• Journal of Environmental Policy
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• v.12 no.2
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• pp.3-16
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• 2013

This review paper examines various terms used for the definitions and classifications of ecosystem services, often times mixed and confused, in the literature and re-establishes the concepts of important terms, including ecosystem functions, services and benefits, to enhance communication among the stake-holders in the process of decision making. The definitions and scopes of ecosystem services are differentiated depending on the policy purposes such as environmental accounting, environmental valuation and natural resource management. The importance of identification and enumeration of final outputs associated with a particular policy is addressed. In addition, the usefulness of an alternative pathway-analysis beginning from benefits, via services and function, to process/structure of ecosystem is emphasized.

• Molecules and Cells
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• v.37 no.7
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• pp.503-510
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• 2014

Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.23 no.7 s.166
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• pp.1205-1214
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• 1999

A new quadrilateral plane stress element is developed for efficient and accurate analysis of thermal stress problems. It is convenient to use the same mesh and the same shape functions for thermal analysis and stress analysis. But, because of the inconsistency between deformation related strain field and thermal strain field, oscillatory responses and considerable errors in stresses are resulted in. To avoid undesired oscillations, strain approximation is enhanced by supplementing several assumed strain terms based on the variational principle. Thermal deformation is incorporated into the generalized mixed variational principle for displacement, strain and stress fields, and basic equations for the modified enhanced assumed strain method are derived. For the stress approximation of bilinear elements, the $5{\beta}$ version of Pian and Sumihara is adopted. The numerical results for several problems show that the present element behaves well and reduces oscillatory responses. it also results in almost the same magnitude of error as compared with the quadratic element.

• Journal of Microbiology and Biotechnology
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• v.7 no.1
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• pp.56-61
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• 1997

A strain producing immunosuppressive substances was isolated from a soil in Cheju island. By morphological, cultural, and physiological studies, the strain was identified as Streptomyces lydicus MCY-524. Cultured broth was purified by silica gel, sephadex LH-20 and preparative HPLC and gave two immunosuppressive compounds, MCH-22 and MCH-32. They dramatically suppressed the B cell activation with lipopolysaccharide, T cell activation by mixed lymphocyte response, and primary T-dependent antibody response at a final concentration of 1 ${\mu}g$/ml. They also markedly suppressed the proliferation of lymphocytes induced by lipopolysaccharide, pokeweed mitogen, and concanavaline A at the same concentration. Their suppressive activities, which were comparable to those of cyclosporin A, suggested that they were potent and broad immunotoxic agents on the immune functions of murine lymphocytes.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.459-465
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• 2008

The present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumor-associated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumor-bearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.7
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• pp.3076-3092
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• 2020

An IKPCA-ELM-based intrusion detection method is developed to address the problem of the low accuracy and slow speed of intrusion detection caused by redundancies and high dimensions of data in the network. First, in order to reduce the effects of uneven sample distribution and sample attribute differences on the extraction of KPCA features, the sample attribute mean and mean square error are introduced into the Gaussian radial basis function and polynomial kernel function respectively, and the two improved kernel functions are combined to construct a hybrid kernel function. Second, an improved particle swarm optimization (IPSO) algorithm is proposed to determine the optimal hybrid kernel function for improved kernel principal component analysis (IKPCA). Finally, IKPCA is conducted to complete feature extraction, and an extreme learning machine (ELM) is applied to classify common attack type detection. The experimental results demonstrate the effectiveness of the constructed hybrid kernel function. Compared with other intrusion detection methods, IKPCA-ELM not only ensures high accuracy rates, but also reduces the detection time and false alarm rate, especially reducing the false alarm rate of small sample attacks.

