• 한국생물공학회:학술대회논문집
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• 2001.11a
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• pp.61-62
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• 2001

• Journal of the Korea Convergence Society
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• v.11 no.9
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• pp.267-276
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• 2020

The purpose of this study was to investigate the relationship between VAI, insulin resistance, and pancreatic beta cell function according to the prevalence of metabolic syndrome in obese adults. From 2017 to 2019, 1,797 obese adults who received medical checkups at a general hospital in Bundang. Diagnosis of metabolic syndrome is NCEP-ATP III. HOMA index was used for insulin resistance and pancreatic beta cell function. VAI was higher in the metabolic syndrome than in the control(p<.001). As the number of risk factors for metabolic syndrome increased, the VAI value was higher(p<.001). The prevalence of metabolic syndrome increased as the VAI quartile increased(p<.001). VAI was also shown to be related to HOMA-IR and HOMA-β in the control, but not in the metabolic syndrome.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.24 no.4
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• pp.566-577
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• 2014

Objectives: The purpose of this study was to evaluate the predictors of metabolic syndrome among police officers and determine its prevalence. Methods: Data were collected through a questionnaire survey and medical examination among 1,089 male police officers from 2010 to 2013. Information about age, marital status, smoking, drinking and exercise were based on data from the self-administered questionnaire. We collected job type, working position, and work duration from company personnel data and the indices of metabolic syndrome through the medical examination. Metabolic syndrome was assessed according to the NCEP-ATP III definition and the Asia-Pacific obesity guidelines. Results: The prevalence of metabolic syndrome among the 1,089 police officers was 33.4%. The prevalence of metabolic influencing factors were 47.5% for abdominal obesity, 30.1% for hypertension, 37.1% for hypertriglyceridemia, 22.0% for low HDL-cholesteralemia and 13.2% for hyperglycemia. Factors such as age, drinking, and family history were significantly associated with metabolic syndrome. Conclusions: Weight control and a moderate drinking program may decrease the prevalence of metabolic syndrome among male police officers.

• Journal of Korean society of Dental Hygiene
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• v.13 no.4
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• pp.581-588
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• 2013

Objectives : The aim of the study si to investigate correlation between metabolic syndrome risk factors and oral health status in workers and to propose the integrated and effective management measures. Methods : Subjects were 4,600 workers in industrial company. Data by medical checkup and oral examination were collected from July 13, 2010 to September 12, 2010. Self-reported questionnaire included general characteristics, job description, smoking, drinking, and metabolic syndrome risk factor indicators. Gingivitis, dental calculus and missing tooth tended to have more metabolic syndrome risk factors. Data were analyzed by descriptive statistics, chi-square test, correlation analysis, logistic regression using SPSS version 18.0. Results : Dental caries revealed 1.146 times higher than the control group. Risk group showed the following results; gingivitis was 1.317 times higher in risk group and 1.612 times in metabolic syndrome. Dental calculus was 1.532 times higher in risk group and 1.557 times in metabolic syndrome. Mssing teeth were 1.976 higher in metabolic syndrome. Conclusions : Metabolic syndrome risk factors had close correlation to poor raol health status. It is necessary to establish the effective plan for the oral health in workers.

• Molecules and Cells
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• v.28 no.2
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• pp.75-80
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• 2009

The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.

• BMB Reports
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• v.50 no.11
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• pp.537-538
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• 2017

Hypoxia affects various physiological and pathophyological processes. Hypoxia changes the expression of hypoxia-responsive genes through two main pathways. First, hypoxia activates transcription factors (TF) such as Hypoxia-inducible Factor (HIF). Second, hypoxia decreases the activity of Jumonji C domain-containing histone demethylases (JMJDs) that require $O_2$ and ${\alpha}$-Ketoglutarate (${\alpha}$-KG) as substrates. The JMJDs affect gene expression through their regulation of active or repressive histone methylations. Profiling of H3K4me3, H3K9me3, and H3K27me3 under both normoxia and hypoxia identified 75 TFs whose binding motifs were significantly enriched in the methylated regions of the genes. TFs showing similar binding strengths to their target genes might be under the 'metabolic control' which changes histone methylation and gene expression by instant changing catalytic activities of resident histone demethylases.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.15 no.2
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• pp.106-114
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• 2008

