Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Short-term Effect of Fine Particulate Matter on Children's Hospital Admissions and Emergency Department Visits for Asthma: A Systematic Review and Meta-analysis

  • Lim, Hyungryul (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Kwon, Ho-Jang (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Lim, Ji-Ae (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Choi, Jong Hyuk (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Ha, Mina (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Hwang, Seung-sik (Department of Social and Preventive Medicine, Inha University School of Medicine) ;
  • Choi, Won-Jun (Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center)
  • Received : 2016.04.07
  • Accepted : 2016.07.14
  • Published : 2016.07.31
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Abstract

Objectives: No children-specified review and meta-analysis paper about the short-term effect of fine particulate matter ($PM_{2.5}$) on hospital admissions and emergency department visits for asthma has been published. We calculated more precise pooled effect estimates on this topic and evaluated the variation in effect size according to the differences in study characteristics not considered in previous studies. Methods: Two authors each independently searched PubMed and EMBASE for relevant studies in March, 2016. We conducted random effect meta-analyses and mixed-effect meta-regression analyses using retrieved summary effect estimates and 95% confidence intervals (CIs) and some characteristics of selected studies. The Egger's test and funnel plot were used to check publication bias. All analyses were done using R version 3.1.3. Results: We ultimately retrieved 26 time-series and case-crossover design studies about the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. In the primary meta-analysis, children's hospital admissions and emergency department visits for asthma were positively associated with a short-term $10{\mu}g/m^3$ increase in $PM_{2.5}$ (relative risk, 1.048; 95% CI, 1.028 to 1.067; $I^2=95.7%$). We also found different effect coefficients by region; the value in Asia was estimated to be lower than in North America or Europe. Conclusions: We strengthened the evidence on the short-term effect of $PM_{2.5}$ on children's hospital admissions and emergency department visits for asthma. Further studies from other regions outside North America and Europe regions are needed for more generalizable evidence.

