• Molecules and Cells
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• v.40 no.3
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• pp.195-201
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• 2017

In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3'UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.

• Food Science and Biotechnology
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• v.17 no.6
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• pp.1139-1145
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• 2008

Bread is an essential food consumed worldwide. Bread rapidly loses its desirable texture and flavor qualities associated with freshness through a process known as staling. The shelf life of bread is limited by this staling leading to economical losses in the range of one billion dollars per year. There are a number of mechanisms thought to be related to the staling process, such as water migration and redistribution, starch retrogradation, and gluten transformation. In this review, roles of water and water migration on bread staling are summarized and discussed.

• Journal of the Economic Geographical Society of Korea
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• v.12 no.4
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• pp.295-318
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• 2009

This paper explores micro-contexts of transnational migration and decision-making process of foreign migrants in Korea with four types, that is, married immigrants, immigrant workers, professional immigrants, and foreign students, analyzing dates of questionaries and interviews. Some findings can be summarized as follows. First, married immigrants and immigrant workers show relative lower level of micro-environments than professional immigrants and foreign students. Secondly, immigrants workers fill closest in geographical contiguity among immigrants' types, while married immigrants recognize more different in cultural comparison than the former. Both immigrants workers and foreign students think living environments of Korea better than other types, but immigrants workers consider relatively higher the level of technology, while foreign students evaluate lower that of education in Korea than other types. Thirdly, married immigrants give a relatively low score to the easiness of immigration, while both immigrant workers and professional immigrants give a high score to the job environment of Korea. Finally, all types of immigrants show a high portion in a self-decision making for international migration, while professional immigrants have much more experiences on visiting other countries than other types, and both married immigrants and foreign students seem to have utilized their networks with family members who live abroad.

• The Southeast Asian review
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• v.28 no.3
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• pp.111-158
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• 2018

This paper pays attention to the recent increase of young Koreans working in the low-skilled service sector in Singapore. Such rapid increase largely results from the Korean government's initiatives to promote labour migration of young people and the concurrent proliferation of migration agencies, against the background of growing youth unemployment in South Korea. By exploring the motivations and trajectories of young people's labour migration to Singapore, this study examines to what extent they think their expectations have been met and how they interpret their migration and work experiences. There has been little research that examines the actual voices of young migrants as part of migration studies, whilst the majority of previous research focuses on the evaluation of government support programmes based on job matching rates, surveys of participant satisfaction and etc. Young people who went to Singapore to improve their English language skills and qualifications for future employment in Korea have become frustrated due to low-skilled service jobs that consist of low pay and high labour intensity. Their credentials are devalued and they experience deskilling through this migration process. Most of them were discontent with the Korean migration agencies they used and critical about programmes offered by government institutions and universities/colleges. Despite being subject to deskilling, they did try to actively cope or resist this situation. This study focuses on the various ways these migrants attempted to manage the gap between their initial expectations and reality. It also demonstrates how these migrants interpreted their work experiences after returning to Korea: whilst most of them did not cash off their Singapore work experience for a decent job after returning to Korea, they did not define their experience as a complete failure. Adding to cultural, social capital they gained through this experience, they acquired 'mobility capital' which includes confidence, the desire to move, and capacity to control one's own movement.

• Journal of Life Science
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• v.26 no.12
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• pp.1367-1375
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• 2016

Cilostazol is known to be a selective inhibitor of phosphodiesterase III and is generally used to treat stroke. Our previous findings showed that cilostazol enhanced capillary density through angiogenesis after focal cerebral ischemia. Angiogenesis is an important physiological process for promoting revascularization to overcome tissue ischemia. It is a multistep process consisting of endothelial cell proliferation, migration, and tubular structure formation. Here, we examined the modulatory effect of cilostazol at each step of the angiogenic mechanism by using human brain microvascular endothelial cells (HBMECs). We found that cilostazol increased the migration of HBMECs in a dose-dependent manner. However, it did not enhance HBMEC proliferation and capillary-like tube formation. We used a cDNA microarray to analyze the mechanisms of cilostazol in cell migration. We picked five candidate genes that were potentially related to cell migration, and we confirmed the gene expression levels by real-time PCR. The genes phosphoserine aminotransferase 1 (PSAT1) and CCAAT/enhancer binding protein ${\beta}$ ($C/EBP{\beta}$) were up-regulated. The genes tissue factor pathway inhibitor 2 (TFPI2), retinoic acid receptor responder 1 (RARRES1), and RARRES3 were down-regulated. Our observations suggest that cilostazol can promote angiogenesis by promoting endothelial migration. Understanding the cilostazol-modulated regulatory mechanisms in brain endothelial cells may help stimulate blood vessel formation for the treatment of ischemic diseases.

