Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Effects of the Seed Extract of Myristicae Semen on the Proliferation of Human Tumor Cell Lines (II)

육두구 추출물의 암세포증식 저해 효과 (제 2보)

  • Lee, Jung-Won (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Choi, Yeon-Hee (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Yoo, Mi-Young (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Choi, Sang-Un (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Hong, Kyung-Sik (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Lee, Byung-Hoi (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Yon, Gyu-Hwan (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Kim, Young-Sup (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology) ;
  • Kim, Young-Kyoon (College of Forest Science, Kookmin University) ;
  • Ryu, Shi-Yong (Phyochemistry Research Lab, Korea Research Institute of Chemical Technology)
  • 이정원 (한국화학연구원 생약화학연구실) ;
  • 최연희 (한국화학연구원 생약화학연구실) ;
  • 유미영 (한국화학연구원 생약화학연구실) ;
  • 최상운 (한국화학연구원 생약화학연구실) ;
  • 홍경식 (한국화학연구원 생약화학연구실) ;
  • 이병회 (한국화학연구원 생약화학연구실) ;
  • 연규환 (한국화학연구원 생약화학연구실) ;
  • 김영섭 (한국화학연구원 생약화학연구실) ;
  • 김영균 (국민대학교 삼림과학대학) ;
  • 유시용 (한국화학연구원 생약화학연구실)
  • Published : 2006.09.30
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Abstract

The methanol extract from seed of Myristica fragrans (Myristicaceae) demonstrated a potent inhibition on the pro-liferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro. By the continuous effort to purify the active components responsible far the anti-proliferative effect on tumor cell lines, we have isolated eleven kinds of lignan components, i. e., safrole (1), machilin A (2), licarin B (3), macelignan (4), mere-dihydroguaiaretic acid (5), mγnstargenol A (6), methoxyeugenol (7), machilin F (8), licarin A (9), nectandrin B (10), and 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol (11) together with a novel furan fatty acid, (E)-3-(3-methyl-5-pentylfuran-2-yl) acrylic acid (12) from seed extract of M. fragrans. Chemical structures of the isolated components (1-12) were established bγ the aid of NMR spectroscopic analyses, i. e., COSY HMQC and HMBC. Each of the Isolates demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OY-3 (ovary), SK-MEL-2 (melanoma) and HCT-15 (colon) in vitro.

Keywords

References

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