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References

  1. Vallero DA. Fundamentals of air pollution. 5th ed. Amsterdam: Academic Press; 2014, p. 48.
  2. Pope CA 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, et al. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 2009;120(11):941-948. https://doi.org/10.1161/CIRCULATIONAHA.109.857888
  3. Lepeule J, Laden F, Dockery D, Schwartz J. Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009. Environ Health Perspect 2012;120(7):965-970. https://doi.org/10.1289/ehp.1104660
  4. Kwon HJ. Epidemiologic study of allergic diseases in Korean children. Cheongju: Korea Centers for Disease Control and Prevention; 2011, p. 23-24 (Korean).
  5. Zheng XY, Ding H, Jiang LN, Chen SW, Zheng JP, Qiu M, et al. Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: a systematic review and meta-analysis. PLoS One 2015;10(9): e0138146. https://doi.org/10.1371/journal.pone.0138146
  6. Fan J, Li S, Fan C, Bai Z, Yang K. The impact of PM2.5 on asthma emergency department visits: a systematic review and meta-analysis. Environ Sci Pollut Res Int 2016;23(1):843-850. https://doi.org/10.1007/s11356-015-5321-x
  7. Norris G, YoungPong SN, Koenig JQ, Larson TV, Sheppard L, Stout JW. An association between fine particles and asthma emergency department visits for children in Seattle. Environ Health Perspect 1999;107(6):489-493. https://doi.org/10.1289/ehp.99107489
  8. Lin M, Chen Y, Burnett RT, Villeneuve PJ, Krewski D. The influence of ambient coarse particulate matter on asthma hospitalization in children: case-crossover and time-series analyses. Environ Health Perspect 2002;110(6):575-581. https://doi.org/10.1289/ehp.02110575
  9. Villeneuve PJ, Chen L, Rowe BH, Coates F. Outdoor air pollution and emergency department visits for asthma among children and adults: a case-crossover study in northern Alberta, Canada. Environ Health 2007;6:40. https://doi.org/10.1186/1476-069X-6-40
  10. Andersen ZJ, Wahlin P, Raaschou-Nielsen O, Ketzel M, Scheike T, Loft S. Size distribution and total number concentration of ultrafine and accumulation mode particles and hospital admissions in children and the elderly in Copenhagen, Denmark. Occup Environ Med 2008;65(7):458-466. https://doi.org/10.1136/oem.2007.033290
  11. Halonen J, Lanki T, Yli-Tuomi T, Kulmala M, Tiittanen P, Pekkanen J. Urban air pollution, and asthma and COPD hospital emergency room visits. Thorax 2008;63(7):635-641. https://doi.org/10.1136/thx.2007.091371
  12. Tecer LH, Alagha O, Karaca F, Tuncel G, Eldes N. Particulate matter (PM(2.5), PM(10-2.5), and PM(10)) and children's hospital admissions for asthma and respiratory diseases: a bidirectional case-crossover study. J Toxicol Environ Health A 2008;71(8):512-520. https://doi.org/10.1080/15287390801907459
  13. Halonen JI, Lanki T, Tiittanen P, Niemi JV, Loh M, Pekkanen J. Ozone and cause-specific cardiorespiratory morbidity and mortality. J Epidemiol Community Health 2010;64(9):814-820. https://doi.org/10.1136/jech.2009.087106
  14. Silverman RA, Ito K. Age-related association of fine particles and ozone with severe acute asthma in New York City. J Allergy Clin Immunol 2010;125(2):367-373. https://doi.org/10.1016/j.jaci.2009.10.061
  15. Strickland MJ, Darrow LA, Klein M, Flanders WD, Sarnat JA, Waller LA, et al. Short-term associations between ambient air pollutants and pediatric asthma emergency department visits. Am J Respir Crit Care Med 2010;182(3):307-316. https://doi.org/10.1164/rccm.200908-1201OC
  16. Li S, Batterman S, Wasilevich E, Wahl R, Wirth J, Su FC, et al. Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: time-series and time-stratified case-crossover analyses with threshold effects. Environ Res 2011;111(8):1137-1147. https://doi.org/10.1016/j.envres.2011.06.002
  17. Glad JA, Brink LL, Talbott EO, Lee PC, Xu X, Saul M, et al. The relationship of ambient ozone and PM(2.5) levels and asthma emergency department visits: possible influence of gender and ethnicity. Arch Environ Occup Health 2012;67(2):103-108. https://doi.org/10.1080/19338244.2011.598888
  18. Iskandar A, Andersen ZJ, Bonnelykke K, Ellermann T, Andersen KK, Bisgaard H. Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children. Thorax 2012;67(3):252-257. https://doi.org/10.1136/thoraxjnl-2011-200324
  19. Winquist A, Klein M, Tolbert P, Flanders WD, Hess J, Sarnat SE. Comparison of emergency department and hospital admissions data for air pollution time-series studies. Environ Health 2012;11:70. https://doi.org/10.1186/1476-069X-11-70
  20. Delfino RJ, Wu J, Tjoa T, Gullesserian SK, Nickerson B, Gillen DL. Asthma morbidity and ambient air pollution: effect modification by residential traffic-related air pollution. Epidemiology 2014;25(1):48-57. https://doi.org/10.1097/EDE.0000000000000016
  21. Gleason JA, Bielory L, Fagliano JA. Associations between ozone, PM2.5, and four pollen types on emergency department pediatric asthma events during the warm season in New Jersey: a case-crossover study. Environ Res 2014;132: 421-429. https://doi.org/10.1016/j.envres.2014.03.035
  22. Strickland MJ, Klein M, Flanders WD, Chang HH, Mulholland JA, Tolbert PE, et al. Modification of the effect of ambient air pollution on pediatric asthma emergency visits: susceptible subpopulations. Epidemiology 2014;25(6):843-850. https://doi.org/10.1097/EDE.0000000000000170
  23. Wendt JK, Symanski E, Stock TH, Chan W, Du XL. Association of short-term increases in ambient air pollution and timing of initial asthma diagnosis among Medicaid-enrolled children in a metropolitan area. Environ Res 2014;131:50-58. https://doi.org/10.1016/j.envres.2014.02.013
  24. Byers N, Ritchey M, Vaidyanathan A, Brandt AJ, Yip F. Short-term effects of ambient air pollutants on asthma-related emergency department visits in Indianapolis, Indiana, 2007-2011. J Asthma 2016;53(3):245-252. https://doi.org/10.3109/02770903.2015.1091006
