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The Time Evolution of Cerebral Apoptosis in the Permanent Middle Cerebral Artery Occlusion Model in Rats

  • Shin, Cheol-Sik;Choi, Byung-Yon;Jung, Eul-Soo;Kim, Sang-Woo;Chang, Chul-Hoon;Cho, Soo-Ho
    • Journal of Korean Neurosurgical Society
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    • v.37 no.1
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    • pp.54-58
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    • 2005
  • Objective: The purpose of this study is to determine the time evolution and distribution of cerebral apoptosis using the middle cerebral artery occlusion model in rats. Methods: A total of twenty four male rats - with 2, 3, 4, 6, 8, 12, 24 and 48 hours of middle cerebral artery occlusion respectively - were studied. The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-end labeling(TUNEL) method was used for the observation of the apoptotic cells. The apoptotic ratio was calculated and the distribution of apoptosis was inspected in the pyriform cortex, basal ganglia and middle cerebral artery territory cortex. The rats were divided into three groups(Group I : $2{\sim}4$ hours of occlusion, Group II : $6{\sim}$12 hours of occlusion, Group III : $24{\sim}48$ hours of occlusion). Results: In this study, the proportion of apoptosis increased with the duration of middle cerebral artery occlusion and reached a maximum after about 12 hours of middle cerebral artery occlusion. The mean values of the apoptotic ratio were $30.7{\pm}11.3%$ in group I, $60.8{\pm}2.6%$ in group II and $48.7{\pm}0.7%$ in group III. The distribution of apoptosis differed in the pyriform cortex, basal ganglia and middle cerebral artery territory cortex according to the duration of time of the middle cerebral artery occlusion. Conclusion: In the middle cerebral artery occlusion model of the rats, apoptosis is found to increase according to the occlusion time, reaching a peak after 6 hours, and the distribution of apoptosis changed from the pyriform cortex to the basal ganglia and middle cerebral artery territory cortex.

The Effect Factors on Stress in Middle-Aged Women (중년여성의 스트레스에 미치는 영향요인)

  • Park, Hyesun;Ma, Ryewon;Lim, Sunyoung
    • Journal of The Korean Society of Integrative Medicine
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    • v.7 no.4
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    • pp.241-251
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    • 2019
  • Purpose : The purpose of this study was to investigate the depression, self-efficacy, and stress level of middle-aged women and to identify the factors affecting on stress, and to provide base line data for the development of nursing intervention for stress reduction of middle-aged women. Methods : Participants were 200 middle-aged women aged 40 to 60 who live in Seoul and Gyeonggi Province. Data collection period was from March 1, 2019 to April 15. In this study, the questionnaire of life events-stress, depression scale, self-efficacy was used. Data were analyzed by average, standard deviation, minimum, maximum, correlation and regression using the SPSS Program 21.0. Results : The results of this study, the correlation between depression, self-efficacy and stress in middle-aged women, depression and self-efficacy (r=-.264, p<.001), self-efficacy and stress (r=-.279, p<.001) had a significant negative correlation, depression and stress (r=.268, p<.001) had a significant positive correlation. Depression and self-efficacy were the factors affecting the stress of middle-aged women. Depression was β =.207 (p<.001) and self-efficacy β =-.222 (p=.003). Depression had the greatest influence on stress, followed by self-efficacy. Conclusion : Middle-aged women are an important time to prepare for a successful old age. Considering that the current middle-aged women are the subjects of the future aging society, their physical, psychological, and social problems are very important in preventing the elderly problems of the aging society. Therefore, effective nursing interventions should be developed that to reduce the depression and stress in middle-aged women and to improve self-efficacy and improve the quality of life of middle-aged women.

A Study on Health Behavior of Middle-Aged Women (일지역 중년기 여성의 건강행위에 대한 서술적 연구)

