• 만화애니메이션 연구
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• 통권27호
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• pp.51-78
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• 2012

만화시장은 크게 출판만화(만화잡지와 단행본) 및 웹툰(webtoon)으로 구분된다. 만화가들이 지속가능한 작품활동을 하기 위해서는 만화시장이 활성화되어야 한다. 만화시장의 활성화를 위한 여러 가지 논의방안이 도출될 수 있으나, 본 연구에서는 출판만화 시장의 한 종류인 단행본시장에서의 만화시장 확대방안을 논의하고자 한다. 단행본 시장에서의 만화시장 확대는 기존의 단행본시장의 활성화와 새로운 단행본시장의 창출이라는 2가지 방안이 있다. 이 중에서 후자인 새로운 만화시장의 창출(확대)을 위해 '장르융합형 지식만화'에 초점을 두고, '장르융합형 지식만화의 만화시장 창출과정'을 살펴본 후, 이를 토대로 새로운 만화시장 창출모델을 개발하고자 한다. 이러한 연구목적을 위해 3개의 장르융합형 지식만화(만화공인중개사, 네모 속의 답을 찾아라, 기적 같은 영문법)를 사례로 선정하였고, 각 사례들의 기획과정과 출판과정 및 (서점)유통과정에 대한 세부사항을 분석하였다. 분석을 위한 연구의 모형으로는 "기획과정 ${\rightarrow}$ 제작과정 ${\rightarrow}$ 유통과정"을 사용하였다. 분석요소를 구체화하기 위한 분석틀로는 "기획과정((1) 제작목표, (2) 크기 분량, (3) 내용구성, (4) 인세 계약조건) ${\rightarrow}$ 제작과정((1) 만화원고 제작, (2) 원고 스캔과 칼라링, (3) 편집 교정, (4) 필름출력 인쇄 제본) ${\rightarrow}$ 유통과정((1) 발행부수 판매부수, (2) 인세수입, (3) 이윤, (4) 파생효과)"을 사용하였다. 분석결과 3가지 사례 모두 파생효과(파생 지식만화의 제작 유통)가 발생함으로써 지속적인 만화창작이 이루어지고 있었다. 이러한 파생효과가 발생한 근본적인 이유는 처음에 기획 제작한 장르융합형 지식만화가 만화시장을 새로이 창출함과 동시에 만화수요자들의 꾸준한 구매에 의하여 수익(작가의 인세수입과 출판사 이윤)을 가져왔기 때문이다. 장르융합형 지식만화의 수익창출(시장매출증가)은 다음과 같은 두 가지 측면에서 파생상품의 창작 제작이 가능한 여건을 조성하였다. 첫째, 만화가들의 경제적 안정이다. 지식만화의 인세수입으로 경제적 생활안정이 된 만화가가 새로운 작품에 대한 창작활동을 더욱 활기차게 진행할 수 있는 여건이 조성된 것이다. 둘째, 출판사의 경제적 이윤창출이다. 지식만화의 판매부수 신장으로 수익(이윤)을 보게 된 출판사가 만화가의 또 다른 작품활동을 통한 파생상품의 출판에 대하여 긍정적으로 허락할 수 있는 여건이 조성된 것이다. 이러한 여건조성은 지식만화의 수익이 파생상품에서도 발생할 것이라는 낙관적 기대감을 형성하기에 가능한 것으로 파악된다. 결과적으로 장르융합형 지식만화의 창작 출판을 통해서 새로운 만화시장의 창출이 가능하다는 사실을 알 수 있었고, 또한 그로부터 '장르융합형 지식만화를 통한 만화시장 창출 모델'을 개발할 수 있었다. 본 연구를 통해 개발한 만화시장 창출 모델을 토대로 여러 분야에서의 지식만화를 다양하게 기획할 수 있는 가능성이 제기 되었으며, 이러한 다양한 기획들이 만화가들의 지속가능한 창작활동에 도움을 줄 것으로 예상된다.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.445-466
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• 2016

Nonparametric Bayesian methods have seen rapid and sustained growth over the past 25 years. We present a gentle introduction to the methods, motivating the methods through the twin perspectives of consistency and false consistency. We then step through the various constructions of the Dirichlet process, outline a number of the basic properties of this process and move on to the mixture of Dirichlet processes model, including a quick discussion of the computational methods used to fit the model. We touch on the main philosophies for nonparametric Bayesian data analysis and then reanalyze a famous data set. The reanalysis illustrates the concept of admissibility through a novel perturbation of the problem and data, showing the benefit of shrinkage estimation and the much greater benefit of nonparametric Bayesian modelling. We conclude with a too-brief survey of fancier nonparametric Bayesian methods.

