• The KIPS Transactions:PartD
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• v.12D no.6 s.102
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• pp.857-862
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• 2005

MND(Ministry of National Defense) has developed MND AF(Ministry of National Defense Architecture Framework) and CADM(Core Architecture Data Model to guarantee interoperability among defense information systems. But, it is very difficult to manage architecture product documented through MND AF and CADM. So, there Is necessity for development of modeling tool and repository system which can develop architecture products and manage architecture product informations in common repository In this paper, we developed architecture product management system which supports development and management of meta model and architecture product of MND AF and CADM. Through architecture product management system architect of each agency can construct architecture product in a more effective and efficient way with modeling method and a user can search and refer useful architecture product informations using query function. Also, architecture product management system provides the basis for system integration and interoperability with integration, analysis and comparison of architecture product.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.157-163
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• 2012

Objective: Glutathione S-transferases (GSTs) are multifunctional enzymes that play a crucial role in the detoxification of both the endogenous products of oxidative stress and exogenous carcinogens. Recent studies investigating the association between genetic polymorphisms in GSTs and the risk of adult brain tumors have reported conflicting results. The rationale of this pooled analysis was to determine whether the presence of a GST variant increases adult glioma susceptibility by combining data from multiple studies. Methods: In our meta-analysis, 12 studies were identified by a search of the MEDLINE, HIGHWIRE, SCIENCEDIRECT and EMBASE databases. Of those 12, 11 evaluated GSTM1, nine evaluated GSTT1 and seven evaluated GSTP1 Ile105Val. Between-study heterogeneity was assessed using ${\chi}^2$-based Q statistic and the $I^2$ statistic. Crude odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to estimate the association between GSTM1, GSTT1 and GSTP1 polymorphisms and the risk of adult gliomas. Results: The quantitative synthesis showed no significant evidence to indicate an association exists between the presence of a GSTM1, GSTT1 or GSTP1 Ile105Val haplotype polymorphism and the risk of adult gliomas (OR, 1.008, 1.246, 1.061 respectively; 95% CI, 0.901-1.129, 0.963-1.611, 0.653-1.724 respectively). Conclusions: Overall, this study did not suggest any strong relationship between GST variants or related enzyme polymorphisms and an increased risk of adult gliomas. Some caveats include absence of specific raw information on ethnic groups or smoking history on glioma cases in published articles; therefore, well-designed studies with a clear stratified analysis on potential confounding factors are needed to confirm these results.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.3
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• pp.201-207
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• 2018

There is no known polynomial time algorithm for random-type quadratic assignment problem(RQAP) that is a NP-complete problem. Therefore the heuristic or meta-heuristic approach are solve the approximated solution for the RQAP within polynomial time. This paper suggests polynomial time algorithm for random type quadratic assignment problem (QAP) with time complexity of $O(n^2)$. The proposed algorithm applies one-to-one matching strategy between ascending order of sum of distance for each location and descending order of sum of quantity for each facility. Then, swap the facilities for reflect the correlation of distances of locations and quantities of facilities. For the experimental data, this algorithm, in spite of $O(n^2)$ polynomial time algorithm, can be improve the solution than genetic algorithm a kind of metaheuristic method.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.3
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• pp.83-89
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• 2016

The group formation problem of the machine and part is a critical issue in the planning stage of cellular manufacturing systems. The machine-part grouping with alternative process plans means to form machine-part groupings in which a part may be processed not only by a specific process but by many alternative processes. For this problem, this study presents an algorithm based on self organizing neural networks, so called SOM (Self Organizing feature Map). The SOM, a special type of neural networks is an intelligent tool for grouping machines and parts in group formation problem of the machine and part. SOM can learn from complex, multi-dimensional data and transform them into visually decipherable clusters. In the proposed algorithm, output layer in SOM network had been set as one-dimensional structure and the number of output node has been set sufficiently large in order to spread out the input vectors in the order of similarity. In the first stage of the proposed algorithm, SOM has been applied twice to form an initial machine-process group. In the second stage, grouping efficacy is considered to transform the initial machine-process group into a final machine-process group and a final machine-part group. The proposed algorithm was tested on well-known machine-part grouping problems with alternative process plans. The results of this computational study demonstrate the superiority of the proposed algorithm. The proposed algorithm can be easily applied to the group formation problem compared to other meta-heuristic based algorithms. In addition, it can be used to solve large-scale group formation problems.

