• Molecules and Cells
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• 제43권8호
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• pp.749-762
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• 2020

The migration, dedifferentiation, and proliferation of vascular smooth muscle cells (VSMCs) are responsible for intimal hyperplasia, but the mechanism of this process has not been elucidated. WD repeat domain 1 (WDR1) promotes actin-depolymerizing factor (ADF)/cofilin-mediated depolymerization of actin filaments (F-actin). The role of WDR1 in neointima formation and progression is still unknown. A model of intimal thickening was constructed by ligating the left common carotid artery in Wdr1 deletion mice, and H&E staining showed that Wdr1 deficiency significantly inhibits neointima formation. We also report that STAT3 promotes the proliferation and migration of VSMCs by directly promoting WDR1 transcription. Mechanistically, we clarified that WDR1 promotes the proliferation and migration of VSMCs and neointima formation is regulated by the activation of the JAK2/STAT3/WDR1 axis.

• Journal of the Korean Geographical Society
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• 제52권1호
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• pp.105-122
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• 2017

The purpose of this study is to understand the urbanization process and identify the Origin-Destination(O-D) of migration in the period of the Japanese occupation, based on the census data about Bu and Jijung-myeon. For this, the study analysed the types and the location of the immigrants' origin(birthplace) whose headed for an urban area. In 1930, as the destinations in the inter-regional migration, the urban areas could be divided into three categories according to the distance: long-, medium- and short-distance. The new urban areas which developed for effective colonial rule by Japanese pulled the long distance immigrant across the Korean Peninsula, and the Chosun Dynasty's traditional cities had the inflow of population from the near and hinterland. All in all, it is proposed that the dual settlement systems of colonial and traditional structures, is the key to understand the Korean urbanization processes basedd on the inter-regional migration during Japanese colonial period.

• Nuclear Engineering and Technology
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• 제54권1호
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• pp.162-176
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• 2022

In Lead-based reactor (LBR) severe accident, the meltdown and migration inside the reactor core will lead to fuel fragment concentration, which may further cause re-criticality and even core disintegration. Accurately predicting the migration and solidification behavior of melt in LBR severe accidents is of prime importance for safety analysis of LBR. In this study, the Moving Particle Semi-implicit (MPS) method is validated and used to simulate the migration and solidification behavior. Two main surface tension models are validated and compared. Meanwhile, the MPS method is validated by the L-plate solidification test. Based on the improved MPS method, the migration and solidification behavior of melt in LBR severe accident was studied furthermore. In the Pb-Bi coolant, the melt flows upward due to density difference. The migration and solidification behavior are greatly affected by the surface tension and viscous resistance varying with enthalpy. The whole movement process can be divided into three stages depending on the change in velocity. The heat transfer of core melt is determined jointly by two heat transfer modes: flow heat transfer and solid conductivity. Generally, the research results indicate that the MPS method has unique advantage in studying the migration and solidification behavior in LBR severe accident.

• Preventive Nutrition and Food Science
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• 제14권3호
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• pp.246-251
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• 2009

The partitioning behavior of five printing ink solvents was studied in cookie ingredients and cookies to examine migration behavior, and to determine if one could predict Kp of a cookie from summing the Kp of each ingredient multiplied by its weight factor in the cookie formula. Solvents were ethyl acetate, hexane, isopropanol, methyl ethyl ketone, and toluene. Gas chromatography was used to measure Kp values on each raw and baked ($260^{\circ}C$ for 10 min) cookie ingredients, and lab-made cookies. The baking process-decreases in water content in each sample generally affected Kp of polar solvents, but did not affect that of the non-polar solvents. Structural changes in cookie ingredients during the baking process also caused some change of migration behavior. While the prediction of Kp of lab-made cookies using the Kp of raw ingredients showed significant differences between calculated and experimentally found values, predictions with baked ingredients showed much smaller differences. This suggests that loss of water and changes of crystallinity in cookies and cookie ingredients due to the baking process are important and affect the Kp.

• The Korean Journal of Petroleum Geology
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• 제11권1호
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• pp.9-17
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• 2005

In the main target area of the block II, Targe-scale faults occur below the unconformity developed around 1 km in depth. The contrast of seismic velocity around the unconformity is generally so large that the strong multiples and the radical velocity variation would deteriorate the quality of migrated section due to serious distortion. More than 15 kinds of data processing techniques have been applied to improve the image resolution for the structures farmed from this active crustal activity. The bad and noisy traces were edited on the common shot gathers in the first step to get rid of acquisition problems which could take place from unfavorable conditions such as climatic change during data acquisition. Correction of amplitude attenuation caused from spherical divergence and inelastic attenuation has been also applied. Mild F/K filter was used to attenuate coherent noise such as guided waves and side scatters. Predictive deconvolution has been applied before stacking to remove peg-leg multiples and water reverberations. The velocity analysis process was conducted at every 2 km interval to analyze migration velocity, and it was iterated to get the high fidelity image. The strum noise caused from streamer was completely removed by applying predictive deconvolution in time space and ${\tau}-P$ domain. Residual multiples caused from thin layer or water bottom were eliminated through parabolic radon transform demultiple process. The migration using curved ray Kirchhoff-style algorithm has been applied to stack data. The velocity obtained after several iteration approach for MVA (migration velocity analysis) was used instead or DMO for the migration velocity. Using various testing methods, optimum seismic processing parameter can be obtained for structural and stratigraphic interpretation in the Block II, Yellow Sea Basin.

