• 한국산학기술학회논문지
• /
• 제17권4호
• /
• pp.392-399
• /
• 2016

본 연구는 70세 이상 고령자들의 연령대에 따른 인구사회학적 및 건강관련행위 특성별 대사증후군의 분포를 비교해 보고자 2011~2014년도에 국민건강보험공단의 건강검진을 받았던 70세 이상 고령자 1,756명(남성 872명, 여성 884명)을 대상으로 대사증후군과 관련요인들 간의 관련성을 로지스틱 회귀분석을 통해 분석하였다. 연구결과, 대사증후군이 나타날 위험비는 남성보다 여성에서, 혼자 사는 군보다 가족과 함께 사는 군에서, 가정의 경제상태가 낮은 군보다 높은 군에서, 정상체중군보다 비만군에서, 뇌졸중 과거력이 없다는 군보다 있다는 군에서, 비흡연군보다 흡연군에서, 비음주군보다 음주군에서 유의하게 증가하였다. 따라서 조사대상자들의 대사증후군은 여러 인구사회학적 및 건강관련행위특성 변수에 따라 유의한 차이를 보이고 있음을 시사하고 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.1963-1969
• /
• 2012

Objectives: Recent data show that the metabolic syndrome may play a role in several cancers, but the etiology for biliary tract cancer is incompletely defined. The present aim was to evaluate risk factors for biliary tract cancer in China. Methods: A case-control study in which cases were biliary tract cancer patients referred to Peking Union Medical College Hospital (PUMCH). Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of PUMCH. Data on the metabolic syndrome, liver diseases, family history, and history of diabetes and hypertension were collected by retrospective review of the patients' records and health examination reports or by interview. Results: A total of 281 patients (102 intrahepatic cholangiocarcinoma (ICC), 86 extrahepatic cholangiocarcinoma (ECC) and 93 gallbladder carcinoma (GC)) and 835 age- and sex-matched controls were enrolled. $HBsAg^+/anti-HBc^+$ (P=0.002), history of diabetes (P=0.000), cholelithiasis (P=0.000), TC (P=0.003), and HDL (P=0.000) were significantly related to ICC. Cholelithiasis (P=0.000), Tri (P=0.001), LDL (P=0.000), diabetes (P=0.000), Apo A (P=0.000) and Apo B (P=0.012) were significantly associated with ECC. Diabetes (P=0.017), cholelithiasis (P=0.000) and Apo A (P=0.000) were strongly inversely correlated with GC. Conclusion: Cholelithiasis, HBV infection and metabolic symptoms may be potential risk factors for the development of biliary tract cancer.

• 사상체질의학회지
• /
• 제27권1호
• /
• pp.82-109
• /
• 2015

Objectives This research was proposed to present Clinical Practice Guideline (CPG) for Prevention of Sasangin disease pattern of Sasang Constitutional Medicine (SCM) and diseases closely related with Sasang constitution. Each CPG was developed by the national-wide experts committee consisting of SCM professors. Methods At first, we searched the literatures related to SCM such as "Dongeuisusebowon", Textbook of SCM and Clinical Guidebook of SCM. Also we searched the articles related to the studies about risk factors for Sasangin disease pattern of both at home and abroad. Finally, we selected leading risk factors of Sasangin disease pattern and developed CPG for prevention of Sasangin disease pattern of SCM. And then, we searched the literatures related SCM such as "Dongeuisusebowon" and the articles on the correlation between disease and Sasang constitution using case-control studies, observational studies or cross sectional studies of both at home and abroad. Next, we selected diseases closely related with Sasang constitution on the basis of articles including prevalence rate and odds ratio between disease and Sasang constitution and finally developed CPG for these diseases. Results and Conclusions We categorized risk factors of Sasang disease pattern into 2 types: non-modifiable and potentially modifiable. 3 items (age, sex and genetic factors) were classified as non-modifiable risk factors of Sasang disease pattern. 6 items (original symptom, stress, diet and nutrition, physical activity, alcohol and drug misuse) were classified as less well-documented or potentially modifiable risk factors of Sasangin disease pattern. We found out Sasang constitution is more likely to develop some diseases. It was proven that Sasang constitution increase the risk of hypertension, diabetes mellitus, metabolic syndrome, stroke, nonalcoholic fatty liver and obstructive sleep apnea. And there is high probability of Sasang constitution being potential risk factor for obesity, hyperlipidemia, allergy and cancer. Also, we found out Taeeumin is independent risk factor for hypertension, diabetes mellitus, metabolic syndrome, stroke, nonalcoholic fatty liver and obstructive sleep apnea. Therefore we recommend that Taeeumin need to prevent these disease by regular checkups and aggressive management.

