• 인간행동과 음악연구
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• 제16권1호
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• pp.73-88
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• 2019

본 연구는 건강 및 경도인지장애 노인의 리듬 재산출 수행력의 차이를 살펴보기 위해 실시되었다. 연구 대상자는 S시 및 A시 소재의 경로당, 치매안심센터, 노인 복지관 등 노인이용기관을 이용하는 만 60세 이상 85세 미만으로 자발적으로 참여를 원하는 건강 노인 30명과 경도인지장애로 진단받은 노인 27명으로 총 57명이다. 모든 검사는 개별적으로 진행되었고 리듬수행과제는 Beat Processing Device(BPD) 앱이 설치된 아이패드를 사용하였다. 본 연구에서 사용된 BPD에는 6가지 리듬꼴이 저장되어 있으며 참여자는 무작위로 재생된 리듬꼴을 듣고 동일하게 2회 재산출하였다. 재산출된 리듬은 전산적으로 저장되었으며 결과 분석을 위해 박간의 간격 비율(R)을 계산하였다. 연구 결과, 건강 노인과 경도인지장애 노인의 리듬 재산출 수행력의 평균값에는 차이가 있었으나 통계적으로 유의하지는 않았다. 박 간의 간격 비율(R)에서 두 집단 모두 <♩ ♩>에서 일치도가 가장 높았으며, <♩. ♪>에서 그 일치도가 가장 낮았다. 수행력 전반에서 건강 노인과 경도인지장애노인 집단 간 유의한 차이는 없었으며, 리듬과제 수행 반복에 따라 두 번째 수행에서 통계적으로 유의하게 낮아진 수행력을 확인할 수 있었다. 이러한 결과는 건강 및 경도인지장애 노인의 리듬 재산출 수행력에 차이는 없었지만 리듬꼴에 따른 난이도를 확인할 수 있었다는 점에서 의의가 있다. 이는 추후 노인 대상 음악치료에서 리듬 연주를 구성할 시 참고할 수 있는 자료로 활용될 수 있다.

• Journal of Ginseng Research
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• 제46권6호
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• pp.750-758
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• 2022

Background: Mild cognitive impairment (MCI) is a transitional condition between normality and dementia. Ginseng is known to have effects on attenuating cognitive deficits in neurogenerative diseases. Ginsenosides are the main bioactive component of ginseng, and their protein targets have not been fully understood. Furthermore, no thorough analysis is reported in ginsenoside-related protein targets in MCI. Methods: The candidate protein targets of ginsenosides in brain tissues were identified by drug affinity responsive target stability (DARTS) coupled with label-free liquid chromatography-mass spectrometry (LC-MS) analysis. Network pharmacology approach was used to collect the therapeutic targets for MCI. Based on the above-mentioned overlapping targets, we built up a proteineprotein interaction (PPI) network in STRING database and conducted gene ontology (GO) enrichment analysis. Finally, we assessed the effects of ginseng total saponins (GTS) and different ginsenosides on mitochondrial function by measuring the activity of the mitochondrial respiratory chain complex and performing molecular docking. Results: We screened 2526 MCI-related protein targets by databases and 349 ginsenoside-related protein targets by DARTS. On the basis of these 81 overlapping genes, enrichment analysis showed the mitochondria played an important role in GTS-mediated MCI pharmacological process. Mitochondrial function analysis showed GTS, protopanaxatriol (PPT), and Rd increased the activities of complex I in a dose-dependent manner. Molecular docking also predicted the docking pockets between PPT or Rd and mitochondrial respiratory chain complex I. Conclusion: This study indicated that ginsenosides might alleviate MCI by targeting respiratory chain complex I and regulating mitochondrial function, supporting ginseng's therapeutic application in cognitive deficits.

• 재활치료과학
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• 제10권4호
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• pp.39-52
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• 2021

목적 : 본 연구의 목적은 기억력 장애를 가진 성인 환자를 대상으로 기억력 향상을 위한 작업치료 중재를 수행한 단일대상연구의 특성을 확인하고 질적 수준을 알아보는 것이다. 연구방법 : 본 연구는 2011년부터 2020년까지 기억력 향상 작업치료 중재 연구 중 단일대상연구 설계를 적용한 총 6편의 논문을 분석한 문헌연구로, 연구내용에 대한 일반적 특성 및 연구방법의 질적 수준을 분석하였다. 결과 : 분석대상의 질적 수준은 66.7%(4편)가 중간 수준이었고 33.3%(2편)는 높은 수준이었으며, 낮은 수준의 연구는 없었다. 단일대상연구 설계 유형은 모두 반전설계로 ABA가 가장 많았다. 대상자는 뇌졸중, 치매, 경도인지장애 환자였으며, 대상자 수는 1~3명이었다. 독립변수는 오차배제훈련, 어플리케이션 활용 중재, 전산화인지훈련, 시간차회상훈련이었다. 종속변수는 공통변수인 기억력과 함께 집중력, 뇌파변화, 수단적 일상생활활동 및 우울이었다. 중재시간은 30~40분, 중재회기는 6~15회기였으며, 총 연구기간은 3~8주로 다양하였다. 중재 결과 모든 연구에서 중재 후 종속변수가 향상된 것으로 보고되었다. 결론 : 기억력훈련에 대한 단일대상연구 적용 작업치료 중재 연구들은 모두 중간 이상의 질적 수준을 보여 임상에서 적용 시 근거기반자료로 의의가 있으며, 기억력 향상에 효과적인 연구들이라는 것을 확인하였다.

