• The Journal of the Acoustical Society of Korea
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• v.29 no.6
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• pp.388-394
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• 2010

In the present study, polyacetal bone mimics with circular cylindrical pores were used to investigate variations of speed of sound and attenuation coefficient with porosity and microarchitecture in bone. The speed of sound and attenuation coefficient of the 6 bone mimics with porosities from 0 % to 65.9 % were measured by a through-transmission method in water, using a pair of broadband, unfocused transducers with a diameter of 12.7 mm and a center frequency of 1.0 MHz. Independently of the structural properties of the bone mimics, the speed of sound decreased almost linearly with the increasing porosity. The attenuation coefficient measured at 1.0 MHz exhibited linear or nonlinear correlations with the porosity, depending on the structural properties of the bone mimics. These results are consistent with those previously published by other researchers using bone samples and mimics, and advances our understanding of the relationships of the ultrasonic parameters for the diagnosis of osteoporosis with the bone density and microarchitecture in human bones.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.1409-1410
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• 2011

• Korean Journal of Exercise Nutrition
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• v.24 no.1
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• pp.1-8
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• 2020

[Purpose] This study compared differences in trabecular bone architecture and strength caused by jump and running exercises in rats. [Methods] Ten-week-old male Wistar rats (n=45) were randomly assigned to three body weight-matched groups: a sedentary control group (CON, n=15); a treadmill running group (RUN, n=15); and a jump exercise group (JUM, n=15). Treadmill running was performed at 25 m/min without inclination, 1 h/day, 5 days/week for 8 weeks. The jump exercise protocol comprised 10 jumps/day, 5 days/week for 8 weeks, with a jump height of 40 cm. We used microcomputed tomography to assess microarchitecture, mineralization density, and fracture load as predicted by finite element analysis (FEA) at the distal femoral metaphysis. [Results] Both jump and running exercises produced significantly higher trabecular bone mass, thickness, number, and fracture load compared to the sedentary control group. The jump and running exercises, however, showed different results in terms of the structural characteristics of trabecular bone. Jump exercises enhanced trabecular bone mass by thickening the trabeculae, while running exercises did so by increasing the trabecular number. FEA-estimated fracture load did not differ significantly between the exercise groups. [Conclusion] This study elucidated the differential effects of jump and running exercise on trabecular bone architecture in rats. The different structural changes in the trabecular bone, however, had no significant impact on trabecular bone strength.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.1217-1220
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• 2005

In this paper, statistical simulation is applied to a superscalar digital signal processor architecture using DSP kernel and DSP application benchmarks. As a result, the performance of a digital signal processor with several microarchitecture configurations can be estimated with the relative error of 3.7 ${\backslash}%$ on the average.

• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.763-766
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• 1998

This paper describes the microarchitecture of the integer processor unit of RAPTOR which is an on-chip multiprocessor. The integer processor unit implements the 64-bit SPARC-V9 architecture and supports by hardware out-of-order instruction execution. The unit is designed to be handy so that multiple copies of the unit cn be integrated with cache memories into a single chip. The design was proceeded in a top-down manner. The hardware description and its verfication were performed using Verilog-HDL.

• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.751-754
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• 1998

This research aims at developing a single chip multiprocessor for high-performance computer system. Our design approach is to design a relatively small and simple processor unit and to integrate multiple copies of the unit in an efficient way. The proposed multiprocessor is composed of four CPUs and one graphic coprocessor. The four CPUs share the graphic coprocessor and each CPU implements the 64-bit SPARC-V9 instruction set architecture. This paper gives an overview of the proposed microarchitecture and discusses the considerations made in the course of the design.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.28B no.7
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• pp.540-547
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• 1991

This paper proposes a machine in dependent automatic microcode generation system using a microtnstruction description language, MDL. The MDL, which has similar structure to C language, is a high-level microarchitecture description language. It defines the hardwaer elements and the operand selection of microoperartions. The proposed system generates microcode automatically by describing the structure information of a target microarchitectuer and accepting thebehavioral information of microoperations which are generated ad a intermediate language from HLML-C. This proposed system is implemented with C language and YACC on a SUN workstation (4.3 BSD).

