• Genomics & Informatics
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• v.11 no.4
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• pp.263-271
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• 2013

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p=0.030). The highest muscle was observed in the children with TT compared with CC (p=0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p=0.029 vs. p=0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p=0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust $r^2$=1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.1
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• pp.89-96
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• 2008

The study, with regard to unsymmetrically inclined backfilled wall, was intended to estimate the lateral earth pressure, develop the equation for lateral earth pressure and eventually identify the mutual behavior, based on the modified Kellogg theory, while changing the width between the walls, wall angle, relative density and wall friction angle. To verify the geostatic pressure obtained from the study, the results in the wake of 62 kinds of model tests performed were compared and evaluated with the behaviors based on theoretical equations. As a result, the wall inclination angle was found to be the factors affecting the earth pressure the most, when both walls were inclined unsymmetrically. And the narrower the backfill space and the larger the wall inclination angle to the horizontal level, the greater the effect of the wall friction. The equation considering the wall friction reaction indicated the value, which was closer to the actually-measured earth pressure, and when the width between the warts was narrow, the arching effect appeared to be great, thereby indicating the difference between the measured earth pressure, theoretically calculated earth pressure and the geostatic pressure proved to be insignificant.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.7
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• pp.100-111
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• 2003

The HAUSAT-1(Hankuk Aviation University SATellite-1) will orbit at the altitude of 650km-800 km with 65 or 98 degree inclination angle. The effects of magnetic field and Earth gravity are more predominant than other space disturbances because the HAUSAT-1 will be positioned in LEO(Low Earth Orbit). The HAUSAT-1 design implements a magnetic control system and gravity-stable system which implement the solar panel deployment system. The simulation using MATLAB was performed to make sure the attitude stability of HAUSAT-1, which is based on the 8th order magnetic field model and non-linear equations of disturbances and the HAUSAT-1 attitude. The stability is investigated for two different HAUSAT-1 configurations and attitude which are affected by disturbances through simulation. The results for gravity-gradient stable and non gravity-gradient stable system are compared. Methodology of attitude stabilization was explored to develop an effective attitude control system for the HAUSAT-1 using magnetic torquers.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.2
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• pp.139-146
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• 2009

In this study, an assessment is made for the helicopter vibration reduction of composite rotor blades using an active twist control concept. The piezoceramic shear actuation mechanism along with elastic couplings of composite blades is used for vibration reduction. The rotor blades are modeled as composite box-beams with actuator layers bonded on the outer surfaces of the thin-walled section. The governing equations of motion for helicopter blades are obtained using Hamilton's principle. A time domain unsteady aerodynamic theory with free wake model is used to obtain the airloads. Various rotor configurations with different elastic couplings with appropriate actuator placement are used to investigate the hub vibration characteristics. Numerical results show that a substantial reduction of $N_b$/rev hub vibration can be achieved using the optimal control algorithm.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.2
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• pp.113-120
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• 2009

To numerically simulate aerodynamics of rotor-airframe interaction in a rigorous manner, we need to solve the Navier-Stokes system for a rotor-airframe combination in a single computational domain. This imposes a computational burden since rotating blades and a stationary body have to be simultaneously dealt with. An efficient alternative is a momentum source method in which the action of rotor is approximated as momentum source in a stationary mesh system built around the airframe. This makes the simulation much easier. The magnitude of the momentum source is usually evaluated by the blade element theory, which often results in a poor accuracy. In the present work, we evaluate the momentum source from the simulation data by using the Navier-Stokes equations only for a rotor system. Using this data, we simulated the time-averaged steady rotor-airfame interaction and developed the unsteady rotor-airframe interaction. Computations were carried out for the simplified rotor-airframe model (the Georgia Tech configuration) and the results were compared with experimental data. The results were in good agreement with experimental data, suggesting that the present approach is a usefull method for rotor-airframe interaction analysis.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.10
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• pp.984-991
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• 2009

In this study, transonic aeroelastic response analyses have been conducted for the DLR-F4(wing-body) aircraft configuration considering shockwave and flow separation effects. The developed fluid-structure coupled analysis system is applied for aeroelastic computations combining computational structural dynamics(CSD), finite element method(FEM) and computational fluid dynamics(CFD) in the time domain. It can give very accurate and useful engineering data on the structural dynamic design of advanced flight vehicles. For the nonlinear unsteady aerodynamics in high transonic flow region, Navier-Stokes equations using the structured grid system have been applied to wing-body configurations. In transonic flight region, the characteristics of static and dynamic aeroelastic responses have been investigated for a typical wing-body configuration model. Also, it is typically shown that the current computation approach can yield realistic and practical results for aircraft design and test engineers.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.6
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• pp.532-540
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• 2008