• Journal of the Economic Geographical Society of Korea
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• 제13권1호
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• pp.64-88
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• 2010

Rapidly increasing transnational migration can be seen as a typical process which has proceeded under macro-contexts of socio-spatial characters of origin and destination country and their relationships, shaped with global uneven regional development in the process of glocalization and development of transportation and communication on the global level. In order to consider macro-contexts of transnational migration, this paper emphasizes the concept of multicultural space and some key elements implied in it, that is, place, territory, network, scale (suggested by Jessop et al.) and spatial flow and difference. As results of questionnaire analysis of foreign immigrants' recognition of macro-contexts, this paper suggests some findings: that is, a high level of recognition of all types of foreign immigrants on global changes, the most negative recognition of migrant workers among 4 types of foreign immigrants on economic and social conditions of their origin country, a positive recognition of people in all regions of their origin (except few countries such as Japan) on international migration, and a low level of their recognition in all types on S. Korea's characters as their destination country.

• The KIPS Transactions:PartD
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• 제16D권4호
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• pp.583-594
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• 2009

Most of the SOA solutions applicable to businesses and organizations are taking a top-down methodology. It starts with an analysis of an organization's requirements, followed by definition of business models and identification of candidate services and ends with finding or developing required services. Challenges in adopting SOA while abandoning legacy systems involve time and cost required during the process. Many businesses and organizations want to gradually migrate into SOA while making the most of the existing system. In this paper, we propose A Method for Migration of Legacy System into Web Service(M-LSWS); it allows legacy system to be migrated into web service accessible by SOA and be used as data repositories. M-LSWS defines procedures for migration into reusable web services through analysis of business processes and identification of candidate services based on design specification and code of legacy system. M-LSWS aims to migrate of legacy system into web service appropriate for SOA. The proposed method consists of four steps: analysis of legacy system, elicitation of reusable service and its specification, service wrapping and service registration. Each step has its own process and guideline. The eligibility of the proposed method will be tested by applying the method to book management system.

• Journal of Korean Neurosurgical Society
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• 제59권2호
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• pp.106-116
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• 2016

Objective : Protein disulfide isomerase (PDI) acts as a chaperone on the cell surface, and it has been reported that PDI is associated with the tumor cell migration and invasion. The aims of this study are to investigate the anti-migration effect of bacitracin, which is an inhibitor of PDI, and the associated factor in this process. Methods : U87-MG glioma cells were treated with bacitracin in 1.25, 2.5, 3.75, and 5.0 mM concentrations. Western blot with caspase-3 was applied to evaluate the cytotoxicity of bacitracin. Adhesion, morphology, migration assays, and organotypic brain-slice culture were performed to evaluate the effect of bacitracin to the tumor cell. Western blot, PCR, and gelatin zymography were performed to investigate the associated factors. Thirty glioma tissues were collected following immunohistochemistry and Western blot. Results : Bacitracin showed a cytotoxicity in 3rd (p<0.05) and 4th (p<0.001) days, in 5.0 Mm concentration. The cell adhesion significantly decreased and the cells became a round shape after treated with bacitracin. The migration ability, the expression of phosphorylated focal adhesion kinase (p-FAK) and matrix metalloproteinase-2 (MMP-2) decreased in a bacitracin dose- and time-dependent manner. The U87-MG cells exhibited low-invasiveness in the 2.5 mM, compared with the untreated in organotypic brain-slice culture. PDI was expressed in the tumor margin, and significantly increased with histological glioma grades (p<0.001). Conclusion : Bacitracin, as a functional inhibitor of PDI, decreased the phosphorylated FAK and the secreted MMP-2, which are the downstream of integrin and play a major role in cell migration and invasion, might become one of the feasible therapeutic strategies for glioblastoma.

• Journal of the Korean Geographical Society
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• 제50권3호
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• pp.289-303
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• 2015

This paper is an introductory research to theorize women migrants' positionality in the era of globalization and the feminization of migration. It particularly examines three recent theoretical approaches within feminist studies and their application to the feminist migration study. Migration means a process of continuous negotiations of one's social and material positions within ever changing relations and situations through crossing various borders including national boundaries. Women migrants face multifaceted oppressions due to gendered relation and greater challenges to transform their identities. They embody politics of location through migration. The paper revolves around theories that explore a potential of feminist subjectivation of marginalized women such as female migrants through their identity negotiation and transformation. The theories in questions are Borderlands and the New Mestiza introduced by Gloria $Anzald{\acute{u}}a$, Intersectionality of oppressions, and Transpositions and the Nomadic Subjects by Rosi Braidotti who borrowed the theories of Deleuze and Guattari through feminist critiques. These theories all represent power relations and subject transformations through spatial metaphors. rough spatialized understandings, the paper proposes interlocking relations among space, gender and migration, and explores conceptual tools as well as epistemological insights for Korean migration study.

• Journal of the Korean association of regional geographers
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• 제13권6호
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• pp.651-673
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• 2007

In the studies on residential move, there has been tendency of dichotomy where short distance moves are largely caused by housing to adjust to changes in households while long distance moves are induced by shift in labor market. However, some empirical studies have proven that residential move is so complex process that the simple dichotomy should be elaborated. In this sense, the present study seeks to identify compounded course of residential move in Korea. In determining migration history, families with younger householders, renters, householders with higher educational attainment and smaller households show a higher probability to move. In case of mobility, women were more prone to move compared to man. Women compared to man, older age augmented the probability to own a house after migration. Families with householders following an occupation of sales and technical service showed lowest tendency to own houses while it marked the highest in the group of professionals. Higher land price of a region was negatively related to owning houses after migration. The present study revealed that factors in macro level as well as micro level significantly affect the move of individuals with varying effects in accordance with migration history.