• 동의신경정신과학회지
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• 제34권3호
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• pp.141-150
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• 2023

Objectives: This study aimed to comprehend the characteristics of Korean medicine patterns in relation to varying degrees of cognitive impairment in an elderly population. Methods: The dataset included 127 elderly individuals with cognitive impairment obtained from three Korean medicine hospitals between 2018 and 2021. The participants were categorized into two groups based on Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores: those with questionable impairment (QI) and those with very mild dementia (VMD). A diagnostic framework for Korean medicine patterns encompassing Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire was employed. Liver blood markers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the AST/ALT ratio, were also analyzed. Results: The scores of the cognitive assessment tools (MoCA-K, MMSE-DS, and K-IADL) of the QI group significantly differed from those of the VMD group. CDR-SB exhibited a positive correlation with the scores of each pattern of Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire, whereas ALT and AST values displayed negative correlations. Binomial logistic analysis, controlling for potential confounders, such as age, education years, body mass index, the presence of chronic disease, and the presence of medication, verified that the VMD group showed higher pattern scores and lower ALT and AST values than the QI group. Conclusions: Increases in pattern scores along with decreased AST and ALT levels might be indicative of more severe cognitive impairment.

• 대한치매학회지
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• 제23권1호
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• pp.22-29
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• 2024

Background and Purpose: Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognition and performance of daily activities. Recent studies have attempted to establish the relationship between AD and sleep. It is believed that patients with AD pathology show altered sleep characteristics years before clinical symptoms appear. This study evaluated the differences in sleep characteristics between cognitively asymptomatic patients with and without some amyloid burden. Methods: Sleep characteristics of 76 subjects aged 60 years or older who were diagnosed with subjective cognitive decline (SCD) but not mild cognitive impairment (MCI) or AD were measured using Fitbit^® Alta HR, a wristwatch-shaped wearable device. Amyloid deposition was evaluated using brain amyloid plaque load (BAPL) and global standardized uptake value ratio (SUVR) from fluorine-18 florbetaben positron emission tomography. Each component of measured sleep characteristics was analyzed for statistically significant differences between the amyloid-positive group and the amyloid-negative group. Results: Of the 76 subjects included in this study, 49 (64.5%) were female. The average age of the subjects was 70.72±6.09 years when the study started. 15 subjects were classified as amyloid-positive based on BAPL. The average global SUVR was 1.598±0.263 in the amyloid-positive group and 1.187±0.100 in the amyloid-negative group. Time spent in slow-wave sleep (SWS) was significantly lower in the amyloid-positive group (39.4±13.1 minutes) than in the amyloid-negative group (49.5±13.1 minutes) (p=0.009). Conclusions: This study showed that SWS is different between the elderly SCD population with and without amyloid positivity. How SWS affects AD pathology requires further research.

• 한국산학기술학회논문지
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• 제17권8호
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• pp.605-614
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• 2016

본 연구는 지역사회에 거주하는 경도인지장애로 진단받은 노인들을 대상으로 작업회상치료(ORT)를 적용한 후 인지기능, 신체적 건강상태, 의사소통과 상호작용 기술 및 우울감에 미치는 효과를 알아보고자 실시하였다. 연구 대상자는 경도인지장애 진단받은 만 65세 이상의 노인으로 YW 보건소에 등록되어 정기적으로 내원하는 자로 실험군과 대조군으로 임의로 할당하였고 실험군에게 1주일에 1회, 1시간씩 총 8회기 작업회상치료를 실시하였다. 작업회상치료 프로그램은 대상자들의 개별 인터뷰를 통해 공통으로 경험한 사건 및 활동을 확인하고, 선행 연구에서 사용된 프로그램들에 대한 문헌을 고찰하여 종합한 후 내용타당도 검증을 실시하였다. 작업회상치료가 미치는 효과에 대한 전 후간 차이 검증은 paired t-test, 중재 후 실험군과 대조군 간의 변화량 차이 검증은 Mann-Whitney U 검정을 실시하였다. 그 결과 실험군(n=9)이 대조군(n=9)에 비해 인지기능, 신체적 건강상태, 의사소통과 상호작용 기술 및 우울감에서 유의미한 향상을 보였다. 이로써, 작업회상치료(ORT)는 경도인지장애 노인의 치매를 예방하고 건강 유지 및 증진에 효과적인 비약물적 치료 방법의 하나로 적극 활용될 수 있기를 기대한다.

