• 한국노년학
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• v.36 no.4
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• pp.1109-1124
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• 2016

We examined the effect of stereotype threat (STT) on spatial working memory and facial emotion recognition in Korean elderly. In addition, we investigated the role of expected moderator such as self-perception of aging. Seventeen seniors (male=7) received basic cognitive tests including K-WMS-IV, MMSE and answered self-report questionnaires including self-perception of aging, anxiety of aging, attitude toward aging and age identity on the first visit. On the second visit, they were exposed to negative stereotype by reading a script detailing cognitive decline related to aging while a control group was exposed to a neutral content. Following the exposure, they were tested on a spatial-working memory task (Corsi-block tapping task) and emotion recognition task (facial expression identification task). The results showed that the seniors exposed to STT showed significantly lower performance on emotion recognition task (p < .05) (i.e., especially on the more difficult facial stimuli). In addition, there was a significant interaction between STT and self-perception of aging (p< .05), indicating that those who have positive self-perception of aging did not show impairment in emotion recognition task and difficult spatial working memory task under STT. On the other hand, those with negative self-perception of aging showed impaired performance under STT. Taken together, the current study suggests that being exposed to STT could negatively influence cognitive and emotional functioning of elderly. Interestingly, having a positive self-perception of aging could protect the underperformance caused by STT.

• Research in Community and Public Health Nursing
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• v.9 no.2
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• pp.336-349
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• 1998

The purpose of this study was to test the effects of music therapy on cognitive function and depression in demented old adults. This study was made with one -group in a pre- and post-test design. The subjects were seven demented old adults over, sixty-five years and with mild to moderate cognitive impairment, residing at a nursing home. Music therapy was given by one researcher and one research assistant for thirty to forty minutes twice a week for 4 months. Music therapy was conducted with the subjects both listening and singing with a cassette player and a double-handed drum. In order to evaluate the effects of music, we measured the level of cognitive function and depression at the beginning and at the end of the music therapy session by means of an MMSE- K developed by Kwon and Park and the Depression Inventory developed by Chon. The Data were analyzed using descriptive statistics and a paired t - test analysis using a SPSS PC package. The results are as follows: 1) The subjects of the music therapy showed improvement in cognitive function. The MMSE-K score was significantly increased after music therapy. Especially, memory recall was very significantly. 2) The subjects of the music therapy showed a slight decrease in depression. However, there was no significant difference in the degree of depression between mean scores measured before and after music therapy. The results suggest that music therapy is effective in improving and maintaining cognitive function in demented old adults. And we suggest that long-term music therapy will be required to improve depression in demented old adults. These findings are encouraging the idea that music therapy may improve cognitive impairment.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.1037-1045
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• 2003

Objectives: Dementia is a kind of chronic, progressive, degenerative disease. The symptoms results in troubles in intellectual functions. memory, orientation, intelligence, judgement, common sense and calculating ability. The Korean version of Mini-Mental State Examination(MMSE-K) has been used widely to screen cognitive impairment of the elderly in Korea. This instrument has been specifically developed and evaluated for the assessment of cognitive function in older Korean populations. Methods: Cognitive function was evaluated by the Korean version of Mini-Mental State Examination(MMSE-K). This patient was diagnosed as Vascular dementia and We treated her cognitive impairment with Gagambosim-tang(Jiajianbuxin-tang). Results: After treated with Gagambosim-tang(Jiajianbuxin-tang), Cognitive function was improved. Conclusion: This report may have a meaning to treat Vascular dementia.

• Korean Journal of Psychosomatic Medicine
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• v.10 no.1
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• pp.55-60
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• 2002

Central pontine myelinolysis(CPM) and Extrapontine myelinolysis(EPM) are uncommon neurologic disorders associated with osmotic inequality between the extracellular fluid compartment and intracellular fluid compartment in the brain. Myelinolysis can occur in hyponatremia and after rapid correction of hyponatremia. It may be caused by various metabolic disturbances such as chronic alcoholism, malnourishment, cancer, chronic renal failure and organ transplantation. The authors reported a 43-year-old male patient who have received a kidney transplantation because of chronic renal failure due to diabetic nephropathy. The patient manifested psychotic symptoms such as delusion, loosened association, hallucination, inappropriate affect and aggressiveness as a sequele of CPM and EPM. He also showed neurocognitive impairment such as disorientation, memory impairment, decresed intelligence and aphasia. These manifestations are rare in CPM and EPM. We discuss the clinical features, diagnosis, course and management of the patient which may be clinically significant in the neuropsychiatric aspect especially at the consultation-liaison field.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.307-312
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• 2016

