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http://dx.doi.org/10.15207/JKCS.2020.11.9.267

Relationship between Visceral Adiposity Index, Insulin Resistance and Pancreatic Beta Cell Function According to the Prevalence of Metabolic Syndrome in Korean Obese Adults  

Shin, Kyung-A (Dept. of Clinical Laboratory Science, Shinsung University)
Publication Information
Journal of the Korea Convergence Society / v.11, no.9, 2020 , pp. 267-276 More about this Journal
Abstract
The purpose of this study was to investigate the relationship between VAI, insulin resistance, and pancreatic beta cell function according to the prevalence of metabolic syndrome in obese adults. From 2017 to 2019, 1,797 obese adults who received medical checkups at a general hospital in Bundang. Diagnosis of metabolic syndrome is NCEP-ATP III. HOMA index was used for insulin resistance and pancreatic beta cell function. VAI was higher in the metabolic syndrome than in the control(p<.001). As the number of risk factors for metabolic syndrome increased, the VAI value was higher(p<.001). The prevalence of metabolic syndrome increased as the VAI quartile increased(p<.001). VAI was also shown to be related to HOMA-IR and HOMA-β in the control, but not in the metabolic syndrome.
Keywords
Visceral adiposity index; Insulin resistance; Beta cell function; Metabolic syndrome; Obesity;
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1 M. K. Garg, M. K. Dutta & N. Mahalle. (2011). Study of beta-cell function (by HOMA model) in metabolic syndrome. Indian Journal of Endocrinology and Metabolism, 15(1), 44-49. DOI : 10.4103/2230-8210.83059   DOI
2 J. B. Dixon, A. F. Dixon & P. E. O'Brien. (2003). Improvements in insulin sensitivity and beta-cell function(HOMA) with weight loss in the severely obese. Homeostatic model assessment. Diabetic Medicine, 20(2), 127-134. DOI : 10.1046/j.1464-5491.2003.00889.x   DOI
3 H. H. Sung et al. (2020). The association of the visceral adiposity index with insulin resistance and beta-cell function in Korean adults with and without type 2 diabetes mellitus. Endocrine Journal, 12. DOI : 10.1507/endocrj.EJ19-0517
4 E. Ferrannini. (1998). Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocrine Reviews, 19(4), 477-490. DOI : 10.1210/edrv.19.4.0336   DOI
5 M. Kasuga. (2006). Insulin resistance and pancreatic beta cell failure. Journal of Clinical Investigation, 116(7), 1756-1760. DOI : 10.1172/JCI29189   DOI
6 S. E. Kah, R. L. Hull & K. M. Utzschneider. (2006). Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 444(7121), 840-846. DOI : 10.1038/nature05482   DOI
7 K. M. Knowles et al. (2011). Waist circumference, body mass index, and other measures of adiposity in predicting cardiovascular disease risk factors among Peruvian adults. International Journal of Hypertension, 24, 931402. DOI : 10.4061/2011/931402
8 D. Canoy et al. (2007). Body fat distribution and risk of coronary heart disease in men and women in the European prospective investigation into cancer and nutrition in Norfolk Cohort: a population-based prospective study. Circulation, 116(25), 2933-2943. DOI : 10.1161/CIRCULATIONAHA.106.673756   DOI
9 M. Lee & L. J. Aronne. (2007). Weight management for type 2 diabetes mellitus: global cardiovascular risk reduction. American Journal of Cardiology, 99(4), 68-79. DOI : 10.1016/j.amjcard.2006.11.007   DOI
10 A. Shuster, M. Patlas, J. H. Pinthus & M. Mourtzakis. (2012). The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis. The British Journal of Radiology, 85(1009), 1-10. DOI : 10.1259/bjr/38447238   DOI
11 M. C. Pouliot et al. (1994). Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. American Journal of Cardiology, 73(7), 460-468. DOI : 10.1016/0002-9149(94)90676-9   DOI
12 M. C. Amato et al. (2010). Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic Risk. Diabetes Care, 33(4), 920-922. DOI : 10.2337/dc09-1825   DOI
13 S. E. Kahn. (2003). The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia, 46(1), 3-19. DOI : 10.1007/s00125-002-1009-0   DOI
14 T. Du, X. Sun, R. Huo & X. Yu. (2014). Visceral adiposity index, hypertriglyceridemic waist and risk of diabetes: the china health and nutrition survey 2009. International Journal of Obesity, 38(6), 840-847. DOI : 10.1038/ijo.2013.181   DOI
