Considering information organization, there was a significant decrease in importance from Library 1.0 to Library 2.0. In addition, there was a significant decrease in frequency and there was no significant difference in difficulty throughout the three generations. In the case of information service, while there was a significant increase in importance among three generations, there was a significant increase in difficulty only from Library 1.0 to Library 2.0. However, there was no generational difference in frequency. With the respect of information system development and management, there was a significant increase in importance and frequency throughout the three generations, but there was no significant difference in difficulty among three generations.

An Analysis of Teachers' Level of Usage and Concern Over the 7th Science Curriculum (제7차 과학 교육과정에 대한 지구과학 교사들의 관심도와 활용도 분석)

  • Lee, Yong-Seob;An, Hyun-Hee;Kim, Sang-Dal;Kim, Jong-Hee
    • Journal of the Korean earth science society
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    • v.24 no.5
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    • pp.378-392
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    • 2003
  • The purpose of this study is to investigate the depth of earth science teachers' concern over the 7th Science Curriculum and levels of their use of it in reality, using the tools "Concern" and "Levels of use" which are two important tools use in CBAM. The results of the study are as follows. How much concern do the earth science teachers have over the 7th Science Curriculum? There are seven stages (from 0 stage to 6 stage) of teachers' concern over the curriculum. o stage represents teachers' indifference to the curriculum and 98% teachers are placed in this stage. According to the study on teachers' teaching experience, teachers having from 10 to 14 years of teaching experience are the most indifferent to the 7th Science Curriculum, compared to other teachers. Which levels of use of the 7th science curriculum do earth science teachers choose in reality? There are five levels of use (from 1 to 5) of the 7th curriculum. 43.97% of teachers are placed in the 3rd level called "Mechanical level", which represents a teacher-concerned learning method with consideration of learners' response. According to the study on teachers' frequency of level of use in the fields of "Instruction objects, Instruction contents, Instruction methods, Instruction materials and Evaluation.", teachers chose high levels of use in the fields of "Instruction objects and Instruction contents" and low levels of use in the other three fields. What factors are barriers for earth science teachers to perform the 7th Science Curriculum in reality? 80.9% of teachers have trouble performing the 7th Science Curriculum in reality because of too much routine work, official papers, and lack of instructional materials, laboratories, training systems and workshops. The two biggest barriers among the above are routine work and of official papers. According to the study on teachers' teaching experience, teachers having from 0 to years of teaching experience have the most trouble in performing the curriculum in reality, compared to other teachers.