Alzheimer's disease is the most common degenerative brain diseases that causes dementia. ${\beta}$-amyloid neuritic plaque density that accumulates in the brain is difficult to perform daily living, such as memory loss, language ability deterioration. It is used to estimate ${\beta}$-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive impairment. Using the $^{18}F$-Florbetaben with high sensitivity and specificity for the ${\beta}$-amyloid neuritic plaque density to evaluate the usefulness for the early diagnosis of Alzheimer's disease. In $^{18}F$-FDG Brain imaging shows no specific findings. And it appeared on the MR-Brain imaging without atrophy of the hippocampus. However, the intake of ${\beta}$-amyloid neuritic plaque density in $^{18}F$-Florbetaben informs that it is the progress of Alzheimer's disease. Therefore, $^{18}F$-Florobetaben is very useful for early diagnosis of Alzheimer's disease.

• Korean Journal of Biological Psychiatry
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• v.9 no.2
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• pp.103-111
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• 2002

Neurocognitive research focusing on cognitive deficits in Depression has resulted in several important but yet potentially contradictory findings. Much literature documents the presence of significant neurocognitive impairments in depressive patients. Studies have shown that dysthymic disorder patients demonstrate a diffuse pattern of cognitive impairment which is frequently indistinguishable from that of focal braindamaged patients. Some reports have suggested that there is a focal pattern of deficit, such as anterior cingulate dysfunction, frontal lobe impairment, or dysfunction of the temporal-limbic cortex. The aim of this study is to evaluate the neurocognitive functions in dysthymic disorder patients, and to compare the functions with those of major depressive disorder patients. The subjects are 17 dysthymic disorder patients. And their neurocognitive functions are compared with those of 23 major depressive episode patients. Patients with a history of neurologic disease, alcohol dependence, substance abuse and mental retardation are excluded. They are assessed with a part of Vienna Test System which is computerized neurocognitive function tests and can evaluate attention, eductive ability, reproductive ability, visuoperceptual analysis, vigilance, visual immediate memory, the speed of information-processing, judgement, and fine motor coordinations. There are no other specific difference between two groups, except the result of cognitrone test. This study provides information about the neurocognitive functions and some difference between major depressive disorder patients and carefully diagnosed dysthymic disorder patients.

• Journal of Microbiology and Biotechnology
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• v.22 no.5
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• pp.708-720
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• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.920-928
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• 2019

Objectives: After epidural hemorrhage, sequelae may cause cognitive impairments, such as attention, memory, and performance disturbances. This case study reports on the use of traditional Korean medicine in a patient with cognitive impairments after a traumatic epidural hemorrhage. Methods: During the 46-day hospitalization period, traditional Korean medicine treatments, including Sunkihwalhyul-tang-gamibang, Ukgan-san-gajinpibanha Granule, Kyungohk-go, acupuncture, and cupping, were administered. The degree of cognitive impairment was measured based on the Mini Mental State Examination-Korea (MMSE-K), Modified Barthel Index (MBI), and correct answer ratio. Results: After traditional Korean medicine treatment, the MMSE-K score increased from 13 to 19 and the MBI score increased from 63 to 71. The patient's conversations in daily life also proceeded more smoothly than before hospitalization, and the correct answer ratio rose. Conclusion: This case reports the improvement of cognitive impairment after traumatic epidural hemorrhage in response to traditional Korean medicine treatment; further study is needed.

• Journal of Microbiology and Biotechnology
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• v.31 no.1
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• pp.51-62
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• 2021

Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in Lactobacillus reuteri strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPS-induced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated-JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3-O-arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3-O-apiosyl(1 → 2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.47-57
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• 2022

Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models of epilepsy. The objective of the present study was to investigate effects of post-treatment with stiripentol on cognitive deficit and neuronal damage in the cornu ammonis 1 (CA1) region of the hippocampus proper following transient ischemia in the forebrain of gerbils. To evaluate ischemia-induced cognitive impairments, passive avoidance test and 8-arm radial maze test were performed. It was found that post-treatment with stiripentol at 20 mg/kg, but not 10 or 15 mg/kg, reduced ischemia-induced memory impairment. Transient ischemia-induced neuronal death in the CA1 region was also significantly attenuated only by 20 mg/kg stiripentol treatment after transient ischemia. In addition, 20 mg/kg stiripentol treatment significantly decreased ischemia-induced astrocyte damage and immunoglobulin G leakage. In brief, stiripentol treatment after transient ischemia ameliorated transient ischemia-induced cognitive impairment in gerbils, showing that pyramidal neurons were protected and astrocyte damage and blood brain barrier leakage were significantly attenuated in the hippocampus. Results of this study suggest stiripentol can be developed as a candidate of therapeutic drug for ischemic stroke.