• IE interfaces
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• v.10 no.2
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• pp.51-56
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• 1997

This paper concerns with the problem of mixed model assembly sequencing using neural net. In recent years, because of two characteristics of it, massive parallelism and learning capability, neural nets have emerged to solve the problems for which more conventional computational approaches have proven ineffective. This paper proposes a method using neural net that can consider line balancing and grouping problems simultaneously. In order to solve the mixed model assembly sequencing of the motor industry, this paper uses the modified ART1 algorithm.

• Journal of the Korean Operations Research and Management Science Society
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• v.37 no.3
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• pp.39-55
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• 2012

This paper presents an endosymbiotic evolutionary algorithm (EEA) to solve both problems of line balancing and model sequencing in a mixed-model two-sided assembly line (MMtAL) simultaneously. It is important to have a proper balancing and model sequencing for an efficient operation of MMtAL. EEA imitates the natural evolution process of endosymbionts, which is an extension of existing symbiotic evolutionary algorithms. It provides a proper balance between parallel search with the separated individuals representing partial solutions and integrated search with endosymbionts representing entire solutions. The strategy of localized coevolution and the concept of steady-state genetic algorithms are used to improve the search efficiency. The experimental results reveal that EEA is better than two compared symbiotic evolutionary algorithms as well as a traditional genetic algorithm in solution quality.

• Journal of the Korean Operations Research and Management Science Society
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• v.35 no.3
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• pp.25-43
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• 2010

We consider a multi-objective balancing and sequencing problem in mixed model assembly lines, which is important for an efficient use of the assembly lines. In this paper, we present a neighborhood symbiotic evolutionary algorithm to simultaneously solve the two problems of balancing and model sequencing under multiple objectives. We aim to find a set of well-distributed solutions close to the true Pareto optimal solutions for decision makers. The proposed algorithm has a two-leveled structure. At Level 1, two populations are operated : One consists of individuals each of which represents a partial solution to the balancing problem and the other consists of individuals for the sequencing problem. Level 2, which is an upper level, works one population whose individuals represent the combined entire solutions to the two problems. The process of Level 1 imitates a neighborhood symbiotic evolution and that of Level 2 simulates an endosymbiotic evolution together with an elitist strategy to promote the capability of solution search. The performance of the proposed algorithm is compared with those of the existing algorithms in convergence, diversity and computation time of nondominated solutions. The experimental results show that the proposed algorithm is superior to the compared algorithms in all the three performance measures.

• Journal of Korean Society of Water and Wastewater
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• v.13 no.3
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• pp.42-55
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• 1999

A mathematical model for biological nutrient removal in a sequencing batch reactor process, which is based on the IAWQ Activated Sludge Model No. 2 with a few modifications, has been developed. Twenty water quality components and twenty three kinetic equations are incorporated in the model. The model is structured in the matrix form based on the law of mass conservation using stoichiometry and kinetic equations. Stoichiometric coefficients and kinetic parameters included in the model equations are chosen from the literature. A multistep predictor-corrector algorithm of variable step-size is adopted for solving the vector nonlinear ordinary differential equations. The simulation for experimental results is conducted to evaluate the validity of the model and to calibrate coefficients and parameters. The simulation using the model well represents the experimental results from laboratory. The mathematical model developed in this study may be utilized for the design and operation of a sequencing batch reactor process under the steady and unsteady-state at various environmental conditions.

• Journal of Korean Institute of Industrial Engineers
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• v.20 no.3
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• pp.15-34
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• 1994

This paper considers the genetic algorithms(GAs) for the mixed model assembly line sequencing(MMALS) in which the objective is to minimize the overall line length. To apply the GAs to the MMALS, the representation, selection, genetic sequencing operators, and genetic parameters are studied. Especially, the existing sequencing binary operators such as partially map crossover(PMX), cycle crossover(CX), and order crossover (OX) are modified to be suitable for the MMALS, and a new sequencing binary operator called immediate successor relationship crossover (ISR) is introduced. These binary operators mentioned above and/or unary operators such as swap, insertion, inversion, displacement, and splice are compared to find operators which work well in the MMALS. Experimental results indicate that 1) among the binary operators ISR operator is the best, followed by the modified OX, and the modified PMX, with the modified CX being the worst, 2) among the unary operators inversion operator is the best, followed by displacement, swap, and insertion, with splice being the worst, and 3) in general, the unary operators perform better than the binary operators for the MMALS.

