• 대한치과의사협회지
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• 제56권1호
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• pp.18-40
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• 2018

Meta-analysis is a statistical method that combines the results of individual studies on the same topic. This method is becoming popular, due to providing the combined result that individual studies cannot provide and giving a more precise result. Despite meta-analysis having such significance, there were few Korean guides for the use of the Review Manager (RevMan) software. This study will provide a step-by-step guide, using orthodontic mini-screw as a dental example, to help researcher carry out meta-analysis more easily and accurately.

• 한국운동역학회지
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• 제30권1호
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• pp.63-72
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• 2020

Objective: The purpose of this study was to investigate meta-analysis on the effects of exercise therapy and physiotherapy on pain in korean patients with chronic low back pain. Method: Meta-analysis was performed on the type and method of treatment. A total of 23 experimental studies were coding into 31 individual studies, into types, methods, visual analogue scale (VAS), each pre/post value of the effect size was calculated by meta-analysis. Results: Sling exercise, stretching, thermal therapy, kinesio-taping, lumbar stabilization exercise, electrotherapy is large effect size (ES ≥ .08). In addition, big effects occurred in order of treatment period is more than 9 weeks, three times a week. Conclusion: Our results indicated that persistent treatment of chronic back pain is the most effective method of self-sufficiency rather than temporary relief.

• 한국응급구조학회지
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• 제23권2호
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• pp.33-42
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• 2019

Purpose: This study aimed to identify the effects of post-traumatic stress disorder intervention programs on firefighters through a meta-analysis. Methods: Seven studies were selected for meta-analysis. The overall average effect size, effect sizes for each intervention variables, and publication bias were analyzed using Comprehensive Meta-Analysis(CMA) version 2.0 (Biostat, Englewood, NJ, USA). Results: Post-traumatic stress disorder intervention programs were found to have a very low, not statistically significant effect (effect size=-.171, confidence interval=-0.361~0.019, Z=-1.768, p>.05). However, these programs was less than 50 (effect size=-.622). Conclusion: The results of this study suggest that further research on the effects of post-traumatic stress disorder intervention among firefighters is needed in order to develop more effective programs.

• Clinical and Experimental Pediatrics
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• 제64권12호
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• pp.642-651
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• 2021

Background: Infantile colic (IC) is excessive crying in otherwise healthy children. Despite vast research efforts, its etiology remains unknown. Purpose: Most treatments for IC carry various side effects. The collection of evidence may inform researchers of new strategies for the management and treatment of IC as well as new clues for understanding its pathogenesis. This review and meta-analysis aimed to evaluate the efficacy and possible mechanisms of probiotics for mananaging IC. Methods: Ten papers met the study inclusion and exclusion criteria, and the meta-analysis was conducted using Review Manager (RevMan) software and a random-effects model. Results: This meta-analysis revealed that probiotics are effective for treating infantile colic, while the review showed that this efficacy may be due to their anti-inflammatory effects. Conclusion: Probiotics may be an important treatment option for managing infantile colic due to their anti-inflammatory properties.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10175-10179
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• 2015

Background: The association between the RTEL1 rs6010620 single nucleotide polymorphism (SNP) and glioma risk has been extensively studied. However, the results remain inconclusive. To further examine this association, we performed a meta-analysis. Materials and Methods: A computerized search of the PubMed and Embase databases for publications regarding the RTEL1 rs6010620 polymorphism and glioma cancer risk was performed. Genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analyses, tests of heterogeneity, cumulative meta-analyses, and assessments of bias were performed in our meta-analysis. Results: Our meta-analysis confirmed that risk with allele A is lower than with allele G for glioma. The A allele of rs6010620 in RTEL1 decreased the risk of developing glioma in the 12 case-control studies for all genetic models: the allele model (OR=0.752, 95%CI: 0.715-0.792), the dominant model (OR=0.729, 95%CI: 0.685-0.776), the recessive model (OR=0.647, 95%CI: 0.569-0.734), the homozygote comparison (OR=0.528, 95%CI: 0.456-0.612), and the heterozygote comparison (OR=0.761, 95%CI: 0.713-0.812). Conclusions: In all genetic models, the association between the RTEL1 rs6010620 polymorphism and glioma risk was significant. This meta-analysis suggests that the RTEL1 rs6010620 polymorphism may be a risk factor for glioma. Further functional studies evaluating this polymorphism and glioma risk are warranted.

• 응용통계연구
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• 제33권4호
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• pp.439-449
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• 2020

메타 분석은 여러 연구 결과들을 종합시켜주는 분석 방법 중 하나이다. 이 때 수집되는 연구 문헌들은 소규모 연구인 경우 통계적으로 유의한 결과를 보이는 연구가 출간될 확률이 높기 때문에, 선택 편향의 특수한 경우인 출판 편향이 종종 발생한다. 선택 편향을 보정하는 방법에는 조건부 가능도와 가중 추정 방정식이 있는데 이 방법들은 실제 얻기 힘든 정확한 선택 확률 모형을 필요로한다. 반면 쌍별 유사가능도 접근법은 선택 확률 모형을 정확히 알 수 없는 경우에도 선택 편향을 보정할 수 있는 방법으로 제안되었다. 본 논문은 메타분석에서 쌍별 유사가능도 접근법의 성능과 문제점을 수치적으로 연구한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3717-3721
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• 2012

