• Title/Summary/Keyword: Model validation

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Application of Response Surface Methodology in Medium Optimization to Improve Lactic Acid Production by Lactobacillus paracasei SRCM201474 (반응표면분석법을 이용한 Lactobacillus paracasei SRCM201474의 생산배지 최적화)

  • Ha, Gwangsu;Kim, JinWon;Im, Sua;Shin, Su-Jin;Yang, Hee-Jong;Jeong, Do-Youn
    • Journal of Life Science
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    • v.30 no.6
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    • pp.522-531
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    • 2020
  • The aim of this study was to establish the optimal medium composition for enhancing L(+)-lactic acid (LLA) production using response surface methodology (RSM). Lactobacillus paracasei SRCM201474 was selected as the LLA producer by productivity analysis from nine candidates isolated from kimchi and identified by 16S rRNA gene sequencing. Plackett-Burman design was used to assess the effect of eleven media components on LLA production, including carbon (glucose, sucrose, molasses), nitrogen (yeast extract, peptone, tryptone, beef extract), and mineral (NaCl, K2HPO4, MgSO4, MnSO4) materials. Glucose, sucrose, molasses, and peptone were subsequently chosen as promising media for further optimization studies, and a hybrid design experiment was used to establish their optimal concentrations as glucose 15.48 g/l, sucrose 16.73 g/l, molasses 39.09 g/l, and peptone 34.91 g/l. The coefficient of determination of the equation derived from RSM regression for LLA production was mathematically reliable at 0.9969. At optimum parameters, 33.38 g/l of maximum LLA increased by 193% when compared with MRS broth as unoptimized medium (17.66 g/l). Our statistical model was confirmed by subsequent validation experiments. Increasing the performance of LLA-producing microorganisms and establishing an effective LLA fermentation process can be of particular benefit for bioplastic technologies and industrial applications.

An FSI Simulation of the Metal Panel Deflection in a Shock Tube Using Illinois Rocstar Simulation Suite (일리노이 록스타 해석환경을 활용한 충격파관 내 금속패널 변형의 유체·구조 연성 해석)

  • Shin, Jung Hun;Sa, Jeong Hwan;Kim, Han Gi;Cho, Keum Won
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.41 no.5
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    • pp.361-366
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    • 2017
  • As the recent development of computing architecture and application software technology, real world simulation, which is the ultimate destination of computer simulation, is emerging as a practical issue in several research sectors. In this paper, metal plate motion in a square shock tube for small time interval was calculated using a supercomputing-based fluid-structure-combustion multi-physics simulation tool called Illinois Rocstar, developed in a US national R amp; D program at the University of Illinois. Afterwards, the simulation results were compared with those from experiments. The coupled solvers for unsteady compressible fluid dynamics and for structural analysis were based on the finite volume structured grid system and the large deformation linear elastic model, respectively. In addition, a strong correlation between calculation and experiment was shown, probably because of the predictor-corrector time-integration scheme framework. In the future, additional validation studies and code improvements for higher accuracy will be conducted to obtain a reliable open-source software research tool.

Study on Effect of Anchor Bolt by Thermal Expansion of Sulfur Storage Tank under High Temperature (고온을 받는 유황저장탱크의 열팽창에 의한 앵커볼트 영향에 관한 연구)

  • Jung, Wook-Hwan;Kim, Jeong-Soo;Kim, Tae-Min;Kim, Moon-Kyum
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.29 no.5
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    • pp.483-490
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    • 2016
  • In plant industry, sulfur storage tank is made of steel and annular plate is connected with concrete foundation of ring wall type by anchor bolt. Due to keep sulfur at high temperature in tank by coil, sulfur storage tank is expanded larger than another tank stores fluid at room temperature. Generally, structural design of tank foundation is performed analysis with loading of temperature gradient between inner and outer surface, this method can't consider the phenomenon that load is intensively transferred to concrete foundation at anchor bolt. This means that temperature load is underestimated and causes crack of concrete near anchor bolt. In this study, evaluation formula considering temperature load transfer mechanism through anchor bolt is proposed and load acting on concrete foundation is rationally decided. For this purpose, it is analyzed variation of thermal load per various anchor bolt number using finite element model including tank annular plate and anchor bolt. Solution is proposed as specified term combining result of analysis and theoretical solution for evaluating load transferred by anchor bolt. For confirmation of validation of proposed formula, it is applied in design of sulfur storage tank at plant site, it shows that the formula can be practically applied.

