• Parasites, Hosts and Diseases
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• v.54 no.5
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• pp.667-671
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• 2016

Myiasis is a relatively common infection of animals kept as pets, although only 1 case of canine myiasis has been described so far in the Republic of Korea. In the present study, we report an additional case of canine wound myiasis with identification of its causative agent, Lucilia sericata. An 8-year-old male Siberian husky dog was referred with anorexia, vomiting, and diarrhea to the Chungbuk National University Veterinary Medical Center, Cheongju-si (city), Chungcheongbuk-do (province), Korea in July 2013. Physical examination indicated the patient had a deep wound filled with a maggot swarm as a left gluteal lesion. A total of 216 maggots were removed by forceps, and the wounded area was sponged with gauzes and disinfected with 70% alcohol and a povidone-iodine solution. After daily care and suturing the wound, the patient was discharged at day 19 after admission. Recovered worms possessed morphological characteristics similar to those of L. sericata, namely, a sub-cylindrical body with 6-8 lobed anterior spiracles, round shaped with a button surrounded by a peritremal ring with no gaps, and similar distances between dorsal, median, and outer papillae of the 12th segment. Additionally, cox1 partial sequences (528 bp) obtained in the present study showed 100% identity with those of L. sericata (GenBank no. KT272854.1). L. sericata is indicated as a pathogen of myiasis infection not only in humans, but also in animals kept as pets in Korea.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.373-378
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• 2020

For improving interoperability of medical information, health level 7 has initiated the development of a next-generation framework for the exchange of medical information called the Fast health interoperability resources (FHIR). However, there was no attempt to exchange the medical three-dimensional (3D) image with clinical data via FHIR. Thus, we designed a new method. The 3D image to be made from computed tomography was converted to the javascript object notation (JSON) file format, and clinical data was added. We made a test FHIR server, and the client used the postman. The JSON file was attached to the body, and was then transmitted. The transmitted 3D image could be seen through a web browser, and attached clinical data was identified in the source code. This is the first attempt to exchange the medical 3D image. Additional researches will be needed to develop applications or FHIR resources that apply this method.

• Journal of Microbiology and Biotechnology
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• v.14 no.6
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• pp.1318-1323
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• 2004

This study describes the purification and characterization of a novel antihypertensive angiotensin 1­converting enzyme (ACE) inhibitory peptide from Saccharomyces cerevisiae. Maximal production of the ACE inhibitor from Saccharomyces cerevisiae was obtained from 24 h of cultivation at $30^{\circ}C$ and its ACE inhibitory activity was increased by about 1.5 times after treatment of the cell-free extract with pepsin. After the purification of ACE inhibitory peptides with ultrafiltration, Sephadex G-25 column chromatography, and reverse-phase HPLC, an active fraction with an $IC_{50}$ of 0.07 mg and $3.5\%$ yield was obtained. The purified peptide was a novel decapeptide, showing very low similarity to other ACE inhibitory peptide sequences, and its amino acid sequence was Tyr-Asp-Gly-Gly-Val-Phe-Arg-Val-Tyr-Thr. The purified inhibitor competitively inhibited ACE and also showed a clear antihypertensive effect in spontaneously hypertensive rats (SHR) at a dosage of 1 mg/kg body weight.

• Korean Journal of Digital Imaging in Medicine
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• v.6 no.1
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• pp.19-23
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• 2003

In recent years, many computer systems that are used for patient diagnostic and treatment purpose s are being introduced within hospitals. Therefore, being in a position to manage the hospital entirely, efforts to integrate their own unique system into one have started. A system values humans and creates the surrounding atmosphere into one which maximizes the abilities of individuals. For this, a scientific integration management operation system is required. The type of system that is demanded due to this requirement is an ERP(Enterprise Resource Planning) system. Lately, even the hospital industry is beginning to show interest in efficient administrative methods. To deliver more predominant medical services, hospitals are trying to introduce scientific administrative methods, whose superiority were proven in enterprises, to the operation system of the hospital organization. ERP values humans over systems, and within a superior system, emphasizes the efficiency of the organization. This sort of process does not just evaluate and manage the working abilities of individuals, but provides an advanced working environment that increases the abilities of members within the organization by fold. Therefore, this research estimates through questionnaires and introductive cases how the introduction of ERP may change the work of customers within hospitals such as the radiologic technology department, and how it may also change the environment of medical services, thus striving to create a radiologic technology department that will not fall behind the times.