• Journal of Korean Clinical Nursing Research
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• v.23 no.3
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• pp.376-387
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• 2017

Purpose: This study was to systematically review the contents and effects of nurse-led transitional care programs for discharged patients from hospital to home. Methods: Randomized controlled trials published between 2005 and 2015 were searched in Pubmed, Embase, Cochrane(Central Register of Controlled Trials) and CINAHL. Data were analyzed using Cochrane Review Manager(Revman) software 5.3. Results: Nine studies were selected and analyzed. Patient assessment, education and discharge planning were included in pre-discharge phase. Referring, communication and care planning were performed by nurses in transition phase. Home and phone visits, monitoring and multidisciplinary advices were included in post-discharge phase. Various outcome measures such as hospital utilization(30 days readmission and emergency department visit), quality of life, and cost were used to identify effectiveness of nurse-led transitional care programs. 30 days readmission(OR=.73, 95% CI 0.54, 0.98; p=.03) and emergency department visit(OR=.67, 95% CI 0.50, 0.88; p=.005) were statistically significant in meta-analysis. However, participant blinding was not done in seven studies which put at the risk of performance bias. Conclusion: The results indicated that nurse-led transitional care program is effective in reducing unnecessary hospital utilization. Nevertheless, small sample size and risk at performance bias are the limitation of this study. Thus, we suggest that well-designed randomized controlled trials need to be conducted.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.24 no.3
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• pp.167-180
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• 2017

Purpose: The aim of this study was to synthesize the best available evidence for active warming interventions during cesarean section. Methods: A database search was done for randomized controlled trials utilizing active warming interventions. Maternal temperature, shivering and neonatal temperature were evaluated as outcome variables. Data were analyzed using Cochrane Review Manager software Version 5.3. Results: Thirteen studies including 1306 patients were reviewed. The degree of lowering of maternal temperature decreased in the warmed fluids (MD 0.51; p=.004) and warming mattress interventions (MD 0.22; p<.001) compared with control groups. Incidence of shivering was also lower in the active warming group (OR 0.55; p=.003). There was no statistically significant difference in maternal temperature with a forced air warming intervention (MD 0.64; p=.15) or in neonatal temperature (MD 0.12; p=.26). Conclusion: Findings show that with warmed fluids and warming mattresses applied during cesarean sections maternal temperature decline was reduced and also the incidence of shivering declined, but no significant effect was observed for forced air warming interventions. These findings provide a basis for developing a warming guideline for women having a cesarean section and will help to improve the quality of care for cesarean section patients.

• Journal of the Korea Convergence Society
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• v.8 no.2
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• pp.269-276
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• 2017

The purpose of this study is to review empirical research on Form-focused instruction (FFI) in Korean language education from a critical perspective to better understand the effectiveness of FFI. To achieve this goal, several databases were searched to locate relevant experimental and quasi experimental studies published in peer-reviewed journals. Out of 66 studies collected, 12 studies met the inclusion criteria. The studies were then analyzed in terms of subjects, target grammar, treatment, measurement, and the learning outcomes of different techniques. In general, several types of FFI techniques had positive effects on helping learners acquire Korean as a second or foreign language. The results of the study will provide a conceptual framework which identifies the major factors affecting the effectiveness of FFI. The results will also be able to inform future meta-analytical research of existing studies.

