• 소성∙가공
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• 제13권1호
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• pp.15-20
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• 2004

본 연구에서는 자동차용 판재 성형시 발생하는 스프링백을 정확히 예측하기 위하여, 수정된Chaboche형에 기초한 혼합형 등방-이동경화규칙이 개발되었다. 또한 판재의 이방성을 위하여 최근 개발된 Barlat의 YId2000-24 비이차 비이방성 항복 함수가 이용되었다. 단순인장실험과 인장/압축(압축/인장) 실험에 의하여 Bauschinger 및 transient 거동과 비이방성이 측정되었으며, 유한요소해석에 의한 구성방정식의 검증을 위해 실제 자동차 부품을 부분 변형시킨 double S-rail이 제작되었다. 수정된 Chaboche 형 조성방정식과 비등방 항복함수를 적용한 유한요소에 의한 수치해석의 결과는 굽힘에 의한 스프링백과 비틀림에 있어서 실험과 잘 일치함을 알 수 있었다.

• 폴리머
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• 제36권4호
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• pp.427-433
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• 2012

이미드/아라미드/설폰기가 교대로 도입된 poly(imide-aramid-sulfone)s을 divinyl sulfone(DVS)과 $N^1,N^4$-bis(4-(vinylsulfonyl)phenyl)terephthalamide (2)를 pyromellitic diimide와 반응하여 높은 수율로 제조하였다. 또한 고분자를 닮은 3가지 모델 화합물인 N-[2-(p-aminophnenylsulfonyl)ethyl]phthalimide (3), 2,2'-(2,2'-sulfonylbis(ethane-2,1-diyl))diisoindoline-1,3-dione (4), 및 N,N-bis(4-(2-(1,3-dioxoisoindolin-2-yl)ethylsulfonyl)phenyl)terephthalamide (5)을p-aminophenyl vinyl sulfone, DVS, 2와 phthalimide와 반응하여 얻었다. 축합 중합은 phthalimide 기와 DVS의 마이클 첨가 반응에 의하여 균일 용액으로 진행되며 tetrabutylammonium hydroxide (TBAH)가 촉매로 작용하여 poly(imide-aramid-sulfone)s 6-12의 분자량이 큰 중합체를 얻을 수 있었다. DVS/2의 구성비는 1/0, 3/1, 2/1, 1/1, 1/2, 1/3, 및 0/1이다. 얻어진 고분자들은 극성 용매인 N,N-dimethylformamide, dimethylsulfoxide, N-methylpyrrolidinone 및 tetrahydrofuran에 잘 용해하였다. 그 밖에 분자량, 점도 그리고 열적 성질을 평가하였다.

• Annals of Clinical Neurophysiology
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• 제19권2호
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• pp.101-112
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• 2017

Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

• Toxicological Research
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• 제18권2호
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• pp.129-138
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• 2002

The mouse lymphoma assay (MLA) has been recently validated as a sensitive and specific test system to determine the genotoxic potential for a chemical. The objective of this study is to evaluate the utility of MLA for detecting mutagens. Especially, to compare MLA with the in vitro chromosomal aberration test (CA), we performed MLA using the microwell method with three chemicals (hydroxyurea, theophylline and amino acid copper complex), which were reportedly positive in the CA. In cell treated with hydroxyurea, anti-neoplastic agent that blocks DNA replication, evidence of a positive response was obtained without S9 mix for 4 h and 24 h. In addition, analysis of colony size distribution at concentration that gave an elevated mutant fraction showed that hydroxyurea induced a high proportion of small type colonies, indicating that hydroxyurea-induced mutation is associated with large chromosomal deletion. Conversely, negative MLA result was obtained for theophylline, which was wed as central nervous system stimulator. Although theophylline increased the mutant frequency at concentration of 1250 $\mu\textrm{g}$/$\textrm{m}{\ell}$ with S9 mix for 4 h, a concentration-related increase in mutant frequency was not observed. The MLA result of amino acid copper complex was considered equivocal because the positive result was obtained at concentration showing 10% or less RS or RTG. Thus, among 3 CA-positive chemicals, positive MLA result was obtained for one. The other two chemicals were negative and equivocal. However MLA, which evaluates mutagenic potential of chemicals through colony formation by cell grouth, may provide a higher predictivity of carcinogenesis than CA.

