• Journal of Internet Computing and Services
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• v.24 no.2
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• pp.1-10
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• 2023

The Multi-access Edge Computing (MEC) paradigm equips network edge telecommunication infrastructure with cloud computing resources. It seeks to transform the edge into an IT services platform for hosting resource-intensive and delay-stringent services for mobile users, thereby significantly enhancing perceived service quality of experience. However, erratic user mobility impedes seamless service continuity as well as satisfying delay-stringent service requirements, especially as users roam farther away from the serving MEC resource, which deteriorates quality of experience. This work proposes a deep reinforcement learning based service mobility management approach for ensuring seamless migration of service instances along user mobility. The proposed approach focuses on the problem of selecting the optimal MEC resource to host services for high mobility users, thereby reducing service migration rejection rate and enhancing service availability. Efficacy of the proposed approach is confirmed through simulation experiments, where results show that on average, the proposed scheme reduces service delay by 8%, task computing time by 36%, and migration rejection rate by more than 90%, when comparing to a baseline scheme.

• Journal of Preventive Medicine and Public Health
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• v.7 no.2
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• pp.285-292
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• 1974

It is well known fact that many tuberculosis patients have often experienced interuption of treatment while their treatment. Because most of cases were inproved subjective symptome by adequate treatment for 3-6 months and patients misunderstood to be heal completely by their own dicision, It become the cause of emergency of drug resistance and chronic incurable diseases. The author intended to clarify the duration of treatment and its outcome by some characteristics of tuberculosis patients. The results obtained were as follows: 1. The rate of treatment for tuberculosis patients by each duration with 1-6, 7-12, 13-13, 19-24 and 25 or more months were 16, 23, 20, 14 and 25 percents respectively. The duration of treatment increased in patients with advancing age, better educated and registered at health center between 7-12 months after diagnosis for tuberculosis. 2. The rate of complete treatment, defaulters, death and migration were 43, 13, 8, and 10 percents respectively. The rate of complete treatment were high in older, better educated and registered at health center between 7-12 months after diagnosis. The rate of defaulters were high in younger, no educated and registered within 1 month after diagnosis. The rate of death was high in older and migration was high in younger.

• Journal of the Korea Society of Computer and Information
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• v.12 no.3
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• pp.165-175
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• 2007

The mobile agent executes a given task by which the agent code moves to the server directly. Therefore, node migration method becomes an important factor which impact on the whole performance of distributed system. In this paper, we propose an adaptive migration path technique of mobile agent using the metadata of naming agent. In this proposed technique, node selection for migration depends on the content of referenced metadata, and the reliability of migrated information is determined by the metadata updating method and cooperative operations of individual agents in multi-agents system. For these, we design the metadata using by the number of hit documents, hit ratio, node processing time and network delay time, and describe the methods for creating, using and updating metadata for which determine the adaptive node migration path of mobile agent according to the cooperation of individual agents and number of hit documents using by designed metadata. And results of evaluated performance for proposed adaptive migration path technique through the proper experiment and analysis gain rate of high effective information earning, because of high hit ratio(72%) about of fathered documents by case of applying metadata move to the 13 nodes. But, in case of non-applying metadata is hit ratio(46%) of gathered documents and rate of effective information earning about of 26 nodes is 36.8%.

• Clinical Endoscopy
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• v.57 no.3
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• pp.375-383
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• 2024

Background/Aims: Endoscopic self-expandable metal stent (SEMS) placement is currently the standard technique for treating unresectable malignant distal biliary obstructions (MDBO). Therefore, covered SEMS with longer stent patency and fewer migrations are required. This study aimed to assess the clinical performance of a novel, fully covered SEMS for unresectable MDBO. Methods: This was a multicenter single-arm prospective study. The primary outcome was a non-obstruction rate at 6 months. The secondary outcomes were overall survival (OS), recurrent biliary obstruction (RBO), time to RBO (TRBO), technical and clinical success, and adverse events. Results: A total of 73 patients were enrolled in this study. The non-obstruction rate at 6 months was 61%. The median OS and TRBO were 233 and 216 days, respectively. The technical and clinical success rates were 100% and 97%, respectively. Furthermore, the rate of occurrence of RBO and adverse events was 49% and 21%, respectively. The length of bile duct stenosis (<2.2 cm) was the only significant risk factor for stent migration. Conclusions: The non-obstruction rate of a novel fully covered SEMS for MDBO is comparable to that reported earlier but shorter than expected. Short bile duct stenosis is a significant risk factor for stent migration.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.17 no.2
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• pp.129-138
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• 2013

A spatio-temporal models as systems of ODE which describe two-species Beddington - DeAngelis type predator-prey system living in a habitat of two identical patches linked by migration is investigated. It is assumed in the model that the per capita migration rate of each species is influenced not only by its own but also by the other one's density, i.e. there is cross diffusion present. We show that a standard (self-diffusion) system may be either stable or unstable, a cross-diffusion response can stabilize an unstable standard system and destabilize a stable standard system. For the diffusively stable model, numerical studies show that at a critical value of the bifurcation parameter the system undergoes a Turing bifurcation and the cross migration response is an important factor that should not be ignored when pattern emerges.