• 디지털융복합연구
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• 제20권2호
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• pp.511-523
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• 2022

본 연구는 코로나19 장기화로 다양한 노인돌봄 방식의 변화가 제기되고 있어, 재가의 경증치매 및 신체허약노인을 대상으로 비대면 방식의 돌봄기술을 적용하였다. 본 연구의 목적은 AI 로봇 통합관리프로그램을 적용하여 인지기능, 일상생활활동, 우울의 정도를 비교하기 위한 비동등성 대조군 전·후 유사실험 연구이다. 자료수집은 2021년 6월 4일부터 9월 17일까지이며 실험군 17명, 대조군 18명 대상자의 설문결과를 SPSS 25.0으로 분석하였다. 연구결과, 실험군은 언어기능, 일상생활활동, 우울에서 유의하게 나타났다. 특히 중등도 이상 우울과 경증 우울이 감소되는 결과를 나타냈다. 인지기능은 장기요양등급과, 일상생활활동은 동거가족과 통계적으로 유의하게 나타났다. 따라서 '위드 코로나 시대'에 노인돌봄 현장에 비대면 방식의 돌봄기술을 도입한다면, 노인의 인지기능훈련 및 우울 감소에 기여할 것으로 사료된다.

• 지역사회간호학회지
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• 제9권2호
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• pp.336-349
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• 1998

The purpose of this study was to test the effects of music therapy on cognitive function and depression in demented old adults. This study was made with one -group in a pre- and post-test design. The subjects were seven demented old adults over, sixty-five years and with mild to moderate cognitive impairment, residing at a nursing home. Music therapy was given by one researcher and one research assistant for thirty to forty minutes twice a week for 4 months. Music therapy was conducted with the subjects both listening and singing with a cassette player and a double-handed drum. In order to evaluate the effects of music, we measured the level of cognitive function and depression at the beginning and at the end of the music therapy session by means of an MMSE- K developed by Kwon and Park and the Depression Inventory developed by Chon. The Data were analyzed using descriptive statistics and a paired t - test analysis using a SPSS PC package. The results are as follows: 1) The subjects of the music therapy showed improvement in cognitive function. The MMSE-K score was significantly increased after music therapy. Especially, memory recall was very significantly. 2) The subjects of the music therapy showed a slight decrease in depression. However, there was no significant difference in the degree of depression between mean scores measured before and after music therapy. The results suggest that music therapy is effective in improving and maintaining cognitive function in demented old adults. And we suggest that long-term music therapy will be required to improve depression in demented old adults. These findings are encouraging the idea that music therapy may improve cognitive impairment.

• 대한한방내과학회지
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• 제18권1호
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• pp.26-47
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• 1997

We had studied about the therapy of pinggan with apoplexy and the rusult were obtaind as follows. 1. The therapy of Pinggan is based on Treatise on Exogenous Febrile Diseases(傷寒論)'s ShaoyaoGancaoTang(芍藥甘草湯) on the ground of The Yellow Emperor's Internal Classic(黃帝內經). 2. Ye Tianshi(葉天士) theorized about the therapy of Pinggan. It was that the internal wind theory combind the theory of that liver and kidney having the same origin. He said that 'Through mild the liver, we calm down the liver to stop the wind, and nourish the kidney and then removed heat'. 3. The prodomal stage was treated by prescription of Ziyin-Huoxue-Xifeng(滋陰活血熄風方), WendanTang(溫膽湯), TianmaGoutongYin(天麻鉤藤飮) and ZhenganXifengTang(鎭肝熄風湯). and The therapy has been used to the symptoms of deficiendy of liver-yin and kidney-yin and psycotic symptoms In convalescence. The prescription of ZhenganXifengTang(鎭肝熄風湯), TianmaGoutongYin(天麻鉤藤飮), and DighuangYinzi(地黃飮子) waked well. 4. Internal cerebral hemorrhage, cerebral infarction, movement disorder and senile dementia were treated by the therapy of pinggan, for the action of hypotensor, lipolysis, ataralgesia, defervesence. 5. The medicines of Pinggan-Xifeng like Gastrodiae Rhizoma, Uncariae Ramulus Et Uncus, Scorpio, Bornbyx Batryticatus, Scolopendra, Saigae Tataricae Cornu, and Pinggan-qianyang like Haernatitum, Ostreae Concha, Margaritifera Usta Concha, Eretmochelyos Carapax, Tribuli Fructus were usually used.

• 동의신경정신과학회지
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• 제24권1호
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• pp.13-26
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• 2013

Objectives : The purpose of this study is to investigate the correlation between pattern identification of traditional Chinese medicine (TCM) and western medicine, examined by a systematic research of Chinese medicine papers. Methods : We searched for the papers regarding pattern identification of TCM published from 1994 to 2012 in CNKI (China National Knowledge Infrastructure http://www.cnki.net) at April, 2012. Results : A total of 30 studies were finally included; 18 studies of them were related to stroke (cerebral infarction) and there were 12 studies regarding other diseases, such as hypertension, chronic colonitis, vascular dementia, mild cognitive impairment and etc. All 30 studies were analyzed and classified by diseases, differentiation of syndromes, numbers of subjects, the instrument of pattern identification, items of western medicine examination and statistical results. Conclusions : According to our study, there are some correlations between pattern identification of TCM and various items of western medicine examination. The result suggests a possibility of using the western medicine examination data for pattern identification of TCM.