A Cross-Validation of the Korean Version of the Revised Memory and Behavioral Problems Checklist(K-RMBPC): Exploratory and Confirmatory Analyses ("한국형 기억 및 행동문제 개정점검표(Korean Version of the Revised Memory and Behavioral Problems Checklist: K-RMBPC)"의 타당화를 위한 탐색적 연구)

  • Lee, Min-Hong;Yoon, Eun-Kyung
    • Korean Journal of Social Welfare
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    • v.59 no.2
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    • pp.65-88
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    • 2007
  • This study evaluates psychometric properties of the Revised Memory and Behavioral Problems Checklist(RMBPC) in Korean version. The sample includes 387 South Korean family caregivers who provide the majority of day to day tasks and emotional care for their older family members with physical and/or cognitive disabilities. The psychometric properties of the RMBPC are verified by item analysis, exploratory factor analysis(EFA) & confirmatory factor analysis(CFA). For cross-validity, the randomly divided two samples are used: one sample for EFA(n=193, 387/2) and the other sample for CFA(n=194, 387/2). The internal consistency of the K-RMBPC is excellent, and the convergent and criterion-related validity of the K-RMBPC with related variables is empirically confirmed. An EFA based on the Principal Component Analysis(PCA) method with varimax rotation explains 65.85% of variance accounted for by the three factors. A CFA also verifies that the model fit was acceptable. The shorter Korean version of the RMBPC is found reliable and valid. The translated checklist would be very useful for clinical and research settings by (a) focusing on observable, conceptually relevant, potentially modifiable behaviors and (b) using objective criteria within a self-administered framework, to enable clinicians and researchers to pinpoint areas of disturbance and target intervention goals for patients and caregivers in a cost-effective manner.

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Development and Validation Study of the Korean Version of Working Relationship Scale (한국형 실천관계 척도 정신장애인 용 개발 연구)

  • Kwon, Jayoung
    • Korean Journal of Social Welfare
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    • v.65 no.3
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    • pp.239-263
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    • 2013
  • This research was carried out in order to develop and validate the Korean Version of Working Relationship Scale for Mentally Disabled Persons, which measures the working relationship between a mentally disabled person and his or her case manager. The first step taken to develop this scale was to construct sample items for the Working Relationship Scale using literature research and three focus group interviews of mentally disabled persons who use local mental health services. Secondly, mentally disabled people were surveyed with these sample items and two professors from the department of social work who specialize in mental health social work and two licensed mental health social workers working in the community mental health field reviewed these sample items to select and compile a final version of the scale. Lastly, the scale's reliability and validity was verified through an empirical study of 569 mentally disabled persons who surveyed the final selection of items. An explanatory factor analysis showed that the sample items can be grouped into three factors. Factor 1 is 'Professional Contribution Factor,' which is related to the professional practice of the case manager; Factor 2 is 'Negative Working Relationship Factor'; and Factor 3 is 'Emotional Bond Factor,' which measures the intimacy between the case manager and the mentally disabled person. A confirmatory analysis of the three-factor format that was discovered in the explanatory factor analysis was carried out with the rest of the randomly divided data, which showed that the model demonstrated a goodness-of-fit. The convergence validity between similar concepts appeared to be appropriate as well. Based on these results, the Korean Version of Working Relationship Scale for Mentally Disabled Persons consisting of a final 33 items is developed and proposed and its implications in social work are discussed.

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New Flood Hazard Mapping using Runoff Mechanism on Gamcheon Watershed (유출메커니즘을 활용한 감천유역에서의 새로운 홍수위험지도 작성)

  • Kim, Tae Hyung;Han, Kun Yeun;Park, Jun Hyung
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.36 no.6
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    • pp.1011-1021
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    • 2016
  • This study performs the potential flood hazard analysis by applying elevation data, soil data and land use data. The susceptibility maps linked to elevation, soil and land use are combined to develop the new types of flood hazard map such as runoff production map and runoff accumulation map. For the development of the runoff production map, land use, soil thickness, permeability, soil erosion and slope data are used as runoff indices. For the runoff accumulation map, elevation, knick point and lowland analysis data are used. To derive an integrated type of flood potential hazard, a TOPSIS (The Technique for Order of Preference by Similarity to Ideal Solution) technique, which is widely applied in MCDM (Multi-Criteria Decision Making) process, is adopted. The indices applied to the runoff production and accumulation maps are considered as criteria, and the cells of analysis area are considered as alternatives for TOPSIS technique. The model is applied to Gamcheon watershed to evaluate the flood potential hazards. Validation with large scale data shows the good agreements between historical data and runoff accumulation data. The analysis procedure presented in this study will contribute to make preliminary flood hazard map for the public information and for finding flood mitigation measures in the watershed.