• 대한본초학회지
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• 제30권5호
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• pp.51-58
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• 2015

Objectives : This paper aimed to verify the applicability of mixed extract ofAngelica gigasNakai,Cnidium officinaleMakino,Paeoniala ctifloraPall,Rechmannia glutinosaLibosch,Scutellaria baicalensisGeorgi, which were prescribed for improving inflammation in Donguibogam, as the materials for beauty food and functional medicinal herb cosmetics by manufacturing such mixed extract and evaluating the biological activity of the extract.Methods : The mixed medicinal herb water extract(MMW) and ethanol extract(MME) were freeze-dried to be used as the specimen. We performed electron donating ability, lipid acidification inhibitory activity, anti-inflammatory activity against skin flora, MTT assay, NO inhibitory activity and the protein expression inhibitory activity of iNOS and COX-2.Results : For anti-oxidation experimentation, the electron donating abilities of MMW and MME were above 60.0% and 90.0% at 500 μg/ml, respectively. In the inhibition rate of lipid peroxidation, MMW and MME showed 43.1% and 52.1% at 1,000 μg/ml, respectively. As a result of antimicrobial activity, both the MMW and MME showed significant clear zones forPropionibacterium acnesat 4 mg/disc, but did not indicated the clearzones forStaphylococcus aureus, Escherichia coliandStaphylococcus epidermidis. Anti-inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited in a concentration-dependent manner. Also, the expression of iNOS and COX-2 proteins were significantly inhibited following treatment with MMW and MME of 50 μg/ml.Conclusions : Accordingly, it can be concluded that mixed medicinal herb extract has the potential to beused as a functional food and cosmetic material.

• 대한한의학회지
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• 제38권4호
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• pp.11-40
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• 2017

Objectives: We investigated whether a mixture of the main component of pomegranate concentrated powder (PCP) with appropriate proportions of Eucommiae Cortex (EC) and Achyranthis Radix (AR) could act synergistically as an effective treatment for osteoarthritis (OA). Methods: In order to evaluate the effects of PCP, EC, and AR against OA, knee thicknesses, maximum extension angle of each knee, anti - inflammation effects, the transcript levels of chondrogenic genes mRNA expressions in femur and tibia articular cartilage (AC) with synovial membrane (SM) were analyzed. In addition, the histopathology and immunohistochemistry of the femur and tibia AC or SM were performed. Results: The surgically-induced OA signs in rats were significantly inhibited by 28 days of continuous treatment of PCP, EC and AR single formulas, and PCP with EC:AR mixed formulas. Especially, PCP with EC:AR 4:1, 2:1 and 1:1 mixed formula treatment constantly showed significantly more favorable inhibitory activities, as compared with those of single formula of PCP, EC and AR treated rats. Conclusion: PCP and EC:AR 4:1 mixed formula showed similar OA refinement effects through potent anti-inflammatory pathways as compared with those of diclofenac treatment, and showed additional chondrocyte proliferating effects on the both femur and tibia AC.

• 전자공학회논문지
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• 제50권1호
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• pp.166-173
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• 2013