• 한국산학기술학회논문지
• /
• 제17권1호
• /
• pp.526-537
• /
• 2016

연구목적: 본 연구는 대사증후군 구성요인의 군집별 변화양상과 군집별 조합 중에서 가장 많이 분포된 조합들을 파악하여 대사증후군을 예방하고자 시행하였다. 연구방법: 2009년부터 2013년까지 총 2회 검진을 받은 1900명을 대상으로 하였고, 대사증후군의 변화를 살펴보기 위해 정상군과 대사증후군으로 진단된 군 두군으로 나누어 코호트연구를 시행하였다. 연구결과: 대사증후군 구성요인의 조합 상태에 따라 대사증후군 진단율에 영향을 미치는 순서는 2개의 조합에서는 TG+HDL, TG+FBS순이고, 3개의 조합은 WC+TG+HDL, TG+BP+FBS순이었고, 4개의 조합은 WC+TG+HDL+BP, WC+TG+HDL+FBS의 순이었다. 결론: 대사증후군을 예방하기 위해서는 대사증후군 진단율에 영향을 주는 조합을 고려하여 대사증후군 고 위험군을 찾아내어 관리하는 보건프로그램이 필요할 것이다.

• Journal of Preventive Medicine and Public Health
• /
• 제44권5호
• /
• pp.226-233
• /
• 2011

Objectives: Being overweight or obese is central to metabolic syndrome, and these characteristics constitute dominant risk factors for chronic diseases. Although behavioral factors, including eating habits and sedentary lifestyles, are considered to be determinants of obesity, the specific childhood factors that contribute to this condition have not been clearly defined. Methods: The subjects consisted of 261 children aged 7- 9 years who were recruited from an elementary school during October 2003. Information was obtained from their parents using a questionnaire focused on eating behaviors and lifestyle factors, additional data were also collected via anthropometric measurements and biochemical examinations, including blood tests. Results: A total of 48 (18.4%) of the 261 children were overweight, and 34 (70.8%) had at least one other component of metabolic syndrome. Eating behaviors emerged as significant lifestyle-related risk factors for being overweight or obese. Those who engaged in overeating more than twice per week had three times the risk of being overweight (odds ratio [OR], 3.10, 95% confidence interval [CI], 1.39 to 6.92), and those who ate rapidly had three times the risk of being overweight (OR, 3.28; 95% CI, 1.68 to 6.41). Those who had fewer family meals (fewer than 2?3/month) had a nine times higher risk of being overweight than those who had family meals more frequently (at least 1/day) (OR, 9.51; 95% CI, 1.21 to 74.82). Conclusions: This study showed that being overweight or obese during preadolescence is associated with a higher risk of metabolic syndrome and is related to unhealthy eating behaviors. Thus, weight-control strategies and healthy eating behaviors should be developed early in life to reduce the risk for metabolic syndrome.

• Nutrition Research and Practice
• /
• 제6권1호
• /
• pp.78-85
• /
• 2012

Whether the $FTO$ polymorphisms interact with environmental factors has not yet been evaluated in associations with metabolic syndrome (MS) risk. The present study investigated the association of the $FTO$ rs9939609 genotypes, body mass index (BMI), and lifestyle-related factors including smoking, alcohol drinking, physical activity, and diet with MS incidence. A population-based prospective cohort study comprised 3,504 male and female Koreans aged 40 to 69 years. At the beginning of the study, all individuals were free of MS and known cardiovascular disease. Incident cases of MS were identified by biennial health examinations during a follow-up period from April 17, 2003 to April 15, 2009. Pooled logistic regression analysis was applied to obtain relative odds (RO) of MS with its 95% confidence interval (CI). After controlling for potential MS risk factors, we observed no association between the rs9939609 genotypes and MS incidence. In analysis stratified by BMI, however, carriers with the $FTO$ risk allele whose BMI is $29kg/m^2$ or greater showed an approximately 6-fold higher RO (95% CI: 3.82 to 9.30) compared with non-carriers with BMI less than $25kg/m^2$. In particular, the association between the rs9939609 variants and MS risk was significantly modified by high BMI (P-value for interaction < 0.05). Such significant interaction appeared in associations with central obesity and high blood pressure among the MS components. Because carriers of the $FTO$ risk alleles who had BMI of $29kg/m^2$ or greater are considered a high risk population, we suggest that they may need intensive weight loss regimens to prevent MS development.

