• Title/Summary/Keyword: Meta-analyses

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2R of Thymidylate Synthase 5'-untranslated Enhanced Region Contributes to Gastric Cancer Risk: a Meta-analysis

  • Yang, Zhen;Liu, Hong-Xiang;Zhang, Xie-Fu
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.1923-1927
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    • 2012
  • Background: Studies investigating the association between 2R/3R polymorphisms in the thymidylate synthase 5'-untranslated enhanced region (TYMS 5'-UTR) and gastric cancer risk have generated conflicting results. Thus, a meta-analysis was performed to summarize the data on any association. Methods: Pubmed, Embase, and CNKI databases were searched for all available studies. The strength of association between TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk was estimated by odds ratios (ORs) with 95% confidence intervals (CIs). Results: Six individual case-control studies with a total of 1, 472 cases and 1, 895 controls were included into this meta-analysis. Analyses of total six relevant studies showed that there was no obvious association between the TYMS 5'-UTR 2R/3R polymorphism and gastric cancer risk. Subgroup analyses based on ethnicity showed 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population ($OR_{Homozygote\;model}$ = 1.71, 95%CI 1.19-2.46, P = 0.004; $OR_{Recessive\;genetic\;model}$ = 1.70, 95%CI 1.18-2.43, P = 0.004). However, the association in Caucasian populations was uncertain due to the limited studies. Conclusions: Our meta-analysis suggests that 2R of TYMS 5'-UTR 2R/3R contributes to gastric cancer risk in the Asian population, while this association in Caucasians populations needs further study.

Meta-Analysis of Factors Related to Patient Safety Nursing in Nursing University Students (간호대학생의 환자안전간호 관련요인에 대한 메타분석)

  • Seo, Youngseon;Seo, Eunju;Hong, Eunhee
    • Journal of Industrial Convergence
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    • v.18 no.2
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    • pp.9-18
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    • 2020
  • Purpose is to systematically examine the factors related to patient safety nursing of nursing university students in a convergent and complex aspect and to identify the effect size through meta-analysis. The research method used PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Medline, Embases, CINAHL, DBpia, Research Information Service System (Riss), and Korean Studies Information Service (Kiss) were used, while overseas databases were searched using MeSH terms and Emtrees. The search term was [(patient safety or patient harm or safety management) and (students, nursing)] or [(patient safety or patient harm or safety management) and (education, nursing, graduate)].The research found that nursing performance, knowledge, attitude, self-confidence, recognition, and cognition were found to be relevant factors in the order of confidence, attitude, recognition, and knowledge.

Importance of Meta-Analysis and Practical Obstacles in Oncological and Epidemiological Studies: Statistics Very Close but Also Far!

  • Tanriverdi, Ozgur;Yeniceri, Nese
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.1303-1306
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    • 2015
  • Studies of epidemiological and prognostic factors are very important for oncology practice. There is a rapidly increasing amount of research and resultant knowledge in the scientific literature. This means that health professionals have major challenges in accessing relevant information and they increasingly require best available evidence to make their clinical decisions. Meta-analyses of prognostic and other epidemiological factors are very practical statistical approaches to define clinically important parameters. However, they also feature many obstacles in terms of data collection, standardization of results from multiple centers, bias, and commentary for intepretation. In this paper, the obstacles of meta-analysis are briefly reviewed, and potential problems with this statistical method are discussed.

A Diagnostic Analysis of LIS Curriculum from the Meta-literacy Perspective (메타리터러시 관점에서의 문헌정보학 전공 커리큘럼 진단연구)

  • Yoo, Sarah
    • Journal of the Korean Society for Library and Information Science
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    • v.52 no.2
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    • pp.191-220
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    • 2018
  • Using Bloom's taxonomy model of thinking ability for learning (RBTT) and new ACRL information literacy framework (2016), this study demonstrates the meta-literacy competencies for library specialists and analyses current LIS curriculum of higher education. Some guidelines for reformation of LIS curriculum, emphasizing meta-literacy competencies which are required from Web3.0 information environment, are provided.

