• The Korean Journal of Pain
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• v.23 no.3
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• pp.179-185
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• 2010

Background: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. Methods: Male Sprague-Dawley rats weighing 220-240 g were used in all experiments. Rats subsequently received daily intraperitoneal injections of either vincristine sulfate (0.1 ml/kg/day) or saline (0.1 ml/kg/day) over 12 days, immediately following behavioral testing. For assessment of mechanical allodynia, mechanical stimuli using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of N-methyl-D-aspartate receptors antagonist (memantine; 2.5, 5, 10 mg/kg intraperitoneal), opioid agonist (morphine; 2.5, 5, 10 mg/kg intraperitoneal) and vehicle (saline) on vicristine-induced neuropathy were evaluated. Results: Mechanical allodynia developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same time. Morphine abolished the reduction in paw withdrawal threshold compared to vehicle and produced dose-responsiveness. Only the highest dose of memantine (10 mg/kg) was able to increase paw withdrawal threshold compared to vehicle. Conclusions: Systemic morphine and memantine have an antinociceptive effect on the vincristine-induced peripheral neuropathy model in rats. These results suggest morphine and memantine may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.2
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• pp.620-627
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• 2010

This study for construction of golf courses is to present basic information and pattern of change of construction cost by looking at the capacity of construction, requiring time and other aspects. The propose of this study is to develop the model of brief cost expected by using cost index and analyzing the actual work cost data gathered in golf course construction industry in Korea. The equation used for the cost-capacity index in other to deliver the expected construction cost is followed next. The results of this study, by regression analysis for the information of 7 golf courses, it could be found the cost-capacity index n, such as 0.72 for whole construction, 0.67 for net construction.

• The Journal of the Korea Contents Association
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• v.15 no.4
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• pp.490-499
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• 2015

In this study, for the introduction factors of ERP system suggested in the prior study, I analyzed the importance of each introduction factor by using Delphi methodology and AHP. As a result of analysing the importance of the introduction factors of the 1st layer, the supplier factor was analyzed to be the most important factor among innovation factor, information technology factor, the user factor, the supplier factor, and in the weight analysis on the 2nd layer considering the importance of 1st layer, the standard work model of the supplier factor was a suitable factor, and the CEO participation factor(.086) was analyzed as the second most important introduction factor. These analysis results enable to determine that domestic Small & Medium enterprises' position hope to introduce by selecting a system in which the company characteristics and management strategies are applied well, because they should operate an ERP system that has already been developed, and in this course, the participation of CEO was also found to be a very important factor.

• Journal of Navigation and Port Research
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• v.28 no.10 s.96
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• pp.827-832
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• 2004

Up to now a lot of the study on ship collision avoidance systems have proceeded actively. However the rate of ship collision accidents hasn't decreased yet. If there is collision risk in close quarters situation in spite of maneuvering ship for collision avoidance according to the system, only use of TCP A and DCP A as input factor for collision risk decision is not useful to avoiding collision action. For the recent 5 years by the analysis of first observation distance about approaching ship in domestic collision accidents, nearly $45\%$ of accidents is close first observation less than 2 miles. Therefore it is essential part for safety navigations to study for collision avoidance action in close encounter. In this paper, as a fundamental study of supporting collision avoidance maneuvering for navigators, we proposed ship collision avoidance support model in close quarters situation through analysis qf collision accidents to effectively get rid of the causes.

• Journal of Korean Neurosurgical Society
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• v.49 no.2
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• pp.83-91
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• 2011

Objective : Minocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury. Methods : To simulate spinal cord injury, the rats' spinal cords were hemisected at the 10th thoracic level (T10). Minocycline was injected intraperitoneally, and was administered 30 minutes prior surgery and every second postoperative day until sacrifice 28 days after surgery. Motor recovery was assessed via the Basso-Beattie-Bresnahan test Mechanical hyperalgesia was measured throughout the 28-day post -operative course via the von Frey test Microglial and astrocyte activation was assessed by immunohistochemical staining for ionized calcium binding adaptor molecule 1 (lba1) and glial fibrillary acidic protein (GFAP) at two sites: at the level of hemisection and at the 5th lumbar level (L5). Results : In rats, spinal cord hemisection reduced locomotor function and induced a mechanical hyperalgesia of the ipsilateral hind limb. The expression of lba1 and GFAP was also increased in the dorsal and ventral horns of the spinal cord at the site of hemisection and at the L5 level. Intraperitoneal injection of minocycline facilitated overall motor recovery and attenuated mechanical hyperalgesia. The expression of lba1 and GFAP in the spinal cord was also reduced in rats treated with minocycline. Conclusion : By inhibiting microglia and astrocyte activation, minocycline may facilitate motor recovery and attenuate mechanical hyperalgesia in individuals with spinal cord injuries.