SoC내의 IP 개수 및 데이터 통신량이 증가함에 따라 온칩 크로스바 네트워크가 SoC의 중추 연결망으로서 널리 사용되어지고 있다. 온칩 크로스바 네트워크는 여러 개의 크로스바 스위치들과 이들간의 연결로 이루어지는데, 시스템의 복잡도가 증가함에 따라 IP들과 스위치들간의 연결 형태를 결정하는 것, 즉 토폴로지를 결정하는 것이 점점 복잡해지고 있다. 이 문제를 해결하기 위해 본 논문에서는 목표 시스템의 칩내 통신 특성을 고려하여 최적의 온칩 크로스바 네트워크의 토폴로지를 찾아주는 방법을 제안한다. 제안하는 토폴로지 합성 방법은 mixed integer linear programming(MIILP)를 이용하여 다른 휴리스틱 합성 방법과 달리 전역 최적점(global optimum)을 찾을 수 있는 장점이 있다. 또한, 기존에 제안 되었던 MILP를 이용한 토폴로지 합성 방법들이 토폴로지를 표현하는데 IP 노드들과 스위치들 간의 인접 행렬들을 이용했던 것과 달리, 본 논문에서는 IP들 간통신을 표현하는 엣지들을 기본으로 하는 새로운 표현 방식을 제안한다. 실험 결과 본 논문에서 제안하는 새로운 MILP 표현 방식을 이용할 경우 기존 MILP 표현 방식을 이용했을 때보다 4개의 예제들에 대해 합성 속도가 평균 77.1 배 향상되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5655-5661
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• 2015

Purpose: To assess the role of two adjuvant chemotherapy regimens, anthracycline-based and CMF on disease free survival and overall survival breast cancer patients by meta-analysis approach in Eastern Mediterranean and Asian countries to determine which is more effective and evaluate the appropriateness and efficiency of two different proposed statistical models. Materials and Methods: Survival curves were digitized and the survival proportions and times were extracted and modeled to appropriate covariates by two multivariate mixed effects models. Studies which reported disease free survival and overall survival curves for anthracycline-based or CMF as adjuvant chemotherapy that were published in English in the Eastern Mediterranean region and Asia were included in this systematic review. The two transformations of survival probabilities (Ln (-Ln(S)) and Ln(S/ (1-S))) as dependent variables were modeled by a multivariate mixed model to same covariates in order to have precise estimations with high power and appropriate interpretation of covariate effects. The analysis was carried out with SAS Proc MIXED and STATA software. Results: A total of 32 studies from the published literature were analysed, covering 4,092 patients who received anthracycline-based and 2,501 treated with CMF for the disease free survival and in order to analyze the overall survival, 13 studies reported the overall survival curves in which 2,050 cases were treated with anthracycline-based and 1,282 with CMF regimens. Conclusions: The findings illustrated that the model with dependent variable Ln (-Ln(S)) had more precise estimations of the covariate effects and showed significant difference between the effects of two adjuvant chemotherapy regimens. Anthracycline-based treatment gave better disease free survival and overall survival. As an IPD meta-analysis in the Italy the results of Angelo et al in 2011 also confirmed that anthracycline-based regimens were more effective for survival of breast cancer patients. The findings of Zare et al 2012 on disease free survival curves in Asia also provided similar evidence.

• 한국안전학회지
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• 제29권4호
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• pp.123-131
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• 2014

Whole amount of waste water, approximately 921.6 liter, for cleaning a ready mixed concrete truck should be used to produce concrete as a mixing water or cleaning water. Recycling water for concrete mixing contains solids, which cause decrease in slump, air and compressive strengths, so it may influence on poor concrete quality. Therefore, it has been maintained to use recycling water with less than 3 percent of solids. Since no evaluation system has been constructed to directly reflect on variability of recycling water from ready mixed concrete plants, it is necessary to develop "Automatic recycling solid measuring system" for quality controls in real time. In this research, sensors measuring waste water concentration in ultrasonic and inductance methods were developed, and automatic system using the sensors were established. The accuracy of measurement sensors developed for recycling water based on various conditions of concentration was proved, and application limits were evaluated. Also, concentration of recycling water using sensors developed from ready mixed concrete plant was measured, and curing method verified the accuracy of the sensors. Moreover, measurement sensors for recycling water in various locations were installed to evaluate the effects on measuring method and spots. The automatic measuring system for recycling water concentration, which is developed in the research, will contribute to improve concrete quality safety through reliable solids maintenance.

