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Seven-Day Continuous Abstinence Rate from Smoking at 1, 2, or 3 Years after the Use of Varenicline

  • Kim, Jin Se;Jang, Ju Young;Park, Eun Hye;Lee, Joo Young;Gu, Kang Mo;Jung, Jae Woo;Choi, Jae Chol;Shin, Jong Wook;Park, In Won;Choi, Byoung Whui;Kim, Jae Yeol
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.2
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    • pp.92-98
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    • 2015
  • Background: Varenicline, a selective partial agonist/antagonist of the ${\alpha}4{\beta}2$ nicotinic receptor, has proven effectiveness for smoking cessation by several randomized, controlled trials. Because few studies have evaluated the long-term efficacy of varenicline, we tried to evaluate the smoking status of varenicline users up to 3 years after the initial prescription of the drug. Methods: We interviewed varenicline users who were prescribed the drug from June 2007 to May 2010 by telephone, from June 2010 to May 2011. Results: One-hundred and thirty-three of 250 varenicline users (53.2%) were available for the survey. Seven-day continuous abstinence from smoking was adhered to by 17 of 39 respondents (43.6%) at 1 year, and 11 of 36 (30.6%) and 19 of 58 (32.8%) at 2 and 3 years since the first use of varenicline, respectively. Compared to current smokers, successful quitters were older (55.0 years vs. 49.9 years, p=0.01), had better compliance to the 12-week course (27.7 vs. 9.3%, p=0.01), and had taken varenicline longer (10.1 vs. 5.9 weeks, p=0.01). Fifty-four of 71 current smokers (76.1%) were willing to stop smoking in the near future. The preferred ways to cease smoking were will-power (48.1%), varenicline (25.9%), nicotine replacement therapy (11.1%), and others (14.9%). Conclusion: Smokers should be encouraged to stick to the proven way for recommended period of time for successful cessation of smoking.

EVALUATION OF ENTEROCOCCUS FAECALIS REMOVAL EFFICACY OF THE ENDOVAC® AND ENDOACTIVATOR® INTRACANAL IRRIGATION METHODS (EndoVac®과 EndoActivator®를 이용한 근관세척법의 Enterococcus faecalis 제거 효율 평가)

  • Song, Seung-Gon;Park, Se-Hee;Cho, Kyung-Mo;Kim, Jin-Woo
    • Restorative Dentistry and Endodontics
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    • v.34 no.5
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    • pp.390-396
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    • 2009
  • The aim of this study was to evaluate endodontic irrigation methods with $EndoVac^{(R)}$ and $EndoActivator^{(R)}$ in the elimination of Enterococcus faecalis from the root canals. Extracted 70 human single-rooted teeth were used. The canals were instrumented by a crown-down technique with .04 taper ProFile to ISO size 40. After the teeth were autoclaved, the canals were inoculated with E. faecalis and incubated for 48 h. The teeth were randomly divided into three experimental groups of 20 teeth each according to canal irrigation methods and two control groups as follows: group 1 - $EndoVac^{(R)}$; group 2 - $EndoActivator^{(R)}$; group 3-Conventional needle irrigation method. After canal irrigation using 2.5% NaOCl. first samples (S1) were taken using sterile paper point. And the canals were filled with sterile brain heart infusion (BHI) broth and incubated for 24 h, then second samples (S2) were taken. The samples were cultured on BHI agar plate to determine the numbers of colony forming units (CFU). In first sampling (S1), only one canal of conventional method among the all experimental groups was positive cultured. In second sampling (S2), $EndoVac^{(R)}$ group showed the least positive culture numbers of E. faecalis. There was statistically significant difference between the $EndoVac^{(R)}$ and conventional needle irrigation methods in the mean value of Log CFU. According to the results of this study, $EndoVac^{(R)}$ showed better efficacy than conventional needle irrigation method in the elimination of E. faecalis from the root canal.

