• 대한임상검사과학회지
• /
• 제51권4호
• /
• pp.468-474
• /
• 2019

뇌심부자극술은 뇌심부핵에 고주파 전기자극을 전달하여 약물 불응성 이상운동질환을 치료하는 효과적인 방법이다. 그리고 미세전극기록은 뇌심부자극 수술 중에 MRI와 함께 뇌심부핵의 위치를 정확히 파악하여 수술 결과를 향상시키고 부작용을 최소화 할 수 있는 보조적인 검사이다. 본 논문의 목적은 이상운동질환에 대한 뇌심부자극 수술 중에 실시한 미세전극기록을 분석하여 신경생리학적 파형과 유용성을 알아보고자 하였다. 2018년 1월부터 12월까지 이상운동질환에 대한 뇌심부자극 수술 중에 미세전극기록를 실시한 환자 대상으로 후향적 조사를 하였다. 총 28명의 환자 중에 시상하핵은 38 개의 MER, 내측 담창구는 10개의 MER, 복내측 시상핵은 4개의 MER을 실시했다. 모두 목표지점을 찾았고 미세자극을 이용해서 부작용의 여부를 확인하고 목표지점을 재조정하였다. 수술 후 총 28명의 환자에서 모두 임상 증상은 호전되었다. 결론적으로. 미세전극기록은 신경생리학적 파형을 이용해서 MRI와 함께 정확한 뇌심부핵 부위를 파악해서 이상운동질환에 대한 뇌심부자극 수술 결과를 향상시키고 부작용을 최소화할 수 있는 유용한 검사이다.

• Journal of Preventive Medicine and Public Health
• /
• 제49권1호
• /
• pp.1-17
• /
• 2016

The Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea in 2015 has drawn public attention regarding the legal regulation of infectious disease control in Korea. This paper discusses the interpretive and legislative concerns regarding the Infectious Disease Prevention and Control Act, its ordinance and enforcement regulations, as well as public statements from the relevant administrative agency. Future improvements are also proposed.

• 한국재난정보학회:학술대회논문집
• /
• 한국재난정보학회 2015년 정기학술대회
• /
• pp.298-299
• /
• 2015

본 논문은 2013년 5월 국제바이러스 분류 위원회에서 중동호흡기증후군을 일으키는 신종 코로나바이러스를 메르스코로나바이러스(MERS-CoV)라 명명한 후, 2015년 5월 국내에 감염자가 들어와 이후 확산되고, 중동 호흡기 증후군 환자 발생 후 국내 첫 사망자가 발생한 일개 병원 지역응급의료센터 내원 후 확산을 막기 위하여 시행하였던 경험들을 공유하고자 한 내용이다.

• Molecules and Cells
• /
• 제43권11호
• /
• pp.953-963
• /
• 2020

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious disease with multiple severe symptoms, such as fever over 37.5℃, cough, dyspnea, and pneumonia. In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, and hsa-miR-196a-1-3p) were found to commonly bind to SARS-CoV, MERS-CoV, and SARS-CoV-2. We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. Especially, hsa-miR-15b-5p and hsa-miR-195-5p showed a large difference in expression, indicating that they may potentially be diagnostic biomarkers for SARS-CoV-2 infection.

• Journal of the Korean Data and Information Science Society
• /
• 제28권1호
• /
• pp.153-161
• /
• 2017

전염병 확산에 대한 확률과정모형으로 활용되는 분기과정은 실제 데이터를 통해 모수를 추정할 수 있다는 장점이 있다. 음이항 분포를 분기과정의 생산 분포 모형으로 적용할 수 있는데 음이항 분포를 적용하기 위해서는 평균과 산포 모수를 추정하여야한다. 기존의 생물학 연구와 역학 연구 분야에서는 이를 최대우도법을 이용하여 추정하고 있다. 그러나 대부분의 역학 자료의 특성상 분기과정에서 이용되는 음이항 분포는 소표본이어서 최대우도 추정량의 정도를 충족시킬 수 없다. 본 논문에서는 소표본 자료에서 좋은 통계량의 성질을 만족한다고 알려져 있는 베이지안을 이용하여 모수를 추정하는 방법을 제안한다. 2015년 국내 메르스 사례에 베이지안 방법을 적용하여 모수를 추정하고 사후 분포를 적합하였다. 그 결과 어떠한 사전 분포를 가정하더라도 안정적으로 모수를 추정하는 것을 알 수 있었다. 추정된 산포 모수를 이용하여 분기과정에서의 전염병 소멸 확률을 유도하였다.

