• Journal of the korean veterinary medical association
• /
• v.38 no.6
• /
• pp.549-558
• /
• 2002

3.5살짜리 래브라도 리트리버(Labrador Retriever)는 매일 처방되는 피질스테로이드제에 무반응으로 비계절적, 심한 소양증을 2년간 앓고 있는 병력을 갖고 있었다. 공기유래 알레르겐(알러젠; Allergens)들에 대한 시험관내 RAST1(Radioallergosorbent testing; 방사선 알레르기 흡착 시험법)에 양성으로 나타난 것을 기초로 한 면역요법(Immunotherapy)을 18개월 동안 시행했으나 성공적이지 않았다. 부신피질호르몬(Adrenocorticotropic Hormone, ACTH)자극 시험법은 이것이 본래 임상수의사에 의해 발생(Iatrogenic)된 것임을 예시하여준다. 피부 찰과물(Skin scrapings)을 검사한 결과 개 천공개선충(Sarcoptic mange)이라는 진단이 내려졌다. 이버맥틴(Ivermectin)치료효과와 피질스테로이드(Corticosteroid)의 투약중지에 대한 반응이 극적으로 나타났다. 10개월 추적기간(10-month follow-up period)동안에 이 질병은 재발되지 않았다. 이것은 비록 계절적인 알레르겐을 배제하기 위해 긴 기간동안 추적이 필요하였으나 개 천공개선충이 오히려 피질스테로이드요법에 대한 2차적인 것보다는 1차적인 질병이라는 것을 말해준다. 아토피의 진단을 위해 혈청학적 시험법의 이용이 논의되었다.

• The Korean Journal of Medicine
• /
• v.99 no.3
• /
• pp.145-148
• /
• 2024

Food allergy is an adverse reaction that occurs after ingesting food and is caused by an aberrant immune response. Taking a detailed medical history is the most important part of diagnosing food allergies. When an immunoglobulin E (IgE)-mediated food allergy is suspected, food-specific IgE testing can confirm the diagnosis. Allergen skin-prick tests or serum tests for specific IgE should be considered as the first line of testing, and depending on the offending food, a further prick-to-prick test with fresh food or a component-resolved diagnostic test may be helpful. Interpretation of the results should be based on the patient's medical history.

• International Journal of Reliability and Applications
• /
• v.9 no.2
• /
• pp.125-140
• /
• 2008

The new better than used failure rate (NBUFR), Abouammoh and Ahmed (1988), and new better than average failure rate (NBAFR) Loh (1984) classes of life distributions, have been considered in the literature as natural weakenings of NBU (NWU) property. The paper considers testing exponentiality against strictly NBUFR (NBAFR) alternatives, or their duals, based on goodness of fit approach that is possible in life testing problems and that it results in simpler procedures that are asymptotically equivalent or better than standard ones. They may also have superior finite sample behavior. The asymptotic normality are proved. Powers, Pitman asymptotic efficiency and critical points are computed. Dealing with censored data case also studied. Practical applications of our tests in the medical sciences are present.

• Journal of the Korean Data and Information Science Society
• /
• v.27 no.3
• /
• pp.835-844
• /
• 2016

We develop the testing procedures about the homogeneity of the shape parameters of several inverse Gaussian distributions in our paper. We propose default Bayesian testing procedures for the shape parameters under the reference priors. The Bayes factor based on the proper priors gives the successful results for Bayesian hypothesis testing. For the case of the lack of information, the noninformative priors such as Jereys' prior or the reference prior can be used. Jereys' prior or the reference prior involves the undefined constants in the computation of the Bayes factors. Therefore under the reference priors, we develop the Bayesian testing procedures with the intrinsic Bayes factors and the fractional Bayes factor. Simulation study for the performance of the developed testing procedures is given, and an example for illustration is given.