• 대한지역사회영양학회지
• /
• 제13권1호
• /
• pp.91-99
• /
• 2008

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

• 한국식품영양학회지
• /
• 제28권6호
• /
• pp.988-994
• /
• 2015

Menopausal status and hormonal changes are important factors related to the prevalence of metabolic syndrome in women. Nutrient intake is also a risk factor for metabolic syndrome. Although, postmenopausal status and hormonal changes result in a 60% increased risk for metabolic syndrome, there has been no method to elucidate the effects of nutrient intake on metabolic syndrome following menopause. This study was conducted to evaluate the effects of nutrient intake by menopausal women on the prevalence of metabolic syndrome. All data were obtained from the Korean National Health and Nutrition Examination Survey 2007-2009. Menopausal women showed a 1.8-fold increase in the prevalence of metabolic syndrome. Metabolic syndrome group showed significantly lower values in calcium, iron, vitamin A, carotin, retinol and riboflavin intake than those of normal group in premenopausal women. In postmenopausal women, there are significant differences in crude fiber, calcium, iron, potassium, riboflavin and niacin. Indeed, different patterns of nutrient intake were observed by menopausal status and metabolic syndrome. As menopause cannot be controlled, a diet with adequate nutrient intake may be useful to control the rapid increase in the prevalence of metabolic syndrome due to menopause.

• 한국산학기술학회논문지
• /
• 제13권11호
• /
• pp.5317-5325
• /
• 2012

본 연구는 대사증후군 및 대사증후군 진단기준 인자의 유병률을 파악하고, 인구사회학적 및 건강관련행위 요인과의 관련성을 검토하며, 진단기준 인자의 군집화를 통해 대사증후군 위험의 분포를 분석하고자 하였다. 조사는 한 대학병원 건강검진센터에서 종합건강검진을 받았던 30세 이상의 지역주민 1,388명을 대상으로 허리둘레, 중성지방, 고밀도지단백콜레스테롤, 수축기혈압, 확장기혈압, 및 공복 시 혈당 등 대사증후군 진단기준 인자를 측정하였다. 분석은 이들 대사증후군 위험인자에 대한 유병률을 파악하고 위험인자의 군집화를 통해 대사증후군 위험의 분포를 파악하였으며, 관련요인에 따른 대사증후군의 위험비를 구하였다. 연구결과 조사대상자의 대사증후군의 유병율은 21.7%로 나타났으며, 대사증후군 위험인자별 유병률은 HDL-C, 혈압, TG, 허리둘레, FBS의 순으로 나타났다. 또한 관련변수에 따른 위험비에서 BMI, 흡연습관, 식품섭취 및 당뇨에 대한 가족력 등이 대사증후군의 위험비를 높이는데 관련된 것으로 나타났다. 따라서 대사증후군의 위험 관리를 위해서는 모든 생활습관 요인에 대한 평가와 중재가 필요함을 시사하고 있다.

• 한국조리학회지
• /
• 제21권5호
• /
• pp.139-146
• /
• 2015

본 연구는 한국 성인 여성을 대상으로 외식빈도, 영양섭취, 대사증후군과 관련된 건강위험 인자의 관계를 조사하고자 하였다. 2013년 국민건강영양조사(KNHANES VI)의 자료를 이용하여 SPSS 20.0 통계 패키지 프로그램을 활용하여 분석하였다. 이를 위하여 20세 이상 여성(3,413명)을 대상으로 생화학적 지표, 검진자료를 바탕으로 외식빈도를 세 그룹(주 1회 미만, 주 2~4회, 주 5회 이상)으로 나누어 각 변수들의 차이를 분석하였다. 그 결과, 외식빈도와 열량, 수분, 단백질, 지방, 칼슘, 나트륨, 비타민 A가 유의적으로 차이가 있었다. 외식빈도에 따른 각 그룹은 비만과 저 HDL 콜레스테롤혈증 수치에도 유의적 차이가 있었다. 마지막으로 본 연구는 대한민국 성인 여성의 외식빈도에 따라 대사증후군 관련 건강인자에 유의적 차이를 발견하였다. 향후 연령을 세분화 하고, 한국의 성인을 대상으로 외식빈도와 영양소 섭취, 대사증후군 관련 건강 위험 인자에 대한 연구가 필요하겠다.