• 대한한방내과학회지
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• 제28권2호
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• pp.363-376
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• 2007

Objectives : This study was undertaken to learn what should be considered in a good clinical trial investigating a herbal medicine as an antidepressant. Methods : Five well-designed clinical trials published from 2000 to 2006 investigating SJWE in depressive disorder were selected. The trials were reviewed and compared in terms of methodology such as trial design, patient selection, efficacy & safety evaluation, and so on. On the basis of this review of the trials and the regulations and guidelines of KFDA, we suggest some points to be considered for a good clinical trial of a herb for depression. Results : Although every trial had its own unique design, procedure, objectives and so on, all trials used randomizing and double blinding methods. If there is no ethical problem, a placebo-controlled design should be considered in a herbal antidepressant clinical trial for depression. Conclusions : Some points to be considered in an optimal & good clinical trial for an antidepressive herbal medicine were suggested as follows: 1) randomizing and double blinding manner is essential, 2) if there is no ethical problem, placebo control design should be considered, 3) the trial period should be 6 weeks, 4) out-patients will be recruited as subjects, 5) investigators will be well-trained psychiatrists or medical doctors, 6) the number of subjects should be calculated by statistical methods, 7) subjects should be diagnosed by DSM-IV criteria, 8) subjects who have current risk of committing suicide should be excluded, etc.

• 한국기계가공학회지
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• 제12권4호
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• pp.114-122
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• 2013

This study introduces an optimization methodology for the determination of gate location that ensures the melt flow balance within a part cavity of injection mold. A new sequential direct-search scheme based on the recursive reduction of the designer-specified gate design area is developed, and it is integrated with a commercial flow simulation tool for optimization. To quantify the level of melt flow balance, we employ the maximum difference among the fill times for the melt fronts to reach the boundary elements of part cavity as objective function. The proposed methodology is successfully applied in the case study of melt flow balancing in molding of a bar code scanner model. The result shows that the melt flow balance at the optimized gate positions is significantly improved from that for the initial gate position.

• 한국농촌건축학회논문집
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• 제22권3호
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• pp.49-60
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• 2020

The purpose of this study utilizes the service design methodology centered on the lives and experiences of rural residents, who are the main beneficiaries of the service, to derive specific problems and needs, and to propose a service improvement plan suitable for the rural residential environment. The study selected Dosan 2-ri Village, Hongseong-gun, Chungcheongnam-do as the target of the survey, used personas and Customer Journey map of service design method to derive specific core issues and insights from the village residents. By developing this, the final five service directions for 'Air care service', 'Self-driving garbage collection and treatment service', 'Emergency/disaster networking service', 'Contaminant removal service' and 'Mobility share service' were derived and presented according to each key keyword. This study is not just a study to grasp the actual conditions of the rural residential environment, but it focuses on the lives and experiences of rural residents and extracts elements that can respond to changes in the lifestyles and patterns of the residents. It can be used as a basic material for more realistic improvement of rural residential environment and service development research. Most of the existing studies on residential environments and spaces is focused on urban areas, and there is a limit to the use of rural areas in residential areas. Therefore, by making recommendations for improvement of residential environment services suitable for rural areas and by creating residential spaces and environments in rural areas in a comfortable and safe manner, it is thought that it is possible to contribute to improvement of satisfaction in rural areas and improvement of healthy housing welfare as well as to improvement of the quality of life of residents of rural areas.

• 한국자동차공학회논문집
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• 제17권5호
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• pp.16-25
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• 2009

Testing engine performance using an engine dynamometer requires high technical researchers and many facilities. Nowadays, different variables of CAE program are used for identifying the engine performance instead of engine dynamometer test. This is more convenience, as it does not necessitate an abundance of engine dynamometer experiments and, in addition, produces better results. However, CAE programs also contain various variables which can affect engine performance. Those are coupled with each other, thus making it difficult to determine the effectiveness of different variables on engines. DoE (Design of Experiments) methodology is an efficient way to verify the magnitude of effectiveness on engine performance as well as making responses to be optimized at once without trial & error. This study used data from WAVE simulations, which modeled the DOHC SI engine with in-line 4 cylinders at 1500, 3000 and 4500rpm. DoE methodology is designed properly to determine the effectiveness of five variables on power, BSFC, and volumetric efficiency, as well as to find the optimal response conditions at each rpm through a minimized number of experiments. After finishing DoE process, all the results are examined concerning the reliability of test through a verification experiment.

• 한국축산식품학회지
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• 제38권2호
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• pp.240-250
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• 2018

This study was undertaken to find the optimum soy-peptone, glucose, yeast extract, and magnesium sulfate amounts for the maximum growth of Lactobacillus plantarum JNU 2116 and to assess the effects of these medium factors through the use of response surface methodology. A central composite design was used as the experimental design for the allocation of treatment combinations. In the analysis of the experiment, due to a significant lack of fit of the second-order polynomial regression model that was used at first, cubic terms were added to the model, and then two-way interaction terms were deleted from the model since they were found to be all statistically insignificant. A relative comparison among the four factors showed that the growth of L. plantarum JNU 2116 was affected strongly by yeast extract, moderately by glucose and peptone, and slightly by magnesium sulfate. The estimated optimum amounts of the medium factors for the growth of L. plantarum JNU 2116 are as follows: soy-peptone 0.213%, glucose 1.232%, yeast extract 1.97%, and magnesium sulfate 0.08%. These results may contribute to the production of L. plantarum L67 as a starter culture that may have potential application in yogurt and fermented meat products.