• The Korean Journal of Petroleum Geology
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• v.1 no.1 s.1
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• pp.47-52
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• 1993

A method and results of computations are presented for the 2-D seismic migration process in the frequency-wavenumber domain for the laterally and vertically inhomogeneous medium. In order to take the intrinsic attenuation effect into account in the migration process the complex-valued wave velocity is used in the wavefield extrapolation operator, improving the generalized frequency-wavenumber migration technique. The imaginary part of the complex-valued wave velocity includes the seismic quality factor Q value. In derivation of the solution of the wave equation for the medium of inhomogeneous wave velocity and anelasticity, the inhomogeneous medium is mathematically converted to an equivalent system which consists of a homogeneous medium of averaged slowness and an inhomogeneous distribution of hypothetical wave source. The strength of the hypothetical wave source depends on the deviation of squared slowness from the averaged value of the medium. Results of numerical computation using the technique show more distinct geologic images than those using the convensional generalized frequency-wavenumber migration. Especially, the obscured images due to the wave attenuation by anelasticity are restored to show sharp boundaries of structures. The method will be useful in the imaging of the reflection data obtained in the regions of possible petroleum or natural gas reservoir and of fractured zone.

• Journal of the Korean Geographical Society
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• v.49 no.4
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• pp.525-545
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• 2014

This study seeks to clarify the influence of the stage migration which has proceeded through generations, on the population growth of local cities in the case of Jeollabuk-do. For this, setting to baby boomer as parents generation and echo boomer as their children, this study traces each generation's birth, distribution and the process of selective migration using aggregate level data. And the stage migration is analyzed by O-D, divided into three regions in each; Jeollabuk-do rural areas, Jeollabuk-do cities and other provinces. The major findings of this study are as follows. First, it was estimated that the number of the baby boomer births in Jeollabuk-do rural areas was seven times more numerous than in cities. Second, both rural and urban born baby boomers overwhelmingly moved into other provinces, especially Seoul metropolitan area and metropolis in their selective migration processes. However, there was also migration stream from rural areas to cities in Jeollabuk-do and the amount of this stream was approximately equal to the amount of outflux from cities in Jeollabuk-do to other provinces. Third, due to baby boomers' stage migration, from rural to urban, echo boomers were born in cities more than in rural areas. Fourth, urban born echo boomers still have moved into other provinces just like their parents generation in selective migration process. But comparing with baby boomer, the number of echo boomers influx from rural areas to cities has decreased. Consequentially the population of echo boomer in Jeollabuk-do cities also has decreased. Finally, the stage migration has been a basic cause of the social growth of urban population, and also influenced on the natural growth, closely connected with migrants' life course, such as marriage, childbirth and rearing. Therefore, this study concludes that the stage migration through generations is one of the crucial factor to understand the population growth in local cities.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.05a
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• pp.687-691
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• 2011

In this paper, we design an 8-bit eSuse OTP (one-time programmable) memory in consideration of EM (electro-migration) and eFuse resistance variation based on a $0.18{\mu}m$ generic process, which is used for an analog trimming application. First, we use an external program voltage to increase the program power applied an eFuse. Secondly, we apply a scheme of precharging BL to VSS prior to RWL (read word line) activation and optimize read NMOS transistors to reduce the read current flowing through a non-programmed cell. Thirdly, we design a sensing margin test circuit with a variable pull-up load out of consideration for the eFuse resistance variation of a programmed eFuse. Finally, we increase program yield of eFuse OTP memory by splitting the length of an eFuse link.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.5 no.2
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• pp.42-58
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• 1999

Packaging materials and articles that are used in food contact applications can transfer constituents in the foodstuffs. This kind of risk of possible health hazards to consumers has been generally recognized for a long time with the consequence of establishing corresponding food regulations in most developed countries. However, the language of these laws, their interpretation, and their level of enforcement vary from country to country. Accordingly, the actual migrating levels from packaging materials can be varied depending on the migration testing methods as prescribed in the national legislation in each countries. Therefore, there are needs of elimination of non-tariff trade barriers raised by sanitary and phytosanitary or technical measures under the Final Act of the UR Agreement. In this connection, the EU and USA are currently in an ongoing process of legislation harmonization to overcome potential barriers to free trade. In general, regulations governing component transfer in the USA are more complicated and comprehensive than similar regulations in Europe. In future, standard migration testing procedures for microwave heat susceptor materials and for the use of fatty food simulant should be established and also harmonized among countries. The objective of this investigation is to compare the current regulations for migration testing for plastic containers and packaging materials in USA, EU and Korea or Japan. For those regulations, Korean standards are required to be kept up with the international standards. By doing this, the related Korean regulation could be amended along with the worldwide progress for harmonization.

• The Korean Journal of Applied Statistics
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• v.33 no.3
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• pp.347-355
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• 2020

An Isolation-with-Migration (IM) model is used to estimate extant population sizes, the splitting time of populations split away from their common ancestral populations, and migration rates between the extant populations. An evolutionary model such as IM models is estimated by analyzing DNA sequences sampled from the extant populations in the model. When a true model includes an unsampled 'ghost' population without data, the unsampled population is often ignored from the evolutionary model to infer. In this paper, we conduct a simulation study to investigate the effect of an unsampled population on the estimation of the size of the sampled population. When there exists an unsampled population that shares migrations with the sampled population, the size estimation of the sampled population was biased. However, the size estimation was improved if an evolutionary model, including the unsampled population, was estimated.