• Journal of the Optical Society of Korea
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• v.14 no.4
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• pp.424-430
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• 2010

In coherent anti-Stokes Raman scattering (CARS) microscopy reported until now, conventional microscope objectives are used, so that they are limited for introduction into a living body. Gradient-index (GRIN) rod lenses might be a solution for miniaturized microscope objectives for in-vivo CARS microscopy. However, due to the inherent large amount of chromatic aberration, GRIN rod lenses cannot be utilized for this purpose. CARS imaging catheter, composed of miniaturized microscope objective and fiber bundle, can be introduced into a living body for minimally invasive diagnosis. In order to design the catheter, we have to first investigate design requirements. And then, the optical design is processed with design strategies and intensive computing power to achieve the design requirements. We report the miniaturized objective lens system with diffraction-limited performance and completely corrected chromatic aberrations for an in-vivo CARS imaging catheter.

• Proceedings of the Korea Electromagnetic Engineering Society Conference
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• 2003.11a
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• pp.251-255
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• 2003

In this paper, a miniaturized directional coupler utilizing lumped element is proposed as a interdigital capacitor. The traditional miniaturization technique of transmission line realized a utilizing MIM(Metal-Insulator-Metal) capacitor on CPW(Coplanar Waveguide). However, we present a simplified design procedure without additional manufacturing process utilizing interdigital capacitor on microstrip with ease of design. The similar characteristics between the conventional directional coupler with ${\lambda}/4$ transmission line and the miniaturized directional coupler with ${\lambda}/8$ transmission line are validated through simulation and measurement results. Miniaturization rate of total size is about 25% while coupled line is about 60%. As a result, this proposed directional coupler can reduce the size of mobile communication system at 2 GHz.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1733-1736
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• 2005

Many studies have been carried out to produce 3D features in the size range between $10{\mu}m\~10,000{\mu}m$, called Meso-scale. If these miniaturized systems have high relative accuracy and good volumetric utilization, it is possible to manufacture more complex and accurate shapes with various materials as well as there are advantages of reducing energy, space and resources. Due to imperfect components and misalignment in assembly, it is necessary to assess the accuracy of the miniaturized system itself to obtain high relative accuracy. Laser interferometers are widely used to measure geometric errors called as quasi-static errors. For miniaturized system, however, it is difficult to install the required accessories such as optics and the measuring range is limited because of the size of the system and also this method is very expensive. Moreover, it is impossible to measure each error component simultaneously. A new system to measure simultaneously multiple geometric errors is proposed using capacitance sensors. Each error was measured using capacitance sensors and a measurement algorithm was mathematically derived. The experiments show that the proposed measurement system can be used effectively to assess the accuracy of miniaturized system at a low cost.

• Molecules and Cells
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• v.40 no.1
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• pp.45-53
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• 2017

Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of ${\beta}-catenin$, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was considered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient's age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.

• Proceedings of the Korea Society of Design Studies Conference
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• 2001.10a
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• pp.54.2-54
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• 2001

• Journal of Welding and Joining
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• v.12 no.4
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• pp.63-75
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• 1994

The conventional SCC(stress corrosion cracking) test methods have much difficulty in evaluating the SCC behaviors of the localized zone like HAZ, bond line and weld metal because of the specimen size. Accordingly, the purpose of this paper is to develop the new SCC test method of the welded zone by evaluating the SCC susceptibility on parent metal and various microstructures of the welded zone by SP(small punch) test method using miniaturized small specimen and SSRT(slow strain rate test) method(SP-SSRT). Besides, this study is to verify the efficiency of the SP-SSRT results through AE(acoustic emission) test which is a useful technique to monitor the microfracture processes of the material. From the results of SCC susceptibility, SEM observation and AE test, it can be concluded that the SP-SSRT test using miniaturized small specimen(10mm*10mm*0.5mm) will be a good test method to evaluate the SCC susceptibility on the local zone such as the welded zone.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.19 no.3
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• pp.334-339
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• 2010

The development of high-speed spindle have been studied extensively for micro machining in advanced industrial countries. The research of miniaturized high-speed air spindle is important part which needs for the micro machining process of high quality. So, This study was to carry out results about design characteristics of miniaturized high-speed air spindle. We had designed 4type turbines and shaft. They were simulated in use the computer simulation programs. We made them as products. They measured RPM (revolutions per minute). As a result of experiments, there was a contrast among 4type Turbines. it reached 384,000rpm in 4.5bar of air pressure. And, We tried to compare the results of measurement whit the results of computer simulation.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.8
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• pp.683-689
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• 2016

Servo mismatch, which affects positioning accuracy of multi-axis machine tools, is usually estimated via the circular test. However, due to mechanical restrictions in measuring instruments, the circular test using a double ball-bar is difficult to apply in miniaturized or super-large sized machine tools. Laser trackers are widely used to measure the form accuracy of parts and the positioning accuracy of driving systems. In this paper, a technique for the servo mismatch estimation of multi-axis machine tools is proposed via the circular test using a laser tracker. To verify the proposed technique, experiments using a double ball-bar and laser tracker are conducted in a 3-axis machine tool. The difference in the evaluation results is 0.05 msec. The servo mismatch for the miniaturized machine tool is also evaluated using the proposed technique.

• Transactions of the Korean hydrogen and new energy society
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• v.26 no.5
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• pp.431-437
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• 2015

Recently, a miniaturized measurement cell of effective thermal conductivity was developed to evaulate the heat transfer characteristics of hydrogen stroage material in the initial step of its development. In this work, the realiablity issues which can occur from this miniaturization of measurement cell were studied in detail by both experiments and numerical simulation of heat transfer. $LaNi_5$ as a reference was used for the reliability evaluation of the miniaturized measurement cell. Numerical simulations of heat transfer for this measurement system were verified through comparison with the experimental data. Under these reliablity studies, we discuss how to overcome the inherent drawbacks of this miniaturized system in order to achieve the high reliability.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.5
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• pp.38-45
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• 2004

As optical communication is being substituted for telecommunication, the demand of a large variety of fiber optic components is increasing. V-groove substrates, one of the module components, are used to connect optical fibers to optical planar circuits and to arrange fibers. Their applications are multi-channel optical connectors and optical waveguide fiber coupling, etc. Because these substrates are a critical part of the splitter in a multiplexer and a multi fiber connector, precise and reliable fabrication process is required. For precisely aligning core pitch between fibers, machined core pitch tolerance should be within sub-microns. Therefore, these are generally produced by state-of-the-art micro-fabrication like MEMS. However, most of the process equipment is very expensive. It is also difficult to change the process line for custom designs to meet specific requirements using various materials. For various design specifications such as different values of the V angle and low-priced process, the fabrication method should be flexible and low cost. To achieve this goal, we have suggested a miniaturized machine tool with high accuracy positioning system. Through this study, it is shown that this cutting process can be applied to produce V-groove subtracts. We also show the possibility of using a miniaturized machining system for producing small parts.