• 한국직업건강간호학회지
• /
• 제27권2호
• /
• pp.77-88
• /
• 2018

Purpose: This study aimed to investigate the degree of role conflict and its ambiguity, and fatigue in clinical nurses and to analyze the effect of these on their self-resilience in order to provide fundamental data for improving their working environment after the Middle East Respiratory Syndrome outbreak. Methods: After the collection of data from 258 clinical nurses in five general hospitals, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression were performed using IBM SPSS Statistics 20.0. Results: A significant positive correlation was found between nurses' role conflict and ambiguity and fatigue; while a negative correlation was found between nurses' role conflict and ambiguity and self-resilience. A significant negative correlation was found between fatigue and self-resilience. According to the study results, the factor that affected clinical nurses' self-resilience the most was role conflict and its ambiguity, followed by marital status, fatigue, educational level, religion, and related tasks, which together accounted for 38% of self-resilience in clinical nurses. Conclusion: To improve weaknesses in nursing care after the Middle East Respiratory Syndrome outbreak, the scope of nursing care was changed upon the expansion of integrated nursing and care-giving services. Therefore, in the rapidly changing environment of nursing, policies to improve nursing performance, as well as successful reaction capability, are suggested.

• 동의생리병리학회지
• /
• 제30권1호
• /
• pp.1-6
• /
• 2016

In recent years, there were frequent exogenous contagious diseases in Eastasia like SARS(severe acute respiratory syndrome), Avian influenza, Swine influenza, MERS etc. But there are various interpretations about their pathological differentiations and lead to controversy to diagnosis and medicinal use. So there needs universal and consistent understanding methods. Several conclusions are obtained from the research on differentiation theories of various epidemic diseases. Essential elements of differential diagnostic system are pathogen, characters and matters of disease and loci, especially three yin and three yang has close affinity with constitutional features or body shape. Binding these 3 categories, an integrated differentiation 3 dimensional coordinates are made. Out of these, each elements of 3 pathogen-axial lines are related with names of exogenous disease, and those of 3 feature-axial lines are related with 8 principal patterns. And those of 3 locus-axial lines implicating therapeutic method are related with steps and location of exterior and interior, 3 yin 3 yang, Defense, Qi, Nutrient and Blood, five viscera and six bowels and tissues. Additionally, 3 lines of each axis consist of factors which have their own affinity each other, so classification of pathogen, feature, locus of disease has layered interconnectedness. This classification system is included in constitutional features of individual patient. Afterwards, these cognitive structure can be used as a general theory guiding method of therapy, prevention and aftercure healthcare.

• 산업융합연구
• /
• 제18권6호
• /
• pp.9-17
• /
• 2020

COVID 19로 인해 전세계적으로 많은 팬데믹 현상이 일어나고 있다. 2020년 1월 이후 전세계적으로 확진자가 큰 폭으로 상승을 하고 잇으며, 각국의 의료시스템이 마비가 되고 있다. 한국은 선제적으로 잘 대응을 하여 K-방역이라는 명칭에 걸맞게 잘 대처를 하고 있다. 그러나 아직까지 법률과 행정적인 한계점에 대한 인식이 부족하다고 할 수 있다. 이에 본 연구에서는 현행 감염병 예방 및 관리체계에 대하여 형사정책적인 관점에서 "감염병의 예방 및 관리에 관한 법률"을 중심으로 우리 법제의 문제점 및 한계를 검토하고, 주요 국가에서의 제도와의 비교･분석을 통해, 감염병 예방 및 관리를 위한 효과적이고 실효적인 형사정책적 대응방안을 제시하고자 한다.

• International Journal of Knowledge Content Development & Technology
• /
• 제11권4호
• /
• pp.101-111
• /
• 2021

The world is going through the most unprecedented time with the outbreak of novel Coronavirus disease (COVID-19), which has become a threat to millions. A Coronavirus is a group of viruses that cause a variety of diseases in mammals and birds leading to a range of illnesses in humans including common cold and more severe forms like severe acute respiratory syndrome Coronavirus (SARS-CoV), Middle East respiratory syndrome Coronavirus (MERS-CoV) and COVID-19, which are life-threatening. The virus gets its name from its shape which takes the form of a crown with protrusions around it. In December 2019, a pneumonia outbreak was reported in the Wuhan City of China, which was later traced to a novel strain of Coronavirus and termed as Novel COVID-19. It typically causes flu-like symptoms including fever, cough and shortness of breath and is transmitted through human-to-human and there is no cure for it till now. Thus, this bibliometric study has been carried out to analyze the research progress in Coronavirus and literature published during a period of 30 years (1989-2019). Data for the study were fetched from Web of Science(WoS) multidisciplinary database and the publication trends in terms of total articles, productive countries, institutions, journals, productive authors, most cited articles and authors, etc have been analyzed. In total, 4917 articles were retrieved; these were from 711 sources and were contributed by 14442 authors. The collaboration index was 3.11, which clearly indicates that there has been a lot of collaboration in this field. The most preferred journal for the study period was "Journal of Virology" and the maximum contribution has been from the University of Hong Kong.

• IMMUNE NETWORK
• /
• 제21권1호
• /
• pp.11.1-11.10
• /
• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.