• Journal of Digital Convergence
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• v.12 no.12
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• pp.203-215
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• 2014

Although many studies about start-up existed, It is almost never shown study about ICT convergence start-up enterprise. This study tries to analyze success factor to start-up enterprise in rapidly growing ICT convergence area. Based on 10 entrepreneurial success cases, We figure out the total 29 units success factors utilizing ERIS model. We classify ICT commercialization with 4 types which are software-R&D centric, software marketing centric, software plus hardware R&D centric, software plus hardware marketing centric. Among success factors the most success factor is related entrepreneur;s ability and include major and professional knowledge about ICT's filed, insight through sensitivity about technical paradigm etc. It was derived the success factors indicated in the course of commercialization of ICT Covergence Unlike other forms of the existing start-up entrepreneurs and contributed to typified in four forms startups for ICT Covergence start-up entrepreneurs.

• Journal of Environmental Health Sciences
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• v.43 no.3
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• pp.214-222
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• 2017

Objectives: A hospital is a complex building that serves many different purposes. The indoor environment in a hospital plays a major role in patient well-being and the work efficiency of the hospital staff. This study was conducted to evaluate overall comfort in two major hospitals over the course of one year. Methods: Various indoor environmental conditions were measured in two general hospitals for one year (April 2014 to April 2015). Monitoring alternated between the hospitals at one month per respective monitoring session. The indoor air temperature, relative humidity (RH), mean radiant temperature and air velocity were measured in order to calculate the predicted mean vote (PMV). Carbon dioxide concentration, noise level and illumination level were concurrently measured and applied to the overall IEQ acceptance model for the hospitals (IEQh). Results: The IEQh at the two general hospitals was different at five spaces within a building. The IEQh for summer and winter were significantly different. Real-time IEQh demonstrated that indoor comfort was affected by the hospital's operating hours due to operation of the HVAC system. The percentage of indoor comfort in the hospitals was higher using PMV than IEQh. Conclusion: IEQh in the hospitals was different at locations with different purposes. Indoor comfort assessment using IEQh was stricter than with PMV. Additional research is needed in order to optimize the IEQh model.

• Korean Journal of Social Welfare
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• v.61 no.4
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• pp.137-161
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• 2009

In an effort to identify predictors of job performance, research studies in social work administration has been so far on the individual practitioners' levels of knowledge and skills, which could be used in a workplace. As the theoretical concept of organizational environment was fully introduced into social work administration research, however, studies on practitioners' job performance began to have interest in the team or the organizational level variables as well as individual level variables. Along the course of this tendency, this study attempted to test the effect of individual, team, and organizational level variables on the job performance of human service workers. The individual level variables consisted of knowledge, skills, job satisfaction, personality, and counter-productive work behaviors of workers. The team or the organizational level variables included situational constraint, organizational justice, job characteristics, government-dependency, and inter-organizational cooperation. Multi-level complex survey data collected by cluster sampling method from 314 practitioners in 23 organizations were analyzed using Hierarchial Linear Model. Results showed that both task and contextual performance were affected by individual, team, and organizational level variables in various ways.

• Journal of the Korean Data and Information Science Society
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• v.23 no.6
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• pp.1173-1181
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• 2012

In order to suggest the basic resources of mathematics education to the specialized high school, we investigate the attitude of students about mathematics education. Questionnaires survey was carried on 654 students and we use the statistical analysis such as chi-square test, gamma, generalized linear model, Anova, regression. Several result can be derived from the questionnaire analysis. There are differences between the general and specialized high school students in the interest, pre-learning ability etc. The specialized school students think the usefulness of mathematics more importantly, while the general school students think more closely related to their course.

• Journal of the Korean earth science society
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• v.24 no.5
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• pp.411-419
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• 2003

The assessment of environmental impact on NO$_2$ (or TSP) emitted by vehicles is important for local residents from the point of view of their health and environmental protection. In the course of field investigations, correct concentrations are measured and meteorological data are observed for numerical simulation. To determine background concentration for numerical simulation, annual average concentrations of NO$_2$ (or TSP) are estimated using the Puff-Plume model. If the estimated result affects the environment, it must be considered in the environmental conservation activity. To make the process of a estimation of environmental assessment more easily, this system is developed. Moreover, this system was supplied a Graphic User Interface (GH) for the user who calculated the concentration of air pollution exhausted from the traffic on general roads except special roads such as interchanges and entrances to tunnels. This system can offer not only the numerical result but also a graphic display. Even a beginner who is not a professional programmer can calculate the result easily.