• Korean Chemical Engineering Research
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• v.46 no.2
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• pp.316-329
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• 2008

Recently the increased attention pays on the processing of multiple, relatively low quantity, high value-added products resulted in adoption of batch process in the chemical process industry such as pharmaceuticals, polymers, bio-chemicals and foods. As there are more possibilities of the improvement of operations in batch process than continuous processes, a lot of effort has been made to enhance the productivity and operability of batch processes. But the chemical process industry faces a range of uncertainties factors such as demands for products, prices of product, lead time for the supply of raw materials and in the production, and the distribution of product. And global competition has made it imperative for the process industries to manage their supply chains optimally. Supply chain management aims to integrate plants with their supplier and customers so that they can be managed as a single entity and coordinate all input/output flows (of materials, information) so that products are produced and distributed in the right quantities, to the right locations, and at the right time.The objective of this study is to solve the purchase, distribution, production planning and scheduling problem, which minimizes the total costs of production, inventory, and transportation under uncertainty. And development of SCM model in chemical industry including batch mode operations. Through that, the enterprise can respond to uncertainty. Also integrated process optimal planning and scheduling model for manufacturing supply chain. The result shows that, the advantage of supply chain integration are quality matters seen by customers and suppliers, order schedules, flexibility, cost reduction, and increase in sales and profits. Also, an integration of supply chain (production and distribution system) generates significant savings by trading off the costs associated with the whole, rather than minimizing supply chain costs separately.

• Journal of Life Science
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• v.20 no.6
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• pp.831-837
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• 2010

KR-31125 (2-butyl-5-dimethoxymethyl-6-phenyl-7-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine) is a potent inhibitor of angiotensin II type 1 ($AT_1$) receptors in human recombinant $AT_1$ receptors and rabbit aorta. These in vitro studies revealed that KR-31125 inhibited specific [$^{125}I$] [$Sar^1$, $Ile^8$]-angiotensin II binding to human recombinant $AT_1$ receptors in a concentration dependent manner with an $IC_{50}$ value of $19.72{\pm}2.65$ nM. However, no interaction with $AT_2$ receptors was detected as displayed by the competition binding of [$^{125}I$] CGP 42112A to human recombinant $AT_2$ receptor. The binding action was also confirmed as a competitive mode that was identical to the previously studied compound, losartan. In addition, KR-31125 caused a nonparallel shift to the right in the concentration response curves to angiotensin II with a 30-80% decrease in the maximum contractile responses ($pK_B$: 7.63). Compared to the previous studies with losartan that showed a parallel right shift in the maximum contractile responses to AII ($pA_2$: 7.59), KR-31125 presented a different mode of action with a similar potency to losartan. These results demonstrate that KR-31125 is a highly potent and $AT_1$ selective angiotensin II receptor antagonist that can be applied to the fields of new diagnostic and research tools with upcoming in vivo study results.

• Journal of Korea Port Economic Association
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• v.28 no.2
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• pp.29-41
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• 2012

Competition between international Hub ports has been more and more intense. In order to invigorate itself, Gwang-Yang port has been making multilateral efforts. However, it has not still reached 300Millions TEU which is the standard to be permitted as a self-reliance Hub port. Therefore, a functional modification of berth should be considered. This study suggests to transform container berths to general berths. This article is focused on reserve berth mode of Gwang Yang hub port and selected three kinds of berths as alternative subjects of the study: general berth, exclusive berth, and multipurpose berth. This research has conducted that The subjects of the survey were in relation with Logistics as professional mutually group about Gwang-Yang hub port. The measurements of this survey were measure section and factor. Also, Fuzzy AHP(Analytic Hierarchy Process) was applied to the survey. According to the result, by measuring weight values of alternatives, the best favored one was multipurpose berth expect stability (32.6%), Exclusive berth was graded the most among the alternatives. Also, based on total weight value, the order of priority is as follows: multipurpose berth(38.2%), exclusive port(33.7%), general berth(28.1%).

