• Proceedings of the Korean Society of Medical Physics Conference
• /
• 2006.08a
• /
• pp.139-139
• /
• 2006

• Proceedings of the Korean Society of Medical Physics Conference
• /
• 2006.08a
• /
• pp.127-127
• /
• 2006

• Journal of Microbiology and Biotechnology
• /
• v.24 no.8
• /
• pp.1059-1064
• /
• 2014

Staphylococcus aureus is a major human pathogen, implicated in both community and hospital acquired infections. The therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult because of multidrug resistance and strong biofilm-forming properties. Schiff bases have attracted attention as promising antibacterial agents. In this study, we investigated the in vitro activity of taurine-5-bromosalicylaldehyde Schiff base (TBSSB) against MRSA. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) were determined using a microtiter broth dilution method. TBSSB effectively inhibited planktonic MRSA, with an MIC of $32{\mu}g/ml$. The time-kill curve confirmed that TBSSB exhibited bactericidal activity against MRSA. TBSSB was also found to significantly inhibit MRSA biofilm formation at 24 h, especially at $1{\times}MIC$ and sub-MIC levels. Furthermore, scanning electron microscopy and transmission electron microscopy showed remarkable morphological and ultrastructural changes on the MRSA cell surface, due to exposure to TBSSB. This study indicated that TBSSB may be an effective bactericidal agent against MRSA.

• Progress in Medical Physics
• /
• v.26 no.1
• /
• pp.1-5
• /
• 2015

The C-band compact linear accelerator (linac) is being developed at Dongnam Institute of radiological & Medical Sciences (DIRAMS) for medical and industrial applications. This paper was focused on the output measurement of the electron beam generated from the prototype electron linac. The dose rate was measured in unit of cGy/min per unit pulse frequency according to the IAEA TRS-398 protocol. Exradin-A10 Markus type plane parallel chamber used for the measurement was calibrated in terms of dose to water at the reference depth in water. The beam quality index ($R_{50}$) was determined by the radiochromic film with a solid water phantom approximately due to low energy electrons. As a result, the determined electron beam output was $17.0cGy/(min{\cdot}Hz$. The results were used to monitor the accelerator performance during the development procedure.

• Proceedings of the Korean Society of Medical Physics Conference
• /
• 2002.09a
• /
• pp.109-112
• /
• 2002

Using Monte Carlo calculations the effects of longitudinal magnetic fields on the beam profiles produced by clinical electron beam were studied. The Monte Carlo calculations were performed using the EGS4 code system modified to account for external magnetic fields. The beam profiles for a 6 MeV electron beam with longitudinal magnetic fields of 0.5-3.0 T were calculated. As a result of these calculations we found that the penumbra widths can be reduced with increased magnetic fields. This means that the electron therapy benefits from the external magnetic fields.

• Journal of the Optical Society of Korea
• /
• v.13 no.1
• /
• pp.42-47
• /
• 2009

The propagation of an intense laser pulse through an upward density-gradient plasma in a self-modulated laser wakefield acceleration (SM-LWFA) is investigated by using particle-in-cell (PIC) simulations. In the fully relativistic and kinetic PIC simulations, the relativistic and kinetic effects including Landau damping enhance the electron dephasing. This electron dephasing is the most important factor for limiting the energy of accelerated electrons. However, the electron dephasing, which is enhanced by relativistic and kinetic effects in the homogeneous plasma, can be forestalled through the detuning process arising from the longitudinal density gradient. Simulation results show that the detuning process can effectively maintain the coherence of the laser wake wave in the spatiotemporal wakefield pattern, hence considerable energy enhancement is achievable. The spatiotemporal profiles are analyzed for the detailed study on the relativistic and kinetic effects. In this paper, the optimum slope of the density gradient for increasing electron energy is presented for various laser intensities.

• Progress in Medical Physics
• /
• v.27 no.4
• /
• pp.272-276
• /
• 2016

To investigate the optimum x-ray tube design for the dental radiology, factors affecting x-ray beam characteristics such as tungsten target thickness and anode angle were evaluated. Another goal of the study was to addresses the anode heel effect and off-axis spectra for different target angles. MCNPX has been utilized to simulate the diagnostic x-ray tube with the aim of predicting optimum target angle and angular distribution of x-ray intensity around the x-ray target. For simulation of x-ray spectra, MCNPX was run in photon and electron using default values for PHYS:P and PHYS:E cards to enable full electron and photon transport. The x-ray tube consists of an evacuated 1 mm alumina envelope containing a tungsten anode embedded in a copper part. The envelope is encased in lead shield with an opening window. MCNPX simulations were run for x-ray tube potentials of 70 kV. A monoenergetic electron source at the distance of 2 cm from the anode surface was considered. The electron beam diameter was 0.3 mm striking on the focal spot. In this work, the optimum thickness of tungsten target was $3{\mu}m$ for the 70 kV electron potential. To determine the angle with the highest photon intensity per initial electron striking on the target, the x-ray intensity per initial electron was calculated for different tungsten target angles. The optimum anode angle based only on x-ray beam flatness was 35 degree. It should be mentioned that there is a considerable trade-off between anode angle which determines the focal spot size and geometric penumbra. The optimized thickness of a target material was calculated to maximize the x-ray intensity produced from a tungsten target materials for a 70 keV electron energy. Our results also showed that the anode angle has an influencing effect on heel effect and beam intensity across the beam.

• The Korean Journal of Zoology
• /
• v.23 no.4
• /
• pp.219-228
• /
• 1980

The ultrastructures of the granular glands in the asiatic land salamander (Hynobius leechi) skin were observed by means of electron microsope The results were as follows; 1. The granular gland of the asiatic land salamander skin consisted of a body of gland and a duct. The body of the granular gland consisted of the glandular epithelial cells and the myoepithelial cells. The duct of the granular gland consisted of the keratinocytes. 2. The glandular epithelial cells in the asiatic land salamander skin were divided into the dark cell and the light cells in accordance with the electron density of the cytoplasm. 3. The secretory granules of the granular glands were round or oval in form and were divided into the various granules, showing the secretory granules showing weak electron density had the parts showing strong electron density near the granular membrane. 4. It is supposed that showing the different electron densities of the granules in a glandular epithelial cell is due to different mature stages and to different level of water absorption, and the chemical components of the granules showing different electron densities are identical.

• Applied Microscopy
• /
• v.48 no.4
• /
• pp.87-95
• /
• 2018

Immunoelectron microscopy using an antigen-antibody reaction in an electron microscope is a very useful tool to identify the components of a tissue in an electron microscope. Many researchers also use immunoelectron microscopy. Nonetheless, immunoelectron microscopy is rarely introduced systematically, and immunoelectron microscopy can be carried out without fully understanding the principles, and cases of poor understanding can often be seen in the vicinity. Therefore, in order to make it easier to understand, we will first introduce the principles of immunoelectron microscopy and describe practical methods.

• Proceedings of the Korean Society of Medical Physics Conference
• /
• 2006.08a
• /
• pp.104-104
• /
• 2006