• Health Policy and Management
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• v.7 no.2
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• pp.19-45
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• 1997

This study was performed to evaluate the appropriateness of resource allocation based on the ranking of health center function. Through the Delphi processes, health center functions were ranked in order of importance as follows; planning and research, followed by health education, health promotion, management of chronic diseases, health screening tests, welfare activities, mental health services, medical personnel management, medical services, prevention of communicable diseases, maternal and infant health services, housekeeping, management of oral hygiene, nutrition services, surveillance for community health services, family planning, and administration of the health center. In relation to the above priorities, the allocation of manpower was not appropriate. Even though the expert groups emphasized on functions such as planning and research, health education, and health promotion, they inputted more personnel for administration of a health center, maternal and infant health services, and medical services which were evaluated with lower importance. The budget allocation showed the same trends as the above. Although the functions such as planning and research, health education, and health promotion, and management of chronic diseases were evaluated highly, the budget was allocated accordingo to the the results of the former fiscal year rather than on the importance of function. However the budget for nutrition services, surveillance for the community health services, family planning, and administration of a health center was allocated according to priority. Based upon the above findings, community health center should be given the opportunity to make their own ranking of health center function and to allocate their resources including personnel and budget in order to improve the responsibilities and roles of the community health center.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.261-269
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• 2023

We propose to design a Holochain-based security and privacy protection system for resource-constrained IoT healthcare systems. Through analysis and performance evaluation, the proposed system confirmed that these characteristics operate effectively in the IoT healthcare environment. The system proposed in this paper consists of four main layers aimed at secure collection, transmission, storage, and processing of important medical data in IoT healthcare environments. The first PERCEPTION layer consists of various IoT devices, such as wearable devices, sensors, and other medical devices. These devices collect patient health data and pass it on to the network layer. The second network connectivity layer assigns an IP address to the collected data and ensures that the data is transmitted reliably over the network. Transmission takes place via standardized protocols, which ensures data reliability and availability. The third distributed cloud layer is a distributed data storage based on Holochain that stores important medical information collected from resource-limited IoT devices. This layer manages data integrity and access control, and allows users to share data securely. Finally, the fourth application layer provides useful information and services to end users, patients and healthcare professionals. The structuring and presentation of data and interaction between applications are managed at this layer. This structure aims to provide security, privacy, and resource efficiency suitable for IoT healthcare systems, in contrast to traditional centralized or blockchain-based systems. We design and propose a Holochain-based security and privacy protection system through a better IoT healthcare system.

• Journal of The Korean Society of Integrative Medicine
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• v.7 no.4
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• pp.193-202
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• 2019

Purpose : The study was conducted to analyze the differences in perceptions, attitudes, and knowledge of health tourism students' medical tourism industry as a basic data for improving the curriculum for human resource development that can be activated by the medical tourism industry. Methods : The questionnaires were directly distributed and retrieved from 394 university students attending 4 year college health department and tourism department of some regions (IRB approval number, KW-2017-05). The questionnaire used the Likert 5-point scale to analyze differences in perceptions, attitudes, and knowledge levels in the medical tourism industry. Independent sample t tests were conducted to examine the differences in perceptions, attitudes, and knowledge about the medical tourism industry between the two groups. Results : Results obtained from this study are as follows. 1. Differences in perceptions of the medical tourism industry were 3.44 points for health and 3.45 points for tourism (p<.05). 2. The difference in attitude level was 2.28 for health and 2.79 for tourism. And that tourism has a high perception and attitude. The knowledge of medical tourism industry was 5.93 in health department and 7.11 in sight tourism, and the tourism sector was significantly higher (p<.001). 3. As a result of analysis on attitudes, interest, direct and indirect experience, practical knowledge acquisition, and development possibility were all statistically significant. 4. 98.6 % of the health students and 97.8 % of the tourism students did not obtain the qualification for the qualification of the international medical tourism coordinator. However, in the future, respondents who answered that they have obtained the certificate of international medical tourism coordinator responded positively to 54.9 % of tourism department and 25.2 % of health department. Conclusion : A systematic education of the medical tourism industry will improve the level of human resource development in the medical tourism industry, including the acquisition of international medical tourism coordinator certification, as well as the level of medical tourism industry awareness, knowledge and attitude.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.2
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• pp.151-162
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• 2014