• Journal of Microbiology and Biotechnology
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• v.16 no.5
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• pp.683-688
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• 2006

We have developed a program for generating shotgun data sets from known genome sequences. Generation of synthetic data sets by computer program is a useful alternative to real data to which students and researchers have limited access. Uniformly-distributed-sampling clones that were adopted by previous programs cannot account for the real situation where sampled reads tend to come from particular regions of the target genome. To reflect such situation, a probabilistic model for biased sampling distribution was developed by using an experimental data set derived from a microbial genome project. Among the experimental parameters tested (varied fragment or read lengths, chimerism, and sequencing error), the extent of sequencing error was the most critical factor that hampered sequence assembly. We propose that an optimum sequencing strategy employing different insert lengths and redundancy can be established by performing a variety of simulations.

• Genomics & Informatics
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• v.16 no.4
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• pp.32.1-32.7
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• 2018

Ovarian cancer is one of the leading causes of cancer-related deaths in gynecological malignancies. Over 70% of ovarian cancer cases are high-grade serous ovarian cancers and have high death rates due to their resistance to chemotherapy. Despite advances in surgical and pharmaceutical therapies, overall survival rates are not good, and making an accurate prediction of the prognosis is not easy because of the highly heterogeneous nature of ovarian cancer. To improve the patient's prognosis through proper treatment, we present a prognostic prediction model by integrating high-dimensional RNA sequencing data with their clinical data through the following steps: gene filtration, pre-screening, gene marker selection, integrated study of selected gene markers and prediction model building. These steps of the prognostic prediction model can be applied to other types of cancer besides ovarian cancer.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.930-935
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• 2002

This paper presents a new method that can efficiently solve the integrated problem of line balancing and model sequencing in mixed-model U-lines (MMULs). Balancing and sequencing problem are important for an efficient use of MMULs and are tightly related with each other. However, in almost all the existing researches on mixed­model production lines, the two problems have been considered separately. In 1his research, an endosymbiotic evolutionary algorithm, which is a kind of evolutionary algorithm, is adopted as a methodology in order to solve the two problems simultaneously. Some evolutionary search capability, rapidity of convergence and population diversity. The proposed algorithm is compared with the existing evolutionary algorithm in terms of solution quality. The experimental results confirm the effectiveness of our approach.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.18 no.33
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• pp.29-37
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• 1995

An Automated Storage/Retrieval Systems(AS/RS) has been gradually emphasized because of the change of production and distribution environment. This paper develops algorithm and Shortest Distance Model that can reduce the traveling time of a stacker crane for efficient operation of AS/RS. In order to reduce the traveling time of a stacker crane, we determine the order processing and then the sequencing of storage/retrieval for each item. Order processing is determined based on the SPT(Shortest Processing Time) concept considering a criterion of retrieval coordinate. The sequencing of storage/retrieval is determined based on the Shortest Distance Model by using a modified SPP(Shortest Path Problem) of network problem. A numerical example is provided to illustrate the developed algorithm and Shortest Distance Model.

• Journal of Korean Institute of Industrial Engineers
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• v.21 no.3
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• pp.329-343
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• 1995

Traditionally, machining process sequence was influenced and constrained by the design information obtained from CAD data base, i.e., class of operations, geometric shape, tooling, geometric tolerance, etc. However, even though all the constraints from design information are considered, there may exist more than one way to feasibly machine parts. This research is focused on the integrated problem of operations sequencing and machine tools selection in the presence of the product mix and their production volumes. With the transitional costs among machining operations, the operation sequencing problem can be formulated as a well-known Traveling Salesman Problem (TSP). The transitional cost between two operations is expressed as the sum of total machining time of the parts on a machine for the first operation and transportation time of the parts from the first machine to a machine for the second operation. Therefore, the operation sequencing problem formulated as TSP cannot be solved without transitional costs for all operation pairs. When solved separately or serially, their mutual optima cannot be guaranteed. Machining operations sequencing and machine tool selection problems are two core problems in process planning for discretely machined parts. In this paper, the interrelated two problems are integrated and analyzed, zero-one integer programming model for the integrated problem is formulated, and the solution methods are developed using a Tabu Search technique.