• Childhood Kidney Diseases
• /
• v.25 no.1
• /
• pp.14-21
• /
• 2021

Chronic kidney disease, the presence of structural and functional abnormalities in the kidneys, is associated with a lower quality of life and increased morbidity and mortality in children. Genetic etiologies account for a substantial proportion of pediatric chronic kidney disease. With recent advances in genetic testing techniques, an increasing number of genetic causes of kidney disease continue to be found. Genetic testing is recommended in children with steroid-resistant nephrotic syndrome, congenital malformations of the kidney and urinary tract, cystic disease, or kidney disease with extrarenal manifestations. Diagnostic yields differ according to the category of clinical diagnosis and the choice of test. Here, we review the characteristics of genetic testing modalities and the implications of genetic testing in clinical genetic diagnostics.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2008.04a
• /
• pp.161-161
• /
• 2008

• Journal of Dental Rehabilitation and Applied Science
• /
• v.22 no.4
• /
• pp.341-348
• /
• 2006

Accurate fit of the implant prosthesis is important in ensuring long term success of osseointegrated implant. Inaccurate fit of the implant prosthesis may give rise to complications and mechanical failure. To evaluate fite of the implant prosthesis, the development of the methods of analyzing the degree of misfit is important in clinical practice. To analyze the degree of the misfit of implant prosthesis, modal testing was used. A 2-dimensional finite element modal testing was accomplished. Four 2-dimensional finite element models with various levels of misfit of implant prostheses were constructed. Thickness gauges were simulated to make misfit in the implant prostheses. With eigenvalue analysis, the natural frequencies of the models were found in the frequency domain representation of vibration. According to the difference of degree of misfit, natural frequencies of the models were changed.

• Safety and Health at Work
• /
• v.2 no.3
• /
• pp.218-228
• /
• 2011

Objectives: The objective of this study was to test the feasibility and acceptability of a new workers' health surveillance (WHS) for fire fighters in a Dutch pilot-implementation project. Methods: In three fire departments, between November 2007 and February 2009, feasibility was tested with respect to i) worker intent to change health and behavior; ii) the quality of instructions for testing teams; iii) the planned procedure in the field; and iv) future WHS organisation. Acceptability involved i) satisfaction with WHS and ii) verification of the job-specificity of the content of two physical tests of WHS. Fire fighters were surveyed after completing WHS, three testing teams were interviewed, and the content of the two tests was studied by experts. Results: Feasibility: nearly all of the 275 fire fighters intended to improve their health when recommended by the occupational physician. The testing teams found the instructions to be clear, and they were mostly positive about the organisation of WHS. Acceptability: the fire fighters rated WHS at eight points (out of a maximum of ten). The experts also reached a consensus about the optimal job-specific content of the future functional physical tests. Conclusion: Overall, it is feasible and acceptable to implement WHS in a definitive form in the Dutch fire-fighting sector.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.22 no.3
• /
• pp.251-260
• /
• 2006

Accurate fit of the implant prosthesis is important in ensuring long term success of osseointegrated implant. Inaccurate fit of the implant prosthesis may give rise to complications and mechanical failure. To evaluate fite of the implant prosthesis, the development of the methods of analyzing the degree of misfit is important in clinical practice. To analyze the degree of the misfit of implant prosthesis, modal testing was used. A 2-dimensional finite element modal testing was accomplished. Four 2-dimensional finite element models with various levels of misfit of implant prostheses were constructed. Thickness gauges were simulated to make misfit in the implant prostheses. With eigenvalue analysis, the natural frequencies of the models were found in the frequency domain representation of vibration. According to the difference of degree of misfit, natural frequencies of the models were changed.

• Nuclear Engineering and Technology
• /
• v.53 no.5
• /
• pp.1626-1633
• /
• 2021

In an industrial field, non-destructive testing (NDT) is commonly used to inspect industrial products. Among NDT methods using radiation sources, X-ray laminography has several advantages, such as high depth resolution and low computational costs. Moreover, an X-ray laminography system with stationary source array and compact detector is able to reduce mechanical motion artifacts and improve inspection efficiency. However, this system, called stationary inverse-geometry X-ray laminography (s-IGXL), causes truncation artifacts in reconstructed images due to limited fields-of-view (FOVs). In this study, we proposed a projection data correction (PDC) method to reduce the truncation artifacts arisen in s-IGXL images, and the performance of the proposed method was evaluated with the different number of focal spots in terms of quantitative accuracy. Comparing with conventional techniques, the PDC method showed superior performance in reducing truncation artifacts and improved the quantitative accuracy of s-IGXL images for all the number of focal spots. In conclusion, the PDC method can improve the accuracy of s-IGXL images and allow precise NDT measurements.