• Journal of Plant Biology
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• v.12 no.2
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• pp.28-42
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• 1969

Field studies were conducted with the split plot design of 20 treatment with a combination of 4 levels of 3, 5, 7 and 9 plants per hill and 5 levels of 60, 80, 100, 120 and 140 hills per 3.3$m^2$ on non-, low- and high-salty areas. Rice variety, Kusabue was grown under jthe standard fertilization and cultivating. Investigation was made on the productive structure of plant population, leaf-area index, light intensity curve by stratum of crop population at the panicle differentiation stage. The competition density effect on the photosynthetic capacity was low as the salt concentration became higher. This seemed to suggest the possiblity of an increased yielding capacity by closer planting in the salty areas. The effect of an increased number of hills per unit area was greater than that of an increased unmber of plants per hill due to the total leaf area and space distribution of the actie assimilation parts of rice plants. The number of ppanicle per unit area in the salty areas were increased when the number of hill per 3.3$m^2$ increased over an increased number of plants per hill, and the panicle weight was reduced by close planting in the non-lalty area, while it was not reduced so much in the salty areas. The number of grains per panicle was significantly decreased by close planting in the salty areas as in the non-salty area, and ratio of matured grain was not decreased even by close planting in the salty areas, while it was significantly decreased by close planting in the non-salty area. An increase in the rice yield was possible by close planting and greatly related to leaf area index in the salty areas but not in the non-salty area. Increasing the number of hills per unit area showed greater effect on the increase of the rice yield than an increased number of plants per hill in the salty areas. Relationships between the growth characteristics and the rice population affected by plant spacing mode for maximum production were discussed.

• Proceedings of the KIEE Conference
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• 2002.11d
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• pp.197-199
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• 2002

The invention of VHDL(Very High Speed Integrated Circuit Hardware Description Language), Technical language of Hardware, is a kind of turning point in digital circuit designing, which is being more and more complicated and integrated. Because of its excellency in expression ability of hardware, VHDL is not only used in designing Hardware but also in simulation for verification, and in exchange and conservation, composition of the data of designs, and in many other ways. Especially, It is very important that VHDL is a Technical language of Hardware standardized by IEEE, intenational body with an authority. The biggest problem in modern circuit designing can be pointed out in two way. One is a problem how to process the rapidly being complicated circuit complexity. The other is minimizing the period of designing and manufacturing to survive in a cutthroat competition. To promote the use of VHDL, more than a simple use of simulation by VHDL, it is requested to use VHDL in composing logical circuit with chip manufacturing. And, by developing the quality of designing technique, it can contribute for development in domestic industry related to ASIC designing. In this paper in designing SMPS(Switching mode power supply), programming PWM by VHDL, it can print static voltage by the variable load, connect computer to chip with byteblaster, and download in Max(EPM7064SLCS4 - 5)chip of ALTER. To achieve this, it is supposed to use VHDL in modeling, simulating, compositing logic and product of the FPGA chip. Despite its limit in size and operating speed caused by the specific property of FPGA chip, it can be said that this method should be introduced more aggressively because of its prompt realization after designing.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.2343-2358
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• 2008

The modal spilt for road has been increased, but, for railroad it has been decreased from 17.2%(1990) to 6.3%(2006). It is important to study on improving competition for railroad transportation so that freight transport industry for railroad which is getting to decrease in Korea will be increased. The objective of this study is to analyze the competitiveness of railroad transport compared with road by providing a high-speed railway. The indicators representing the competitiveness of railroad transport are determined. The main influenced factors for mode choice include transport cost, transport time, level of service. Precisely, three commodities type, container, cement, steel, are analyzed.

• The Journal of the Korea Contents Association
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• v.13 no.4
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• pp.361-375
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• 2013

While the mobile application market is growing fast, the revenues of the majority apps are declining. Moreover, paid mobile application prices and purchases have been slow because of intensifying competition. However, the conventional studies focused only on the acceptance factor of mobile applications, so they cannot explain the phenomenon such as acceptance resistance for paid mobile applications. Therefore, our study tries to analyze the factors for the acceptance resistance of users for paid mobile applications. The research model in this paper, which is based on S-O-R model, verified through surveys how social influence and app characteristics affect user perception and how user perception affects to app resistance. The results of our study showed that paid mobile applications happened to be destroyed in front of the chasm because of the perceived loss. Consequently, the results implicate that the developers should lower the initial price and actively react to the negative reviews in order to lower the perceived loss. Moreover, the results verified that a sense of self-efficacy can lower application acceptance resistance by including personal properties to our research model as control variables.