This study proposes an optimization model to plan the patient distribution and medical resource allocation considering the diverse characteristics of disaster. For reflecting the particularity of disaster response, we configured a few scenarios such as availability of emergency surgery of non-major medical staff and the change in number of patients estimated reflecting the uncertainty, urgency and convergence of disaster. And we finally tested the effects of the scenarios' combination on the objective function defined as maximum number of survival patients. Our experimental results are expected to highlight the significance of the proposed model as well as the applicability of scenarios under disaster response.

• Parasites, Hosts and Diseases
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• v.54 no.2
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• pp.181-185
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• 2016

Human sparganosis is a zoonotic disease caused by infection with larval forms (procercoid/plerocercoid) of Spirometra spp. The purpose of this study was to identify Spirometra spp. of infected snakes using a multiplex PCR assay and phylogenetic analysis of mitochondrial DNA sequence data from the spargana of terrestrial snakes obtained from Korea and China. A total of 283 snakes were obtained that included 4 species of Colubridae comprising Rhabdophis tigrinus tigrinus (n=150), Dinodon rufozonatum rufozonatum (n=64), Elaphe davidi (n=2), and Elaphe schrenkii (n=7), and 1 species of Viperidae, Agkistrodon saxatilis (n=60). The snakes were collected from the provinces of Chungbuk, Chungnam, and Gyeongbuk in Korea (n=161), and from China (n=122). The overall infection rate with spargana was 83% (235/283). The highest was recorded for D. rufozonatum rufozonatum (100%), followed by A. saxatilis (85%) and R. tigrinus tigrinus (80%), with a negative result for E. davidi (0%) and E. schrenkii (0%). The sequence identities between the spargana from snakes (n=50) and Spirometra erinaceieuropaei (KJ599680) or S. decipiens (KJ599679) control specimens were 90.8% and 99.2%, respectively. Pairwise genetic distances between spargana (n=50) and S. decipiens ranged from 0.0080 to 0.0107, while those between spargana and S. erinaceieuropaei ranged from 0.1070 to 0.1096. In this study, all of the 904 spargana analyzed were identified as S. decipiens either by a multiplex PCR assay (n=854) or mitochondrial cox1 sequence analysis (n=50).

• Parasites, Hosts and Diseases
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• v.53 no.3
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• pp.299-305
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• 2015

Tapeworms of the genus Spirometra are pseudophyllidean cestodes endemic in Korea. At present, it is unclear which Spirometra species are responsible for causing human infections, and little information is available on the epidemiological profiles of Spirometra species infecting humans in Korea. Between 1979 and 2009, a total of 50 spargana from human patients and 2 adult specimens obtained from experimentally infected carnivorous animals were analyzed according to genetic and taxonomic criteria and classified as Spirometra erinaceieuropaei or Spirometra decipiens depending on the morphology. Morphologically, S. erinaceieuropaei and S. decipiens are different in that the spirally coiled uterus in S. erinaceieuropaei has 5-7 complete coils, while in S. decipiens it has only 4.5 coils. In addition, there is a 9.3% (146/1,566) sequence different between S. erinaceieuropaei and S. decipiens in the cox1 gene. Partial cox1 sequences (390 bp) from 35 Korean isolates showed 99.4% (388/390) similarity with the reference sequence of S. erinaceieuropaei from Korea (G1724; GenBank KJ599680) and an additional 15 Korean isolates revealed 99.2% (387/390) similarity with the reference sequences of S. decipiens from Korea (G1657; GenBank KJ599679). Based on morphologic and molecular databases, the estimated population ratio of S. erinaceieuropaei to S. decipiens was 35: 15. Our results indicate that both S. erinaceieuropaei and S. decipiens found in Korea infect humans, with S. erinaceieuropaei being 2 times more prevalent than S. decipiens. This study is the first to report human sparganosis caused by S. decipiens in humans in Korea.