Study on Damage Detection Method using Meta Model (메타모델을 이용한 손상추정 기법 연구)

  • Min, Cheon-Hong;Cho, Su-Gil;Oh, Jae-Won;Kim, Hyung-Woo;Hong, Sup;Nam, Bo-Woo
    • Journal of Ocean Engineering and Technology
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    • v.29 no.5
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    • pp.351-358
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    • 2015
  • This paper presents an effective damage detection method using a meta model. A meta model is an approximation model that uses the relations between the design and response variables. It eliminates the need for repetitive analyses of computationally expensive models during the optimization process. In this study, a response surface model was employed as the meta model. The surface model was estimated using the correlation of the stiffness and natural frequencies of the structures. The locations and values of the damages were identified using a meta model-based damage detection method. Two numerical examples (a cantilever beam and jacket structure) were considered to verify the performance of the proposed method. As a result, the damages to the structures were accurately detected.

Effects of Sling Exercise on Balance and Gait in Patients with Stroke: Meta-Analysis of Studies in Korea

  • Cho, Woonsu;Lee, Seongjin;Kim, Byeonggeun
    • Journal of International Academy of Physical Therapy Research
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    • v.11 no.3
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    • pp.2164-2172
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    • 2020
  • Background: Stroke patients have multiple disorders, but most have problems with balance and gait. Post-stroke rehabilitation exercise has been shown to be very important for functional recovery. Objectives: To systematically review and meta-analyze the effects of sling exercise (SE) on patients with stroke in studies published in Korea. Design: Meta-analysis. Methods: Five databases, namely, RISS, KISS, NDSL, DBpia and Earticle, were used to collect articles on vibration. Keywords such as "Stroke," "Hemiplegia," "Sling," and "Sling Exercise" were used in the search for published articles. Interventions and comparisons were SE and other exercise (OE). Outcome measures were berg balance scale (BBS) and timed up and go (TUG). Consequently, eight studies were selected in the second screening using meta-analyses. Results: Based on the results of the meta-analysis, SE was effective for BBS in the comparison of SE and OE [2.71, 95% CI (1.42, 4.01)]. It was effective for TUG in the comparison of SE and OE [-1.89, 95% CI (-3.01, -0.77)]. Conclusion: Based on eight limited studies, SE improved BBS and TUG over OE, suggesting improved stroke balance and gait. Therefore, more studies and large-scale sample randomized controlled trials are needed to confirm clinical application.

Effect of Breastfeeding Individual Visits Program: A Systematic Review and a Meta-Analysis (모유 수유 개별 방문 프로그램의 효과: 체계적 문헌고찰과 메타분석)

  • Cho, Moon-Ju;Kim, Hye-Young;Park, Seo-A
    • Korean Parent-Child Health Journal
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    • v.22 no.1
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    • pp.30-42
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    • 2019
  • Purpose: This study was a systematic review and meta-analysis designed to evaluate the effects of breastfeeding individual visit program. Methods: Based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), a systematic search was conducted using four core electronic databases from October 28, 2018 to November 14, 2018. The topics of breastfeeding individual visit program were analyzed using descriptive analysis and the effects of intervention were meta-analyzed using the Review Manager 5.3 software. Results: A total of 13 studies were included in the review and 12 were included for meta-analysis. Breastfeeding individual visit programs were found to be more effective in breastfeeding rates, attitude, skill and self-efficacy compared to group education or non-education. Conclusion: Effective breastfeeding education can help mothers to start and sustain breastfeeding. Breastfeeding individual visits programs that are more effective than group education to maintain breastfeeding for pregnant women should be developed and applied.