Recently there are growing interests in calculating aerodynamic characteristics of aircraft configurations with structural deformation using the FSI(Fluid-Structure Interaction) system in which CFD(Computational Fluid Dynamics) and CSD(Computational Structure Dynamics) modules are coupled. In this paper the FSI system comprised of CAD, CFD, CSD, VSI(Volume Spline Interpolation) and grid deformation modules was constructed in order to investigate aerodynamic characteristics of the deformed shape. In the process VSI and grid generation modules are developed to combine CSD and CFD routines and to regenerate the aerodynamic grids for the deformed shape, respectively. For the CFD and CSD analysis, commercial programs FLUENT and NASTRAN were used. As a test model, DLR-F4 wing configuration was chosen and its aerodynamic characteristics were calculated by applying the static FSI system. It was shown that lift and drag coefficients of the wing at mach number 0.75 are reduced to 20.26% and 18.5%, respectively, owing to the structural deformation.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.4
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• pp.383-388
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• 2015

$K^+$ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the same age (postnatal day (P) 0-P6) were used as controls. Similar slow rising $K^+$ currents were observed in both genotypes, but their biophysical and pharmacological properties were quite different. The values of Vhalf for activation were significantly different in the heterozygous (+/cir) and homozygous (cir/cir) mice ($-8.1{\pm}2.2mV$, heterozygous (+/cir) mice (n=7) and $-17.2{\pm}4.2mV$, homozygous (cir/cir) mice (n=5)). The inactivation curve was expressed by a single first order Boltzmann equation in the homozygous (cir/cir) mice, while it was expressed by a sum of two first order Boltzmann equations in the heterozygous (+/cir) mice. The $K^+$ current of homozygous (cir/cir) mice was more sensitive to TEA in the 1 to 10 mM range, while the 4-AP sensitivities were not different between the two genotypes. Removal of external $Ca^{2+}$ did not affect the $K^+$ currents in either genotype, indicating that the higher sensitivity of $K^+$ current to TEA in the homozygous (cir/cir) mice was not due to an early expression of $Ca^{2+}$ activated $K^+$ channels. Our results suggest that the $K^+$ outward current of developing homozygous (cir/cir) mice OHCs is different in both biophysical and pharmacological aspects than that of heterozygous (+/cir) mice.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.1
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• pp.203-210
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• 2017

In this paper, we propose a electrical/mechanical method to effectively diagnose the local deterioration of a 10m long power shielded twist pair cable defined by the American Wire Gauge (AWG) 14 specification using electrical/mechanical methods. The rapid deterioration of the cable proceeded by using the heating furnace, which is based on the Arrhenius equations proceeds from 0 to 35 years with the deteriorated equivalent model. In this paper, we introduce a method to diagnose the characteristics of locally deteriorated cable by using $S_{21}$ phase and frequency change rate measured by vector network analyzer which is the electrical diagnostic method. The measured $S_{21}$ phase and rate of change of frequency show a constant correlation with the number of years of locally deteriorated cable, thus it can be useful for diagnosing deteriorated cables. The change of modulus due to deterioration was measured by a modulus measuring device, which is defined by the ratio of deformation from the force externally applied to the cable, and the rate of modulus change also shows a constant correlation with the number of years of locally deteriorated cable. Finally, By combining the advantages of electrical/mechanical diagnostic methods, we can efficiently diagnose the local deterioration in the power shielded cable.

• Journal of information and communication convergence engineering
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• v.9 no.4
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• pp.475-482
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• 2011

In this research, we have attempted to estimate the water quality of fish farms in terms of parameters such as water temperature, dissolved oxygen, pH, and salinity by employing observational data obtained from a coastal ocean observatory of a national institution located close to the fish farm. We requested and received marine data comprising nine factors including water temperature from Korea Hydrographic and Oceanographic Administration. For verifying our results, we also established an experimental fish farm in which we directly placed the sensor module of an optical mode, YSI-6920V2, used for self-cleaning inside fish tanks and used the data measured and recorded by a environment monitoring system that was communicating serially with the sensor module. We investigated the differences in water temperature and salinity among three areas - Goheung Balpo, Yeosu Odongdo, and the experimental fish farm, Keumho. Water temperature did not exhibit significant differences but there was a difference in salinity (significance <5%). Further, multiple regression analysis was performed to estimate the water quality of the fish farm at Keumho based on the data of Goheung Balpo. The water temperature and dissolved-oxygen estimations had multiple regression linear relationships with coefficients of determination of 98% and 89%, respectively. However, in the case of the pH and salinity estimated using the oceanic environment with nine factors, the adjusted coefficient of determination was very low at less than 10%, and it was therefore difficult to predict the values. We plotted the predicted and measured values by employing the estimated regression equation and found them to fit very well; the values were close to the regression line. We have demonstrated that if statistical model equations that fit well are used, the expense of fish-farm sensor and system installations, maintenances, and repairs, which is a major issue with existing environmental information monitoring systems of marine farming areas, can be reduced, thereby making it easier for fish farmers to monitor aquaculture and mariculture environments.