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Inhibitory Effects of the Seed Extract of Myristicae Semen on the Proliferation of Human Tumor Cell Lines (II)  

Lee, Jung-Won (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Choi, Yeon-Hee (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Yoo, Mi-Young (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Choi, Sang-Un (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Hong, Kyung-Sik (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Lee, Byung-Hoi (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Yon, Gyu-Hwan (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Kim, Young-Sup (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Kim, Young-Kyoon (College of Forest Science, Kookmin University)
Ryu, Shi-Yong (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.3, 2006 , pp. 206-211 More about this Journal
Abstract
The methanol extract from seed of Myristica fragrans (Myristicaceae) demonstrated a potent inhibition on the pro-liferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro. By the continuous effort to purify the active components responsible far the anti-proliferative effect on tumor cell lines, we have isolated eleven kinds of lignan components, i. e., safrole (1), machilin A (2), licarin B (3), macelignan (4), mere-dihydroguaiaretic acid (5), mγnstargenol A (6), methoxyeugenol (7), machilin F (8), licarin A (9), nectandrin B (10), and 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (11) together with a novel furan fatty acid, (E)-3-(3-methyl-5-pentylfuran-2-yl) acrylic acid (12) from seed extract of M. fragrans. Chemical structures of the isolated components (1-12) were established bγ the aid of NMR spectroscopic analyses, i. e., COSY HMQC and HMBC. Each of the Isolates demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OY-3 (ovary), SK-MEL-2 (melanoma) and HCT-15 (colon) in vitro.
Keywords
Myristica fragrans; Myristicaceae; anti-proliferation; lignan;
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Times Cited By KSCI : 1  (Citation Analysis)
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