• Herbal Formula Science
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• v.20 no.1
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• pp.123-132
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• 2012

Objectives : The purpose of this study is to find out herb-pair prototype composed of Zanthoxyli Fructus, to examine compatibility regulation between them and to classify them into seven features of compatibility. Methods : To search usages of Zanthoxyli Fructus compatibility, we have investigated the classics of herb and prescription such as "五十二病方"(Fifty-two kinds of Diseases), "黃帝內經"(The Medical Classic of Yellow Emperor), "傷寒論"(Treatise on Febrile Caused by Cold), "金匱要略"(Synopsis of Prescriptions of The Golden), "附廣肘后方"(Handbook of Prescriptions for Emergencies), "本草綱目"(Compendium of Materia Medica), "得配本草"(Deukbae Materia Medica). Results : In these books Zanthoxyli Fructus was paired with below herbs; 桂(Cinnamomi Cortex), 薑(Zingiberis Rhizoma), 吳茱萸(Evodiae Fructus), 細辛(Asari Radix), 茴香(Foeniculi Fructus), 肉荳蔲(Cistanches Herba), 釜下土(Terba Flava Usta), 益智仁(Alpinae Oxyphyllae Fructus), 飴(Saccharum Granorum), 葱白(Allii Radix), 梨(Pyrus), 牙皂(Gleditsia Fructus), 杏仁(Armeniacae Amarum Semen), 蕎麥粉(Fagopyrum esculentum Moench), 胡粉(Minium), 白朮(Atractylodis Rhizoma White), 蒼朮(Atractylodis Rhizoma), 麻子仁(Cannabis Fructus), 大麥蘗(Hordei Fructus Germiniatus), 麴(Massa Medicata Fermentata), 生地黃(Rehmanniae Radix), 茯苓(Poria), 牡蛎(Ostreae Concha), 白礬(Alumen), 雄黃(Realgar), 烏頭(Aconiti Radix), 附子(Aconiti Lateralis Preparata Radix). Conclusions : Zanthoxyli Fructus herb-pair classified by seven features of compatibility are as follows; 1. Mutual reinforcement compatibility with : Cinnamomi Cortex, Zingiberis Rhizoma, Evodiae Fructus, Asari Radix, Foeniculi Fructus, Cistanches Herba, Terba Flava Usta, Alpinae Oxyphyllae Fructus, Saccharum Granorum, Allii Radix, Pyrus, Gleditsia Fructus. 2. Mutual assistance compatibility with : Armeniacae Amarum Semen, Fagopyrum esculentum Moench, Minium, Atractylodis Rhizoma White, Atractylodis Rhizoma, Cannabis Fructus, Hordei Fructus Germiniatus, Massa Medicata Fermentata, Rehmanniae Radix, Poria, Ostreae Concha, Alumen. 3. Mutual restraint compatibility with: Realgar, Aconiti Radix, Aconiti Lateralis Preparata Radix) 4. Mutual detoxication compatibility with: 桑汁(Juice of Mori Folium), 桑根汁(Juice of Morus Cortex), 大蒜(Allii Bulbus), 薺苨(Remotiflori Radix), 桂汁(Juice of Cinnamomi Cortex).

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.463-470
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• 2019

Currently, the consumption process of Medical Marijuana is complicated, so it is necessary to provide patient-centered services. This study defined the consumption process of Medical Marijuana as three steps and five procedures for the user-centered consumption process direction study, and created a consumption journey map through user interviews with experience of purchasing Medical Marijuana to find the pain point in the consumption process. Then, based on the case studies of the United States and Canada, three scenarios applicable to Korea were presented according to the scope of implementation. It is meaningful that it is a user-centered study based on the experience of Medical Marijuana consumers and it is expected to be used as reference data in improving the consumption process in the future.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.7-7
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• 2019

우리나라에서의 대마는 마약류로 분류되어 기호용과 의료용 모두 법적인 제재를 받아왔으나 최근에 의료용 대마가 법적으로 허용이 되어 환자들에게 처방 받을 수 있게 되었다. 하지만 우리나라 사람들에게 대마는 환각성분을 가진 마약류로 깊이 인식되어 왔으며 의료용 대마에 대한 연구는 거의 전무한 실정이다. 노지재배에서 발생할 수 있는 범죄의 위험성, 자연교배에 의한 품질저하를 피할 수 있으며 재배조건(양액, 광조건, 광주기, 대기환경조성) 등을 제어할 수 있는 밀폐형 LED 식물공장은 의료용 대마 생산에 제일 적합한 모델이 될 수 있다. 식물체의 광합성은 가시광선 중 특정 파장 450nm 청색광과 660nm 적생광을 주로 이용하며 'LED (Light Emitting Diode) 발광다이오드'는 식물체의 광합성에 적합한 파장으로 광원을 조사할 수 있는 장점이 있다. 이러한 LED를 이용한 광합성은 식물체의 2차 대사물질 Anthocyanins, phenolic compounds 등의 향상과 생육에도 긍정적인 영향을 미치며 식물 뿐만 아니라 광합성을 하는 미세조류(micro algae)에서도 이용이 가능하며 해마토 코쿠스(Hematococcus)의 세포증식과 항산화물질 아스타잔틴(astaxathin)생산에 유용하게 쓰이고 있다. 최근 미국과 다른 나라에서도 기호용, 의료용 대마사업에 대한 관심이 높아지고 있으며 캐나다와 미국에서는 밀폐형 유리온실과 식물공장을 이용한 의료용 대마를 생산, 추출, 가공까지 하여 산업적인 영역을 넓히고 있는 실정이다. 특히, 실내재배에서는 광원이 필수적인 요소이며 식물생육에 선택적인 파장을 조사할 수 있는 LED와 재배조건을 정밀하게 제어할 수 있는 밀폐형 식물공장을 이용한 의료용 대마 생산에 대한 연구가 절실히 필요한 시점이다.

• Journal of Life Science
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• v.33 no.4
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• pp.343-348
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• 2023

Acne is one of the most common skin diseases, mainly occurring in adolescence. The pathophysiology of acne involves not only hormonal, genetic and environmental factors, but also other factors including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes and overgrowth of Cutibacterium acnes (C. acnes). Cannabidiol (CBD) is known to relieve pain, stress and inflammation. Moreover, cannabis extracts containing CBD have been reported to be effective in treating acne. However, the therapeutic effect of CBD on acne remains unclear. Therefore, this study aimed to investigate the effect and mechanism of CBD on lipogenesis in SEB-1 sebocytes. We treated sebocytes with CBD and found that it not only inhibited lipid synthesis, but also inhibited cell proliferation by inducing apoptosis. We then demonstrated that sterol response element-binding protein-1 (SREBP-1) mediates the inhibitory effect of CBD on lipogenesis. Furthermore, Akt and adenosine monophosphate-activated protein kinase (AMPK), upstream regulators of SREBP-1, were regulated by CBD treatment. Taken together, our studies demonstrate that CBD inhibits adipogenesis by regulating the Akt/AMPK-SREBP-1 signaling pathway, providing potential for use as a therapeutic agent for acne. Further research is needed to confirm the effect of CBD on inflammation caused by hyperkeratosis, which will increase the possibility of using CBD for acne treatment.