• 대한한의학회지
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• 제38권4호
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• pp.11-40
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• 2017

Objectives: We investigated whether a mixture of the main component of pomegranate concentrated powder (PCP) with appropriate proportions of Eucommiae Cortex (EC) and Achyranthis Radix (AR) could act synergistically as an effective treatment for osteoarthritis (OA). Methods: In order to evaluate the effects of PCP, EC, and AR against OA, knee thicknesses, maximum extension angle of each knee, anti - inflammation effects, the transcript levels of chondrogenic genes mRNA expressions in femur and tibia articular cartilage (AC) with synovial membrane (SM) were analyzed. In addition, the histopathology and immunohistochemistry of the femur and tibia AC or SM were performed. Results: The surgically-induced OA signs in rats were significantly inhibited by 28 days of continuous treatment of PCP, EC and AR single formulas, and PCP with EC:AR mixed formulas. Especially, PCP with EC:AR 4:1, 2:1 and 1:1 mixed formula treatment constantly showed significantly more favorable inhibitory activities, as compared with those of single formula of PCP, EC and AR treated rats. Conclusion: PCP and EC:AR 4:1 mixed formula showed similar OA refinement effects through potent anti-inflammatory pathways as compared with those of diclofenac treatment, and showed additional chondrocyte proliferating effects on the both femur and tibia AC.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.1-8
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• 2002

A Branch-and-Cut algorithm is a branch-and-bound algorithm in which rutting planes are generated throughout the branch-and-bound tree. It is now one of the most widespread and successful methods for solving mixed integer programming problems. In this paper we presents efficient implementation techniques of branch-and-cut algorithm for miked integer programming problems.

• Journal of Korean Biological Nursing Science
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• 제23권1호
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• pp.72-82
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• 2021

Purpose: This study used a mixed methods research design in an attempt to verify the effects of robot-assisted rehabilitation on the gait ability of stroke patients with hemiplegia, and thereby further understand the benefits and challenges of stroke patients' experiences relying on robot-assisted rehabilitation. Methods: An exploratory sequential mixed methods study design was used in order to combine both quantitative and qualitative data. For the quantitative data collection, a total of 30 stroke patients with hemiplegia were recruited from one rehabilitation hospital. Qualitative data were collected through individual interviews using semi-structured questionnaires for a group of 15 patients who were currently undergoing robot-assisted rehabilitation. The data were analyzed through qualitative content analysis. Results: As a result of the quantitative analysis, there were significant differences between the two groups in terms of daily living activity patterns, total number of steps, and average walking speed. As a result of the qualitative analysis, the four main themes derived consisted of, 'curiosity about the usage of robot-assisted rehabilitation,' 'pleasure experienced while using the robots,' 'insufficient information about robots,' and 'a lack of education about robot-assisted rehabilitation.' Conclusions: Robot-assisted rehabilitation had a significant effect on the walking ability of stroke patients with hemiplegia. Additionally, stroke patients with hemiplegia experienced difficulty during the course of their robot-assisted rehabilitation, due to a lack of sufficient information on correct usage techniques. These quantitative and qualitative findings could provide the basic foundation for the development of an educational program on robot-assisted rehabilitation.

• Journal of Hospice and Palliative Care
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• 제25권2호
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• pp.85-97
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• 2022

Purpose: This study aimed to describe nurses' perceived needs and barriers to pediatric palliative care (PPC). Methods: Mixed methods with an embedded design were applied. An online survey was conducted for nurses who participated in the End-of-Life Nursing Education Consortium- Pediatric Palliative Care (ELNEC-PPC) train-the-trainer program, of whom 63 responded. Quantitative data were collected with a survey questionnaire developed through the Delphi method. The 47 items for needs and 15 items for barriers to PPC were analyzed with descriptive statistics. Qualitative data were collected through open-ended questions and analyzed with topic modeling techniques. Results: The mean scores of most subdomains of the PPC needs were 3.5 or higher out of 4, and those of PPC barriers ranged from 3.22 to 3.56, indicating the items in the questionnaire developed in this study properly reflect each factor. The needs for PPC were divided into 4 categories: "children and adolescents," "families," "PPC management system," and "community-based PPC." Meanwhile, PPC barriers were divided into 3 categories: "healthcare delivery system," "healthcare provider," and "client." The keywords derived from the topic modeling were perception, palliative, children, and education for necessities and lack, perception, medical care, professional care providers, service, and system for barriers to PPC. Conclusion: In this study, by using mixed-methods, items of nurses' perceived needs and barriers to PPC were identified, categorized, and weighted, and their meanings were explored. For the stable establishment of PPC, the priority should be given to improving perceptions of PPC, establishing an appropriate system, and training professional care providers.