Spatial Variation in Land Use and Topographic Effects on Water Quality at the Geum River Watershed (토지이용과 지형이 수질에 미치는 영향의 공간적 변동성에 관한 연구 - 금강 권역을 중심으로)

  • Park, Se-Rin;Choi, Kwan-Mo;Lee, Sang-Woo
    • Korean Journal of Ecology and Environment
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    • v.52 no.2
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    • pp.94-104
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    • 2019
  • In this study, we investigated the spatial variation in land use and topographic effects on water quality at the Geum river watershed in South Korea, using the ordinary least squares(OLS) and geographically weighted regression (GWR) models. Understanding the complex interactions between land use, slope, elevation, and water quality is essential for water pollution control and watershed management. We monitored four water quality indicators -total phosphorus, total nitrogen, biochemical oxygen demand, and dissolved oxygen levels - across three land use types (urban, agricultural, and forested) and two topographic features (elevation and mean slope). Results from GWR modeling revealed that land use and topography did not affect water quality consistently through space, but instead exhibited substantial spatial non-stationarity. The GWR model performed better than the OLS model as it produced a higher adjusted $R^2$ value. Spatial variation in interactions among variables could be visualized by mapping $R^2$ values from the GWR model at fine spatial resolution. Using the GWR model, we were able to identify local pollution sources, determine habitat status, and recommend appropriate land-use planning policies for watershed management.

Synthesis of Low-Priced Catalyst from Coal Fly Ash for Pyrolysis of Waste Low Density Polyethylene (석탄비산재(石炭飛散災)로부터 저밀도(低密度) 폴리에틸렌 폐기물(廢棄物) 열분해용(熱分解用) 저가(低價) 촉매(觸媒) 합성(合成))

  • Jeong, Byung-Hwan;Na, Jeong-Geol;Kim, Sang-Guk;Mo, Se-Young;Chung, Soo-Hyun
    • Resources Recycling
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    • v.16 no.2 s.76
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    • pp.48-55
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    • 2007
  • A low-priced catalyst for pyrolysis of LDPE has been synthesized. Fly ash, which is waste material generated from coal-fired power plants was used as silica and alumna sources for solid acid catalyst. Amorphous silica-alumina catalysts (FSAs) were pre-pared by dissolution of silica and alumina from fly ash, followed by co-precipitation of the dissoluted ions. A series of LDPE pyrolysis were carried out in a thermogravimetric analyzer to investigate the effects of synthesis conditions such as NaOH/fly ash weight ratio and activation time one catalytic performance of FSAs. The physical properties of FSAs were examined and related to their catalytic performances. FSA(1.2-8) synthesized with NaOH/fly ash weight ratio of 1.2 and the activation time of 8 hours showed the best catalytic performance. The catalytic performance of FSA(1.2-8) was comparable with that of commercial catalysts and it was concluded that the FSA could be a good candidate for catalytic use in the recycling of waste polyolefins.

Effects of Feeding Rate on Growth and Body Composition of Adult Flounder Paralichthys olivaceus During the Summer Season (사료급이율이 여름철에 사육된 넙치 성어의 성장 및 체조성에 미치는 영향)

  • Kim, Kyoung-Duck;Kang, Yong-Jin;LeeMoon, Jong-Yun;Kim, Kang-Woong;Lee, Hae-Young;Jang, Mi-Soon;Choi, Se-Min;Nam, Myung-Mo;Lee, Sang-Min
    • Journal of Aquaculture
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    • v.22 no.1
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    • pp.1-4
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    • 2009
  • A 10-week feeding trial was conducted to investigate the effects of feeding rate on growth and body composition of adult flounder during the summer season. Three replicated groups of the fish (initial mean weight of $535{\pm}4.1\;g$) were hand-fed a extruded diet twice a day at the different feeding rates of satiation (100%), 90%, 80% and 70% of satiation for 10 weeks. Mean Water temperature was $19.2{\pm}2.8^{\circ}C$ during the feeding trial. Weight gain and condition factor increased significantly with increase in daily feeding rate (P<0.05), but there was no significant difference in weight gain of fish fed the diet between 100% and 90% of satiation. Survival and feed efficiency were not significantly different among all groups. Proximate composition of dorsal muscle was not significantly affected by feeding rate. Based on the results of this study, optimum feeding rate for growth and condition factor of adult flounder (535-928 g) seemed to be 90% of satiation.