  25. Gleason JA, Fagliano JA. Associations of daily pediatric asthma emergency department visits with air pollution in Newark, NJ: utilizing time-series and case-crossover study designs. J Asthma 2015;52(8):815-822.
  26. Strickland MJ, Hao H, Hu X, Chang HH, Darrow LA, Liu Y. Pediatric emergency visits and short-term changes in PM2.5 concentrations in the U.S. State of Georgia. Environ Health Perspect 2016;124(5):690-696.
  27. Alhanti BA, Chang HH, Winquist A, Mulholland JA, Darrow LA, Sarnat SE. Ambient air pollution and emergency department visits for asthma: a multi-city assessment of effect modification by age. J Expo Sci Environ Epidemiol 2016;26(2):180-188. https://doi.org/10.1038/jes.2015.57
  28. Weichenthal SA, Lavigne E, Evans GJ, Godri Pollitt KJ, Burnett RT. PM2.5 and emergency room visits for respiratory illness: effect modification by oxidative potential. Am J Respir Crit Care Med 2016. doi: http://dx.doi.org/10.1164/rccm.201512-2434OC.
  29. Lee SL, Wong WH, Lau YL. Association between air pollution and asthma admission among children in Hong Kong. Clin Exp Allergy 2006;36(9):1138-1146. https://doi.org/10.1111/j.1365-2222.2006.02555.x
  30. Ko FW, Tam W, Wong TW, Lai CK, Wong GW, Leung TF, et al. Effects of air pollution on asthma hospitalization rates in different age groups in Hong Kong. Clin Exp Allergy 2007;37(9): 1312-1319. https://doi.org/10.1111/j.1365-2222.2007.02791.x
  31. Jalaludin B, Khalaj B, Sheppeard V, Morgan G. Air pollution and ED visits for asthma in Australian children: a case-crossover analysis. Int Arch Occup Environ Health 2008;81(8):967-974. https://doi.org/10.1007/s00420-007-0290-0
  32. Hua J, Yin Y, Peng L, Du L, Geng F, Zhu L. Acute effects of black carbon and PM2.5 on children asthma admissions: a time-series study in a Chinese city. Sci Total Environ 2014;481:433-438. https://doi.org/10.1016/j.scitotenv.2014.02.070
  33. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7(3):177-188. https://doi.org/10.1016/0197-2456(86)90046-2
  34. Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, et al. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. Seoul: National Evidence-based Healthcare Collaborating Agency; 2011, p. 141-142 (Korean).
  35. Anderson HR, Atkinson RW, Peacock JL, Marston L, Konstantinou K. Meta-analysis of time-series studies and panel studies of particulate matter (PM) and ozone (O3): report of a WHO task group. Copenhagen: WHO Regional Office for Europe; 2004, p. 8.
  36. Ruana Y, Liangb R, Liana H, Zhaoa X, Liua X, Fan Z. Endothelial function and short-term exposure to particulate matter: a systematic review and meta-analysis. J Environ Anal Chem 2015; 2(5):159.
  37. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315 (7109):629-634. https://doi.org/10.1136/bmj.315.7109.629
  38. World Health Organization Regional Office for Europe. Effects of air pollution on children's health and development: a review of the evidence. Copenhagen: World Health Organization Regional Office for Europe; 2005, p. 12.
  39. Gavett SH, Koren HS. The role of particulate matter in exacerbation of atopic asthma. Int Arch Allergy Immunol 2001;124 (1-3):109-112. https://doi.org/10.1159/000053685
  40. Salam MT, Islam T, Gauderman WJ, Gilliland FD. Roles of arginase variants, atopy, and ozone in childhood asthma. J Allergy Clin Immunol 2009;123(3):596-602. https://doi.org/10.1016/j.jaci.2008.12.020
  41. North ML, Khanna N, Marsden PA, Grasemann H, Scott JA. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. Am J Physiol Lung Cell Mol Physiol 2009;296(6):L911-L920. https://doi.org/10.1152/ajplung.00025.2009
  42. North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, et al. Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. Respir Res 2011;12:19. https://doi.org/10.1186/1465-9921-12-19
  43. Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol 2006;117(1):119-126. https://doi.org/10.1016/j.jaci.2005.09.026
  44. Sarnat SE, Coull BA, Schwartz J, Gold DR, Suh HH. Factors affecting the association between ambient concentrations and personal exposures to particles and gases. Environ Health Perspect 2006;114(5):649-654.
  45. Lee PK, Brook JR, Dabek-Zlotorzynska E, Mabury SA. Identification of the major sources contributing to PM2.5 observed in Toronto. Environ Sci Technol 2003;37(21):4831-4840. https://doi.org/10.1021/es026473i
  46. Perrone MG, Gualtieri M, Ferrero L, Lo Porto C, Udisti R, Bolzacchini E, et al. Seasonal variations in chemical composition and in vitro biological effects of fine PM from Milan. Chemosphere 2010;78(11):1368-1377. https://doi.org/10.1016/j.chemosphere.2009.12.071
  47. Li X, Wang Y, Guo X, Wang Y. Seasonal variation and source apportionment of organic and inorganic compounds in PM2.5 and PM10 particulates in Beijing, China. J Environ Sci (China) 2013;25(4):741-750. https://doi.org/10.1016/S1001-0742(12)60121-1
  48. Pui DY, Chen SC, Zuo Z. PM2.5 in China: measurements, sources, visibility and health effects, and mitigation. Particuology 2014;13:1-26. https://doi.org/10.1016/j.partic.2013.11.001
  49. Lu F, Xu D, Cheng Y, Dong S, Guo C, Jiang X, et al. Systematic review and meta-analysis of the adverse health effects of ambient PM2.5 and PM10 pollution in the Chinese population. Environ Res 2015;136:196-204. https://doi.org/10.1016/j.envres.2014.06.029
  50. Franklin M, Zeka A, Schwartz J. Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. J Expo Sci Environ Epidemiol 2007;17(3):279-287. https://doi.org/10.1038/sj.jes.7500530
  51. Wong GW, Chow CM. Childhood asthma epidemiology: insights from comparative studies of rural and urban populations. Pediatr Pulmonol 2008;43(2):107-116. https://doi.org/10.1002/ppul.20755
  52. Schröder PC, Li J, Wong GW, Schaub B. The rural-urban enigma of allergy: what can we learn from studies around the world? Pediatr Allergy Immunol 2015;26(2):95-102. https://doi.org/10.1111/pai.12341
  53. Seong SC, Son MS. National health insurance statistical yearbook 2014. Seoul: Korean Health Insurance Review & Assessment Service; 2015, p. 470-473 (Korean).

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