• Animal cells and systems
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• v.12 no.3
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• pp.127-136
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• 2008

Caspase-11 has been known as a dual regulator of cytokine maturation and apoptosis. Although the role of caspase-11 under pathological conditions has been well documented, its physiological role has not been studied much. In the present study, we investigated a possible physiological function of caspase-11 during immune response. In the absence of caspase-11, immunized spleen displayed increased cellularity and abnormal germinal center structure with disrupted microarchitecture. The rate of cell proliferation and apoptosis in the immunized spleen was not changed in the caspase-11-deficient mice. Furthermore, the caspase-11-deficient peritoneal macrophages showed normal phagocytotic activity. However, caspase-11-/-splenocytes and macrophages showed defective migrating capacity. The dysregulation of cell migration did not seem to be mediated by caspase-3, interleukin-$1{\alpha}$ or interleukin-$1{\beta}$ which acts downstream of caspase-11. These results suggest that a direct regulation of immune cell migration by caspase-11 is critical for the formation of germinal center microarchitecture during immune response. However, humoral immunity in the caspase-11-deficient mice was normal, suggesting the formation of germinal center structure is not essential for the affinity maturation of the antibodies.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2777-2783
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• 2014

The purpose of this study was to explore the expression of ATAD2 in ovarian tumor tissue as well as its relationship with degree of malignancy. Tumor tissue from 110 cases of ovarian cancer was collected in accordance with the Declaration of Helsinki for evaluation of ATAD2 expression iimmunohistochemistry, quantitative PCR (qPCR) and Western blotting. The correlation between the ATAD2 expression and and the prognosis of ovarian cancer was evaluated by Cox regression model. In addition, HO-8910 and OVCAR-3 cells were transfected with two siRNAs targeting ATAD2. Cell viability was evaluated with MTT assay, and cell migration by transwell migration assay. ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels. Moreover, highly expression was positively correlated with degree of malignancy. Knock-down of ATAD2 in HO-8910 and OVCAR-3 cells was found to reduce cell migration. In addition, follow-up visits of the patients demonstrated that the 5-year survival rate was lower in patients with high expression of ATAD2. Our study suggested that ovarian tumor tissue may have highly expressed ATAD2, which is associated with tumor stage, omentum-metastasis, ascites and CA-125. Increased ATAD2 may play important roles in tumor proliferation and migration. ATAD2 could serve in particular as a prognostic marker and a therapeutic target for ovarian cancer.

• Korean Journal of Soil Science and Fertilizer
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• v.30 no.4
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• pp.314-327
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• 1997

A 2-dimensional soil water flow model was developed to describe the migration of soil moisture in drip-irrigated root zone employing cylindrical coordinate system. Several natural phenomena were incorporated into the model such as transpiration, various types of evaporation, and ponding due to the increase in irrigation rate. Model was solved numerically by finite difference method. The model was verified in several ways leading to the conclusion that it can describe the soil moisture migration in drip-irrigated root zone fairly well. From sensitivity analysis, vertical migration of soil moisture was found to move faster than the horizontal one, which indicates the vertical location just under the dripping point are adequate for measuring points of soil moisture. The pot shape of soil moisture in irrigated zone was proved to be caused by evaporation at the soil surface. Also, it was found that the hydraulic conductivity has greatly influential to the soil moisture migration, and that the soil moisture continues to migrate vertically after irrigation stops.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2555-2559
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• 2015

Purpose: To investigate effects of the TESTIN (TES) gene on proliferation and migration of highly metastatic nasopharyngeal carcinoma cell line 5-8F and the related mechanisms. Materials and Methods: The target gene of human nasopharyngeal carcinoma cell line 5-8F was amplified by PCR and cloned into the empty plasmid pEGFP-N1 to construct a eukaryotic expression vector pEGFP-N1-TES. This was then transfected into 5-8F cells. MTT assays, flow cytometry and scratch wound tests were used to detect the proliferation and migration of transfected 5-8F cells. Results: A cell model with stable and high expression of TES gene was successfully established. MTT assays showed that the OD value of 5-8F/TES cells was markedly lower than that of 5-8F/GFP cells and 5-8F cells (p<0.05). Flow cytometry showed that the apoptosis rate of 5-8F/TES cells was prominently increased compared with 5-8F/GFP cells and 5-8F cells (p<0.05). In vitro scratch wound assays showed that, the width of the wound area of 5-8F/TES cells narrowed slightly, while the width of the wound area of 5-8F/ GFP cells and 5-8F cells narrowed sharply, suggesting that the TES overexpression could inhibit the migration ability. Conclusions: TES gene expression remarkably inhibits the proliferation of human nasopharyngeal carcinoma cell line 5-8F and reduces its migration in vitro. Thus, it may be a potential tumor suppressor gene for nasopharyngeal carcinoma.

• Journal of Preventive Medicine and Public Health
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• v.7 no.1
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• pp.197-201
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• 1974

The rapid economic development of Korea since 1960 has also brought a rapid urbanization process, and recently many rural areas have begun to show actual depopulation, in which particularly the young, productive and high educated groups are leaving for cities. More than 70% of migrators go to large cities such as Seoul, Pusan and Taegu. Their main motives for migration are to seek a job in urban areas. The study showed following results; The rate of migration a year was 1% of total population. Regarding the age of migrators belong to between 10-39 years old, especially migrator aged 10-29 years are comprised 87%. The educational level of migrators was a little higher than that of the residents. Considering the sibling order of migrators, the traditional value system for first son seemed to change. Concerning the place of destination, more than 70% of migrators moved to large cities such as Seoul. Pusan and Taegu. The main motivation of migration was to seek a job in urban areas. The occupation at the place of destination were factory workers, employee at company, students, salesmen, farmers and public officials in that order.