• Journal of Korean Public Health Nursing
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• v.29 no.2
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• pp.219-230
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• 2015

Purpose: This research study not only examine the relationship between cognitive function, IADL, depression and quality of life, but also clarifies factors impacting quality of life for the elderly. The purpose of this study is to administer health promotion programs and to improve quality of life for the elderly. Methods: Data were collected from May 20, to June 10, 2014. The participants were 157 elderly persons with mild cognitive injury (MCI), who had under 23 points on MoCa-K from three different senior welfare centers in Daejeon. The questionnaires were conducted by four university students after receiving instruction from the researcher and consisted of general characteristics, cognitive function, depression and quality of life. SPSS WIN 19.0 program was used for data analysis. Results: Cognitive function showed positive correlation with quality of life (r=175, p=.028). IADL did not show correlation with quality of life (r=-.005, p=.947). However cognitive function(r=-.344, p<.001) and depression (r=-.623, p<.001) showed negative correlation with quality of life. In addition, the factors impacting quality of life were cognitive function (${\beta}=.14$, p=.29) and depression (${\beta}=-.61$, p<.001) which accounted for 39% of quality of life. Conclusion: These findings showed that the participants had depression and their cognitive function was low. As a result, the more participants' cognitive function decreased, the more their quality of life decreased. In addition, the more their depression decreased, the more their quality of life improved.

• Journal of Korea Multimedia Society
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• v.15 no.12
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• pp.1449-1455
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• 2012

This paper has developed a system for early diagnosis of senile dementia and mild cognitive impairment (MCI) by developing software to measure the volume of hippocampus. This software consists of two parts; segmentation and analysis. The segmentation part uses ROI and region growing to segment hippocampus region. On the other hand, the analysis part creates a volume rendering of hippocampus. This software is expected contribute in these research fields for dementia diagnosis and its medication planning.

• Journal of Music and Human Behavior
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• v.16 no.1
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• pp.73-88
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• 2019

This research was conducted to compare the rhythm reproduction abilities between older adults with and without mild cognitive impairment (MCI) and analyze the abilities depending on the rhythm idiom. Participants between 60-85 years of age were recruited from senior community centers, dementia prevention centers, and senior welfare centers. A total of 57 participants were included in this study: 27 diagnosed with MCI and 30 healthy older adults (HOA). The experiment was conducted individually in a private room in which a participant was given random binary time rhythm idioms and instructed to reproduce the rhythmic idioms with finger tapping. Each participant's beat production was recorded with the Beat Processing Device (BPD) for iPad. BPD calculated rhythm reproduction as measured through rhythm ratio and error among beats. Results showed marginal differences between the two groups in terms of mean scores of rhythm reproduction abilities. In terms of the rhythm ratio among beats, both groups' highest rhythm reproduction rate was for <♩ ♩>, and their lowest reproduction rate was for <♩. ♪>. In conclusion, there was no significant difference in rhythm reproduction ability between the HOA and MCI groups. However, the study found an interesting result related to performance level of rhythmic idioms. This result provides therapeutic insight for formulating rhythm tasks for older adults.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.605-614
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• 2016

This study was conducted to apply occupational reminiscence therapy (ORT) to the elderly diagnosed with mild cognitive impairment (MCI) who reside in the local community and determine its effects on cognitive functions, physical health, communication and interaction skills, and depression. The participants were elderly diagnosed with MCI who visited YW community health center on a regular basis and were randomly divided into an experimental group and a control group. The experimental group received eight one hour sessions of ORT once a week. Individual interviews were then conducted with the participants to determine if an event or activity had been commonly experienced, after which the program was modified and supplemented as necessary by referring to previous programs. The Content Validity Index (CVI) was calculated, and differences before and after ORT's were identified by paired t-tests. Moreover, the Mann-Whitney U-test was conducted to identify differences in variances between groups. Only participants in the experimental group (n=9) reported significant improvements in cognitive function, physical health status, communication and interaction skills, and depression when compared to those in the control group (n=9). Therefore, it is expected that ORT will be actively used as a non-pharmacological intervention for preventing dementia and improving the health of elderly persons with MCI.