Purpose: Any association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk remains inconclusive. For a more precise estimate, we performed the present meta-analysis. Methods: PUBMED, OVID and EMBASE were searched for the studies which met inclusion criteria. Data in all eligible studies were evaluated and extracted by two authors independently. The meta-analysis estimated pooled odds ratio (OR) with 95% confidence interval (CI) for endometrial cancer risk attributable to the CYP1A1 Ile462Val polymorphism. Results: A total of 7 studies were included in this meta-analysis. The results indicated no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism (for Val vs Ile allele model [OR 1.09, 95% CI 0.73-1.62]; for Val.Val vs Ile.Ile genotype model [OR 1.54, 95% CI 0.56-4.23]; for (Ile.Val + Val.Val) vs Ile.Ile genotpye model [OR 1.08, 95% CI 0.71-1.63]; for Val.Val vs (Ile.Ile + Ile.Val) genotype model [OR 1.46, 95% CI 0.53-4.04]). Conclusions: This meta-analysis suggests that there is no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4733-4737
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• 2013

Purpose: Numerous observational epidemiological studies have evaluated associations between breastfeeding and the risk of childhood Hodgkin lymphoma; however, the existing results are inconsistent. We therefore conducted a systematic review and meta-analysis. Methods: Medical literature was searched in the Pubmed and Embase databases to identify all English-language relevant studies up to April 10, 2013. Reference lists were thereafter hand-searched for additional articles. Studies that reported relative risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were included. This meta-analysis was conducted in accordance with the guidelines for the meta-analysis of observational studies in epidemiology. Results: We finally included 10 case-control studies in our meta-analysis, involving 1,618 childhood Hodgkin lymphoma cases and 8,181 controls. Overall, we did found a borderline significant association between breastfeeding and reduced risk of childhood Hodgkin lymphoma comparing ever breastfed children to never breastfed children (pooled OR =0.79; 95%CI, 0.58-1.08; P=0.13), with limited evidence for between-study heterogeneity (P =0.12, $I^2$ = 35.70%). Conclusion: There is limited evidence for an inverse association between breastfeeding and risk of childhood Hodgkin lymphoma.

• 한국운동역학회지
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• 제32권2호
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• pp.56-68
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• 2022

Objective: The purpose of this systematic review and meta-analysis was to investigate potential effects of HRT (hormone replacement therapy) on motor functions in postmenopausal women. Method: In this meta-analysis, 19 studies that examined changes in motor functions between postmenopausal women with and without HRT intervention were qualified. We additionally conducted moderator variable analyses including: (1) motor function type, (2) hormone type, and (3) duration of HRT intervention. Results: The random effects model showed no significant overall effects (SMD = 0.199; SE = 0.115; 95% CI = -0.026~0.425; Z = 1.730; p = 0.084; I² = 93.258%). Additional three moderator variable analyses revealed no significant effect sizes indicating that specific HRT protocols did not improve different motor functions in postmenopausal women. Conclusion: These meta-analytic findings suggest that HRT had no positive effects on motor functions in postmenopausal women.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.515-527
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• 2003

Objectives： A meta-analysis of the literatures was conducted to evaluate the cost-effectiveness of medical nutrition therapy by dietitians. Methods : The 30 studies were identified from a computerized search of published research on MEDLINE, Science-Direct and the PQD database until May, 2002 and a review of reference lists. The main search terms were“dietitian”,“dietary intervention”,“nutrition intervention”, “cost”,“cost-effectiveness”and“cost-benefit analysis”. The subgroup analysis was performed by publication year, study design, intervention provider, type of patient (in/out-patient) and type of cost (total cost/direct cost). Two reviewers independently selected trials for inclusion, assessed the quality and extracted the data. Results : The 30 studies were identified using the electric database search and bibliographies. The 17 trials were eligible for inclusion criteria, then the systematic review and a meta-analysis were conducted on effectiveness and cost-effectiveness of medical nutrition therapy. The quality of the studies was evaluated using the quality assessment tool for observational studies. The quality score was 0.515 $\pm$ 0.121 (range : 0.279-0.711, median : 0.466). The meta-analysis of 17 studies based on the random effect model showed that medical nutrition therapy was highly effective in treating the diseases (effect size 0.3092 : 95% confidence interval 0.2282-0.3303). The vote-counting method, one of meta-analysis methods, was applied to evaluate the cost-effectiveness of medical nutrition therapy conducted by dietitians. Two criteria (method 1, method 2) for voting were used. The calculated p-values for method 1 (more conservative method) and method 2 (less conservative method) were 0.1250 and 0.0106, respectively. Medical nutrition therapy by dietitians was significantly cost-effective in the method 2. Conclusion. This meta-analysis showed that the effectiveness of medical nutrition therapy was statistically significant in treating disease (effect size 0.3092), and that the cost-effectiveness of medical nutrition therapy was statistically significant in the method 2 (less conservative method) of vote counting. (Korean J Nutrition 36(5): 515~527, 2003)