• Genomics & Informatics
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• 제20권1호
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• pp.3.1-3.10
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• 2022

The recent development of whole-genome sequencing technologies paved the way for understanding the genomes of microorganisms. Every whole-genome sequencing (WGS) project requires a considerable cost and a massive effort to address the questions at hand. The final step of WGS is data analysis. The analysis of whole-genome sequence is dependent on highly sophisticated bioinformatics tools that the research personal have to buy. However, many laboratories and research institutions do not have the bioinformatics capabilities to analyze the genomic data and therefore, are unable to take maximum advantage of whole-genome sequencing. In this aspect, this study provides a guide for research personals on a set of bioinformatics tools available online that can be used to analyze whole-genome sequence data of bacterial genomes. The web interfaces described here have many advantages and, in most cases exempting the need for costly analysis tools and intensive computing resources.

• Genomics & Informatics
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• 제18권4호
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• pp.35.1-35.7
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• 2020

Identifying the patterns of gene expression in breast cancers is essential to understanding their pathophysiology and developing anticancer drugs. Breast cancer is a heterogeneous disease with different subtypes determined by distinct biological features. Luminal breast cancer is characterized by a relatively high expression of estrogen receptor (ER) and progesterone receptor (PR) genes, which are expressed in breast luminal cells. In ~25% of invasive breast cancers, human epidermal growth factor receptor 2 (HER2) is overexpressed; these cancers are categorized as the HER2 type. Triple-negative breast cancer (TNBC), in which the cancer cells do not express ER/PR or HER2, shows highly aggressive clinical outcomes. TNBC can be further classified into specific subtypes according to genomic mutations and cancer immunogenicity. Herein, we discuss the brief history of TNBC classification and its implications for promising treatments.

• 한국호스피스완화의료학회:학술대회논문집
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• 한국호스피스완화의료학회 2008년도 하계학술대회
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• pp.19-21
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• 2008

Hospice movement in Taiwan emerged early in 1983. There was a nurse visiting terminal cancer patients by herself in Taipei city. It was ceased after one year. This stage of hospice movement might be called as "compassionate era". In early 1990, the first in-patient hospice ward was set up in north Taiwan. She demonstrated high touch in the high technology medical atmosphere. There was a great echo in Taiwan society to this action. In the following years, quite a few new hospice settings were founded. Medical professionals were aroused again to talk and think about life and death, dignity of dying and holistic care. This stage of hospice movement might be called as "ethical stage". Around 2000, obstructions were discovered in our development. We do need system and rules. Standard of setting and care, Curriculum of education and training, Accreditation system and specialist system and Nature Death Act are some of the systems we approached. This stage of hospice movement might be called as "Act stage". Among the "Act stage", the Nature Death Act is actually the mile stone in our history. What listed below are the translated one for the reference:

• 디지털융복합연구
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• 제10권6호
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• pp.341-347
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• 2012

시스템 및 네트워크에 설치/운용되는 의료자산보호 솔루션 중 네트워크 접근통제 시스템은 내부 네트워크에 접근하는 정보통신 디바이스의 안전성을 검증한 후 자원을 사용하게 하는 프로세스를 제공한다. 그러나 인가된 정보통신 디바이스의 위장 및 허가된 사용자의 이석 시간을 이용한 비인가 사용 등으로 내부 네트워크에 대한 의료 정보절취 위협은 여전히 존재하고 있고, 장시간 운영되는 정보통신 디바이스의 경우는 사용자가 인지하지 못하는 시간대에 악성코드 감염에 의한 외부 네트워크 임의 접속 및 의료 정보유출도 발생할 수 있기 때문에 이러한 위협을 차단하기 위한 보안 대책이 필요하다. 따라서 본 논문에서는 의료 정보유출 방지를 위해 현행 네트워크 접근통제 시스템을 개선하여 적용한 네트워크 이중 접근통제 모델을 제시한다. 제안한 네트워크 이중 접근통제 모델은 사용자가 실제 조직 내부에 위치하고 있어 인가된 정보통신 디바이스를 활용하는 때에만 내부 네트워크 접속을 허용한다. 그러므로 비인가자의 내부 네트워크 접근을 차단하고, 허가된 사용자 부재 시의 불필요한 외부 인터넷 접속을 차단함으로써 의료 정보를 보호할 수 있는 안전한 의료자산 환경을 제공한다.

• Genomics & Informatics
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• 제2권3호
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• pp.126-130
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• 2004

T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The protein known as signal transducers and activators of transcription 6 (STAT6) is a key transcription factor involved in both IL-4- and -13-mediated biological responses. Two polymorphisms of the STAT 6 gene (exon 1 and G2964A variant) have been found. We investigated whether these STAT6 gene polymorph isms were associated with allergic rhinitis. Blood samples for genetic analysis were obtained from 285 individuals with allergic rhinitis and from 271 healthy subjects without atopic disease. The G2964A variant of the STAT6 gene was genotyped using PCR-RFLP analysis. The GT repeat polymorphism in exon 1 of the STAT6 gene was genotyped by fragment analysis. There was no association between the 2964A variant and GT repeat polymorphism in exon 1 of the STAT6 and allergic rhinitis in a Korean population (both p > 0.05). Our results suggest that a combination of STAT6 gene polymorphisms is not a useful marker for predicting allergic rhinitis.