• Journal of the Korean Society of Radiology
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• v.8 no.5
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• pp.231-240
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• 2014

The purpose of this study were to analyze that the Seoul neuropsychological screening battery (SNSB) for the evaluating cognitive assessment of the Parkinson's disease patients with mild cognitive impairment (PD-MCI) and the changes of the cerebral ventricle volume in the brain magnetic resonance imaging (MRI), and we has been bring forward the guideline to determine the diagnostic criteria for the PD-MCI. To achieve this, we was diagnosed with Parkinson's disease patients (PD-MCI group: 34 patients; Parkinson's disease with normal cognition, PD-NC group: 34 patients) to perform the SNSB test for the attention, language, memory, visuospatial, and frontal/executive functions and the brain MRI. Additionally, to compared the change of the cerebral ventricle volume, we performed the brain MRI for the 32 normal control (NC) group. The volumetric analysis for a specific cerebral ventricle performed by using Freesurfer Ver. 5.1 (Massachusetts general Hospital, Boston MA, USA). As a results, compared to the PD-NC group, the PD-MCI group were statistically significant reduction in the ability to perform the memory and the visuospatial function (p<0.05). The volumetric changes for a specific cerebral ventricle were statistically significant variation in the left and right lateral ventricle, left and right inferior lateral ventricle, and 3rd ventricle. Although, in order to compared the objectification, the normalized percentage applied to the volumetric changes showed to extend the PD-MCI group than the PD-NC group. Specially, the left and right ventricle extension for the PD-MCI patients conspicuously had showed a quantitative linear relationship between the memory and the visuospatial function for the SNSB (r>0.5, p<0.05). Therefore, we were able to judge the diagnostic criteria of the PD-MCI through that can observe the volumetric variation of the specific cerebral ventricle by using Freesurfer in brain MRI, and to analyze the correlation between the SNSB.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.37-43
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• 2020

The aim of this study was to examine the relationships between upper limb muscle strength and cognitive function in older Korean adults. A total of 130 Community-dwelling older adults, who were able to independently conduct activities of daily living, participated in the study. We assessed upper limb muscle strength using a handgrip strength and arm curl test, and their cognitive function using a Montreal cognitive assessment (MoCA) and general practitioner assessment of cognition (GPCOG) tests. Out of 130 participants, 26 (20%) had normal cognitive functions, while 104 older adults (80%) had mild cognitive impairments (MCI). Handgrip strength was significantly different between older adults with and without MCI (p<.05) and was related to MoCA and GPCOG (p<.05). In the result, there is a correlation between physical ability and cognitive function of the older adults. Therefore, it is necessary to develop exercise program to improve mental health.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.3
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• pp.83-90
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• 2019

Recently, the need to prevent or treat cognitive impairment in older adults has been arising. In particular, they tried to diagnose MCI as an early stage of Alzheimer's disease and to delay the progression to dementia through training cognitive function. Most of cognitive function training have been manufactured to game contents which related to several cognitive function, and it needs to be verified quantitatively whether subjects are paying attention to cognitive function training. Thus in this study, we measured and analyzed EEG signals while performing attention training game contents. As an analysis method, we utilized CI, which shows how much they are focusing on, and RI, which shows how stable they are. The result of this study can be seen that all the subjects' CI were increased, which means that the subjects performed game contents with concentration.