• 대한약침학회지
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• 제18권1호
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• pp.44-55
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• 2015

Objectives: Scolopendra subspinipes mutilans (S. subspinipes mutilans) is known as a traditional medicine and includes various amino acids, peptides and proteins. The amino acids in the pharmacopuncture extracted from S. subspinipes mutilans by using derivatization methods were analyzed quantitatively and qualitatively by using high performance liquid chromatography (HPLC) over a 12 month period to confirm its stability. Methods: Amino acids of pharmacopuncture extracted from S. subspinipes mutilans were derived by using O-phthaldialdehyde (OPA) & 9-fluorenyl methoxy carbonyl chloride (FMOC) reagent and were analyzed using HPLC. The amino acids were detected by using a diode array detector (DAD) and a fluorescence detector (FLD) to compare a mixed amino acid standard (STD) to the pharmacopuncture from centipedes. The stability tests on the pharmacopuncture from centipedes were done using HPLC for three conditions: a room temperature test chamber, an acceleration test chamber, and a cold test chamber. Results: The pharmacopuncture from centipedes was prepared by using the method of the Korean Pharmacopuncture Institute (KPI) and through quantitative analyses was shown to contain 9 amino acids of the 16 amino acids in the mixed amino acid STD. The amounts of the amino acids in the pharmacopuncture from centipedes were 34.37 ppm of aspartate, 123.72 ppm of arginine, 170.63 ppm of alanine, 59.55 ppm of leucine and 57 ppm of lysine. The relative standard deviation (RSD %) results for the pharmacopuncture from centipedes had a maximum value of 14.95% and minimum value of 1.795% on the room temperature test chamber, the acceleration test chamber and the cold test chamber stability tests. Conclusion: Stability tests on and quantitative and qualitative analyses of the amino acids in the pharmacopuncture extracted from centipedes by using derivatization methods were performed by using HPLC. Through research, we hope to determine the relationship between time and the concentrations of the amino acids in the pharmacopuncture extracted from centipedes.

• 반도체디스플레이기술학회지
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• 제22권3호
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• pp.119-124
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• 2023

In this study, experimental approach of the measurement of condensation and evaporation heat transfer coefficients is discussed for mixed refrigerants using in the ultra low-temperature cooling system for semiconductor etching process. An experimental apparatus was described performing the condensation and evaporation heat transfer measurements for mixed refrigerants. The mixed refrigerant used in this study was composed of the optimal mixture determined in previous research, with a composition of Ar:R14:R23:R218 = 0.15:0.4:0.15:0.3. The experiments were conducted over a temperature range from -82℃ to 15℃ and at pressures ranging from 18.5 bar to 5 bar. The convection heat transfer coefficients of the mixed refrigerant were measured at flow rates corresponding to actual operating conditions. The condensation heat transfer coefficient ranged from approximately 0.7 to 0.9 kW/m2K, while the evaporation heat transfer coefficient ranged from 1.0 to 1.7 kW/m2K. The detailed discussion of the experimental methods, procedures, and results were described in this paper.

• 한국사회복지학
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• 제63권3호
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• pp.55-82
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• 2011