Short-term Effect of Fine Particulate Matter on Children's Hospital Admissions and Emergency Department Visits for Asthma: A Systematic Review and Meta-analysis

  • Lim, Hyungryul;Kwon, Ho-Jang;Lim, Ji-Ae;Choi, Jong Hyuk;Ha, Mina;Hwang, Seung-sik;Choi, Won-Jun
    • Journal of Preventive Medicine and Public Health
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    • v.49 no.4
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    • pp.205-219
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    • 2016
  • Objectives: No children-specified review and meta-analysis paper about the short-term effect of fine particulate matter ($PM_{2.5}$) on hospital admissions and emergency department visits for asthma has been published. We calculated more precise pooled effect estimates on this topic and evaluated the variation in effect size according to the differences in study characteristics not considered in previous studies. Methods: Two authors each independently searched PubMed and EMBASE for relevant studies in March, 2016. We conducted random effect meta-analyses and mixed-effect meta-regression analyses using retrieved summary effect estimates and 95% confidence intervals (CIs) and some characteristics of selected studies. The Egger's test and funnel plot were used to check publication bias. All analyses were done using R version 3.1.3. Results: We ultimately retrieved 26 time-series and case-crossover design studies about the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. In the primary meta-analysis, children's hospital admissions and emergency department visits for asthma were positively associated with a short-term $10{\mu}g/m^3$ increase in $PM_{2.5}$ (relative risk, 1.048; 95% CI, 1.028 to 1.067; $I^2=95.7%$). We also found different effect coefficients by region; the value in Asia was estimated to be lower than in North America or Europe. Conclusions: We strengthened the evidence on the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. Further studies from other regions outside North America and Europe regions are needed for more generalizable evidence.

Meta-analysis for the studies on extrasolar planets using Kepler mission data

  • Jung, So-Yoon;Yoon, Tae Seog;Lee, Hyunsook
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.1
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    • pp.78.4-79
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    • 2016
  • This study aims to overview research articles on extrasolar planets using Kepler mission data during the period of 2009-2015 in order to discover research trends in them. Kepler space observatory is a NASA space observatory for extrasolar planet expedition launched in March 2009, contributed to the discovery and tracking of extrasolar planets and its candidates. In order to achieve the goal of this study, we classified research subjects from studies on Kepler mission data year by year and found the most frequent research topics each year. We also conducted a comparative analysis on the research subjects based on time series and examined any changes with respect to the goal of Kepler mission. Statistical meta-analysis is employed as the analysis method for the key words presented in the research articles. This study is a part of on-going research to find the correlation between the physical parameters of the host star and extrasolar planets. The results of this study could offer new directions in researches utilizing Kepler mission data as those meta-analyses in social sciences often suggest new opportunities. We have high expectations that more extrasolar planet studies will follow as we make further progresses in various analyses.

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Factors Influencing the Adoption of Cloud Computing in Healthcare Organizations: A Systematic Review

  • Qiu, Hong;Shen, Beimin;Wang, Yuhao;Mei, Yu;Gu, Wenjie
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.16 no.12
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    • pp.3960-3975
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    • 2022
  • To analyze and compare the most influencing factors on cloud computing adoption (CCA) in the healthcare organization, a systematic review and meta-analyses of studies was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane collaboration recommendations. A search of PubMed, ScienceDirect, Springer, Wiley Online, and Taylor & Francis Online digital libraries (From inception to January 19, 2022) was performed. A total of 17 studies met the defined studies' inclusion and exclusion criteria. Statistical significance difference favoring most influencing factors on CCA were (MD 0.76, 95% CI -1.48 - 3.01, p <0.00001, I2 = 90%), (MD 1.40, 95% CI -4.76 - 7.55, p < 0.00007, I2 = 97%) (MD 0.17, 95% CI -2.69 - 3.03, p<0.00001, I2 = 96%) for technology vs. organizational, technology vs. environmental and business vs. human factors, respectively. Organizational and environmental factors had greater impacts on CCA compared with technological factors. Moreover, business factors were more influential than the human factors.