• Journal of Biomedical Engineering Research
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• v.33 no.4
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• pp.213-222
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• 2012

While much has been learned about the mechanisms of metastatic spread of cancer to bone, there has been little headway in establishing guidelines for monitoring the alteration in bone quality and estimating fracture risk. The aims of this study are, therefore, 1) to evaluate bone quality induced by metastatic bone tumor by analyzing the characteristics on bone microarchitecture and degree of bone mineralization and 2) analyze fracture risk increased secondary to the bone quality changes by metastatic bone tumor through calculating mechanical rigidities based on in-vivo micro CT images. For this study, eighteen female SD rats (12 weeks old, approximate 250 g) were randomly allocated in Sham and Tumor groups. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was inoculated in the right femur (intraosseous injection) in Tumor group, while 0.9% NaCl (saline solution) was injected in Sham group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters and degree of bone mineralization at 0 week, 4 weeks, 8 weeks, and 12 weeks after surgery. At the same time, urine was collected by metabolic cages for a biochemical marker test in order to evaluate bone resorption. Then, bone metastasis had been directly identified by positron emission tomography. Finally, axial, bending and torsional rigidities had been calculated based on in-vivo micro CT images for predict fracture risk. The results of this study showed that metastatic bone tumor might induce significant decrease in bone quality and increase of fracture risk. This study may be helpful to monitoring a degree of bone metastasis and predicting fracture risk due to metastatic bone tumor. In addition, this noninvasive diagnostic methodology may be utilized for evaluating other bone metabolic diseases such as osteoporosis.

• Imaging Science in Dentistry
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• v.37 no.1
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• pp.53-59
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• 2007

Purpose : Bone mineral density (BMD) and bone microarchitecture are important determinants for bone strength. Recently micro-CT have provided possibilities for measuring a variety of structural indices to characterize bone microarchitecture. The objective of this study was to compare the BMD and micro-CT parameters with Young's modulus calculated by finite element analysis (FEA) for the evaluation of bone strength. Materials and Methods Bone specimens were obtained from the 18 female rabbits aged 16 weeks. Of those, 36 samples (right and left femur) were selected for 3D micro-CT analysis $(ANT^{TM},\;SKYSCAN,\;Belgium)$ and BMD by PIXlmus 2 (GE Lunar Co. USA). Five microstructural parameters of micro-CT, such as trabecular thickness (Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DOA) were studied. Young's modulus was obtained by software program (ANSYS 9.0, ANSYS Inc, Canonsburg, PA) based on micro-CT three dimensional images. Results : Young's modulus assessed by FEA correlated significantly with Tb.Th, BV/TV, BS/BV and SMI respectively. Young's modulus showed higher correlation with these rnicrostructural parameters of micro-CT than BMD. Microstructural parameters except DOA showed significant correlations within the examined group. Conclusion The microarchitectural parameters o( micro-CT and BMD represented some informations in the evaluation of bone strength assessed by FEA.

• The KIPS Transactions:PartA
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• v.13A no.3 s.100
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• pp.191-198
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• 2006

Today's portable electric consumer devices, which are operated by battery, tend to integrate more multimedia processing capabilities. In the multimedia processing devices, multimedia system-on-chips can handle specific algorithms which need intensive processing capabilities and significant power consumption. As a result, the power-efficiency of multimedia processing devices becomes important increasingly. In this paper, we propose a reconfigurable data caching architecture, in which data allocation is constrained by software support, and evaluate its performance and power efficiency. Comparing with conventional cache architectures, power consumption can be reduced significantly, while miss rate of the proposed architecture is very similar to that of the conventional caches. The reduction of power consumption for the reconfigurable data cache architecture shows 33.2%, 53.3%, and 70.4%, when compared with direct-mapped, 2-way, and 4-way caches respectively.