• Journal of the Korean Data and Information Science Society
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• v.26 no.2
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• pp.347-354
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• 2015

This paper deals with a method for intrablock anlaysis of balanced incomplete block designs on the basis of projections under the assumption of mixed effects model. It shows how to construct a model at each step by the stepwise procedure and discusses how to use projection for the analysis of intrablock. Projections are obtained in vector subspaces orthogonal to each other. So the estimates of the treatment effects are not affected by the block effects. The estimability of a parameter or a function of parameters is discussed and eigenvectors are dealt for the construction of estimable functions.

• Environmental Analysis Health and Toxicology
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• v.13 no.1_2
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• pp.33-41
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• 1998

Chlorpyrifos, o,o diethyl-o-(3,5,6-trichloro-2-pyridyl) phosphorothioate, is a broad spectrum organophosphate insecticide. The use of chlorpyrifos has been increased more and more as pesticide. But the effects of chlorpyrifos on the immune alterations has not been yet observed. Therefore, we investigated the effects of chlorpyrifos on the immune alterations in CICA male mice. Chlorpyrifos was administered to mice by a single intraperitoneal injection for the purpose of observing acute effects. On the one hand to get the information on immunopathologic alterations we observed hematological values, counted total circulating leukocytes and assessed the ratio of lymphocytes and neutrophils from the peripheral blood, measured the ratio of organ/body weight and counted splenic cellularity in CBA male mice which treated chlorpyrifos intraperitoneally. But we could not find any significant immunopathologic alterations statistically by a single intraperitoneal injection. Also, the exposure of chlorpyrifos caused no significant change in the number of PFC/10$^6$ spleen cells at any three given doses. On the other hand a singte intraperitoneal injection of chlorpyrifos decreased the lymphocyte proliferation response slightly to ConA or LPS stimulation at a dose of 6 mg/kg b.w. Administrations of chlorpyrifos reduced mixed leukocyte response(MLR). MLR was decreased moderately at doses of 3mg/kg b.w. and 6mg/kg b.w. Therefore, all these findings suggest that chlorpyrifos may alter the immune functions acutely. especially by the changes of T lymphocyte activity.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.10 no.5
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• pp.619-629
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• 1998

An experimental work was conducted to investigate a feasibility of simultaneous measurement of gas-liquid two-phase flowrates with double orifice plates using air and water. The tests were carried out under the atmospheric pressure and at the ambient temperature using two different tube sizes. Qualities of an air-water flow in the present study have values less than 0.1 and thus the mixed flow showed bubbly, plug, slug flow regimes. The probability density function (PDF) and the power spectral density function (PSDF) of the instantaneous pressure drop traces for the flow regimes were obtained. It is found that some distinctive features exist in the distribution of these functions, depending upon the two-phase flow pattern. The time-averaged value of the instantaneous pressure drop increases with increasing gas and liquid flowrates, showing a single-valued function for the total mass flowrate and the quality. It is also found that the two-phase discharge coefficient exhibits a consistent trend for variation of dimensionless parameters such as the superficial velocity ratio and the gas Reynolds number. The results indicate that simultaneous measurement of two-phase flowrate may be possible based upon a statistical analysis of the instantaneous pressure drop curves monitored using double orifice plates.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.188-195
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• 2006

The development of a general hospital has a close connection with the trend of the society in general and it flows to the ways that satisfies the demanded value of the time. Therefore, various internal changes have occurred since a hospital has built. The changes is appearing through the time not only in the quantitative changes, but also in functional changes and correlations between each department. This study focused on these changes, and observed the St. Mary's Hospital - one of the major hospitals - which is constructed in 1980's. And then, it was divided into the D/T, O.P.D and ward as function that focused on the time of hospital's establishment (1980), the present (2006), and new hospital (2009) to observe the changing aspect of the function and department. As a result, according as age passes, this study shows function of each department is mixed. Among the D/T, O.P.D and ward, mixing functions of O.P.D is most notable. The mixing function brings changes in hospital's arrangement type. In the past, verticality style hospital was evaded, but recently verticality style hospital is appearing. Through this study, it is expected to forecast the new aspects of hospital and apply it to the new project.