• Journal of Power Electronics
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• 제18권4호
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• pp.1075-1085
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• 2018

To deal with the operation performance degradation of permanent magnet synchronous machine (PMSM) drives with uncertainties and unmodeled dynamics, this paper presents a finite-time nonlinear disturbance observer (FTNDO) based discretized integral sliding mode (DISM) composite control scheme. Based on the reaching-law approach, a DISM speed controller featuring a superior dynamic quality and global robustness against disturbances is constructed. This controller can avoid the reaching phase and overlarge control action. In addition, a sliding mode differentiator based FTNDO is devised and extended to the discrete-time domain for disturbance estimation. The attractive features of the FTNDO are that it can provide a finite-time converging estimation and alleviate the chattering effect in conventional sliding mode observers, while retaining robustness to parameter variations. By feeding the estimate forward to the pre-stage DISM controller, both disturbances and chattering can be significantly suppressed. Moreover, considering the estimation error of a FTNDO caused by discrete sampling, a stability analysis of the composite controller is discussed. Experimental results validate the superiority of the presented scheme.

• JSTS:Journal of Semiconductor Technology and Science
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• 제17권3호
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• pp.401-410
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• 2017

In this work, we show that the excessive lattice heating problem due to parasitic pnp transistor action in the diode electrostatic discharge (ESD) protection device in the diode input protection circuit, which is favorably used in CMOS RF ICs, can be solved by adopting a symmetrical cathode structure. To explain how the recipe works, we construct an equivalent circuit for input human-body model (HBM) test environment of a CMOS chip equipped with the diode protection circuit, and execute mixed-mode transient simulations utilizing a 2-dimensional device simulator. We attempt an in-depth comparison study by varying device structures to suggest valuable design guidelines in designing the protection diodes connected to the $V_{DD}$ and $V_{SS}$ buses. Even though this work is based on mixed-mode simulations utilizing device and circuit simulators, the analysis given in this work clearly explain the mechanism involved, which cannot be done by measurements.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 춘계학술대회논문집
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• pp.431-435
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• 2001

The active structural control has emerged as structural safety of structures against natural loadings such as earthquake and wind loadings. Of many control algorithms, Sliding-Mode Control (SMC) can design both linear controller and nonlinear controller. The robustness against parameter variations as well as excitation uncertainties that is imparted to the SMC due to its nonlinear control action, could make SMC an attractive control algorithm when dealing with structures where the external excitation constitutes the main uncertainty in the system. This paper demonstrates experimentally the efficacy of the SMC algorithm based on the active mass driver system in reducing the response of seismically excited buildings. The SMC control strategy is verified with the experimental study on the one-story building model equipped with the active mass driver.

• Parasites, Hosts and Diseases
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• 제57권4호
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• pp.359-368
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• 2019

In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmanicidal activity against promastigote and amastigote, apoptosis and gene expression levels of free solution and niosomal-encapsulated tioxolone along with benzoxonium chloride. Span/Tween 60 niosome had good physical stability and high encapsulation efficiency (more than 97%). The release profile of the entrapped compound showed that a gradual release rate. The combination of niosomal forms on promastigote and amastigote were more effective than glucantime. Also, the niosomal form of this compound was significantly less toxic than glucantime ($P{\leq}0.05$). The flowcytometric analysis on niosomal form of drugs showed that higher number of early apoptotic event as the principal mode of action (89.13% in $200{\mu}g/ml$). Also, the niosomal compound increased the expression level of IL-12 and metacaspase genes and decreased the expression level of the IL-10 gene, which further confirming the immunomodulatory role as the mechanism of action. We observed the synergistic effects of these 2 drugs that induced the apoptotic pathways and also up regulation of an immunomodulatory role against as the main mode of action. Also, niosomal form of this combination was safe and demonstrated strong anti-leishmaniasis effects highlights further therapeutic approaches against anthroponotic cutaneous leishmaniasis in future planning.