• Journal of the Korea Society of Computer and Information
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• v.9 no.3
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• pp.115-120
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• 2004

As a part of working on development of the learning management system, a adaptive learning management system which is able to provide individual learner with different learning contents or paths customized to learner's learning behaviors by expanding SCORM was proposed in this dissertation. In terms of instructional technology interrelated with technology of CBI and ITS, new learning environments and learner preferences were analyzed. A related laboratory system was implemented by packaging a process on how to expand the meta data for contents and a process on how to utilize the web-based learning contents dynamically. In order to evaluate the usability of the implemented system, a sample content was provided to some selected learners and their learning achievement resulted from the new learning environment was analysed. A result of the experiment indicated that the adaptive learning management system proposed in this dissertation could provide every learner with the different content tailored to their individual learning preference and behavior. and it worked also to promote the learning performance of every learner.

• Journal of Korean Academy of Nursing
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• v.26 no.2
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• pp.372-386
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• 1996

Recently, the ratio of elderly in the population are fast growing due to socio-economical development and the better medical service. Proportionally, the health problems in elderly are increasing, too. Medical professionals must try so that the elderly have the better life through health promotion and disease prevention as well as disease treatment. This study evaluated the effect of walking exercise program on the cardiorespiratory function and the flexibility in the elderly women. The design of research was one group pretest-posttest design. The subjects were eleven elderly women over sixty years old to live in K-city, Kyonggi-do. The type of exercise was walking, which was the most popular exercise in questionnaire. The exercise intensity was 40％∼60％ of the target heart-rate by Karvonen's method and maintained by the heart-rate monitor. The exercise period was five weeks and the exercise frequency was three times per week. The exercise duration was forty minutes at first and gradually increased up to an hour. In order to evaluate the effect of walking exercise, we measured VO/sub₂ max, resting heart -rate, systolic/diastolic blood pressure, FVC, FEV/sub₁, the flexibility before and after the five week's exercise program. The data are analyzed by the paired t-test and Wilcoxon signed rank test using SAS package. The results are as follows : 1) The hypothesis that cardiorespiratory function will be improved was partly supported. In VO/sub₂ max（p＝0.0001）, resting heart-rate（p＝0.0030）, systolic/diastolic blood-pressure（p＝0.0387／ p＝0.0024）, there was significant difference. FVC and FEV/sub₁ were increased after the exercise, but there were no significant difference. 2) The hypothesis that the flexibility will be improved was supported. There was significant difference in the flexibility（p＝0.0140）. As the further study, it is necessary to reevaluate the effect with more refined design. We also need to try meta-analysis about the results of previous studies obtained in the experimental setting and compare our result obtained in the field setting with them.

• Tuberculosis and Respiratory Diseases
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• v.83 no.1
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• pp.20-30
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• 2020

Tuberculosis (TB) remains a threat to public health and is the leading cause of death globally. Isoniazid (INH) is an important first-line agent for the treatment of TB considering its early bactericidal activity. Resistance to INH is now the most common type of resistance. Resistance to INH reduces the probability of treatment success and increases the risk of acquiring resistance to other first-line drugs such as rifampicin (RIF), thereby increasing the risk of multidrug-resistant-TB. Studies in the 1970s and 1980s showed high success rates for INH-resistant TB cases receiving regimens comprised of first-line drugs. However, recent data have indicated that INH-resistant TB patients treated with only firs-tline drugs have poor outcomes. Fortunately, based on recent systematic meta-analyses, the World Health Organization published consolidated guidelines on drug-resistant TB in 2019. Their key recommendations are treatment with RIF-ethambutol (EMB)-pyrazinamide (PZA)-levofloxacin (LFX) for 6 months and no addition of injectable agents to the treatment regimen. The guidelines also emphasize the importance of excluding resistance to RIF before starting RIF-EMB-PZA-LFX regimen. Additionally, when the diagnosis of INH-resistant TB is confirmed long after starting the first-line TB treatment, the clinician must decide whether to start a 6-month course of RIF-EMB-PZA-LFX based on the patient's condition. However, these recommendations are based on observational studies, not randomized controlled trials, and are thus conditional and based on low certainty of the effect estimates. Therefore, further work is needed to optimize the treatment of INH-resistant TB.