• Asian-Australasian Journal of Animal Sciences
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• 제30권10호
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• pp.1372-1381
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• 2017

Objective: Our study provides information on phenotypes of local chickens and guinea fowl and their body measures as well as on major genes in local chickens in northern Ghana. Methods: Qualitative and morphometric traits were recorded on 788 local chickens and 394 guinea fowl in urban households in Tamale, Ghana. Results: The results showed considerable variation of color traits and numerous major genes in local chickens, while color variations and related genotypes in guinea fowl were limited. In local chickens, white was preferred for plumage, whereas dark colors were preferred for beak and shanks. More than half of the chickens carried at least one major gene, but the contributions of single gene carriers were low. All calculated allele frequencies were significantly lower than their expected Mendelian allele frequencies. We observed higher mean body weight and larger linear body measures in male as compared to female chickens. In female chickens, we detected a small effect of major genes on body weight and chest circumference. In addition, we found some association between feather type and plumage color. In guinea fowl, seven distinct plumage colors were observed, of which pearl grey pied and pearl grey were the most prevalent. Male pearl grey pied guinea fowl were inferior to pearl grey and white guinea fowl in terms of body weight, body length and chest circumference; their shank length was lower than that of pearl grey fowl. Conclusion: Considerable variation in qualitative traits of local chickens may be indicative of genetic diversity within local chicken populations, but major genes were rare. In contrast, phenotypic and genetic diversity in local guinea fowl is limited. Broader genetic diversity studies and evaluation of trait preferences of local poultry producers are required for the design of appropriate breeding programs.

• 한국건축시공학회지
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• 제15권2호
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• pp.249-255
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• 2015

성과향상을 위해서는 현장 조직과 구성원에 대해서도 혁신을 도입해야 한다. 하지만, 일반적으로 건설업은 보수적이며, 현장관리자도 보수적인 특성이 있기 때문에 혁신에 대해 저항이 있다. 따라서 본 연구는 건축공사 현장관리자의 혁신행동에 영향을 미치는 요인을 파악하는 것이 목적이다. 셀프리더십, 피드백추구행동, 직무몰입 중에서 셀프리더십의 행동지향 전략, 직무몰입이 혁신행동과 상관관계가 있는 것으로 파악되었다. 또한 결혼여부, 경력, 직급, 고용형태에 따라서 혁신행동이 차이가 있는 것으로 파악되었다. 본 연구결과는 현장조직의 직무수행관리 체제를 개선시키는데 도움을 줄 수 있을 것으로 기대된다.

• Biomolecules & Therapeutics
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• 제23권4호
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• pp.320-326
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• 2015

The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK pathway, Spry2, in acquired resistance using BRAF inhibitor-resistant derivatives of the BRAF-V600E melanoma (A375P/Mdr). Real-time RT-PCR analysis indicated that the expression of Spry2 was higher in A375P cells harboring the BRAF V600E mutation compared with wild-type BRAF-bearing cells (SK-MEL-2) that are resistant to BRAF inhibitors. This result suggests the ability of BRAF V600E to evade feedback suppression in cell lines with BRAF V600E mutations despite high Spry2 expression. Most interestingly, Spry2 exhibited strongly reduced expression in A375P/Mdr cells with acquired resistance to BRAF inhibitors. Furthermore, the overexpression of Spry2 partially restored sensitivity to the BRAF inhibitor PLX4720 in two BRAF inhibitor-resistant cells, indicating a positive role for Spry2 in the growth inhibition induced by BRAF inhibitors. On the other hand, long-term treatment with PLX4720 induced pERK reactivation following BRAF inhibition in A375P cells, indicating that negative feedback including Spry2 may be bypassed in BRAF mutant melanoma cells. In addition, the siRNA-mediated knockdown of Raf-1 attenuated the rebound activation of ERK stimulated by PLX4720 in A375P cells, strongly suggesting the positive role of Raf-1 kinase in ERK activation in response to BRAF inhibition. Taken together, these data suggest that RAF signaling may be released from negative feedback inhibition through interacting with Spry2, leading to ERK rebound and, consequently, the induction of acquired resistance to BRAF inhibitors.

