• 약학회지
• /
• 제36권1호
• /
• pp.56-65
• /
• 1992

The present study examined the effects of carbon monoxide (CO) intoxication and aging on learning and memory deficit in young($5{\sim}8$ weeks) and aged($52{\sim}66$ weeks) mice, using the step down and step through passive avoidance failure techniques. We also investigated the effects of ginseng saponins on memory deficit. Significant decrease in memory registration, retention and retrieval function in young mice and decrease in memory registration and retention function in aged mice were observed. Normal young mice were apt to perform to a great degree of passive avoidance response than normal aged mice, but there was no difference between both groups by CO exposure. Administration of ginseng saponins showed an improvement on passive avoidance failure induced by CO exposure.

• 생명과학회지
• /
• 제9권5호
• /
• pp.548-555
• /
• 1999

Long-term effects of Ganoderma lucidum (GL) on memory and oxidative stress of senescence-accelerated mice (SAM) were investigated. Senescence-resistant (R1) and prone (P8) strains of SAM were fed GL diets, premixed with low (20 mg/kg/day, T1) or high (200 mg/kg/day, T2) levels of GL powder for 9 months starting from young (3 months of age) or for 5 months starting from old (7 months of age). After the final feeding at 12 months of age, all animals were subjected to passive avoidance test for the evaluation of memory function. In addition, the changes in hepatic thiobarbituric acid-reactive substance (TBARS) and glutathione were analyzed. SAMP8 fed GL diets from old age (7 months) exhibited the improvement of memory, although GL rather inhibited the memory function of both SAMR1 and SAMP8 mice fed diets from young (3 months of age). Hepatic TBARS contents were decreased in SAMP8 fed high GL diet for 9 months and in SAMR1 fed low GL diet for 5 months. Hepatic glutathione content was also remarkably increased in SAMR1 following both feeding periods, and less extent in SAMP8 fed diet for 5 months of age. Taken together, it is proposed that GL extracts may play an anti-aging role through antioxidant action, and thereby may improve the senescence-related memory dysfunction.

• 한국멀티미디어학회논문지
• /
• 제18권11호
• /
• pp.1367-1374
• /
• 2015

In this paper, we propose a model which can prioritize the performance improvement work by analyzing the major risks and their influence, which can cause performance degradation in the system and show an example of a performance improvement using this model. In presentation-tier, as a result of log data analysis before and after the performance improvement of key processes which handle financial transactions, this model brought the CPU utilization and memory enhancement in the performance improvement work of the financial system which was carried out by applying the proposed model. It has been confirmed that the entire end-user can be accommodated. In the web-tier, the available memory increased by 200MB and we were able to improve the server restart(Recycling) that was sustained in the existing system. In the business logic-tier, we have been able to see better figures after performance improvements through the graph which analyzes the log collected with the key performance counters such as CPU%, Batch Requests/sec. In the data-tier, it has been confirmed that CPU usage and standby operation were reduced and the throughput was found to increase.

• Clinical Psychopharmacology and Neuroscience
• /
• 제16권4호
• /
• pp.461-468
• /
• 2018

Objective: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants. Methods: This study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores. Results: All PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement. Conclusion: Cognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제28권2호
• /
• pp.106-114
• /
• 2017

Objectives: This study was to examine the effectiveness of computerized cognitive ability enhancement program (CCAEP) using Smarttoy. The CCAEP using Smart-toy which can interact with children via bluetooth is a kids-friendly and convenient method for improving children's cognitive abilities by increasing their motivation for performing the program. We developed the CCAEP which designed to train auditory-verbal memory, visual-spatial memory, auditory-verbal working memory, and visual-spatial working memory. Methods: Eighteen children aged 8 to 10 participated in CCAEP individual training composed of 8 sessions of 40 minutes each for 4 weeks. The effect of the training was measured with Smart Toyweb's cognitive assessment tasks (smart device based assessment) as well as traditional neuropsychological tests before and after the training. Results: Children showed significant improvement in auditory-verbal memory, visual-spatial memory, auditory-verbal working memory and visual-spatial working memory abilities after the training. Conclusion: This study demonstrated promising results suggesting the effectiveness of CCAEP using Smart-Toy in clinical settings as well as school and home situations. Further controlled study with larger sample size including various clinical groups is needed to confirm the present results.