• 대한한방부인과학회지
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• 제32권3호
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• pp.1-19
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• 2019

Objectives: To select the optimal ranges showing obvious synergic anti-osteoporotic potential after adjust mixed formula consisted of Morindae Radix (MR) and Cistanchis Herba (CH) as compared with those of each single formula or risedronate sodium (RES) using bilateral ovariectomized (OVX) female mice. Methods: Fourteen groups, total eight sham or 104 OVX mice were selected based on the body weights at 34 days after OVX surgery. After that, 9 types mixed compositions, single formula of MR and CH, and RES were orally administered for 35 days. And we measured changes in body weight and gain, femur weight, bone mineral density (BMD), bone strength (failure load) and mineral content - calcium (Ca) and inorganic phosphorus (IP), osteocalcin contents and bone specific alkaline phosphatase (bALP) activities of all mice. Results: The OVX-induced estrogen-deficient osteoporotic signs were significantly inhibited by 35 days of continuous oral treatment of all treated mice as compared with OVX control mice. Especially, MR:CH 1:3 and 1:1 mixed formula treated mice showed significantly more favorable inhibitory activities against estrogen-deficient osteoporosis symptoms as compared to those of each single formula of MR and CH. Although RES also ameliorated the decreases of the femur BMD, strength and trabecular bone architectures through the inhibited the increases of bone turnover, but they did not critically influenced on the bone formations. Conclusions: The results suggest that MR:CH 1:3 mixed formula showed somewhat lower anti-resorptive effects as compared to those of RES, but they also showed bone formation effects. therefore, it is expected that MR:CH 1:3 mixture will be promising as a potent protective agents for relieving the osteoporosis in menopausal women.

• 산업과 과학
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• 제2권1호
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• pp.39-44
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• 2023

본 연구의 목적은 코로나 팬데믹 시기 대학의 온라인 수업과 비대면 혼합수업의 성과와 만족도를 비교하기 위함이다. 연구는 일 대학 간호학과에서 성인간호학 강의를 수강하는 4학년 학생을 대상으로 하였으며 전면 비대면 수업에 참여한 113명과 비대면 혼합수업에 참여한 134명의 학습 성과와 수업 만족도를 비교하였다. 연구결과 비대면 혼합수업의 성과와 만족도가 전면 비대면 수업보다 통계적으로 유의하게 높았다. 코로나 팬데믹 시기를 지나오면서 대학 구성원은 수업의 질을 결정하는 요인은 대면이냐 비대면이냐 형식의 문제라기보다는 가르치는 사람의 성의와 배우는 사람의 열의가 더욱 중요함을 모두 경험했다. 따라서 교육과 학습에 대한 성의와 열의를 기본으로 하여 앞으로의 교육환경 변화에 대비한 새로운 교육방법 개발 운영, 이에 따른 효과연구는 계속되어야 할 것으로 생각된다.

• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.403-424
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• 1996

Cell culture methods have been used to assess the cytotoxicity of dental materials. Different paramaters are used to monitor cytotoxic effects. But it is difficult to compare each investigator's results with different methods. The objective of this study was to investigate cytotoxic effect of several retrograde filling materials according to cell lines and assay methods. Cytotoxicity of Bestalloy (Dogmyung, Korea), Prisma APH(Densply International Inc., U.S.A.), Clearfil FII (Kuraray Co., Japan), Fuji II (GC Co., Japan), Fuji II LC (GC Co., Japan) and IRM (Densply Co., U.S.A.) on L929, 3T3 and KB permanent cell lines was measured. Radiochromium, Lactate dehydrogenase (LDH) release method and colorimetric assays, namely neutral red (NR) and MTT were used. Each material was mixed according to the manufacturer's instruction. They were tested as solid and extracted state. Cell culture media were added to each mixed or solid materials then the solution was collected and used as extract solutions. Solid Fuji II showed mild cytotoxicity on three cell lines using radiochromium release method. There was no difference in cytotoxicity of extract solution group using radiochromium release method. In colorimetric assay immediate Fuji II group and all the IRM groups showed severe cytotoxic effect. Difference in cyctotoxicity was due to rather kinds of cell lines than assay methods. Solid Fuji II and IRM showed mild cytotoxicity on three cell lines. But extract solutions had different cytotoxic effect according to cell lines using LDH release assay. Light-cured glass ionomer had mild to moderate degree of cytotoxicity on three cell lines. Cytotoxicity was affected by specimen prepaton. Susceptibility of each cell ines were also affected by assay emthods. It was suggested that cytotoxicity study using only one cell line and/or assay method might not accurately reflect the real toxic nature of dental biomaterials.