• Journal of Power Electronics
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• v.18 no.4
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• pp.1075-1085
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• 2018

To deal with the operation performance degradation of permanent magnet synchronous machine (PMSM) drives with uncertainties and unmodeled dynamics, this paper presents a finite-time nonlinear disturbance observer (FTNDO) based discretized integral sliding mode (DISM) composite control scheme. Based on the reaching-law approach, a DISM speed controller featuring a superior dynamic quality and global robustness against disturbances is constructed. This controller can avoid the reaching phase and overlarge control action. In addition, a sliding mode differentiator based FTNDO is devised and extended to the discrete-time domain for disturbance estimation. The attractive features of the FTNDO are that it can provide a finite-time converging estimation and alleviate the chattering effect in conventional sliding mode observers, while retaining robustness to parameter variations. By feeding the estimate forward to the pre-stage DISM controller, both disturbances and chattering can be significantly suppressed. Moreover, considering the estimation error of a FTNDO caused by discrete sampling, a stability analysis of the composite controller is discussed. Experimental results validate the superiority of the presented scheme.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.3
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• pp.401-410
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• 2017

In this work, we show that the excessive lattice heating problem due to parasitic pnp transistor action in the diode electrostatic discharge (ESD) protection device in the diode input protection circuit, which is favorably used in CMOS RF ICs, can be solved by adopting a symmetrical cathode structure. To explain how the recipe works, we construct an equivalent circuit for input human-body model (HBM) test environment of a CMOS chip equipped with the diode protection circuit, and execute mixed-mode transient simulations utilizing a 2-dimensional device simulator. We attempt an in-depth comparison study by varying device structures to suggest valuable design guidelines in designing the protection diodes connected to the $V_{DD}$ and $V_{SS}$ buses. Even though this work is based on mixed-mode simulations utilizing device and circuit simulators, the analysis given in this work clearly explain the mechanism involved, which cannot be done by measurements.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.431-435
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• 2001

The active structural control has emerged as structural safety of structures against natural loadings such as earthquake and wind loadings. Of many control algorithms, Sliding-Mode Control (SMC) can design both linear controller and nonlinear controller. The robustness against parameter variations as well as excitation uncertainties that is imparted to the SMC due to its nonlinear control action, could make SMC an attractive control algorithm when dealing with structures where the external excitation constitutes the main uncertainty in the system. This paper demonstrates experimentally the efficacy of the SMC algorithm based on the active mass driver system in reducing the response of seismically excited buildings. The SMC control strategy is verified with the experimental study on the one-story building model equipped with the active mass driver.

• Parasites, Hosts and Diseases
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• v.57 no.4
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• pp.359-368
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• 2019

In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmanicidal activity against promastigote and amastigote, apoptosis and gene expression levels of free solution and niosomal-encapsulated tioxolone along with benzoxonium chloride. Span/Tween 60 niosome had good physical stability and high encapsulation efficiency (more than 97%). The release profile of the entrapped compound showed that a gradual release rate. The combination of niosomal forms on promastigote and amastigote were more effective than glucantime. Also, the niosomal form of this compound was significantly less toxic than glucantime ($P{\leq}0.05$). The flowcytometric analysis on niosomal form of drugs showed that higher number of early apoptotic event as the principal mode of action (89.13% in $200{\mu}g/ml$). Also, the niosomal compound increased the expression level of IL-12 and metacaspase genes and decreased the expression level of the IL-10 gene, which further confirming the immunomodulatory role as the mechanism of action. We observed the synergistic effects of these 2 drugs that induced the apoptotic pathways and also up regulation of an immunomodulatory role against as the main mode of action. Also, niosomal form of this combination was safe and demonstrated strong anti-leishmaniasis effects highlights further therapeutic approaches against anthroponotic cutaneous leishmaniasis in future planning.

• BMB Reports
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• v.43 no.5
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• pp.362-368
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• 2010

Dermcidin is a human antibiotic peptide that is secreted by the sweat glands and has no homology to other known antimicrobial peptides. As an initial step toward understanding dermcidin's mode of action at bacterial membranes, we used homonuclear and heteronuclear NMR to determine the conformation of the peptide in 50% trifluoroethanol solution. We found that dermcidin adopts a flexible amphipathic $\alpha$-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. Spin-down assays of dermcidin and several related peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic $\alpha$-helical structure and its length (>30 residues); its negative net charge and acidic pI have little effect on binding. These findings suggest that the mode of action of dermcidin is similar to that of other membrane-targeting antimicrobial peptides, though the details of its antimicrobial action remain to be determined.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.131-135
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• 2006

Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular nuclear neurons of rat by whole-cell patch-clamp technique. Sprague-Dawley rats, aged 14 to 16 days, were used. After enzymatic digestion, dissociated medial vestibular neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous action potentials were recorded by standard patch-clamp techniques. In current-clamp mode, the frequency of spontaneous action potential of medial vestibular nuclear neurons was decreased by phenylephrine (n=15). Phenylephrine increased the amplitude of afterhyperpolarization without changes in the resting membrane potential and spike width. In voltage-clamp mode, the whole potassium currents of the medial vestibular nuclear neurons were increased by phenylephrine (n=12). These experimental results suggest that ${\alpha}-receptor$ mediates the inhibitory effects on the neuronal activity of the medial vestibular nuclear neuron.

• The Korean Journal of Pain
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• v.29 no.3
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• The Korean Journal of Mycology
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• v.24 no.4 s.79
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• pp.255-264
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• 1996

The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephaloxporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.

• Journal of Korean Society of Steel Construction
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• v.28 no.6
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• pp.459-465
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• 2016

In this paper, it was performed the fatigue test to examine the effect of cyclic loading for the simple T-joint. Axial force of bolt by clamping and the change of the force by applied load were measured in the joint. And the bolt force, the failure mode and the fatigue strength under cyclic loading were investigated. The parameters of the tension joint were set to be the flange thickness and the diameter of bolt to a different stiffness of the joint in response to the combination. From the fatigue test, failure mode of tensile joints under cyclic loading could be evaluated using a static ultimate load of the specific failure mode in EC3. The fatigue strength of the tension joints was considerably higher than the fatigue strength of the EC3(36) that does not consider a lever action. However, the additional axial force by lever action occurs to an increase in the axial force of the bolt it requires a careful evaluation of the fatigue strength.

• Journal of Electrical Engineering and Technology
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• v.4 no.4
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• pp.499-509
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• 2009

Electric vehicles (EV) are developing fast during this decade due to drastic issues on the protection of environment and the shortage of energy sources, so new technologies allow the development of electric vehicles (EV) by means of electric motors associated with static converters. The proposed propulsion system consists of two induction motors (IM) that ensure the drive of the two back driving wheels. The electronic differential system ensures the robust control of the vehicle behavior on the road. It also allows controlling, independently, every driving wheel to turn at different speeds in any curve. This paper presents the study of an hybrid Fuzzy-sliding mode control (SMC) strategy for the electric vehicle driving wheels, stability improvement, in which the fuzzy logic system replace the discontinuous control action of the classical SMC law. Our electric vehicle fuzzy-sliding mode control's simulated in Matlab SIMULINK environment, the results obtained present the efficiency of the proposed control with no overshoot, the rising time is perfected with good disturbances rejections comparing with the classical control law.