• 재활간호학회지
• /
• 제5권2호
• /
• pp.205-216
• /
• 2002

This quasi-experimental study was done to test the effects of meta-memory enhancing program for elderly women. Data were collected 12 to 30, August 2002 from 34elderly women over 65 years living in Busan city. Subjects were 15 of experimental group and 19 of control group. The metamemory enhancing program was developed by five sessions composing of 1.5-2.0 hours one session. In experiment group, this program was performed for three weeks, twice per week. The degrees of four memory performance tasks were measured using instrument of Elderly Verbal Learning Test(Choi Kyung Mi, 1988) and Face Recognition Instrument(Min Hye Sook, 1999) and the metamemory were measured using MIA questionnaire(Dixon et al., 1988). Research results are as following. 1. After participating in five times memory training programs, experimental group has the significant increase of metamemory in comparison with control group.(t=59.58, p< 0.0001). In particular, the concepts of strategy(t=20.44, p< 0.0001), achievement (t=21.94, p< 0.0001), and locus degree (t=59.58, p< 0.0001) among sub-concepts of the metamemory are increasing significantly. 2. After participating in five time memory training programs, the degree of immediate word recall(t=17.25, p< 0.0001) and face recognition(t=16.69, p< 0.0001) among four memory tasks in experimental group are increasing significantly compared with those measures of control group. Considering this results, this metamemory enhancing program was found as an effective nursing program for metamemory improvement of elderly women's memory.

• 한국정보과학회논문지:시스템및이론
• /
• 제33권11호
• /
• pp.810-819
• /
• 2006

본 논문에서는 네트워크 통신에서 혼잡으로 인한 패킷의 손실을 최소화하기 위하여 새로운 버퍼 모델인 적응적인 이중 버퍼 모델을 제안한다. 이는 제약된 메모리 환경에서 송수신 버퍼가 서로의 여유 공간을 공유하여 패킷의 손실을 최대한 줄일 수 있는 버퍼 모델이다. 또한 리스트와 비슷한 성능을 지니는 본 버퍼 모델은 자유 리스트를 사용한 버퍼와 달리 메모리 누수로 인한 버블(bubbles) 현상을 방지하므로 제한된 환경의 네트워크 버퍼에 적용할 수 있으며 배열을 사용하는 경우와 비교 할 때 최대 100% 성능 향상을 기대할 수 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제28권2호
• /
• pp.123-131
• /
• 2017

Objectives: Executive dysfunction including working memory deficit has been suggested to be one of the major neuropsychological etiologies of attention-deficit hyperactivity disorder (ADHD). The purpose of this study was to investigate the augmentative effects of Cogmed working memory training on the symptoms and neurocognitive functions in medicated children and adolescents with ADHD. Methods: Twenty-five children with ADHD, aged 7 to 19 years, taking ADHD medication participated in this study. The participants were trained for 5 weeks with a commercially available and computerized working memory program ($Cogmed^{(R)}$) without any changes to their medication. The Korean version of the ADHD Rating Scale, Clinical Global Impression Scale, and Comprehensive Attention Test were administered before training and 4 weeks and 7 months after training, respectively. Results: After completing the training, the clinical symptoms and function, rated by the parents and clinician, were improved. In addition, the level of commission errors was significantly reduced in the selective attention (visual/auditory) task, sustained attention to response task, and flanker task. The untrained visuospatial short-term memory and working memory were also improved. These effects were still observed 7 months after the training. Conclusion: Cogmed working memory training can be a promising training option for the additional improvement of the symptoms and deficits in working memory and response inhibition in medicated children with ADHD.

• 전자공학회논문지
• /
• 제51권4호
• /
• pp.33-41
• /
• 2014

본 논문에서는 모바일 시스템 환경에서 멀티포트 메모리 컨트롤러의 특성을 고려한 직접 메모리 접근 컨트롤러를 사용하여 고속 데이터 전송을 효과적으로 수행하는 메모리 액세스 방법을 보인다. 제안된 직접 메모리 접근 컨트롤러는 여러 개의 직접 메모리 접근 채널을 제어 할 수 있는 통합 채널 관리 기능을 제공하며, 그 채널들은 물리적으로 분리되어 서로 독립적으로 동작한다. 제안된 직접 메모리 접근 방법을 통한 데이터 전송을 이용함으로써 읽기 동작에 대하여 72%, 쓰기 동작에 대하여 69%의 데이터 전송 성능 향상을 얻었다. 특히, 4 채널 접근 모드에 대해서 제안된 방법이 기존 직접 메모리 접근 방법에 비하여 63% 적은 전체 전송 사이클을 가짐으로써 전송 성능 향상에 기여할 수 있음을 보인다.

• 품질경영학회지
• /
• 제30권1호
• /
• pp.162-171
• /
• 2002

A practical algorithm of generating most probable states in decreasing order of probability, given the probability of each unit\`s state, is suggested for approximating reliability(performability) evaluation of a network with multistate(multimode) units. Method of approximating network reliability for a given measure with most probable states is illustrated with a numerical example. The proposed method in this paper is compared with the previous method regarding memory requirement. Our method has some advantages for computation and achieves improvement with regard to memory requirement for a certain condition judging from the computation experiment.