• BMB Reports
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• 제43권5호
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• pp.362-368
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• 2010

Dermcidin is a human antibiotic peptide that is secreted by the sweat glands and has no homology to other known antimicrobial peptides. As an initial step toward understanding dermcidin's mode of action at bacterial membranes, we used homonuclear and heteronuclear NMR to determine the conformation of the peptide in 50% trifluoroethanol solution. We found that dermcidin adopts a flexible amphipathic $\alpha$-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. Spin-down assays of dermcidin and several related peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic $\alpha$-helical structure and its length (>30 residues); its negative net charge and acidic pI have little effect on binding. These findings suggest that the mode of action of dermcidin is similar to that of other membrane-targeting antimicrobial peptides, though the details of its antimicrobial action remain to be determined.

• The Korean Journal of Physiology and Pharmacology
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• 제10권3호
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• pp.131-135
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• 2006

Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular nuclear neurons of rat by whole-cell patch-clamp technique. Sprague-Dawley rats, aged 14 to 16 days, were used. After enzymatic digestion, dissociated medial vestibular neurons were transferred to a recording chamber mounted on an inverted microscope, and spontaneous action potentials were recorded by standard patch-clamp techniques. In current-clamp mode, the frequency of spontaneous action potential of medial vestibular nuclear neurons was decreased by phenylephrine (n=15). Phenylephrine increased the amplitude of afterhyperpolarization without changes in the resting membrane potential and spike width. In voltage-clamp mode, the whole potassium currents of the medial vestibular nuclear neurons were increased by phenylephrine (n=12). These experimental results suggest that ${\alpha}-receptor$ mediates the inhibitory effects on the neuronal activity of the medial vestibular nuclear neuron.

• The Korean Journal of Pain
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• 제29권3호
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• 한국균학회지
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• 제24권4호통권79호
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• pp.255-264
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• 1996

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xlyotetraose로부터 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변환 실험결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다.

• 한국강구조학회 논문집
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• 제28권6호
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• pp.459-465
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• 2016

본 연구에서는 인장이음에 대한 반복하중의 영향을 파악하기 위하여 단순 인장이음을 대상으로 피로시험을 수행하였다. 인장이음의 볼트체결에 따른 축력과 작용하중에 의한 축력의 변화를 측정하였고 반복하중에 의한 볼트의 축력과 파괴양상, 이음의 피로강도를 조사하였다. 인장이음의 구조 상세 변수는 플랜지 두께와 고장력 볼트의 직경으로서 이들의 조합에 따라 볼트와 연결부의 강성이 달라지도록 하였다. 피로시험결과, 반복하중을 받는 인장이음의 파괴모드는 EC3에서 제시하고 있는 정적 파괴모드별 극한하중을 이용하여 평가될 수 있었다. 인장이음의 피로강도는 지레작용을 고려하지 않은 EC3(36)의 피로강도보다 상당히 안전측의 결과로 나타났다. 그러나, 지레작용에 의한 부가축력은 볼트 축력의 증가를 일으키기 때문에 피로강도에 대한 신중한 평가가 필요하다.

• Journal of Electrical Engineering and Technology
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• 제4권4호
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• pp.499-509
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• 2009

Electric vehicles (EV) are developing fast during this decade due to drastic issues on the protection of environment and the shortage of energy sources, so new technologies allow the development of electric vehicles (EV) by means of electric motors associated with static converters. The proposed propulsion system consists of two induction motors (IM) that ensure the drive of the two back driving wheels. The electronic differential system ensures the robust control of the vehicle behavior on the road. It also allows controlling, independently, every driving wheel to turn at different speeds in any curve. This paper presents the study of an hybrid Fuzzy-sliding mode control (SMC) strategy for the electric vehicle driving wheels, stability improvement, in which the fuzzy logic system replace the discontinuous control action of the classical SMC law. Our electric vehicle fuzzy-sliding mode control's simulated in Matlab SIMULINK environment, the results obtained present the efficiency of the proposed control with no overshoot, the rising time is perfected with good disturbances rejections comparing with the classical control law.