• Molecules and Cells
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• v.38 no.2
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• pp.122-129
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• 2015

DBM-2198, a six-membered azasugar nucleotide (6-AZN)-containing phosphorothioate (P = S) oligonucleotide (AZPSON), was described in our previous publication [Lee et al. (2005)] with regard to its antiviral activity against a broad spectrum of HIV-1 variants. This report describes the mechanisms underlying the anti-HIV-1 properties of DBM-2198. The LTR-mediated reporter assay indicated that the anti-HIV-1 activity of DBM-2198 is attributed to an extracellular mode of action rather than intracellular sequence-specific antisense activity. Nevertheless, the antiviral properties of DBM-2198 and other AZPSONs were highly restricted to HIV-1. Unlike other P = S oligonucleotides, DBM-2198 caused no host cell activation upon administration to cultures. HIV-1 that was pre-incubated with DBM-2198 did not show any infectivity towards host cells whereas host cells pre-incubated with DBM-2198 remained susceptible to HIV-1 infection, suggesting that DBM-2198 acts on the virus particle rather than cell surface molecules in the inhibition of HIV-1 infection. Competition assays for binding to HIV-1 envelope protein with anti-gp120 and anti-V3 antibodies revealed that DBM-2198 acts on the viral attachment site of HIV-1 gp120, but not on the V3 region. This report provides a better understanding of the antiviral mechanism of DBM-2198 and may contribute to the development of a potential therapeutic drug against a broad spectrum of HIV-1 variants.

• The Korean Journal of Air & Space Law and Policy
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• v.3
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• pp.233-258
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• 1991

This paper examines current developing status of space law as defined in terms of its unique principle that "the utilization of outer space for all mankind's interest". As commercialization of space activities has brought about heated debate on its legitimacy with respect to that principle, space law has come to witness a dual situation. One is the realization of that principle in establishing commercial space activities system where all mankind's interest is respected through the non-discriminatory distribution mode of space benefit. In satellite telecommunication system, the INTELSAT Organization assures its public service policy while protecting itself against a competition from separate systems. For remote sensing, commercialization of LANDSAT Systems promoted since 1984 seems not to affect present non-discriminatory distribution of data and information obtained. On the other hand, active participation of private entity aiming at commercial profit enables national government to manage more effective control and supervision of those activities with a view to promoting national interests. Also, newly developed private rules and regulations are emerging in business relations about commercial space activities. Extended capacity of national government assuring its national interest in production and distribution of international resources that is outer space, and regulation of space activities by newly developed rules and customs provoke a concern about a identity problem of space law. The best way to summarize this perspective might consist in saying that non space law regulations, which are not assumed as aiming at the promotion of all mankind's interest, are confirming their role about space related activities. For those reasous, we are now facing a developing status of space law as developments of commercial space activities continues.

• Journal of Industrial Convergence
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• v.20 no.4
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• pp.71-77
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• 2022

It is a reality that office workers in modern society cannot overlook their appearance management for promotion in the workplace that does not fall behind in competition with others and smooth human relationships. According to this social trend, it is time to conduct an in-depth cosmetology study on the appearance management and perception of office workers, including hair styles. Therefore, this study analyzed the hair style type and preference closely by cross-analyzing the differences between groups by classifying the occupational persons of female airline crew, female soldiers, female sportsmen, female lawyers, and female nurses into age, marriage, academic background, and occupation. As result of study, it was found that different women in each occupational group had different results, such as their current hair style type and hair texture, the use of current hair styling products, and their personal preference for women's hairstyles and hair colors. This study will be used as basic data for developing new mode items that meet customer needs in the beauty marketing market and researching customer demand.