• Title/Summary/Keyword: Methylcellulose

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The Effect of HPMC Concentration on the Morphology and Post Drawing of Wet Spun Regenerated SF/HPMC Blend Filaments

  • Ko, Jae-Sang;Um, In-Chul
    • International Journal of Industrial Entomology and Biomaterials
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    • v.19 no.1
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    • pp.181-185
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    • 2009
  • In this paper, the regenerated silk fibroin (SF)/hydroxypropyl methylcellulose (HPMC) blend filaments were prepared by wet spinning and the effect of HPMC concentration on the post drawing and morphology of blend filaments was elucidated. The result of maximum draw ratio indicated that the wet spinnability of wet spun SF / HPMC was improved with increasing HPMC concentration until 8% and remained constant after that concentration. The SEM observation revealed that the enhanced wet spinnability of blend filaments was strongly related to the morphological change by increasing HPMC concentration. Regardless of HPMC concentration, as SF content was reduced, the wet spinnability of blend film decreased resulting in reduced maximum draw ratio. It was also found by SEM observation that the cross section of blend filament deviated from circularity with an increase of HPMC content.

Preparation and Properties of Hydroxyapatite/Methylcellulose for Bone Graft

  • Tak, Woo-Seong;Kim, Dong-Jun;Ryu, Su-Chak
    • Journal of the Korean Ceramic Society
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    • v.55 no.2
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    • pp.145-152
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    • 2018
  • Although many bone graft materials have been developed, powder graft materials are somewhat difficult to use in surgery. To solve this problem, a bone graft material in the form of a viscous paste was prepared. Hydroxyapatite was used as a bone graft material, and methyl cellulose was used to impart viscosity. Three cases of samples were prepared, and freeze-dried block type and sintered specimens were made from the paste. The recrystallization of the graft material in a simulated body fluid and the degree of graft adhesion with a tooth were observed by scanning electron microscopy (SEM). The test for cytotoxicity was carried out and the sample was grafted into the back of a mouse to confirm the presence or absence of side effects in the animal's body. Based on these investigations, composites of this type are expected to be applicable for bone grafts.

Synthesis and Characterization of HPMC Derivatives as Novel Duodenum-Specific Coating Agents

  • Huang Yuan;Zheng ling Ii;Liu Jun;Zhang Zhi rong
    • Archives of Pharmacal Research
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    • v.28 no.3
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    • pp.364-369
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    • 2005
  • HPMC (Hydroxypropyl methylcellulose) was chemically modified, using maleic anhydrides, to obtain pH-sensitive HPMCAM (Hydroxypropyl methylcellulose acetate maleate) polymers for use as novel duodenum-specific coating agents. The pharmaceutical properties of HPMCAM, such as film forming, acid values, pH-sensitive values, water vapor permeability, tensile strength and Tg, were investigated, and found to show good film forming properties. The pH­sensitive values were 3.0 to 3.7. In vitro results demonstrate that HPMCAM could completely suppress drug release within 2h in a simulated gastric fluid (pH 1.2) and rapidly release the drug in a simulated pathological duodenal fluid (pH 3.4). These results indicate that HPMCAM might be a useful material for a duodenum-specific drug delivery system.

Application of Carrageenan for Sustained Drug Release (약물의 서방출을 위한 ${\kappa}-Carrageenan$의 응용)

  • Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.23 no.4
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    • pp.213-216
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    • 1993
  • ${\kappa}-Carrageenan$, an anionic polysaccharide, was employed in tablet formulations and its function as a drug release sustaining agent was investigated. Tablets composed of ${\kappa}-carrageenan$ and hydroxypropyl methylcellulose were fabricated by using direct compression method. Lactose and sodium alginate were utilized as controls for ${\kappa}-carrageenan$. Drug release experiments performed at pHs 1.2 and 7.4 revealed that ${\kappa}-carrageenan$ retains pH-dependent sustained release effects due to its anionic characteristics. Also, the ionic interaction between ${\kappa}-carrageenan$ and drugs exerted significant affects on drug release kinetics. ${\kappa}-Carrageenan$ was found out to be a useful additive for sustained release tablet formulations.

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Preparation and characterization of silanized-hydroxypropyl methylcellulose/phase transformed calcium phosphate composite bone cements (실란처리된 하이드록시프로필 메틸셀룰로오스/상전이된 칼슘포스페이트 복합체 골시멘트의 제조 및 특성평가)

  • Jeong, Nahyun;Kim, Dong-Hyun;Cho, Hoon-Sang;Yoon, Seog-Young
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.26 no.6
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    • pp.243-251
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    • 2016
  • Silanized-hydroxypropyl methylcellulose (Si-HPMC)/phase transformed calcium phosphate (PTCP) composites are prepared to purpose application of injectable bone cements with enhanced biocompatibility. The crystal structure and chemical state of the synthesized PTCP and Si-HPMC as solid and liquid phase of the composite cements were measured by XRD and FT-IR. The handling and mechanical properties of cements were measured by injectability tests and three-point bending tests. The in-vitro mechanical properties, XRD, and SEM results of bone cements were showed that enhanced hardening behavior was an inherent function of bone cements after in-vitro test. The cytotoxicity result of bone cements also was showed enhanced biocompatibility. Therefore, these injectable cements had potential be used as calcium phosphate cements for biomedical applications.