EFFECT OF DENTIN SURFACE WETNESS ON TENSILE BOND STRENGTH OF SELF ADHESIVE RESIN CEMENTS (상아질 표면 젖음성이 수종 자가접착레진시멘트의 인장접착강도에 미치는 영향)

  • Yoon, Sung-Young;Park, Se-Hee;Kim, Jin-Woo;Cho, Kyung-Mo
    • Restorative Dentistry and Endodontics
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    • v.34 no.2
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    • pp.113-119
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    • 2009
  • The purpose of this study was to compare the tensile bond strength of several self-adhesive resin cements bonded to dentin surfaces with different wet conditions. Three self-adhesive resin cements: Rely-X Unicem (3M ESPE, St. Paul, MN. USA). Embrace Wetbond (Pulpdent. Oakland. MA. USA). Maxcem (Kerr. Orange. CA. USA) were used. Extracted sixty human molars were used. Each self-adhesive resin cement was adhered to the dentin specimens (two rectangular sticks from each molar) in different wet conditions. Tensile bond strength were measured using universal testing machine (EZ Test. Shimadzu corporation. Kyoto. Japan) at a crosshead speed of 1.0mm/min. After the testing. bonding failures of specimens were observed by Operative microscope (OPMI pro, Carl Zeiss. Oberkochen, Germany). T-test was used to evaluate the effect of dentin surface wetness. One-way ANOVA test was used to evaluate the tensile bond strength of self-adhesive resin cements in the same condition. Scheffe's test was used for statistical analyzing at the 95% level of confidence. The result showed that wetness of dentin surface didn't affect tensile bond strength of self-adhesive resin cements and Maxcem showed the lowest tensile bond strength.

PHYSICAL PROPERTIES OF DIFFERENT SELF-ADHESIVE RESIN CEMENTS AND THEIR SHEAR BOND STRENGTH ON LITHIUM DISILICATE CERAMIC AND DENTIN (수종의 자가 접착 레진 시멘트의 물성 및 lithium disilicate ceramic과 상아질에 대한 전단결합강도 비교)

  • Shin, Hye-Jin;Song, Chang-Kyu;Partk, Se-Hee;Kim, Jin-Woo;Cho, Kyung-Mo
    • Restorative Dentistry and Endodontics
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    • v.34 no.3
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    • pp.184-191
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    • 2009
  • The purpose of this study was to evaluate the physical properties of different self-adhesive resin cements and their shear bond strength on dentin and lithium disilicate ceramic and compare these result with that of conventional resin cement. For this study, four self-adhesive resin cements (Rely-X Unicem, Embrace Wetbond, Mexcem, BisCem), one conventional resin cement (Rely-X ARC) and one restorative resin composite (Z-350) were used. In order to evaluate the physical properties, compressive strength, diametral tensile strength and flexural strength were measured. To evaluate the shear bond strength on dentin, each cement was adhered to buccal dentinal surface of extracted human lower molars. Dentin bonding agent was applied after acid etching for groups of Rely-X ARC and Z-350. In order to evaluate the shear bond strength on ceramic, lithium disilicate glass ceramic (IPS Empress 2) disks were prepared. Only Rely-X ARC and Z-350 groups were pretreated with hydrofluoric acid and silane. And then each resin cement was adhered to ceramic surface in 2 mm diameter. Physical properties and shear bond strengths were measured using a universal testing machine. Results were as follows 1. BisCem showed the lowest compressive strength, diametral tensile strength and flexural strength. (P<0.05) 2. Self-adhesive resin cements showed significantly lower shear bond strength on the dentin and lithium disilicate ceramic than Rely-X ARC and Z-350 (P<0.05) In conclusion, self-adhesive resin cements represent the lower physical properties and shear bond strength than a conventional resin cement.

Performance Comparison of Reinforcement Learning Algorithms for Futures Scalping (해외선물 스캘핑을 위한 강화학습 알고리즘의 성능비교)

  • Jung, Deuk-Kyo;Lee, Se-Hun;Kang, Jae-Mo
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.5
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    • pp.697-703
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    • 2022
  • Due to the recent economic downturn caused by Covid-19 and the unstable international situation, many investors are choosing the derivatives market as a means of investment. However, the derivatives market has a greater risk than the stock market, and research on the market of market participants is insufficient. Recently, with the development of artificial intelligence, machine learning has been widely used in the derivatives market. In this paper, reinforcement learning, one of the machine learning techniques, is applied to analyze the scalping technique that trades futures in minutes. The data set consists of 21 attributes using the closing price, moving average line, and Bollinger band indicators of 1 minute and 3 minute data for 6 months by selecting 4 products among futures products traded at trading firm. In the experiment, DNN artificial neural network model and three reinforcement learning algorithms, namely, DQN (Deep Q-Network), A2C (Advantage Actor Critic), and A3C (Asynchronous A2C) were used, and they were trained and verified through learning data set and test data set. For scalping, the agent chooses one of the actions of buying and selling, and the ratio of the portfolio value according to the action result is rewarded. Experiment results show that the energy sector products such as Heating Oil and Crude Oil yield relatively high cumulative returns compared to the index sector products such as Mini Russell 2000 and Hang Seng Index.