• 한국콘텐츠학회논문지
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• 제17권10호
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• pp.483-491
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• 2017

국내 의료기관별 전자의무기록 시스템의 높은 보급률에 비해 진료정보교류는 활성화되어 있지 않다. 본 연구는 진료정보교류가 도입되고 확산될 수 있도록 최근에 신설된 "의료법" 및 하위법령을 고찰하였다. "의료법" 및 하위법령에서는 환자의 동의하에 진료기록을 의료기관 간 전송할 수 있도록 하였으며 안전한 진료정보교류를 지원하기 위해 진료기록전송지원시스템을 구축 운영할 수 있도록 하였다. 이 외에도 표준적용 및 상호운용성 확보를 위한 전자의무기록 시스템의 인증제도 시행을 명시하고 있어 주목된다. 진료정보교류에 대한 법제도적 근거가 마련되었으나 진료정보교류의 성공적인 도입 및 확산을 위해서는 개발자 대상 교육, 인증체계 마련, 인센티브 제도 마련, 진료정보교류에 대한 홍보 활동 강화 등 지속적인 정책개발 및 연구가 필요할 것이다.

• Environmental Analysis Health and Toxicology
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• 제29권
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• pp.6.1-6.6
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• 2014

Objectives Hospitalized patients are vulnerable to sleep disturbances because of environmental stresses including noise. While most previous studies on hospital noise and sleep have been performed for medical machines in intensive care units, there is a limited data for patients hospitalized in medical wardrooms. The purpose of present study was to measure noise level of medical wardrooms, identify patient-perceived sources of noise, and to examine the association between noise levels and sleep disturbances in hospitalized patients. Methods Noise dosimeters were used to measure noise level in 29 inpatient wardrooms at a university hospital. Sleep pattern and disturbance were assessed in 103 hospitalized patients, using the Pittsburgh Sleep Quality Index (PSQI) and Leeds Sleep Evaluation Questionnaire. Results The mean equivalent continuous noise level for 24 hours was 63.5 decibel A (dBA), which was far higher than 30 dBA recommended by the World Health Organization for hospital wardrooms. Other patients sharing a room were perceived as the most common source of noise by the patients, which was usually preventable. Of the patients in the study, 86% had bad sleep as assessed by the PSQI. The sleep disturbance was significantly correlated with increasing noise levels in a dose response manner. Conclusions Systemic organizational interventions are needed to keep wardrooms private and quiet to reduce sleep disturbance.

• 대한한의학회지
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• 제41권3호
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• pp.125-137
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• 2020

Objectives: This study was aimed to present the experts' opinions for the successful application of Korean traditional medical practices (KTMPs) to the International Classification of Health Intervention (ICHI). Methods: Two doctors of Korean Medicine and two health information managers who had tried coding 131 KTMPs using ICHI participated in the focus group discussion. The remarks from the discussion were summarized according to the thematic analysis method. Results: The participants expected ICHI to be mainly used for statistics when applied to TKMPs. It can be used for payment systems as well, but it was expected that additional work would be required. They thought the current version of the ICHI did not sufficiently reflect the KMTPs of the real world, and even the interventions already included in the ICHI were not explained enough in the system. They thought it would not be easy to explain more KTMPs within the current structure of the ICHI, but they also said it seemed possible. In the process, rather than adding entirely new stem codes, it would be better to generate new combinations of the existing codes, to suppose subdivided codes, and to utilize the include terms or extension codes. Conclusions: For the successful introduction of ICHI, clarifying the definition of each intervention of KTMPs is a top priority. In addition, it is necessary to continue the matching work of ICHI - KMPTs and also required to make this effort together with the field of traditional medicine and complementary medicine worldwide.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7221-7227
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• 2013

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

• 한국병원경영학회지
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• 제17권4호
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• pp.1-20
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• 2012

The purpose of this study is to find out the job satisfaction of the korean medical clinic workers, and understand the factors that affect the satisfaction thereby increasing the efficiency of human resource management and providing the basic data to establish the management strategy. We visited 50 korean medical clinics which were chosen randomly from the korean medical clinics in the city of Changwon, Gyungnam. First, we explained the purpose of the study and survey contents to the surveyees, then distributed the Questionnaire and collected them. The data analysis was done statistically using the SPSS WIN IBM 20.0 program. The results were as follows: Professional career, interpersonal relationship, work autonomy, and overall job satisfaction showed significant differences depending on ages. While satisfaction of interpersonal relationship showed significant difference depending on final education. Depending on marriage status, while married persons showed significantly high satisfaction on professional career, interpersonal relationship, work autonomy, administration, and overall job satisfaction, there is no significant difference on income satisfaction. The number of years worked in the current clinic showed significant difference on administration satisfaction. Also, daytime working hours showed significant difference on administration and overall job satisfaction. The work area showed significant difference on overall job satisfaction. The income level showed significant differences on professional career, administration, and overall job satisfaction. From this study, it was confirmed that demographic characteristics and work environment factors showed significant differences on overall job satisfaction of workers in korean medical clinics. Therefore, in order to facilitate efficient manpower utilization and organization efficiency maximization, and motivation of human resources, a detailed plan should be developed to improve working environment and take demographic characteristics into consideration.