Cable vibration control with internal and external dampers: Theoretical analysis and field test validation

  • Di, Fangdian;Sun, Limin;Chen, Lin
    • Smart Structures and Systems
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    • v.26 no.5
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    • pp.575-589
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    • 2020
  • For vibration control of stay cables in cable-stayed bridges, viscous dampers are frequently used, and they are regularly installed between the cable and the bridge deck. In practice, neoprene rubber bushings (or of other types) are also widely installed inside the cable guide pipe, mainly for reducing the bending stresses of the cable near its anchorages. Therefore, it is important to understand the effect of the bushings on the performance of the external damper. Besides, for long cables, external dampers installed at a single position near a cable end can no longer provide enough damping due to the sag effect and the limited installation distance. It is thus of interest to improve cable damping by additionally installing dampers inside the guide pipe. This paper hence studies the combined effects of an external damper and an internal damper (which can also model the bushings) on a stay cable. The internal damper is assumed to be a High Damping Rubber (HDR) damper, and the external damper is considered to be a viscous damper with intrinsic stiffness, and the cable sag is also considered. Both the cases when the two dampers are installed close to one cable end and respectively close to the two cable ends are studied. Asymptotic design formulas are derived for both cases considering that the dampers are close to the cable ends. It is shown that when the two dampers are placed close to different cable ends, their combined damping effects are approximately the sum of their separate contributions, regardless of small cable sag and damper intrinsic stiffness. When the two dampers are installed close to the same end, maximum damping that can be achieved by the external damper is generally degraded, regardless of properties of the HDR damper. Field tests on an existing cable-stayed bridge have further validated the influence of the internal damper on the performance of the external damper. The results suggest that the HDR is optimally placed in the guide pipe of the cable-pylon anchorage when installing viscous dampers at one position is insufficient. When an HDR damper or the bushing has to be installed near the external damper, their combined damping effects need to be evaluated using the presented methods.

Development of Real-time based Hardware-In-Loop Simulator for performance evaluation of wind turbine control system (풍력발전기 제어시스템 성능평가를 위한 실시간 처리 기반의 Hardware-In-Loop 시뮬레이터 개발)

  • Kim, Dae-Jin;Ryu, Kyung-Sang;Kim, Byungki;Jang, Moon-Seok;Ko, Hee-Sang;Yoo, Cheol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.10
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    • pp.794-805
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    • 2017
  • This paper proposes a Hardware-In-Loop(HIL) Simulator for a Wind Turbine and an operational control algorithm to evaluate the performance of a wind turbine control system. It provides not only for the validation of the control logics, safety functions and H/W failure, but also for the high reliability of the wind turbines (by reducing/and the reduction of the operating expense(OPEX) through performance evaluation tests with complex scenarios. On the other hand, the proposed simulator uses MATLAB, CODER, and the PLC library to operate in synchronization with the hardware, and a real-time processing-based wind turbine module including a dynamic model and control system, wind module, grid module and host PC to manage the HIL-simulator. Several experiments were carried out under the above concept to verify the effectiveness of the proposed WT HIL-simulator.

Validation of the Need for Closure Scale-Short Form (단축형 종결 욕구의 타당화)

  • Kim, Eunkyung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.10
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    • pp.166-173
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    • 2020
  • The purpose of the present study was to validate the Need for Closure Scale-Short Form (NFCS-SF), which measures the need for cognitive closure. Participants completed questionnaires regarding need for cognitive closure, intolerance of uncertainty, depression, and anxiety. Of the 536 data collected between May and July 2017, data from a total of 495 participants were analyzed using SPSS 20.0 and M-Plus. The results of the study are as follows. First, a 15-item selection comprised three items from each facet scale via exploratory factor analysis. Second, the NFCS-SF demonstrated good internal consistency (Study 1, Cronbach's α=.85; Study 2, Cronbach's α=.84). Third, the results of the confirmatory factor analyses supported a 5-factor model (χ2(80)=178.34, p<.001; CFI=.87, TLI=.83, RMSEA=.07, SRMR=.08). Fourth, the NFCS-SF showed significant correlation with the measures of intolerance of uncertainty (r=.58, p<.01), depression (r=.16, p<.05), and anxiety (state anxiety, r=.31, p<.01; trait anxiety, r=.29, as well as the NFCS (r=.86, p<.01). Based on these findings, significance and limitations of the results as well as suggestions for further study are discussed.

A Hippocampus Segmentation in Brain MR Images using Level-Set Method (레벨 셋 방법을 이용한 뇌 MR 영상에서 해마영역 분할)

  • Lee, Young-Seung;Choi, Heung-Kook
    • Journal of Korea Multimedia Society
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    • v.15 no.9
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    • pp.1075-1085
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    • 2012
  • In clinical research using medical images, the image segmentation is one of the most important processes. Especially, the hippocampal atrophy is helpful for the clinical Alzheimer diagnosis as a specific marker of the progress of Alzheimer. In order to measure hippocampus volume exactly, segmentation of the hippocampus is essential. However, the hippocampus has some features like relatively low contrast, low signal-to-noise ratio, discreted boundary in MRI images, and these features make it difficult to segment hippocampus. To solve this problem, firstly, We selected region of interest from an experiment image, subtracted a original image from the negative image of the original image, enhanced contrast, and applied anisotropic diffusion filtering and gaussian filtering as preprocessing. Finally, We performed an image segmentation using two level set methods. Through a variety of approaches for the validation of proposed hippocampus segmentation method, We confirmed that our proposed method improved the rate and accuracy of the segmentation. Consequently, the proposed method is suitable for segmentation of the area which has similar features with the hippocampus. We believe that our method has great potential if successfully combined with other research findings.