이 연구는 Creswell과 Clark(2007)의 혼합방법론 중 내재적 모형(embedded design)을 활용하여 장애아동청소년 거주서비스의 쟁점을 다양한 측면에서 탐색하고자 한 것이다. 그동안 장애인복지는 상대적으로 성인장애인을 중심으로 쟁점들이 도출되었고 주도되었다. 그 과정에서 장애아동청소년은 상대적으로 소외되는 경향이 나타났으며, 거주시설의 장애아동청소년은 더욱 열악한 상황에 놓여 있었다. 이러한 국내 현실에 근거하여 본 연구는 현재 거주시설 장애아동청소년이 당면하고 있는 주요 쟁점은 무엇인지를 심층적으로 규명하고자 한 것이다. 연구결과, 질적 분석에서는 아동청소년으로서의 지위 부재, 입소에 대한 완충장치의 미비, 별도의 시설과 관련한 의견의 혼재, 생애주기 관련 서비스 및 성인기 전환서비스 부족, 중증 장애아동청소년 서비스의 한계, 법적 지원체계의 미비, 인적자원의 보충과 질 관리가 필요함이 주요쟁점으로 제시되었다. 양적분석에서는 거주서비스의 목표와 기능, 연령 및 장애유형별 구분, 서비스 수요 및 공급에 관한 의견 조사를 실시하였고, 그 결과를 질적 연구의 결과에 내재시켜 장애아동청소년 거주서비스의 쟁점 논의에 통합하였다. 이 연구는 거주시설 장애아동 청소년이 당면한 실제적 쟁점을 혼합방법론을 활용하여 있는 그대로 드러내고 분석하고자 한 최초의 탐색적 시도라는 점에 그 의의가 있으며, 향후 기초 연구로서 관련 연구의 논의 확장에 기여할 것으로 본다.

• 한국어교육
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• 제28권4호
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• pp.87-119
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• 2017

The purpose of this study is to classify research methods used in Korean language education studies with a focus on identifying how and what quantitative research methods are utilized in these studies. Analyzing articles published in the Journal of Korean Language Education from 2005 to 2016, we found a trend that as a replacement for secondary research, primary research played a more prominent role after 2010, as the number of quantitative studies and studies using mixed methods increased. We also found that within quantitative studies of Korean language education, research themes and statistical analyses became diversified after 2010. In order for quantitative research to contribute continuously to Korean language education, the quality of research has to improve. In particular, quantitative researchers in this area should: (a) increase their general understanding of statistical methods, (b) conduct "power analysis" to determine the appropriate sample size for hypothesis testing, and (c) be aware of measurement issues such as measurement equivalence and DIF when measuring latent psychological constructs. It is also important to notice that these points above should be considered carefully in the planning and designing stage for researchers.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 가을 학술발표회 논문집
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• pp.491-496
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• 2001

In recent years, the research and development about the new material proceed rapidly and actively in the building industry. As building structures become bigger, higher and more specialized, so does the demand for material with higher strength. In the future, we will need to research repair and rehabilitation to make high strength concrete mixed steel fibrous building safe. The carbon fiber reinforced plastic bonding method is widely used in reinforcing the existing concrete structure among the various methods. The repair of initiate loaded reinforced high-strength concrete beams mixed steel fibrous with epoxy bonded Carbon Fiber Sheets(CFS) was investigated experimentally. The CFS thickness and length were varied to assess the peel failure at the curtailment of CFS, The behaviour of the repaired beams was represented by load-longitudinal steel strain relation and failure modes were discussed. The test results indicate that CFS is very effective for strengthening the demand beams and controlling deflections of reinforced high strength concrete beams mixed steel fibrous happen diagonal crack, the increase in the number of CFS layers over two layers didn't effect the increase in the strength of beams.

• Communications for Statistical Applications and Methods
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• 제30권1호
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• pp.65-73
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• 2023

Contemporary biomedical data often involve an ill-posed problem owing to small sample size and large number of multi-collinear variables. Partial least squares (PLS) method could be a plausible alternative to an ill-conditioned ordinary least squares. However, in the case of a PLS model that includes a random-effect, how to deal with a random-effect or mixed effects remains a widely open question worth further investigation. In the present study, we propose a modified multivariate PLS method implementing mixed-effect model (PLSM). The advantage of PLSM is its versatility in handling serial longitudinal data or its ability for taking a randomeffect into account. We conduct simulations to investigate statistical properties of PLSM, and showcase its real clinical application to predict treatment outcome of esthetic surgical procedures of human faces. The proposed PLSM seemed to be particularly beneficial 1) when random-effect is conspicuous; 2) the number of predictors is relatively large compared to the sample size; 3) the multicollinearity is weak or moderate; and/or 4) the random error is considerable.