15 J. Y. Oh, Y. A. Sung & H. J. Lee. (2013). The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome. Obesity (Silver Spring), 21(8), 1690-1694. DOI : 10.1002/oby.20096   DOI
16 G. A. Balsan, J. L. da Costa Vieira, A. M. de Oliveira & V. L. Portal. (2015). Relationship between adiponectin, obesity and insulin resistance. Revista da Associacao Medica Brasileira (1992), 61(1), 72-80. DOI : 10.1590/1806-9282.61.01.072   DOI
17 G. Kloppel, M. Lohr, K. Habich, M. Oberholzer & P. U. Heitz. (1985). Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Survey and Synthesis of Pathology Research, 4(2), 110-125. DOI : 10.1159/000156969
18 B. L. Wajchenberg. (2007). Beta-cell failure in diabetes and preservation by clinical treatment. Endocrine Reviews, 28(2), 187-218. DOI : 10.1210/10.1210/er.2006-0038   DOI
19 D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher & R. C. Turner. (1985). Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412-419. DOI : 10.1007/BF00280883   DOI
20 S. Cernea & M. Dobreanu. (2013). Diabetes and beta cell function: from mechanisms to evaluation and clinical implications. Biochemia Medica, 23(3), 266-280. DOI : 10.11613/bm.2013.033
21 K. A. Shin & Y. J. Kim. (2019). Usefulness of surrogate markers of body fat distribution for predicting metabolic syndrome in middle-aged and older Korean populations. Diabetes, Metabolic Syndrome and Obesity, 12, 2251-2259. DOI : 10.2147/DMSO.S217628   DOI
22 M. Bozorgmanesh, F. Hadaegh & F. Azizi. (2010). Predictive performances of lipid Accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: tehran lipid and glucose study. Lipids in Health and Disease, 16(9), 100. DOI : 10.1186/1476-511X-9-100
23 N. M. Al-Daghri et al. (2013). Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances. European Journal of Clinical Investigation, 43(2), 183-189. DOI : 10.1111/eci.12030   DOI
24 M. Stepien et al. (2014). New obesity indices and adipokines in normotensive patients and patients with hypertension: comparative pilot analysis. Angiology, 65(4), 333-342. DOI : 10.1177/0003319713485807   DOI
25 S. W. Oh, S. A. Shin, Y. H. Yun, T. W. Yoo & B. Y. Huh. (2004). Cut-off point of BMI and obesity-related comorbidities and mortality in middle-aged Koreans. Obesity Research, 12(12), 2031-2040. DOI : 10.1038/oby.2004.254   DOI
26 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. (2001). Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). The Journal of the American Medical Association, 285(19), 2486-2497. DOI : 10.1001/jama.285.19.2486   DOI
27 E. E. Calle & R. Kaaks. (2004). Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Reviews Cancer, 4(8), 579-591. DOI : 10.1038/nrc1408   DOI
28 World Health Organization. (2000). The Asia-Pacific perspective: redefining obesity and its treatment. Sydney : Health Communications Australia.
29 S. Lee et al. (2006). Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults. Journal of Korean Medical Science, 21(4), 695-700. DOI : 10.3346/jkms.2006.21.4.695   DOI
30 Y. Song et al. (2007). Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the women's health initiative observational study. Diabetes Care, 30(7), 1747-1752. DOI : 10.2337/dc07-0358   DOI
31 B. M. Popkin, L. S. Adair & S. W. Ng. (2012). Global nutrition transition and the pandemic of obesity in developing countries. Nutrition Reviews, 70(1), 3-21. DOI : 10.1111/j.1753-4887.2011.00456.x   DOI
32 J. P. Despres & I. Lemieux. (2006). Abdominal obesity and metabolic syndrome. Nature, 444(7121), 881-887. DOI : 10.1038/nature05488   DOI
33 E. Mazzuca et al. (2014). Gender-specific anthropometric markers of adiposity, metabolic syndrome and visceral adiposity index (VAI) in patients with obstructive sleep apnea. Journal of Sleep Research, 23(1), 13-21. DOI : 10.1111/jsr.12088   DOI
34 B. Elisha et al. (2013). The visceral adiposity index: relationship with cardiometabolic risk factors in obese and overweight postmenopausal women-a MONET group study. Applied Physiology, Nutrition, and Metabolism, 38(8), 892-899. DOI : 10.1139/apnm-2012-0307   DOI
35 N. S. Kalupahana & N. Moustaid-Moussa. (2012). The renin-angiotensin system: a link between obesity, inflammation and insulin resistance. Obesity Reviews, 13(2), 136-149. DOI : 10.1111/j.1467-789X.2011.00942.x   DOI
36 L. Ramalingam et al. (2017). The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1863(5), 1106-1114. DOI : 10.1016/j.bbadis.2016.07.019   DOI