• 혜화의학회지
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• 제9권1호
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• pp.155-167
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• 2000

To evaluate the antitumor activity and antimetastatic effects of Gobongeerlhobang(GG1B), studies were done experimentally. The results were obtained as follows: 1. GG1B extracts exhibited a significant cytotoxicity against HT1080, A549, SK-MEL-2 and SK-OV-3 cell lines. 2. The T/C% was 120.7% in GG1B treated group in S-180 bearing ICR mice. 3. GG1B extracts exhibited inefficient adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 4. GG1B extracts showed a significant inhibition of lung metastasis of B16-BL6 cells in C57BL/6. 5. In CAM assays, angiogenesis was insignificantly inhibited in GG1B treated group than control group. These results suggested that GG1B extracts might be usefully applied for prevention and treatment of cancer.

• 생약학회지
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• 제37권3호
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• pp.206-211
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• 2006

The methanol extract from seed of Myristica fragrans (Myristicaceae) demonstrated a potent inhibition on the pro-liferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro. By the continuous effort to purify the active components responsible far the anti-proliferative effect on tumor cell lines, we have isolated eleven kinds of lignan components, i. e., safrole (1), machilin A (2), licarin B (3), macelignan (4), mere-dihydroguaiaretic acid (5), mγnstargenol A (6), methoxyeugenol (7), machilin F (8), licarin A (9), nectandrin B (10), and 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (11) together with a novel furan fatty acid, (E)-3-(3-methyl-5-pentylfuran-2-yl) acrylic acid (12) from seed extract of M. fragrans. Chemical structures of the isolated components (1-12) were established bγ the aid of NMR spectroscopic analyses, i. e., COSY HMQC and HMBC. Each of the Isolates demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OY-3 (ovary), SK-MEL-2 (melanoma) and HCT-15 (colon) in vitro.

• Archives of Pharmacal Research
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• 제23권1호
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• pp.42-45
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• 2000

6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung). SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl) amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

• 한국지능시스템학회논문지
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• 제14권2호
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• pp.201-206
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• 2004

This study attempted to develop a speech recognition module applied to a wheelchair for the physically handicapped. In the proposed speech recognition module, TMS320C32 was used as a main processor and Mel-Cepstrum 12 Order was applied to the pro-processor step to increase the recognition rate in a noisy environment. DTW (Dynamic Time Warping) was used and proven to be excellent output for the speaker-dependent recognition part. In order to utilize this algorithm more effectively, the reference data was compressed to 1/12 using vector quantization so as to decrease memory. In this paper, the necessary diverse technology (End-point detection, DMA processing, etc.) was managed so as to utilize the speech recognition system in real time

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.202.2-202.2
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• 2003

A bioassay-guided fractionation of the whole extract of Viscum album (a parasitic plant : Loranthaceae) led to the isolation of two triterpenoidal components, oleanolic acid (1), ${\beta}$-amyrin acetate (2), homoflavoyadorinin B (3) as well as large quantity of free fatty acid mixtures as active ingredients of the extract responsible for the antitumoral property. The EtOAc soluble part and BuOH soluble part of the extract demonstrated a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro, whereas the remaining water soluble part exhibited a poor inhibition. (omitted)

• 생약학회지
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• 제26권4호
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• pp.323-326
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• 1995

Through bioassay-guided separation of the chemical constituents from the heartwood of Dalbergia odorifera, an 2'-O-methoxyisoliquiritigenin(1) was isolated as cytotoxic principle. 1 showed potent cytotoxic activity against the three kinds of human cancer cell lines (A-549, SK-MEL-2 and SK-OV-3) with similar activity to 5-Fluorouracil.

• 혜화의학회지
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• 제5권2호
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• pp.503-507
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• 1997

The cytotoxicity-guided fractionation of the roots of Sophora flavescens (Leguminosae) extracts led to the isolation of fifteen active principles 1~15, responsible for the cytotoxicity against five kinds of cultured human tumor cell lines, i.e., A549(non small cell lung), SK-OV-3(ovary), SK-MEL-2(skin), XF498(central nerve system) and HCT-15(colon), evaluated by SRB method in vitro. Compounds 2~14 were classified as unusual flavonoid occurred exclusively in this species and the proliferation of each examined tumor cells were significantly inhibited during the continuous exposure to compounds 1~15 for 48 hours, respectively.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1998년도 학술발표대회 논문집 제5권
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• pp.60-63
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• 1998

본 논문에서는 사용자가 별도의 훈련과정 없이 인식대상 어휘를 추가 및 변경이 가능한 가변어휘 인식시스템에 관하여 기술한다. 가변어휘 음성인식에서는 미리 구성된 음소모델을 토대로 인식대상 어휘가 결정되명 발음사전에 의거하여 이들 어휘에 해당하는 음소모델을 연결함으로써 단어모델을 만든다. 사용된 음소모델은 현재 음소의 앞뒤의 음소 context를 고려한 문맥종속형(Context-Dependent)음소모델인 triphone을 사용하였고, 연속확률분포를 가지는 Hidden Markov Model(HMM)기반의 고립단어인식 시스템을 구현하였다. 비교를 위해 문맥 독립형 음소모델인 monophone으로 인식실험을 병행하였다. 개발된 시스템은 음성특징벡터로 MFCC(Mel Frequency Cepstrum Coefficient)를 사용하였으며, test 환경에서 나타나지 않은 unseen triphone 문제를 해결하기 위하여 state-tying 방법중 음성학적 지식에 기반을 둔 tree-based clustering 기법을 도입하였다. 음소모델 훈련에는 ETRI에서 구축한 POW (Phonetically Optimized Words) 음성 데이터베이스(DB)[1]를 사용하였고, 어휘독립인식실험에는 POW DB와 관련없는 22개의 부서명을 50명이 발음한 총 1.100개의 고립단어 부서 DB[2]를 사용하였다. 인식실험결과 문맥독립형 음소모델이 88.6%를 보인데 비해 문맥종속형 음소모델은 96.2%의 더 나은 성능을 보였다.

• 대한한의학방제학회지
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• 제9권1호
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• pp.83-103
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• 2001

I studied conductant drug(使藥) in a prescription. As results of these studies, conductant drug(使藥) with meaning of medicinal guide(引經) were Achyranthis Bidentatae Radix(牛膝), Platycodi Radix(桔梗), Cinnabaris(朱砂), Sal Maritimus(食鹽), alcoholic drink(酒,) Cimicifugae Rhizoma(升麻) and Bupleuri Radix(柴胡). Conductant drugs with meaning of harmonizing medicines in a prescription were almost Glycyrrhizae Radix(甘草). And sometimes Mel(蜂蜜) was used with meaning of harmonizing medicines in pill. And Jujubae Fructus was used with meaning of harmonizing medicines in purgation medicines.

• Archives of Pharmacal Research
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• 제24권6호
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• pp.518-521
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• 2001

Six bioactive alkaloids, aristolactam B(1), poperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionalton of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549,SK-OV-3,SK-MEL-2, XF-498 and HCT-15) in vitro.