  • Choi, Kong-Ok;Jo, Hyun-Sook;Kim, Chung-Youb
    • Women's Health Nursing
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    • v.6 no.1
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    • pp.82-95
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    • 2000
  • The purpose of this study is to provide a basis to recognize the health behaviors of middle-aged women that are constructive to a healthy life style. Data were collected from interview of questionnaires completed by 208 middle-aged women living in Incheon from November 1 to 30, 1999. The questionnaires used in this study were obtained from publications on health-related topics shown in literature review. These topics included : health concept, diseases, use of tobacco, alcohol, caffeine, drug, exercise and diet, cause of stress and stress management. The data were analyzed by descriptive statistics using the SPSS program. The results of this study were as follows. 1. Middle-aged women though of concept of health as a doing daily living pattern(48.1%). 2. 49.5% of the middle-aged women had illness or disease, which included gastritis, arthritis, anemia, hypertension, indigestion and allergies. 3. 1.4% of the middle-aged women smoked cigarettes. Most of them began to smoke due to stress. 4. 42.3% of the middle-aged women drink alcohol. Most of them began drinking due to peer pressure. 5. 28.8% of the middle-aged women consumed caffeine-containing products 5-7 times per week. 6. 55.3% of the middle-aged women took drugs. Most of the drugs were digestant and analgesics. 7. 21.2% of the middle-aged women exercised more than 2 times per week. 8. Most of causes of stress were economic difficulties and sickness. The method of stress management were enduring and sleeping.

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Comparison of association between physical activity and resting metabolic rate in young and middle-aged Korean adults

  • Hwang, Hyejung;Jung, Won-Sang;Kim, Jisu;Park, Hun-Young;Lim, Kiwon
    • Korean Journal of Exercise Nutrition
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    • v.23 no.2
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    • pp.16-21
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    • 2019
  • [Purpose] The purpose of this study was to comparatively investigate the correlation among body composition, resting metabolic rate (RMR), and physical activity (PA) between young and middle-aged Korean adults. [Methods] A total of 53 [male n=23, female n=30] subjects were included in this study, among whom 34 subjects were healthy young adults [male n=18, female n=16] and 19 were middle-aged adults [male n=5, female n=14]. The body composition and RMR of all the participants were measured after overnight fasting (≥8 h). The Korean version of the WHO Global Physical Activity Questionnaire (GPAQ) was used to assess physical activity. [Results] Body composition was not significantly different between young adults and middle-aged adults. Whole-body bone mineral density and bone mineral contents (BMC) were significantly lower in middle-aged adults than in young adults. Total blood cholesterol (TC) and blood glucose levels were significantly higher in middle-aged adults (TC; 195.21 ± 43.34, glucose; 103.57 ± 12.61 mg/dL) than in young adults. RMR was significantly lower in middle-aged adults (1619.57 ± 290.28 kcal/day) than in young adults (1894.37 ± 405.00 kcal/day). In middle-aged adults physical activity (PA). PA (METs, min, EE) was inversely correlated with fat mass (FM, kg, and %) and blood triglyceride (TG) level in young adults. In middle-aged adults, PA showed a significant positive correlation with lean body mass (LBM), FM (%), and RMR. Furthermore, PA EE showed significant interrelatedness with BMC among middle-aged adults. [Conclusion] These results demonstrated that high PA levels enable LBM and RMR maintenance in middle-aged adults. Furthermore, in young adults, more PA is required to induce change in body composition.

Reciprocity on intergenerational resource transfers from middle-aged children to elderly parents (중년기 자녀의 노부모에 대한 자원이전의 호혜성)

  • Koh, Sun-Kang
    • Journal of Family Resource Management and Policy Review
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    • v.16 no.2
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    • pp.103-121
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    • 2012
  • This study examines whether reciprocity exists in intergenerational resource transfers from middle-aged children to elderly parents. Analyzing data from a sample of 1123 middle-aged adults, this study highlights the importance of reciprocity in the transfer of resources between middle-aged adults and their elderly parents. The possibility of an inheritance shows a very strong effect on care-giving to elderly parents. Furthermore, past financial transfers from parents to middle-aged children correlates strongly with financial transfers from middle-aged children to their elderly parents.

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Influencing Factors on Fatigue of Middle Aged Women (중년여성의 피로에 영향을 미치는 요인)

  • Chang, Hae-Kyung
    • Korean Journal of Adult Nursing
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    • v.22 no.6
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    • pp.634-643
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    • 2010
  • Purpose: The purpose of this study was to identify the reported factors influencing fatigue of middle aged women. Methods: Two hundred seven middle aged women between 40 and 59 years of age were recruited from five areas in Korea from March 1, 2010, to April 20, 2010. Data were collected by self-reported questionnaires. Data analysis was done using SPSS/WIN 15.0 program for descriptive statistics, Pearson correlation coefficients and stepwise multiple regression. Results: The average score of fatigue was $2.34{\pm}0.40$. There were significant differences in reported fatigue according to economic status and health status. The reported fatigue was significantly correlated with somatic attribution, psychological attribution, normalizing attribution, depression, marital adjustment, stress, and social support. The major factors that affect fatigue in middle aged women were stress, depression, and normalizing attribution, which explained 32.3% of fatigue. Conclusion: The findings can reduce the fatigue by controlling stress and depression. Additionally, this study can understand the attribution of fatigue in middle aged women. More studies are needed to identify other variables that influence on the fatigue of middle aged women.