• Nuclear Engineering and Technology
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• 제56권3호
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• pp.803-811
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• 2024

Nuclear accidents such as Fukushima Daiichi have highlighted the potential of passive safety systems to replace or complement active safety systems as part of the overall prevention and/or mitigation strategies. In addition, passive systems are key features of Small Modular Reactors (SMRs), for which they are becoming almost unavoidable and are part of the basic design of many reactors available in today's nuclear market. Nevertheless, their potential to significantly increase the safety of nuclear power plants still needs to be strengthened, in particular the ability of computer codes to determine their performance and reliability in industrial applications and support the safety demonstration. The PASTELS project (September 2020-February 2024), funded by the European Commission "Euratom H2020" programme, is devoted to the study of passive systems relying on natural circulation. The project focuses on two types, namely the SAfety COndenser (SACO) for the evacuation of the core residual power and the Containment Wall Condenser (CWC) for the reduction of heat and pressure in the containment vessel in case of accident. A specific design for each of these systems is being investigated in the project. Firstly, a straight vertical pool type of SACO has been implemented on the Framatome's PKL loop at Erlangen. It represents a tube bundle type heat exchanger that transfers heat from the secondary circuit to the water pool in which it is immersed by condensing the vapour generated in the steam generator. Secondly, the project relies on the CWC installed on the PASI test loop at LUT University in Finland. This facility reproduces the thermal-hydraulic behaviour of a Passive Containment Cooling System (PCCS) mainly composed of a CWC, a heat exchanger in the containment vessel connected to a water tank at atmospheric pressure outside the vessel which represents the ultimate heat sink. Several activities are carried out within the framework of the project. Different tests are conducted on these integral test facilities to produce new and relevant experimental data allowing to better characterize the physical behaviours and the performances of these systems for various thermo-hydraulic conditions. These test programmes are simulated by different codes acting at different scales, mainly system and CFD codes. New "system/CFD" coupling approaches are also considered to evaluate their potential to benefit both from the accuracy of CFD in regions where local 3D effects are dominant and system codes whose computational speed, robustness and general level of physical validation are particularly appreciated in industrial studies. In parallel, the project includes the study of single and two-phase natural circulation loops through a bibliographical study and the simulations of the PERSEO and HERO-2 experimental facilities. After a synthetic presentation of the project and its objectives, this article provides the reader with findings related to the physical analysis of the test results obtained on the PKL and PASI installations as well an overall evaluation of the capability of the different numerical tools to simulate passive systems.

• 농업과학연구
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• 제10권2호
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• pp.354-364
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• 1983

pH 7.0~14.0의 중성에서 강염기성 용액에 이르는 넓은 pH 범위에서 Cinnamonitrile의 알카리 가수분해 반응속도 상수를 $25^{\circ}C$의 50% methanol 물 혼합용매로 부터 측정하여 실험사실을 잘 설명할 수 있는 반응 속도식을 유도하여 가수분해 반응 메카니즘을 제안하고, 반응 속도론적으로 고찰 검토하였으며 (Z)형의 형태에 관하여 분자의 안정성과 반응성을 알아보기 위하여 cinnamonitrile의 분자궤도 함수를 EHT와 CNDO/2방법으로 계산하였다. (1) Cinnamonitrile의 전체 에너지 계산 결과로부터 ${\theta}_1$ 회전에 따르는 형태의 안정도는 (E)형을 포함하여 (E)-planar > (E)-gauche > (Z)-gauche > (Z)-planar이였고 (E)-gauche와 (Z)-gauche의 에너지 차는 1.94Kcal/mole이였다. 따라서 반응은 가장 안정한 (E)-planar의 $C_7({\alpha})$ 원자에 chydroxide 이온이나 물분자의 첨가로 ${\alpha}C-{\beta}C$ 결합이 분열하게 된다. (2) pH7.0~14.0 범위에서 측정한 반응속도상수로 부터 유도된 전체 반응속도식은 다음과 같다. $$k_t=k_o+k^{\prime}[OH^-]=({\frac{1.41{\times}10^{-14}+1.21{\times}10^{-7}/[H_3O^+]}{2.65{\times}10^{-7}+1.64/[H_3O^+]})+9.14{\times}10^9/[H_3O^+]$$ (3) 분자 궤도함수의 계산 결과와 반응 속도식을 토대로 하여 pH10.0~14.0에서는 hydroxide 이온의 첨가로 가수분해가 진행되는 Scheme(I)과 같은 Michael형의 친핵성 첨가반응 메카니즘을 그리고 pH7.0~10.0사이의 중성 용액중에서는 물분자의 첨가로 반응이 진행되는 Scheme(II)와 같은 가수분해 반응메카니즘을 제안하였다. (4) pH10.0~12.0사이의 약 알칼리성 용액중에서는 Scheme(I)과 Scheme(II)의 두 반응이 서로 경쟁적으로 일어나는 대단히 복잡한 일련의 가수분해 반응이 진행됨을 알았으며 분해 생성물은 공히 benzaldehyde와 methylnitrile 그리고 acetic acid 이였다. 앞으로의 과제는 cinnamonitrile 의 ${\alpha}{\cdot}{\beta}$ 탄소불포화 이중결합에 미치는 치환기에 의한 자유에너지 직선성의 상관관계와 물 L-cysteine 및 hydrogene cyanide 등의 서로 다른 친핵체들과의 반응으로 부터 이들의 친핵 첨가반응성을 검토하고자 한다.