Purpose: We analyzed the self-care behavior and metabolic control rates in diabetic patients based on the National Health and Nutrition Examination Survey in Korea (2005). Methods: The study group included 311 patients who were over 126 mg/dL on the FBS test. Data were analyzed using SPSS PC WIN 12.0. Results: The average score of self-care behavior was $12.08{\pm}1.05$ points, and significantly different according to DM treatment status, disease duration (years), admission experiences (within 1 year) and education about DM. Glucose, total cholesterol, triglycerides were decreased in self care subjects, but not significantly. Conclusion: An educational program for diabetic patients would help maintain metabolic control rates to improve self-care behavior.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.5
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• pp.385-399
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• 2005

The phenotypic response of a cell results from a well orchestrated web of complex interactions which propagate from the genetic architecture through the metabolic flux network. To rationally design cell factories which carry out specific functional objectives by controlling this hierarchical system is a challenge. Transcriptome analysis, the most mature high-throughput measurement technology, has been readily applied In strain improvement programs in an attempt to Identify genes involved in expressing a given phenotype. Unfortunately, while differentially expressed genes may provide targets for metabolic engineering, phenotypic responses are often not directly linked to transcriptional patterns, This limits the application of genome-wide transcriptional analysis for the design of cell factories. However, improved tools for integrating transcriptional data with other high-throughput measurements and known biological interactions are emerging. These tools hold significant promise for providing the framework to comprehensively dissect the regulatory mechanisms that identify the cellular control mechanisms and lead to more effective strategies to rewire the cellular control elements for metabolic engineering.

• Journal of Korean Public Health Nursing
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• v.27 no.2
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• pp.313-326
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• 2013

Purpose: The aim of this study was to evaluate the effects of lifestyle modification program on body composition and metabolic syndrome makers, depression in obese postmenopausal women. Method: The research design of this study included a non-equivalent control group pretest-posttest design. The lifestyle modification program was administered twice a week for 12 weeks the experimental group, whereas the control group had no program. The experimental group consisted of 22 obese postmenopausal women while the control group contained 19 subjects. The study also attempted to measure the effects of the program on body composition, metabolic syndrome markers, and depression in obese postmenopausal women. The data were analyzed by descriptive statistics and a t-test using the SPSS/WIN 17.0 program. Results: After participating in the lifestyle modification program, the experimental group showed statistically significant decreases in systolic pressure, diastolic pressure and depression, but no change in body composition. Conclusions: The result of this study show that the lifestyle modification program had a significant impact on obese postmenopausal women. In the future, it is necessary to offer more tailed program for a longer period.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3873-3877
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• 2012

Objective: Colorectal cancer (CRC) and the metabolic syndrome (MetS) are both on the rise in Malaysia. A multi-centric case-control study was conducted from December 2009 to January 2011 to determine any relationship between the two. Methods: Patients with confirmed CRC based on colonoscopy findings and cancer free controls from five local hospitals were assessed for MetS according to the International Diabetes Federation (IDF) definition. Each index case was matched for age, gender and ethnicity with two controls (140: 280). Results: MetS among cases was highly prevalent (70.7%), especially among women (68.7%). MetS as an entity increased CRC risk by almost three fold independently (OR=2.61, 95%CI=1.53-4.47). In men MetS increased the risk of CRC by two fold (OR=2.01, 95%CI, 1.43-4.56), demonstrating an increasing trend in risk with the number of Mets components observed. Conclusion: This study provides evidence fora positive association between the metabolic syndrome and colorectal cancer. A prospective study on the Malaysian population is a high priority to confirm these findings.