• 한국식품조리과학회지
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• 제25권3호
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• pp.337-344
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• 2009

The principal objective of this study was to determine the optimal mixing conditions of three different amounts of small black soybeans, sugar, and plain yogurt, for the preparation of a small black soybean smoothie. The experimental design utilized herein was based on the Central composite design methodology of response surface, which included 16 experimental points, including 2 replicates for the small black soybeans, sugar, and plain yogurt. The physiochemical and sensory properties of the test were measured, and these values were applied to the mathematical models. A canonical form and perturbation plot showed the influence of each ingredient on the mixed final product. The L value and a value decreased with increasing quantities of small black soybeans, but the b values increased with greater additions of small black soybeans. Sweetness increased with increasing amount of added sugar. The results of sensory evaluation showed very significant values for color (p<0.01), taste (p<0.05) and overall quality (p<0.05) in the predicted model. As a result, the optimum formulations by numerical and graphical methods were calculated as follows: small black soybean 79.46 g, plain yogurt 275.07 g, sugar 21.20 g.

• Journal of Microbiology and Biotechnology
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• 제20권4호
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• pp.835-843
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• 2010

The objectives of this study were to investigate the effect of fermentation medium on the hydroxyl radical scavenging activity of exopolysaccharides from Inonotus obliquus by response surface methodology (RSM). A two-level fractional factorial design was used to evaluate the effect of different components of the medium. Corn flour, peptone, and $KH_2PO_4$ were important factors significantly affecting hydroxyl radical scavenging activity. These selected variables were subsequently optimized using path of steepest ascent (descent), a central composite design, and response surface analysis. The optimal medium composition was (% w/v): corn flour 5.30, peptone 0.32, $KH_2PO_4$ 0.26, $MgSO_4$ 0.02, and $CaCl_2$ 0.01. Under the optimal condition, the hydroxyl radical scavenging rate (49.4%) was much higher than that using either basal fermentation medium (10.2%) and single variable optimization of fermentation medium (35.5%). The main monosaccharides components of the RSM optimized polysaccharides are rhamnose, arabinose, xylose, mannose, glucose, and galactose with molar proportion at 1.45%, 3.63%, 2.17%, 15.94%, 50.00%, and 26.81%.

• Earthquakes and Structures
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• 제14권5호
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• pp.389-398
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• 2018

The seismic isolation system makes a structure isolated from ground motions to protect the structure from seismic events. Seismic isolation techniques have been implemented in full-scale buildings and bridges because of their simplicity, economic effectiveness, inherent stability and reliability. As for the responses of an isolated structure due to seismic events, it is well known that the most uncertain aspects are the seismic loading itself and structural properties. Due to the randomness of earthquakes and uncertainty of structures, seismic response distributions of an isolated structure are needed when evaluating the seismic fragility assessment (or probabilistic seismic safety assessment) of an isolated structure. Seismic response time histories are useful and often essential elements in its design or evaluation stage. Thus, a large number of non-linear dynamic analyses should be performed to evaluate the seismic performance of an isolated structure. However, it is a monumental task to gather the design or evaluation information of the isolated structure from too many seismic analyses, which is impractical. In this paper, a new methodology that can evaluate the seismic fragility assessment of an isolated structure is proposed by using stochastic response database, which is a device that can estimate the seismic response distributions of an isolated structure without any seismic response analyses. The seismic fragility assessment of the isolated nuclear power plant is performed using the proposed methodology. The proposed methodology is able to evaluate the seismic performance of isolated structures effectively and reduce the computational efforts tremendously.

• 한국CDE학회논문집
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• 제15권1호
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• pp.51-59
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• 2010

People evaluate urban residential regions quite frequently and sensitively, considering issues such as locations or ease of use of in-site facilities or nearby urban facilities, and those results are bound to be reflected to real estate costs quite immediately. However, there have been frequently recurring questions regarding objectivity of evaluations in terms of results and methods reflected on indexes such as land costs for various reasons. RPMS -Residence Performance Management System- which targets currently in most cases on urban residential areas, suggests instrumental methodology of objective approach toward sensitive urban residence performance evaluation. This paper explains and suggests instrumental utilization of RPMS and its implementations, evaluation methodology and quantitative way of evaluation. In terms of implementation we explain issues such as adding target locations into new residence planning sites, quantification of properties on evaluation indexes of residential performance and/or habitability in terms of checklists, formulas for evaluation, delicate adjustment of evaluation results by setting weights on evaluation indexes, as well as reports on results. Research on appropriate weights and weight settings regarding evaluation indexes, however, exceeds the range of this paper so that this paper focuses on explaining residence performance evaluation and management methodology.

• Integrative Medicine Research
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• 제6권4호
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• pp.388-394
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• 2017

Background: The present study optimized ultrasound-assisted extraction conditions to maximize extraction yields of glycyrrhizic acid from licorice. Methods: The optimal extraction temperature ($X_1$), extraction time ($X_2$), and methanol concentration ($X_3$) were identified using response surface methodology (RSM). A central composite design (CCD) was used for experimental design and analysis of the results to obtain the optimal processing parameters. Results: Statistical analyses revealed that three variables and the quadratic of $X_1$, $X_2$, and $X_3$ had significant effects on the yields and were followed by significant interaction effects between the variables of $X_2$ and $X_3$ (p<0.01). A 3D response surface plot and contour plots derived from the mathematical models were applied to determine the optimal conditions. The optimum ultrasound-assisted extraction conditions were as follows: extraction temperature, $69^{\circ}C$; extraction time, 34?min; and methanol concentration, 57%. Under these conditions, the experimental yield of glycyrrhizic acid was 3.414%, which agreed closely with the predicted value (3.406%). Conclusion: The experimental values agreed with those predicted by RSM models, thus indicating the suitability of the model employed and the success of RSM in optimizing the extraction conditions.