동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제34권3호
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  • Pages.141-150
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  • 2023
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  • 1226-6396(pISSN)
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  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
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경도인지장애와 경도치매 단계에서의 한의 변증 및 간 혈액지표 연관성 탐색 연구

Association of Korean Medicine Pattern Identifications and Liver Blood Markers with the Severity of Cognitive Impairment in an Elderly Population

  • 김가혜 (한국한의학연구원 디지털임상연구부) ;
  • 차지윤 (한국한의학연구원 디지털임상연구부) ;
  • 김슬기 (한국한의학연구원 디지털임상연구부) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 한방신경정신과학교실) ;
  • 김재욱 (한국한의학연구원 디지털임상연구부)
  • Kahye Kim (Digital Health Research Department, Korea Institute of Oriental Medicine) ;
  • Jiyun Cha (Digital Health Research Department, Korea Institute of Oriental Medicine) ;
  • Seul Gee Kim (Digital Health Research Department, Korea Institute of Oriental Medicine) ;
  • Hyung-Won Kang (Department of Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • Yeoung-Su Lyu (Department of Neuropsychiatry, College of Korean Medicine, Wonkwang University) ;
  • In Chul Jung (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Jaeuk U. Ki (Digital Health Research Department, Korea Institute of Oriental Medicine)
  • 투고 : 2023.09.04
  • 심사 : 2023.09.18
  • 발행 : 2023.09.30
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초록

Objectives: This study aimed to comprehend the characteristics of Korean medicine patterns in relation to varying degrees of cognitive impairment in an elderly population. Methods: The dataset included 127 elderly individuals with cognitive impairment obtained from three Korean medicine hospitals between 2018 and 2021. The participants were categorized into two groups based on Clinical Dementia Rating-Sum of Boxes (CDR-SB) scores: those with questionable impairment (QI) and those with very mild dementia (VMD). A diagnostic framework for Korean medicine patterns encompassing Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire was employed. Liver blood markers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the AST/ALT ratio, were also analyzed. Results: The scores of the cognitive assessment tools (MoCA-K, MMSE-DS, and K-IADL) of the QI group significantly differed from those of the VMD group. CDR-SB exhibited a positive correlation with the scores of each pattern of Qi deficiency, Yin deficiency, Phlegm dampness, and Heat-fire, whereas ALT and AST values displayed negative correlations. Binomial logistic analysis, controlling for potential confounders, such as age, education years, body mass index, the presence of chronic disease, and the presence of medication, verified that the VMD group showed higher pattern scores and lower ALT and AST values than the QI group. Conclusions: Increases in pattern scores along with decreased AST and ALT levels might be indicative of more severe cognitive impairment.

키워드

과제정보

This study was funded by the Ministry of Health and Welfare of South Korea (HB16C0044, NHN2311070) and the Korea Institute of Oriental Medicine (KSN1823130).

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