• Genomics & Informatics
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• v.21 no.3
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• pp.28.1-28.13
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• 2023

Mild cognitive impairment (MCI) is a clinical syndrome characterized by the onset and evolution of cognitive impairments, often considered a transitional stage to Alzheimer's disease (AD). The genetic traits of MCI patients who experience a rapid progression to AD can enhance early diagnosis capabilities and facilitate drug discovery for AD. While a genome-wide association study (GWAS) is a standard tool for identifying single nucleotide polymorphisms (SNPs) related to a disease, it fails to detect SNPs with small effect sizes due to stringent control for multiple testing. Additionally, the method does not consider the group structures of SNPs, such as genes or linkage disequilibrium blocks, which can provide valuable insights into the genetic architecture. To address the limitations, we propose a Bayesian bi-level variable selection method that detects SNPs associated with time of conversion from MCI to AD. Our approach integrates group inclusion indicators into an accelerated failure time model to identify important SNP groups. Additionally, we employ data augmentation techniques to impute censored time values using a predictive posterior. We adapt Dirichlet-Laplace shrinkage priors to incorporate the group structure for SNP-level variable selection. In the simulation study, our method outperformed other competing methods regarding variable selection. The analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) data revealed several genes directly or indirectly related to AD, whereas a classical GWAS did not identify any significant SNPs.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.3
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• pp.37-45
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• 2021

Purpose : This study aimed to present normative data and cut-off points for older Korean adults completing the Montreal Cognitive Assessment - Korean (MoCA-K), which is used as a screening test for mild cognitive impairment in Korea. Methods : A total of 195 healthy adults ≥60 years were recruited. All participants completed the MoCA-K and the Korean - Mini-Mental State Examination (MMSE-K) to assess their cognitive function. Participants were divided into six groups based on their age: 60-64 years, 65~69 years, 70~74 years, 75~79 years, 80~84 years, and 85~89 years. Results : The results revealed that MoCA-K score decreased significantly with age (mean score ± standard deviation [SD]; 27.63±2.80 in subjects aged 60~64 years; 27.00±2.39 in subjects aged 65~69 years; 24.94±2.96 in subjects aged 70~74 years; 24.74±3.37 in subjects aged 75~79 years; 22.59±4.72 in subjects aged 80~84 years; and 18.83±5.38 in subjects aged 85~89 years; p<.001). Additionally, MoCA-K score also increased significantly with educational level (mean score±standard deviation [SD]; 19.95±4.78 in no formal education group; 24.95±2.22 in elementary school graduated group; 26.35±2.72 in middle school graduated group; 28.32±1.36 in high school graduated group; and 28.50±1.51 in more than college graduated group; p<.001). The optimal cut-off points were 24/25 for 60~69 years old group, 21/22 for 70~79 years old group, 17/18 for 80~84 years old group, and 13/14 for 85~89 years old group. The optimal cut-off points were 15/16 for individuals who were illiterate, 22/23 for individuals with 6 years of education, 22/24 for individuals with 9 years of education, and 26/27 for individuals with 12 or more years of education. Conclusions : This study presents normative data and cut-off points for the MoCA-K in older Korean adults. This data will facilitate more accurate detection and follow-up of the risk of mild cognitive impairment in this population, taking into consideration age and education. Future studies are required that should focus on the cut-off score on the level of education according to age.

• Journal of Biomedical Engineering Research
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• v.39 no.6
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• pp.237-242
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• 2018

$^{18}F$-fludeoxyglucose PET (FDG-PET) can help finding an abnormal metabolic activity in brain. In this study, we evaluated an efficiency of volume- and cortical surface-based analysis which were used to determine whether standardized uptake value ratio (SUVR) of FDG-PET was different among Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control (HC). Each PET image was rigidly co-registered to the corresponding magnetic resonance imaging (MRI) using mutual information. All voxels of the co-registered PET images were divided by the mean FDG uptake of the cerebellum cortex which was thresholded by partial volume effect (>0.9). Also, the SUVR value of each vertex was linearly interpolated from volumetric SUVR image which was thresholded by gray matter partial volume effect (>0.1). Lobar mean values were calculated from both volume- and cortical surface-based SUVRs. Statistical analysis was conducted to compare two measures for AD, MCI and HC groups. Even though the results of volume (SUVR_vol) and cortical surface-based SUVR (SUVR_surf) analysis were not significantly different from each other, the latter would be better for detecting group differences in SUVR of PET.