Subjectivity on Stressful Life Events of Middle-aged Women - A Q Methodology Approach - (중년여성의 스트레스 생활사건에 관한 주관성 연구)

  • 신혜숙
    • Journal of Korean Academy of Nursing
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    • v.32 no.3
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    • pp.406-415
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    • 2002
  • This study measures the subjectivity on stressful life events of middle- aged women. Method: Q-Methodological method was used for that purpose. As for the research method, Q-statements were collected preliminary to the study of through in-depth interviews and a literature review. For the study 38 Q-statements were selected. There were 28 middle aged women as subjects for the research. Q-Factor Analysis by using PC Quanl Program to supply the material. Result: Through the result of this study, the stressful life events of middle-aged women could be identified by 4 types. The type I is called the conflict in relationship with husband's family members. The type II is called lack of marital intimacy. The type III is called low self-esteem. The type IV is called changing life cycle itself. Conclusion: Therefore, identifing the subjectivity on the stressful life events of middle-aged women would be a basic step for the understanding of middle aged women.

Family Life Issues of middle Aged Apartment-Residents in Seoul : Focused on Economic Life (서울시 아파트 거주 중년기 가정의 생활실태와 문제(II) : 경제생활을 중심으로)

  • 이기영
    • Journal of the Korean Home Economics Association
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    • v.33 no.5
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    • pp.115-127
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    • 1995
  • The purpose of this research was to investigate the economic status and problems of the middle aged apartment-residents in Seoul as a part of collaborative study on family issues of them. The sampling households were divided into Kangnam and Kangbuk area according to their residential location and upper-middle and lower-middle groups according the size of the apartment unit. The analysis of this research was specially focused on the latter division. The data were collected from 307 fulltime housewives with at least one child in a middle or high school. This data were gathered from the structured questionnaire. The major findings of this research were as follows: 1. The significant differences between upper-middle and lower-middle groups were showed in such areas as household income, monthly living expenses, household assets and savings. 2. The most serious economic problem was the private education expenses in both groups. 3. The economic satisfaction of the group in the Kangbuk area was a little higher than the group in Kangnam area.

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Stereotypes of the Elderly Held by Adolescents and Middle-Aged Adults (청소년과 중년이 갖고 있는 노인의 고정관념 비교연구)

  • 박경란;이영숙
    • Journal of Families and Better Life
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    • v.19 no.6
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    • pp.221-239
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    • 2001
  • The purpose of this research was to identify arid to compare stereotypes toward the elderly held by adolescents and middle-aged adults. Stereotypes toward the elderly were examined at two levels: to assess students′and middle-aged adults′beliefs about the traits of the elderly and to categorize the traits into stereotypes. Traits groupings were analyzed with hierarchical cluster analysis. The main results of this study were as follows: First, both adolescents and middle-aged adults believed the negative stereotypes were more characteristic of the elderly than the positive ones. Second, middle-aged adults reported more complex negative stereotype sets of the elderly than adolescents. Third, Adolescents reported even more negative physical appearance trails of elderly persons than the middle-aged. Fourth, the traits endorsed as characteristics of elderly persons were often contradictory within two age groups. For example, adolescents perceived "sacrifice" as a positive trait of the elderly, while middle-aged adults perceived it as a negative one.

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Family Life Issues of Middle Aged Apartment-Residents in Seoul : Focused on Case Studies (서울시 아파트 거주 중년기 가정의 생활실태와 문제(V) -부인에 대한 사례조사를 중심으로-)

  • 임정빈
    • Journal of the Korean Home Economics Association
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    • v.34 no.3
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    • pp.327-343
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    • 1996
  • This study is the last part of a collaborative study on the Family Life Issues of Middle aged Apartment-Residents in Seoul. This study is focused on case studies. The data were collected from 15 fulltime housewives who are in the upper-middle and the lower-middle families having at least one child in a middle or high school from Kangbuk and Kangnam areas. In this study, the whole family life issues were divided into the following 4 subareas ; 1. housewives' own life, 2. family life, 3. economic environments, 4. housing environments. The major result of this study is : the most important factor influencing the quality of life of the middle age family was the existence of children attending junior and senior high school, which brought various problems into the family with relation to self identity, time management and leisure of middle aged housewife, educational cost, shared family activities, housing space. Therefore the whole family life would be improved through the change of the current education system.

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