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The Pharmaceutical Society of Korea (대한약학회)
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Cytotoxic Alkaloids from Houttuynia cordata

  • Published : 2001.12.01
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Abstract

Six bioactive alkaloids, aristolactam B(1), poperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionalton of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549,SK-OV-3,SK-MEL-2, XF-498 and HCT-15) in vitro.

Keywords

References

  1. Phytochemistry v.14 Oxoaporphine alkaloids from the callus tissue of Stephania cepharantha Acasu,M.;Itogawa,H.;Fujita,M.
  2. Tetrahedron Lett. v.41 Four new fluorescent components isolated from the Callus tissue of Stephania cepharantha Acasu,M.;Itogawa,H.;Fujita,M.
  3. A new 4,5-dioxoaporphine and other constituents of Aristolochia indica Heterocycles v.19 Studies on Indian medicinal plants. Achari,B.;Chakrabarty,S.;Bandyopadhyay,S.;Pakrashi,S.C.
  4. J. Nat. Prod. v.54 no.5 6a,7-dehydro-2-hydroxy-4,5-dioxonoraporphine and other alkaloids from Monocyclanthus vignei: $^{13}C$-NMR studies on 4,5-dioxoaporphines Achenbach,H.;Frey,D.;Waibel,R.
  5. Pharmacology and applications of chinese materia Media Chang,H.;But,P.
  6. Phytochemistry v.13 Aristololactams of Aristolochia argentina Crohare,R.;Priestap,H.A.;Farine,M.;Ruveda,E.
  7. Phytochemistry v.27 no.5 Aristololactams and 4,5-dioxoporphines from Piper longum Desai,S.J.;Prabhu,B.R.;Mulchandani,N.B.
  8. Phytochemistry v.17 The structure of alkaloids Y from Scherffromitra subaequalis Dyke,S.F.;Gellert,E.
  9. J. Nat. Pro. v.38 no.6 Aporphine-type alkaloids from Piper auritum Hansel,R.;Leuschke,A.
  10. Chem. Rev. v.65 Ultraviolet spectra of alkaloids Sanster,A.W.;Stuart,K.L.
  11. Phytochemistry v.24 no.4 Seven aristololactams from Aristolochia argentina Priestap,H.A.
  12. The isoquinoline alkaloids Shamma,M.
  13. J. Natl. Cancer. Inst. v.82 New colorimetric cytotoxicity assay for anticancer-drug screening Skan,P.;Streng,R.;Scudiero,D.;Monks,A.;Mcmahon,J.;Kenney,S.;Boyd,M.R.
  14. Can. J. Chem. v.57 Splendidine, a new oxoaporphine alkaloid from Abuta rufescens Aublet Skiles,J.W.;Saa,J.M.;Cava,M.P.
  15. J. Nat. Prod. v.50 no.5 New cytotoxic aristololactams from Pararistolochia flosavis Sun,N.J.;Antoun,M.;Chang,C.J.;Cassady,J.M.
  16. J. Nat. Prod. v.53 no.2 Chemistry of Saururus cernuus, v. Sauristolactam and other nitrogeneous constituents Rao,K.V.;Reddy,G.C.S.