Optimum Packaging Design of Packaging Tray and Cushion Pad of Korean Pears for Exporting using FEA Simulation (FEA 시뮬레이션 기법을 이용한 수출용 한국 배 포장 트레이 및 완충패드 최적 포장설계)

  • Choi, Dong-Soo;Son, Jae-Yong;Kim, Jin-Se;Kim, Yong-Hoon;Park, Chun-Wan;Jung, Hyun-Mo;Hwang, Sung-Wook
    • Journal of the Korean Society of Industry Convergence
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    • v.23 no.5
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    • pp.843-852
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    • 2020
  • Among the many packaging materials used in cushion packaging, there is a lack of optimum design for packaging trays and cushion pads used in pear packaging for export and domestic distribution. It causes over-packaging due to excessive material input, and can be solved by applying various parameters needed to optimize the design of the packaging tray and cushion pad considering the packaging material and the number of pears in the box. In the case of a cushion pad for pears, the economic efficiency of material and thickness should be considered. Therefore, it is possible to design a packaging tray and cushion pad depending on eco-friendly packaging materials (PLA, PET) used by applying appropriate design parameters. The static characteristics of the materials used for the packaging of pears were analyzed using FEA (finite element analysis) simulation technique to derive the optimal design parameters. In this study, we analyzed the contact stress and deformation of PET, PLA tray (0.1, 0.5 1.0, 1.5 and 2 mm) and PET foam (2.0, 3 .0 and 4.0 mm) with pears to derive appropriate cushion packaging design factors. The contact stress between the pear and PET foam pad placed on PLA, PET trays were simulated by FEA considering the bioyield strength (192.54±28 kPa) of the pears and safety factor (5) of packaging design, which is the criterion of damage to the pears. For the combination of PET tray and PET foam buffer pad, the thickness of the PET foam is at least 3 mm, the thickness of the PET foam is at least 1.0 mm, the thickness of the foam is at least 2 mm, and if the thickness of the PET tray is at least 1.5 mm, the thickness of the foam is at least 1 mm, suitable for the packaging design. In addition, for the combination of PLA tray and PET foam pad, the thickness of the PET foam was not less than 2 mm if the thickness of the PLA tray was 0.5 mm, and 1 mm or more if the thickness of the PLA tray was not less than 1.0 mm, the thickness of the PET foam was suitable for the packaging design.

Evaluation of Dynamic Group Pile Effect in Dry Sand by Centrifuge Model Tests (원심모형 실험을 이용한 건조토 지반에서의 군말뚝 효과 분석)

  • Yoo, Min-Taek;Cha, Se-Hwan;Choi, Jung-In;Han, Jin-Tae;Kim, Myoung-Mo
    • Journal of the Korean Geotechnical Society
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    • v.28 no.1
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    • pp.67-77
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    • 2012
  • In this study, a series of centrifuge shaking-table tests for a $3{\times}3$ group pile and a single pile applied by sinusoidal wave was performed in dry sand for various pile spacings, ranging from three to seven times the pile diameter. A comparison of centrifuge tests of both single pile and group pile showed that the lateral ground response of the group pile was smaller than that of the single pile. In addition, the reduction in subgrade reaction for the group pile increased with decreasing pile spacing. The side piles, that is, the 1st row and 3rd row piles showed identical dynamic p-y behavior and the center pile in the 2nd row caused a lower reduction effect compared with the 1st and 3rd row piles. From the comparison between the p-y curves of the 2nd row piles, it was found that the lateral ground response of the outer pile in the 2nd row was less than that of the center pile in the 2nd row. The p-multipliers for the side piles, for the center pile and for the outer pile ranged from 0.28 to 0.77, from 0.55 to 1.0 and from 0.39 to 0.87, respectively.