• 벤처혁신연구
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• 제1권1호
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• pp.1-14
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• 2018

4차 산업혁명이 쓰나미와 같이 우리 기업에 큰 변화를 주고 있다. 디지털시대로 대변되는 CPS시스템은 물리적인 영역에서 축적된 데이터를 기반으로 디지털 기술을 통해 과거에 상상하지 못했던 비즈니스를 현실로 만들어 내고 있다. 이로 인해 4차 산업혁명시대의 비즈니스 모델은 이전과는 다른 양상을 보이고 있다. 이에 본 연구에서는 비즈니스혁신 이론 연구의 흐름을 시대별 흐름과 쟁점을 분석하였다. 이후 디지털시대의 비즈니스 혁신 모델을 이전 시대와 비교 분석하였다. 이를 기반으로 4차 산업혁명 시대에 적합한 비즈니스 모델을 탐색하였으며, 기존 비즈니스 모델들로는 디지털 시대의 모형을 설명하기에는 많은 어려움이 있었고, 보다 많은 실증적인 연구가 뒷받침 되어야하겠지만 마이클 포터의 다이아몬드 모델이 가장적합함을 확인하였고, 이를 응용하여 4가지 유형의 비즈니스 모델을 도출하여 해당 사례를 살펴보았다. Type A : sharing outcome with customer로 고객 성과 창출 기반에 따라 차등적으로 비용을 지불하는 모델이며, Type B : Value Chain Digitalization로 제품, 서비스 및 SCM 디지털화로 보다 빠르고 저렴한 비용으로 제품, 서비스를 고객에 제공함으로 경쟁우위를 가지는 모델이며, Type C : Digital Platform는 가장 큰 파급효과를 가져다 주는 모델로 디지털 플랫폼 기반의 공유 경제 창출로 새로운 시장을 창출하여 더 확실한 수익성 확보가 가능한 모델이다. 마지막으로 Type D : Sharing Resources는 관련 산업 내 파트너와 협업으로 경쟁 우위 모델 구축하는 모델로 다른 파트너의 핵심 역량과 자신의 핵심 역량을 서로 보완하는 가장 효과적인 성공 방법이라 할 수 있겠다. 4차 산업혁명시대에 다수의 요소 기술과 수많은 유니콘, 데카콘 기업들이 자신들이 속해 있는 산업별 차별적 디지털 경쟁우위를 가지고 있음에도 불구하고 특정 대표기업의 디지털 비즈니스 모델을 상세 분석하여 학문적이고 실무적인 시사점을 도출하는 것 보다는 단편적으로 나열함에 한계가 있었다. 향후 연구에서는 더욱더 구체적인 실증적인 분석을 통해 디지털시대의 비즈니스모델을 더욱더 상세하게 규명할 필요가 있다. 아울러 산업별로 디지털 비즈니스 모델이 상이할 수 있으므로 산업간 비교분석을 해볼 필요 역시 있다.